SIMILAR PATTERNS OF AMINO ACIDS FOR 6HD6_A_STIA603_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		4 LEU A 368
TYR A 342
ILE A   7
GLY A  64
 None
HEM  A 430 (-4.2A)
None
None
 0.99A 6hd6A-1cptA:
undetectable		 6hd6A-1cptA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkp PHYTASE

(Escherichia
coli) 		PF00328
(His_Phos_2) 		4 LEU A  58
TYR A  61
ILE A 348
GLY A 373
 None
 1.07A 6hd6A-1dkpA:
undetectable		 6hd6A-1dkpA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dof ADENYLOSUCCINATE
LYASE

(Pyrobaculum
aerophilum) 		PF00206
(Lyase_1) 		4 LEU A 398
ILE A 323
MET A 129
GLY A 153
 None
 1.06A 6hd6A-1dofA:
undetectable		 6hd6A-1dofA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2z CYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		4 LEU A 246
TYR A 146
ILE A  49
GLY A  80
 None
 1.07A 6hd6A-1e2zA:
undetectable		 6hd6A-1e2zA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ik6 PYRUVATE
DEHYDROGENASE

(Pyrobaculum
aerophilum) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 LEU A 237
TYR A 214
ILE A 317
GLY A 271
 None
 0.64A 6hd6A-1ik6A:
undetectable		 6hd6A-1ik6A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE

(Thermococcus
litoralis) 		PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926) 		4 TYR A 502
ILE A 603
MET A 642
GLY A 573
 None
 1.08A 6hd6A-1k1xA:
undetectable		 6hd6A-1k1xA:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nr9 PROTEIN YCGM

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 LEU A  12
TYR A  14
ILE A  45
GLY A  95
 None
 1.05A 6hd6A-1nr9A:
undetectable		 6hd6A-1nr9A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 267
ILE A 312
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
None
None
P16  A   2 (-3.4A)
 0.86A 6hd6A-1opkA:
36.7		 6hd6A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 263
TYR A 303
ILE A 124
GLY A 158
 None
FAD  A 304 (-3.5A)
None
None
 1.05A 6hd6A-1qgzA:
undetectable		 6hd6A-1qgzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rvk ISOMERASE/LACTONIZIN
G ENZYME

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 160
TYR A 165
ILE A 278
GLY A 331
 None
 0.99A 6hd6A-1rvkA:
undetectable		 6hd6A-1rvkA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s5p NAD-DEPENDENT
DEACETYLASE

(Escherichia
coli) 		PF02146
(SIR2) 		4 LEU A 204
TYR A 201
ILE A 131
GLY A 224
 None
 1.02A 6hd6A-1s5pA:
undetectable		 6hd6A-1s5pA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v02 DHURRINASE

(Sorghum bicolor) 		PF00232
(Glyco_hydro_1) 		4 LEU A 288
ILE A 242
MET A 325
GLY A 327
 None
 0.84A 6hd6A-1v02A:
undetectable		 6hd6A-1v02A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vme FLAVOPROTEIN

(Thermotoga
maritima) 		PF00258
(Flavodoxin_1) 		4 LEU A 239
TYR A 243
ILE A  82
GLY A 172
 None
 1.05A 6hd6A-1vmeA:
undetectable		 6hd6A-1vmeA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdu TRAS1 ORF2P

(Bombyx mori) 		PF14529
(Exo_endo_phos_2) 		4 LEU A 137
ILE A 223
MET A 178
GLY A 174
 None
 1.00A 6hd6A-1wduA:
undetectable		 6hd6A-1wduA:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epk N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
gordonii) 		PF00728
(Glyco_hydro_20) 		4 LEU X 390
ILE X 331
MET X  90
GLY X 373
 None
 1.02A 6hd6A-2epkX:
undetectable		 6hd6A-2epkX:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		4 LEU A 165
TYR A 162
ILE A 125
GLY A 405
 None
 1.09A 6hd6A-2g3nA:
undetectable		 6hd6A-2g3nA:
9.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		4 LEU A 351
ILE A  38
MET A 307
GLY A 311
 None
 0.96A 6hd6A-2guuA:
undetectable		 6hd6A-2guuA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2guu ODCASE

(Plasmodium
vivax) 		PF00215
(OMPdecase) 		4 LEU A 351
ILE A 327
MET A 307
GLY A 311
 None
 0.99A 6hd6A-2guuA:
undetectable		 6hd6A-2guuA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ijd PICORNAIN 3C,
RNA-DIRECTED RNA
POLYMERASE

