SIMILAR PATTERNS OF AMINO ACIDS FOR 6HD6_B_STIB601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 VAL A 143
ILE A 209
MET A 234
GLY A 404
 None
 0.78A 6hd6B-1b8aA:
undetectable		 6hd6B-1b8aA:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 TYR A 217
ILE A  76
GLY A 143
ALA A 136
 None
 0.82A 6hd6B-1dnvA:
undetectable		 6hd6B-1dnvA:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1drt CLAVAMINATE SYNTHASE
1

(Streptomyces
clavuligerus) 		PF02668
(TauD) 		4 TYR A 120
GLY A  99
ARG A 281
ALA A 160
 None
 0.81A 6hd6B-1drtA:
undetectable		 6hd6B-1drtA:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dwa MYROSINASE MA1

(Sinapis alba) 		PF00232
(Glyco_hydro_1) 		4 VAL M  85
ILE M 133
GLY M 326
ALA M  34
 None
 0.78A 6hd6B-1dwaM:
undetectable		 6hd6B-1dwaM:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL H  20
ILE H  48
GLY H 100
ALA H  93
 None
 0.90A 6hd6B-1fptH:
undetectable		 6hd6B-1fptH:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gm5 RECG

(Thermotoga
maritima) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF17190
(RecG_N)
PF17191
(RecG_wedge) 		4 VAL A 405
ILE A 495
GLY A 348
ARG A 375
 None
 0.85A 6hd6B-1gm5A:
undetectable		 6hd6B-1gm5A:
8.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz4 NAD-DEPENDENT MALIC
ENZYME

(Homo sapiens) 		PF00390
(malic)
PF03949
(Malic_M) 		5 TYR A 434
VAL A 392
ILE A 389
GLY A 510
ALA A 444
 None
ATP  A 601 (-3.6A)
None
None
None
 1.42A 6hd6B-1gz4A:
undetectable		 6hd6B-1gz4A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hh2 N UTILIZATION
SUBSTANCE PROTEIN A

(Thermotoga
maritima) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		4 VAL P 204
ILE P 212
ARG P 232
ALA P 259
 None
 0.87A 6hd6B-1hh2P:
undetectable		 6hd6B-1hh2P:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibj CYSTATHIONINE
BETA-LYASE

(Arabidopsis
thaliana) 		PF01053
(Cys_Met_Meta_PP) 		5 VAL A 409
ILE A 332
MET A 273
ARG A 323
ALA A 276
 None
None
PLP  A1400 ( 4.7A)
None
None
 1.40A 6hd6B-1ibjA:
undetectable		 6hd6B-1ibjA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1inl SPERMIDINE SYNTHASE

(Thermotoga
maritima) 		PF01564
(Spermine_synth)
PF17284
(Spermine_synt_N) 		4 TYR A  76
VAL A 264
GLY A  99
ALA A  81
 None
 0.89A 6hd6B-1inlA:
undetectable		 6hd6B-1inlA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcn INOSINE
MONOPHOSPHATE
DEHYDROGENASE I

(Homo sapiens) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 323
ILE A 300
MET A  82
GLY A  86
 None
 0.84A 6hd6B-1jcnA:
undetectable		 6hd6B-1jcnA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 VAL A 323
ILE A 300
MET A  82
GLY A  86
 None
 0.85A 6hd6B-1jr1A:
undetectable		 6hd6B-1jr1A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 239
ILE A 264
MET A 269
GLY A 272
ARG A 313
 None
 1.01A 6hd6B-1k9aA:
26.2		 6hd6B-1k9aA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwm PROCARBOXYPEPTIDASE
B

(Homo sapiens) 		PF00246
(Peptidase_M14)
PF02244
(Propep_M14) 		4 VAL A  37
ILE A 113
GLY A   6
ALA A  20
 None
 0.86A 6hd6B-1kwmA:
undetectable		 6hd6B-1kwmA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		4 VAL A 150
ILE A 218
MET A 242
GLY A 523
 None
 0.81A 6hd6B-1l0wA:
undetectable		 6hd6B-1l0wA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1llp LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ILE A  24
GLY A 131
ARG A  43
ALA A 110
 None
None
HEM  A 350 (-3.2A)
None
 0.85A 6hd6B-1llpA:
undetectable		 6hd6B-1llpA:
11.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		4 MET A 657
GLY A 660
ARG A 723
ALA A 741
 None
 0.44A 6hd6B-1lufA:
33.9		 6hd6B-1lufA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mw5 HYPOTHETICAL PROTEIN
HI1480