(Enterovirus C) 		PF00548
(Peptidase_C3)
PF00680
(RdRP_1) 		4 LEU 1 102
ILE 1  49
MET 1 160
GLY 1 159
 None
 1.03A 6hd6A-2ijd1:
undetectable		 6hd6A-2ijd1:
8.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jfq GLUTAMATE RACEMASE

(Staphylococcus
aureus) 		PF01177
(Asp_Glu_race) 		4 LEU A 190
TYR A 187
ILE A  36
GLY A 145
 None
 1.04A 6hd6A-2jfqA:
undetectable		 6hd6A-2jfqA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p17 PIRIN-LIKE PROTEIN

(Geobacillus
kaustophilus) 		PF02678
(Pirin)
PF05726
(Pirin_C) 		5 LEU A 184
TYR A 188
ILE A  60
MET A 169
GLY A 152
 None
 1.39A 6hd6A-2p17A:
undetectable		 6hd6A-2p17A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 161
TYR A 159
ILE A 330
GLY A 208
 None
 1.06A 6hd6A-2pozA:
undetectable		 6hd6A-2pozA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5e PUTATIVE SERINE
PROTEASE

(Mamastrovirus 1) 		PF13365
(Trypsin_2) 		4 LEU A 526
TYR A 521
ILE A 490
GLY A 435
 None
 1.06A 6hd6A-2w5eA:
undetectable		 6hd6A-2w5eA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww2 ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		4 LEU A 635
TYR A 636
ILE A 675
GLY A 604
 None
 0.90A 6hd6A-2ww2A:
undetectable		 6hd6A-2ww2A:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj8 PUTATIVE SKI2-TYPE
HELICASE

(Pyrococcus
furiosus) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF14520
(HHH_5) 		4 LEU A 189
ILE A 117
MET A 166
GLY A 168
 None
 0.90A 6hd6A-2zj8A:
undetectable		 6hd6A-2zj8A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c7k GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(O) SUBUNIT
ALPHA

(Mus musculus) 		PF00503
(G-alpha) 		4 LEU A 235
ILE A 265
MET A 244
GLY A 230
 None
 1.00A 6hd6A-3c7kA:
undetectable		 6hd6A-3c7kA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fse TWO-DOMAIN PROTEIN
CONTAINING
DJ-1/THIJ/PFPI-LIKE
AND FERRITIN-LIKE
DOMAINS

(Trichormus
variabilis) 		PF01965
(DJ-1_PfpI)
PF09537
(DUF2383) 		4 LEU A 332
TYR A 329
ILE A 210
GLY A 307
 None
 1.04A 6hd6A-3fseA:
undetectable		 6hd6A-3fseA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		4 LEU A 344
TYR A   4
MET A 136
GLY A 139
 None
 0.99A 6hd6A-3hfwA:
undetectable		 6hd6A-3hfwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hgq HDA1 COMPLEX SUBUNIT
3

(Saccharomyces
cerevisiae) 		PF11496
(HDA2-3) 		4 LEU A  90
ILE A 235
MET A 143
GLY A 140
 None
 0.96A 6hd6A-3hgqA:
undetectable		 6hd6A-3hgqA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 1

(Thermus
thermophilus) 		PF01512
(Complex1_51K)
PF10531
(SLBB)
PF10589
(NADH_4Fe-4S) 		4 LEU 1 300
ILE 1 394
MET 1 322
GLY 1 293
 None
 0.95A 6hd6A-3i9v1:
undetectable		 6hd6A-3i9v1:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 LEU A 309
ILE A  31
MET A  87
GLY A  84
 None
 0.99A 6hd6A-3j31A:
undetectable		 6hd6A-3j31A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j31 COAT PROTEIN

(Sulfolobus
turreted
icosahedral
virus 1) 		no annotation 4 LEU A 309
ILE A 155
MET A  87
GLY A  84
 None
 0.93A 6hd6A-3j31A:
undetectable		 6hd6A-3j31A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kmu INTEGRIN-LINKED
KINASE
ALPHA-PARVIN

(Homo sapiens;
Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF00307
(CH) 		4 LEU B 364
TYR B 368
ILE A 400
GLY B 337
 None
 0.98A 6hd6A-3kmuB:
undetectable		 6hd6A-3kmuB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l5h INTERLEUKIN-6
RECEPTOR SUBUNIT
BETA