(Haemophilus
influenzae) 		no annotation 4 VAL A 103
ILE A 109
ARG A 134
ALA A 143
 None
 0.77A 6hd6B-1mw5A:
undetectable		 6hd6B-1mw5A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nnv HYPOTHETICAL PROTEIN
HI1450

(Haemophilus
influenzae) 		PF04269
(DUF440) 		4 VAL A  50
MET A  24
GLY A  26
ALA A  88
 None
 0.83A 6hd6B-1nnvA:
undetectable		 6hd6B-1nnvA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o60 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Haemophilus
influenzae) 		PF00793
(DAHP_synth_1) 		4 VAL A  50
ILE A  11
GLY A 193
ALA A 234
 None
 0.69A 6hd6B-1o60A:
undetectable		 6hd6B-1o60A:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		4 VAL A  90
ILE A 101
GLY A 142
ALA A 147
 None
 0.90A 6hd6B-1ocmA:
undetectable		 6hd6B-1ocmA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 TYR A 272
VAL A 308
ILE A 332
MET A 337
GLY A 340
 P16  A   2 (-3.6A)
None
P16  A   2 (-4.1A)
None
P16  A   2 (-3.4A)
 0.75A 6hd6B-1opkA:
36.8		 6hd6B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 VAL A 308
ILE A 332
MET A 337
GLY A 340
ALA A 399
 None
P16  A   2 (-4.1A)
None
P16  A   2 (-3.4A)
P16  A   2 (-3.5A)
 0.58A 6hd6B-1opkA:
36.8		 6hd6B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pc3 PHOSPHATE-BINDING
PROTEIN 1

(Mycobacterium
tuberculosis) 		PF12849
(PBP_like_2) 		4 VAL A 338
ILE A 100
GLY A  89
ALA A 274
 None
 0.89A 6hd6B-1pc3A:
undetectable		 6hd6B-1pc3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvd PYRUVATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 TYR A 263
VAL A 208
ILE A 216
ARG A 317
ALA A 279
 None
 1.49A 6hd6B-1pvdA:
undetectable		 6hd6B-1pvdA:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2l PROTEASE III

(Escherichia
coli) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF16187
(Peptidase_M16_M) 		4 TYR A 281
VAL A 368
ILE A 456
GLY A 178
 None
 0.81A 6hd6B-1q2lA:
undetectable		 6hd6B-1q2lA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q47 SEMAPHORIN 3A

(Mus musculus) 		PF01403
(Sema) 		4 VAL A 327
ILE A 227
GLY A  72
ALA A 491
 None
 0.86A 6hd6B-1q47A:
undetectable		 6hd6B-1q47A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 ILE A  24
GLY A 131
ARG A  43
ALA A 110
 None
None
HEM  A 350 (-3.1A)
None
 0.88A 6hd6B-1qpaA:
undetectable		 6hd6B-1qpaA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qsa PROTEIN (SOLUBLE
LYTIC
TRANSGLYCOSYLASE
SLT70)

(Escherichia
coli) 		PF01464
(SLT)
PF14718
(SLT_L) 		4 VAL A 588
ILE A 474
MET A 498
GLY A 500
 None
None
SO4  A 709 ( 4.5A)
SO4  A 709 (-3.4A)
 0.83A 6hd6B-1qsaA:
undetectable		 6hd6B-1qsaA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rfz HYPOTHETICAL PROTEIN
APC35681

(Geobacillus
stearothermophilus) 		PF04608
(PgpA) 		4 VAL A 107
GLY A 125
ARG A  53
ALA A 150
 None
None
SO4  A 401 (-4.3A)
None
 0.82A 6hd6B-1rfzA:
undetectable		 6hd6B-1rfzA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rr9 ATP-DEPENDENT
PROTEASE LA

(Escherichia
coli) 		PF05362
(Lon_C) 		4 VAL A 734
ILE A 682
GLY A 631
ALA A 602
 None
 0.82A 6hd6B-1rr9A:
undetectable		 6hd6B-1rr9A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5j DNA POLYMERASE I