(Homo sapiens) 		PF00041
(fn3)
PF06328
(Lep_receptor_Ig)
PF09240
(IL6Ra-bind) 		4 LEU A 392
TYR A 312
ILE A 472
GLY A 481
 None
 1.08A 6hd6A-3l5hA:
undetectable		 6hd6A-3l5hA:
9.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll9 ISOPENTENYL
PHOSPHATE KINASE

(Methanothermobacter
thermautotrophicus) 		PF00696
(AA_kinase) 		4 LEU A 228
ILE A 248
MET A 220
GLY A 222
 None
None
ADP  A 267 (-4.5A)
None
 1.08A 6hd6A-3ll9A:
undetectable		 6hd6A-3ll9A:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 LEU A 192
ILE A 237
MET A 266
GLY A 269
 AMP  A 577 ( 4.3A)
None
None
None
 0.79A 6hd6A-3nyoA:
16.1		 6hd6A-3nyoA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o8l 6-PHOSPHOFRUCTOKINAS
E, MUSCLE TYPE

(Oryctolagus
cuniculus) 		PF00365
(PFK) 		4 LEU A 711
ILE A 485
MET A 684
GLY A 680
 None
 0.89A 6hd6A-3o8lA:
undetectable		 6hd6A-3o8lA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		4 LEU A 873
TYR A 876
ILE A 844
GLY A 815
 None
 1.08A 6hd6A-3psfA:
undetectable		 6hd6A-3psfA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6v BETA-LACTAMASE

(Serratia
fonticola) 		PF00753
(Lactamase_B) 		4 LEU A 300
TYR A 297
ILE A  53
GLY A 232
 None
 0.84A 6hd6A-3q6vA:
undetectable		 6hd6A-3q6vA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 LEU A 765
TYR A 769
ILE A 469
GLY A 158
 None
 1.01A 6hd6A-3s29A:
undetectable		 6hd6A-3s29A:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6d PUTATIVE
TRIOSEPHOSPHATE
ISOMERASE

(Coccidioides
immitis) 		PF00121
(TIM) 		4 LEU A 156
ILE A 274
MET A 265
GLY A 245
 None
 1.02A 6hd6A-3s6dA:
undetectable		 6hd6A-3s6dA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si1 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Mus musculus) 		PF04389
(Peptidase_M28) 		4 LEU A 192
ILE A 124
MET A 242
GLY A 241
 None
 1.00A 6hd6A-3si1A:
undetectable		 6hd6A-3si1A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 LEU A 232
TYR A 179
ILE A 110
GLY A 175
 None
 0.99A 6hd6A-3slcA:
undetectable		 6hd6A-3slcA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		4 LEU A 310
TYR A 306
ILE A 251
GLY A 215
 None
 0.89A 6hd6A-3slcA:
undetectable		 6hd6A-3slcA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 LEU X2037
TYR X2038
MET X1925
GLY X1927
 None
 1.05A 6hd6A-3su8X:
undetectable		 6hd6A-3su8X:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 LEU A 582
TYR A 595
ILE A 398
GLY A 488
 None
 0.91A 6hd6A-3ucqA:
undetectable		 6hd6A-3ucqA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulz BRASSINOSTEROID
INSENSITIVE
1-ASSOCIATED
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 LEU A 295
ILE A 338
MET A 366
GLY A 369
 None
 1.07A 6hd6A-3ulzA:
22.4		 6hd6A-3ulzA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 LEU A 103
ILE A 232
MET A  89
GLY A  91
 None
 1.05A 6hd6A-3v9aA:
undetectable		 6hd6A-3v9aA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vse PUTATIVE
UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF10672
(Methyltrans_SAM) 		4 LEU A 339
ILE A 290
MET A 363
GLY A 364
 None
 1.05A 6hd6A-3vseA:
undetectable		 6hd6A-3vseA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3waj TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Archaeoglobus
fulgidus) 		PF02516
(STT3) 		4 LEU A 754
TYR A 755
ILE A 612
GLY A 638
 None
 1.08A 6hd6A-3wajA:
undetectable		 6hd6A-3wajA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		4 TYR A 168
ILE A  61
MET A 299
GLY A 201
 None
 0.94A 6hd6A-3wvoA:
undetectable		 6hd6A-3wvoA:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		4 LEU A 305
TYR A 313
ILE A 158
GLY A 324
 None
 1.07A 6hd6A-4at0A:
undetectable		 6hd6A-4at0A:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 LEU A 579
TYR A 592
ILE A 390
GLY A 480
 None
 0.91A 6hd6A-4aysA:
undetectable		 6hd6A-4aysA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3i FATTY ACID
BETA-OXIDATION
COMPLEX ALPHA-CHAIN
FADB