(Sulfolobus
solfataricus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 TYR A 306
VAL A 433
ILE A 354
GLY A 262
 None
 0.84A 6hd6B-1s5jA:
undetectable		 6hd6B-1s5jA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sb3 4-HYDROXYBENZOYL-COA
REDUCTASE ALPHA
SUBUNIT
4-HYDROXYBENZOYL-COA
REDUCTASE BETA
SUBUNIT

(Thauera
aromatica;
Thauera
aromatica) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C) 		4 VAL B 316
ILE A 635
GLY B 301
ALA B 236
 None
 0.84A 6hd6B-1sb3B:
undetectable		 6hd6B-1sb3B:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szp DNA REPAIR PROTEIN
RAD51

(Saccharomyces
cerevisiae) 		PF08423
(Rad51)
PF14520
(HHH_5) 		4 VAL A 323
ILE A 218
GLY A 103
ALA A 309
 None
 0.82A 6hd6B-1szpA:
undetectable		 6hd6B-1szpA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL B 489
ILE B 531
GLY B 740
ALA B 554
 None
None
MCN  B4921 (-3.5A)
None
 0.70A 6hd6B-1t3qB:
undetectable		 6hd6B-1t3qB:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ua4 ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
furiosus) 		PF04587
(ADP_PFK_GK) 		4 VAL A  70
ILE A  77
GLY A 111
ARG A 102
 None
None
GLC  A1457 ( 3.5A)
None
 0.85A 6hd6B-1ua4A:
undetectable		 6hd6B-1ua4A:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 VAL A 725
ILE A 796
GLY A 395
ALA A 802
 None
 0.83A 6hd6B-1ut9A:
undetectable		 6hd6B-1ut9A:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vq7 50S RIBOSOMAL
PROTEIN L30P

(Haloarcula
marismortui) 		PF00327
(Ribosomal_L30) 		5 VAL W  35
ILE W  26
GLY W 127
ARG W  42
ALA W  53
 None
None
A  01098 ( 3.1A)
None
None
 1.17A 6hd6B-1vq7W:
undetectable		 6hd6B-1vq7W:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wop AMINOMETHYLTRANSFERA
SE

(Thermotoga
maritima) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 VAL A  62
ILE A  69
GLY A 187
ALA A  81
 None
 0.73A 6hd6B-1wopA:
undetectable		 6hd6B-1wopA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0u HYPOTHETICAL
METHYLMALONYL-COA
DECARBOXYLASE ALPHA
SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01039
(Carboxyl_trans) 		4 VAL A 131
ILE A 116
GLY A  27
ALA A  43
 None
 0.90A 6hd6B-1x0uA:
undetectable		 6hd6B-1x0uA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		4 VAL A 590
ILE A 636
GLY A 612
ALA A 580
 None
 0.80A 6hd6B-1xm9A:
undetectable		 6hd6B-1xm9A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yew PARTICULATE METHANE
MONOOXYGENASE, B
SUBUNIT

(Methylococcus
capsulatus) 		PF04744
(Monooxygenase_B) 		4 VAL A  81
ILE A 118
GLY A 106
ARG A  43
 None
 0.85A 6hd6B-1yewA:
undetectable		 6hd6B-1yewA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 VAL A 282
ILE A 136
GLY A 275
ARG A 265
 None
 0.89A 6hd6B-1z6tA:
undetectable		 6hd6B-1z6tA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA

(Mycobacterium
tuberculosis) 		PF13184
(KH_5) 		4 ILE A 207
GLY A 228
ARG A 244
ALA A 234
 None
 0.83A 6hd6B-2asbA:
undetectable		 6hd6B-2asbA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d2e SUFC PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran) 		4 ILE A 205
MET A 189
GLY A 191
ALA A 196
 None
 0.90A 6hd6B-2d2eA:
undetectable		 6hd6B-2d2eA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE X  80
MET X  85
GLY X  88
ARG X 129
ALA X 147
 None
None
STU  X 902 (-3.5A)
PTR  X 160 ( 3.4A)
STU  X 902 ( 4.1A)
 0.82A 6hd6B-2dq7X:
31.6		 6hd6B-2dq7X:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dy3 ALANINE RACEMASE