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 LEU A 353
ILE A 445
MET A 336
GLY A 339
 None
 1.06A 6hd6A-4b3iA:
undetectable		 6hd6A-4b3iA:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cw5 DFNA

(Bacillus
velezensis) 		PF03060
(NMO) 		4 LEU A 386
ILE A 556
MET A 332
GLY A 355
 FMN  A1753 (-3.2A)
None
FMN  A1753 (-3.6A)
None
 1.04A 6hd6A-4cw5A:
undetectable		 6hd6A-4cw5A:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1122
ILE A1170
MET A1199
GLY A1202
 0UV  A1501 (-3.8A)
None
None
0UV  A1501 (-3.6A)
 0.74A 6hd6A-4fodA:
30.4		 6hd6A-4fodA:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gwn MEPRIN A SUBUNIT
BETA

(Homo sapiens) 		PF00629
(MAM)
PF01400
(Astacin) 		4 LEU A 252
TYR A 253
ILE A 147
GLY A 129
 None
 0.85A 6hd6A-4gwnA:
undetectable		 6hd6A-4gwnA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxt A CONSERVED
FUNCTIONALLY UNKNOWN
PROTEIN

(Anaerococcus
prevotii) 		PF12710
(HAD) 		4 LEU A 226
TYR A 227
ILE A 192
GLY A 315
 None
 1.02A 6hd6A-4gxtA:
undetectable		 6hd6A-4gxtA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hu8 GH10 XYLANASE

(Globitermes
brachycerastes) 		PF00331
(Glyco_hydro_10)
PF02368
(Big_2) 		4 LEU A 148
TYR A 152
ILE A 295
GLY A 431
 None
 0.91A 6hd6A-4hu8A:
undetectable		 6hd6A-4hu8A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 LEU A 370
TYR A 373
ILE A  32
GLY A 180
 None
 1.08A 6hd6A-4j05A:
undetectable		 6hd6A-4j05A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5t MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Saccharomyces
cerevisiae) 		PF03200
(Glyco_hydro_63)
PF16923
(Glyco_hydro_63N) 		4 LEU A 664
ILE A 451
MET A 592
GLY A 590
 None
 1.00A 6hd6A-4j5tA:
undetectable		 6hd6A-4j5tA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5u SERINE
HYDROXYMETHYLTRANSFE
RASE

(Rickettsia
rickettsii) 		PF00464
(SHMT) 		4 LEU A 127
ILE A 251
MET A 135
GLY A 137
 None
 0.94A 6hd6A-4j5uA:
undetectable		 6hd6A-4j5uA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		4 LEU A 209
TYR A 220
ILE A  74
GLY A  58
 None
None
None
SAH  A1001 (-3.1A)
 1.05A 6hd6A-4k6mA:
undetectable		 6hd6A-4k6mA:
8.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzv EPITHELIAL CELL
ADHESION MOLECULE

(Homo sapiens) 		PF00086
(Thyroglobulin_1) 		4 LEU A  34
TYR A  32
ILE A 146
MET A  69
 None
None
DMU  A 301 (-4.6A)
None
 1.00A 6hd6A-4mzvA:
undetectable		 6hd6A-4mzvA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE

(Entamoeba
histolytica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 LEU A 130
ILE A 220
MET A 113
GLY A 117
 None
 1.08A 6hd6A-4nfyA:
undetectable		 6hd6A-4nfyA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovk PERIPLASMIC BINDING
PROTEIN