(Corynebacterium
glutamicum) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 VAL A 140
ILE A 123
GLY A  58
ALA A  99
 None
 0.83A 6hd6B-2dy3A:
undetectable		 6hd6B-2dy3A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		5 TYR A 105
VAL A 233
ILE A 283
GLY A 243
ALA A 237
 None
 1.49A 6hd6B-2e7uA:
undetectable		 6hd6B-2e7uA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehj URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Escherichia
coli) 		PF14681
(UPRTase) 		4 VAL A  87
ILE A  96
GLY A 150
ALA A 126
 None
 0.91A 6hd6B-2ehjA:
undetectable		 6hd6B-2ehjA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 204
ILE A 234
GLY A 240
ALA A 319
 None
 0.73A 6hd6B-2eu9A:
15.4		 6hd6B-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew1 RAS-RELATED PROTEIN
RAB-30

(Homo sapiens) 		PF00071
(Ras) 		4 TYR A  77
VAL A 117
ILE A 106
GLY A  42
 None
 0.82A 6hd6B-2ew1A:
undetectable		 6hd6B-2ew1A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f43 ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		5 VAL A  99
ILE A 202
GLY A 207
ARG A 128
ALA A 246
 None
 1.44A 6hd6B-2f43A:
undetectable		 6hd6B-2f43A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe8 REPLICASE
POLYPROTEIN 1AB

(Severe acute
respiratory
syndrome-related
coronavirus) 		PF08715
(Viral_protease) 		4 VAL A 117
ILE A 105
GLY A  39
ALA A 150
 None
 0.86A 6hd6B-2fe8A:
undetectable		 6hd6B-2fe8A:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257

(Bacteroides
thetaiotaomicron) 		PF01661
(Macro) 		4 VAL A  18
ILE A 148
GLY A  81
ALA A  77
 None
 0.88A 6hd6B-2fg1A:
undetectable		 6hd6B-2fg1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 VAL A 542
ILE A 269
GLY A 297
ALA A 131
 None
 0.91A 6hd6B-2gq3A:
undetectable		 6hd6B-2gq3A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsk VITAMIN B12
TRANSPORTER BTUB

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 VAL A  22
ILE A 110
GLY A 369
ALA A 356
 None
 0.86A 6hd6B-2gskA:
undetectable		 6hd6B-2gskA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 ILE A 336
MET A 341
GLY A 344
ALA A 403
 H8H  A 534 ( 4.5A)
None
H8H  A 534 (-3.3A)
H8H  A 534 ( 4.0A)
 0.75A 6hd6B-2h8hA:
29.9		 6hd6B-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 MET A 341
GLY A 344
ARG A 385
ALA A 403
 None
H8H  A 534 (-3.3A)
None
H8H  A 534 ( 4.0A)
 0.48A 6hd6B-2h8hA:
29.9		 6hd6B-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 291
ILE A 314
MET A 319
GLY A 322
ALA A 381
 None
1BM  A 499 (-3.9A)
None
1BM  A 499 (-3.5A)
1BM  A 499 ( 3.7A)
 0.68A 6hd6B-2hk5A:
31.5		 6hd6B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 291
MET A 319
GLY A 322
ARG A 363
ALA A 381
 None
None
1BM  A 499 (-3.5A)
None
1BM  A 499 ( 3.7A)
 0.92A 6hd6B-2hk5A:
31.5		 6hd6B-2hk5A:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 289
ILE A 313
MET A 318
GLY A 321
ARG A 362
ALA A 380
 None
GIN  A 600 (-3.8A)
None
None
None
GIN  A 600 (-3.1A)
 0.77A 6hd6B-2hz0A:
33.9		 6hd6B-2hz0A:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0z NAD(FAD)-UTILIZING
DEHYDROGENASES

(Bacillus cereus) 		PF03486
(HI0933_like) 		4 VAL A  61
ILE A 392
MET A  16
GLY A  20
 None
 0.75A 6hd6B-2i0zA:
undetectable		 6hd6B-2i0zA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i14 NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Pyrococcus
furiosus) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 VAL A 298
GLY A 164
ARG A 121
ALA A 150
 None
 0.88A 6hd6B-2i14A:
undetectable		 6hd6B-2i14A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7x PROTEIN CFT2

(Saccharomyces
cerevisiae) 		PF16661
(Lactamase_B_6) 		4 VAL A 277
ILE A 319
MET A 250
GLY A 252
 None
 0.84A 6hd6B-2i7xA:
undetectable		 6hd6B-2i7xA:
8.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lkm MORTALITY FACTOR
4-LIKE PROTEIN 1

(Homo sapiens) 		PF05712
(MRG) 		4 TYR B 258
ILE B 193
MET B 228
GLY B 230
 None
 0.82A 6hd6B-2lkmB:
undetectable		 6hd6B-2lkmB:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 ILE A 314
MET A 319
GLY A 322
ARG A 363
ALA A 381
 1N8  A 501 ( 4.6A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
None
1N8  A 501 ( 3.3A)
 0.61A 6hd6B-2og8A:
26.2		 6hd6B-2og8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)
PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus;
Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C)
PF13361
(UvrD_C) 		4 TYR A 358
MET B 560
ARG B 602
ALA B 567
 None
 0.79A 6hd6B-2pjrA:
undetectable		 6hd6B-2pjrA:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 VAL A 309
ILE A 267
GLY A 229
ALA A 258
 None
 0.67A 6hd6B-2pwhA:
undetectable		 6hd6B-2pwhA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 VAL D 240
ILE D 285
GLY D 182
ALA D 179
 None
 0.88A 6hd6B-2qe7D:
undetectable		 6hd6B-2qe7D:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjv UNCHARACTERIZED
IOLB-LIKE PROTEIN

(Salmonella
enterica) 		PF04962
(KduI) 		4 VAL A 223
ILE A  18
GLY A 111
ALA A 245
 MLY  A 222 ( 3.1A)
MLY  A 222 ( 4.9A)
None
None
 0.80A 6hd6B-2qjvA:
undetectable		 6hd6B-2qjvA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qy0 COMPLEMENT C1R
SUBCOMPONENT

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE B 541
GLY B 578
ARG B 478
ALA B 473
 None
 0.83A 6hd6B-2qy0B:
undetectable		 6hd6B-2qy0B:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ILE A 751
MET A 756
GLY A 759
ARG A 799
 None
None
None
SO4  A   1 ( 3.1A)
 0.91A 6hd6B-2r2pA:
31.2		 6hd6B-2r2pA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxy ALIPHATIC AMIDASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 VAL A 201
ILE A 236
GLY A  98
ALA A 218
 None
 0.91A 6hd6B-2uxyA:
undetectable		 6hd6B-2uxyA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		4 VAL A 139
ILE A 351
GLY A 154
ARG A 125
 None
 0.85A 6hd6B-2v7yA:
undetectable		 6hd6B-2v7yA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		4 VAL A  26
ILE A  29
GLY A 166
ALA A 142
 None
 0.83A 6hd6B-2v7zA:
undetectable		 6hd6B-2v7zA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vos FOLYLPOLYGLUTAMATE
SYNTHASE PROTEIN
FOLC

(Mycobacterium
tuberculosis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 VAL A 174
ILE A 189
GLY A 216
ALA A  72
 None
 0.86A 6hd6B-2vosA:
undetectable		 6hd6B-2vosA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vro ALDEHYDE
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF00171
(Aldedh) 		5 TYR A 111
ILE A 106
GLY A 498
ARG A  68
ALA A 170
 None
 1.09A 6hd6B-2vroA:
undetectable		 6hd6B-2vroA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 TYR A 184
VAL A 162
ILE A 181
ALA A 231
 None
 0.87A 6hd6B-2wzsA:
undetectable		 6hd6B-2wzsA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x05 EXO-BETA-D-GLUCOSAMI
NIDASE

(Amycolatopsis
orientalis) 		PF00703
(Glyco_hydro_2)
PF02837
(Glyco_hydro_2_N) 		4 ILE A 235
GLY A 267
ARG A 454
ALA A 232
 None
 0.89A 6hd6B-2x05A:
undetectable		 6hd6B-2x05A:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x32 CELLULOSE-BINDING
PROTEIN

(Saccharophagus
degradans) 		PF04264
(YceI) 		4 VAL A  30
GLY A 109
ARG A  62
ALA A  74
 None
None
None
OTP  A1174 ( 4.9A)
 0.88A 6hd6B-2x32A:
undetectable		 6hd6B-2x32A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A  93
GLY A 101
ARG A 139
ALA A 157
 None
J60  A1294 ( 3.8A)
TPO  A 174 ( 2.9A)
J60  A1294 ( 4.2A)
 0.64A 6hd6B-2xikA:
18.3		 6hd6B-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		4 VAL A 233
GLY A 340
ARG A 176
ALA A 151
 None
 0.86A 6hd6B-2xxlA:
undetectable		 6hd6B-2xxlA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 ILE A 697
MET A 702
GLY A 705
ARG A 745
 Q9G  A1898 ( 4.6A)
None
Q9G  A1898 ( 3.8A)
None
 0.90A 6hd6B-2xyuA:
32.0		 6hd6B-2xyuA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yia RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 VAL A 488
ILE A 513
GLY A 472
ALA A 387
 None
 0.89A 6hd6B-2yiaA:
undetectable		 6hd6B-2yiaA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yib RNA-DIRECTED RNA
POLYMERASE