(Veillonella
parvula) 		PF01497
(Peripla_BP_2) 		4 LEU A 331
TYR A 329
MET A 314
GLY A 318
 None
 1.03A 6hd6A-4ovkA:
undetectable		 6hd6A-4ovkA:
14.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		4 LEU A  14
ILE A  55
MET A  84
GLY A  87
 ACP  A1264 ( 4.5A)
None
None
ACP  A1264 (-3.5A)
 0.84A 6hd6A-4ueuA:
22.4		 6hd6A-4ueuA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		4 LEU A 193
ILE A 238
MET A 267
GLY A 270
 ANW  A 601 ( 4.0A)
None
None
ANW  A 601 ( 4.5A)
 0.78A 6hd6A-4wboA:
16.1		 6hd6A-4wboA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzz PUTATIVE SUGAR ABC
TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF13407
(Peripla_BP_4) 		4 LEU A 329
TYR A 335
ILE A 113
GLY A 350
 None
 1.03A 6hd6A-4wzzA:
undetectable		 6hd6A-4wzzA:
13.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 LEU B 267
ILE B 312
MET B 337
GLY B 340
 1N1  B 601 (-3.7A)
None
None
1N1  B 601 (-3.5A)
 0.98A 6hd6A-4xeyB:
34.3		 6hd6A-4xeyB:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 LEU A 261
TYR A 237
ILE A 170
GLY A 145
 None
 0.99A 6hd6A-4y23A:
undetectable		 6hd6A-4y23A:
10.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yu9 GLUTAMINYL-PEPTIDE
CYCLOTRANSFERASE

(Homo sapiens) 		PF04389
(Peptidase_M28) 		4 LEU A 191
ILE A 123
MET A 241
GLY A 240
 None
 1.05A 6hd6A-4yu9A:
undetectable		 6hd6A-4yu9A:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z5y COENZYME PQQ
SYNTHESIS PROTEIN B

(Pseudomonas
putida) 		PF12706
(Lactamase_B_2) 		4 LEU A 217
ILE A 140
MET A 210
GLY A 213
 None
 0.97A 6hd6A-4z5yA:
undetectable		 6hd6A-4z5yA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ere EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Desulfohalobium
retbaense) 		PF13458
(Peripla_BP_6) 		4 LEU A 324
TYR A 265
ILE A 216
GLY A 287
 None
 0.96A 6hd6A-5ereA:
0.7		 6hd6A-5ereA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eul PROTEIN TRANSLOCASE
SUBUNIT SECY

(Geobacillus
thermodenitrificans) 		PF00344
(SecY) 		4 TYR Y 149
ILE Y  34
MET Y 128
GLY Y 131
 None
 1.02A 6hd6A-5eulY:
undetectable		 6hd6A-5eulY:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5evi BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00144
(Beta-lactamase) 		4 LEU B 282
ILE B 118
MET B 264
GLY B 263
 None
 1.08A 6hd6A-5eviB:
undetectable		 6hd6A-5eviB:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsl 778AA LONG
HYPOTHETICAL
BETA-GALACTOSIDASE

(Pyrococcus
horikoshii) 		PF02449
(Glyco_hydro_42) 		4 LEU A 382
TYR A 381
ILE A 162
GLY A 104
 None
PO4  A 802 (-4.2A)
None
PO4  A 802 (-3.9A)
 1.03A 6hd6A-5gslA:
undetectable		 6hd6A-5gslA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		4 LEU A 380
TYR A 379
ILE A 160
GLY A 102
 None
GCS  A 801 (-4.2A)
None
GCS  A 801 (-3.4A)
 0.98A 6hd6A-5gsmA:
undetectable		 6hd6A-5gsmA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxd AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Dinoroseobacter
shibae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		4 LEU A 237
TYR A 235
ILE A 303
GLY A 394
 None
 1.05A 6hd6A-5gxdA:
undetectable		 6hd6A-5gxdA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		4 LEU A   6
TYR A 474
ILE A 399
GLY A  42
 None
 1.05A 6hd6A-5h42A:
undetectable		 6hd6A-5h42A:
5.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy3 MRNA
ENDORIBONUCLEASE
LSOA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		4 LEU A 253
TYR A 250
ILE A 329
GLY A 266
 None
 1.05A 6hd6A-5hy3A:
undetectable		 6hd6A-5hy3A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzr SNF2-FAMILY ATP
DEPENDENT CHROMATIN
REMODELING FACTOR
LIKE PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C)
PF14619
(SnAC) 		4 LEU A 790
ILE A 881
MET A 581
GLY A 584
 None
None
SO4  A1206 (-3.9A)
SO4  A1206 (-3.6A)
 1.07A 6hd6A-5hzrA:
undetectable		 6hd6A-5hzrA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 LEU A 472
ILE A 452
MET A 522
GLY A 519
 None
None
ID8  A 601 (-4.2A)
None
 1.07A 6hd6A-5ikrA:
undetectable		 6hd6A-5ikrA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 TYR A 475
ILE A 452
MET A 522
GLY A 519
 None
None
ID8  A 601 (-4.2A)
None
 1.06A 6hd6A-5ikrA:
undetectable		 6hd6A-5ikrA:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjh 4-ALPHA-GLUCANOTRANS
FERASE

(Corynebacterium
glutamicum) 		PF02446
(Glyco_hydro_77) 		4 LEU A 611
TYR A 616
ILE A 574
GLY A 625
 None
 1.01A 6hd6A-5jjhA:
undetectable		 6hd6A-5jjhA:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9h 0940_GH29

(unidentified) 		PF00754
(F5_F8_type_C)
PF01120
(Alpha_L_fucos) 		4 LEU A 149
TYR A 153
ILE A 308
MET A  82
 None
 0.95A 6hd6A-5k9hA:
undetectable		 6hd6A-5k9hA:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc9 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-1

(Mus musculus) 		PF01094
(ANF_receptor) 		4 LEU A 321
TYR A 322
ILE A 396
GLY A 379
 CL  A 518 ( 4.9A)
None
None
None
 1.09A 6hd6A-5kc9A:
undetectable		 6hd6A-5kc9A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		4 LEU b 108
TYR b 200
ILE b 228
GLY b  77
 None
 1.08A 6hd6A-5l9wb:
undetectable		 6hd6A-5l9wb:
10.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		4 LEU A   9
ILE A  51
MET A  34
GLY A 223
 None
 0.91A 6hd6A-5mzyA:
undetectable		 6hd6A-5mzyA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5syd AZURIN, CHIMERIC
CONSTRUCT

(Pseudomonas
aeruginosa) 		PF00127
(Copper-bind) 		4 LEU A  28
TYR A  32
ILE A 100
MET A   4
 None
 0.99A 6hd6A-5sydA:
undetectable		 6hd6A-5sydA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 LEU A 333
TYR A 329
ILE A 116
GLY A 291
 None
 1.08A 6hd6A-5tulA:
undetectable		 6hd6A-5tulA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ws4 MACROLIDE EXPORT
ATP-BINDING/PERMEASE
PROTEIN MACB

(Acinetobacter
baumannii) 		no annotation 4 LEU A  85
TYR A  89
ILE A 216
GLY A  71
 None
 1.09A 6hd6A-5ws4A:
undetectable		 6hd6A-5ws4A:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ww1 PULULLANASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A  56
TYR A  57
ILE A  35
GLY A  44
 None
 0.84A 6hd6A-5ww1A:
undetectable		 6hd6A-5ww1A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xne -

(-) 		no annotation 4 LEU B 225
ILE B  64
MET B  28
GLY B 184
 None
 0.91A 6hd6A-5xneB:
undetectable		 6hd6A-5xneB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xsy SODIUM CHANNEL
PROTEIN

(Electrophorus
electricus) 		PF00520
(Ion_trans)
PF06512
(Na_trans_assoc) 		4 LEU A 727
ILE A 751
MET A 732
GLY A 711
 None
 1.03A 6hd6A-5xsyA:
2.9		 6hd6A-5xsyA:
3.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 4 LEU A  54
ILE A 261
MET A 360
GLY A  59
 None
 1.07A 6hd6A-5ygrA:
undetectable		 6hd6A-5ygrA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 4 LEU A  63
ILE A 106
MET A  35
GLY A  37
 None
 0.85A 6hd6A-6cauA:
undetectable		 6hd6A-6cauA:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 4 LEU B1004
ILE B 767
MET B 931
GLY B1007
 None
 1.03A 6hd6A-6f42B:
undetectable		 6hd6A-6f42B:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4e CATALYTIC DOMAIN OF
BOTULINUM NEUROTOXIN
X

(Clostridium
botulinum) 		no annotation 4 LEU A 297
TYR A 294
ILE A 253
GLY A 180
 None
 0.87A 6hd6A-6f4eA:
undetectable		 6hd6A-6f4eA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 4 LEU A 247
TYR A   9
ILE A 151
GLY A  85
 None
 0.89A 6hd6A-6f9mA:
undetectable		 6hd6A-6f9mA:
12.35