(Infectious
pancreatic
necrosis virus) 		PF04197
(Birna_RdRp) 		4 VAL D 488
ILE D 513
GLY D 472
ALA D 387
 None
 0.87A 6hd6B-2yibD:
undetectable		 6hd6B-2yibD:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		5 ILE A 317
MET A 322
GLY A 325
ARG A 366
ALA A 384
 None
 0.96A 6hd6B-2zv7A:
30.9		 6hd6B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		5 VAL B 239
ILE B 237
MET B 310
GLY B 309
ALA B 299
 None
 1.33A 6hd6B-3aeqB:
undetectable		 6hd6B-3aeqB:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 VAL A 561
GLY A 209
ARG A 226
ALA A 216
 None
 0.87A 6hd6B-3agrA:
undetectable		 6hd6B-3agrA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1f PUTATIVE PREPHENATE
DEHYDROGENASE

(Streptococcus
mutans) 		PF02153
(PDH) 		4 VAL A 105
ILE A  80
GLY A  12
ALA A  97
 None
None
NAD  A1001 (-3.4A)
NAD  A1001 (-4.7A)
 0.84A 6hd6B-3b1fA:
undetectable		 6hd6B-3b1fA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		5 VAL A 197
ILE A 158
GLY A  75
ARG A 311
ALA A 218
 None
 1.41A 6hd6B-3biwA:
undetectable		 6hd6B-3biwA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 MET A1160
GLY A1163
ARG A1203
ALA A1221
 None
CKK  A1500 ( 4.5A)
None
CKK  A1500 (-3.4A)
 0.57A 6hd6B-3c1xA:
29.6		 6hd6B-3c1xA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c6c 3-KETO-5-AMINOHEXANO
ATE CLEAVAGE ENZYME

(Cupriavidus
pinatubonensis) 		PF05853
(BKACE) 		4 VAL A 189
ILE A 124
GLY A 226
ALA A 223
 None
 0.89A 6hd6B-3c6cA:
undetectable		 6hd6B-3c6cA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 VAL A 239
ILE A 264
MET A 269
GLY A 272
ARG A 313
 None
 1.01A 6hd6B-3d7uA:
26.7		 6hd6B-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		4 ILE A 709
MET A 714
GLY A 717
ARG A 757
 None
None
IHZ  A1001 ( 3.9A)
None
 0.89A 6hd6B-3dkoA:
30.3		 6hd6B-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwl ACTIN-RELATED
PROTEIN 3

(Schizosaccharomyces
pombe) 		PF00022
(Actin) 		4 VAL A 374
ILE A 377
GLY A 187
ARG A 348
 None
None
ATP  A 428 (-3.2A)
None
 0.91A 6hd6B-3dwlA:
undetectable		 6hd6B-3dwlA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY

(Trichormus
variabilis) 		PF08241
(Methyltransf_11) 		4 VAL A  22
ILE A  37
GLY A  82
ALA A  42
 None
 0.88A 6hd6B-3egeA:
undetectable		 6hd6B-3egeA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euw MYO-INOSITOL
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 VAL A 190
ILE A 225
GLY A 120
ALA A 311
 None
 0.84A 6hd6B-3euwA:
undetectable		 6hd6B-3euwA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		4 VAL A 105
ILE A 145
GLY A 315
ALA A  49
 None
None
LLP  A 312 ( 4.6A)
None
 0.83A 6hd6B-3f6tA:
undetectable		 6hd6B-3f6tA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF00202
(Aminotran_3) 		4 VAL A 337
ILE A 102
GLY A 323
ALA A 328
 None
 0.87A 6hd6B-3fcrA:
undetectable		 6hd6B-3fcrA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		4 VAL A 155
ILE A 162
GLY A 211
ALA A 175
 None
 0.89A 6hd6B-3fsxA:
undetectable		 6hd6B-3fsxA:
13.21