SIMILAR PATTERNS OF AMINO ACIDS FOR 6HD4_B_STIB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 LEU A  77
VAL A  63
PHE A 418
GLY A 131
 None
 0.98A 6hd4B-1ad3A:
undetectable		 6hd4B-1ad3A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus gallus) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 LEU A 797
VAL A 833
PHE A 677
GLY A 871
 None
 0.99A 6hd4B-1efyA:
undetectable		 6hd4B-1efyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU A 103
TYR A 364
VAL A 205
PHE A 355
 None
 1.02A 6hd4B-1f82A:
undetectable		 6hd4B-1f82A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 LEU A 373
VAL A 250
PHE A 358
GLY A  15
 None
None
None
SAH  A 392 (-3.1A)
 0.90A 6hd4B-1g55A:
undetectable		 6hd4B-1g55A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		4 LEU A  84
VAL A  42
PHE A 272
GLY A 170
 None
 1.01A 6hd4B-1jjfA:
undetectable		 6hd4B-1jjfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 LEU A 347
VAL A 375
PHE A 369
GLY A 352
 None
 0.85A 6hd4B-1l5jA:
undetectable		 6hd4B-1l5jA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 LEU A  32
TYR A   4
VAL A   9
GLY A 387
 None
None
FAD  A2457 ( 4.7A)
None
 0.96A 6hd4B-1lqtA:
undetectable		 6hd4B-1lqtA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 LEU A 206
VAL A 263
PHE A 185
GLY A 182
 None
 1.01A 6hd4B-1lwhA:
undetectable		 6hd4B-1lwhA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
TYR A 272
VAL A 308
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
None
None
P16  A   2 (-3.4A)
 0.84A 6hd4B-1opkA:
36.9		 6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
VAL A 308
PHE A 336
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
None
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
 0.56A 6hd4B-1opkA:
36.9		 6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A  14
TYR A  15
VAL A  99
GLY A  50
 None
None
FAD  A 304 (-3.8A)
None
 0.97A 6hd4B-1qgzA:
undetectable		 6hd4B-1qgzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 409
PHE A 437
MET A 438
GLY A 441
 None
 0.76A 6hd4B-1snxA:
29.5		 6hd4B-1snxA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 LEU A 334
VAL A 242
PHE A 327
GLY A 255
 None
 0.96A 6hd4B-1vbgA:
2.3		 6hd4B-1vbgA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc2 ENDOGLUCANASE

(Mytilus edulis) 		no annotation 4 TYR A 173
VAL A 140
PHE A  41
GLY A  31
 None
 1.01A 6hd4B-1wc2A:
undetectable		 6hd4B-1wc2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wm6 PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAI

(Thermus
thermophilus) 		PF03061
(4HBT) 		4 LEU A   9
VAL A 114
PHE A  42
GLY A  25
 None
 0.99A 6hd4B-1wm6A:
undetectable		 6hd4B-1wm6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 LEU A 163
VAL A  77
PHE A 181
MET A 182
GLY A 151
 None
 1.45A 6hd4B-2bb0A:
undetectable		 6hd4B-2bb0A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 219
VAL A 225
MET A  67
GLY A  71
 None
 0.97A 6hd4B-2cu0A:
undetectable		 6hd4B-2cu0A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 LEU A  93
VAL A 169
MET A  86
GLY A  88
 None
 1.02A 6hd4B-2go7A:
undetectable		 6hd4B-2go7A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
PHE A 340
MET A 341
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
 0.75A 6hd4B-2hckA:
29.4		 6hd4B-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 291
PHE A 318
MET A 319
GLY A 322
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 0.95A 6hd4B-2hk5A:
26.5		 6hd4B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A  18
VAL A  32
PHE A  51
GLY A  48
 None
 1.03A 6hd4B-2hpiA:
undetectable		 6hd4B-2hpiA:
5.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
PHE A 317
MET A 318
GLY A 321
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-4.3A)
None
None
 0.54A 6hd4B-2hz0A:
33.9		 6hd4B-2hz0A:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN

(Thermus
aquaticus) 		PF00436
(SSB) 		4 LEU A 196
VAL A  78
MET A   1
GLY A   4
 None
 1.05A 6hd4B-2ihfA:
undetectable		 6hd4B-2ihfA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		4 LEU A 339
VAL A 229
PHE A 176
GLY A 332
 None
 0.98A 6hd4B-2obmA:
undetectable		 6hd4B-2obmA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 TYR A 120
VAL A  29
PHE A  80
GLY A 263
 None
 1.04A 6hd4B-2p3xA:
undetectable		 6hd4B-2p3xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		4 LEU A  25
TYR A  10
VAL A  44
GLY A  20
 None
NAD  A 601 (-4.6A)
None
None
 1.04A 6hd4B-2qjoA:
undetectable		 6hd4B-2qjoA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		4 LEU A 173
VAL A 216
PHE A 190
GLY A 166
 None
 1.06A 6hd4B-2qpqA:
undetectable		 6hd4B-2qpqA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 121
PHE B 149
MET B 150
GLY B 153
 None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
 0.87A 6hd4B-2wtkB:
21.7		 6hd4B-2wtkB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 263
VAL A 349
MET A 271
GLY A 268
 None
 1.03A 6hd4B-2z6hA:
undetectable		 6hd4B-2z6hA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1002
VAL A1050
MET A1079
GLY A1082
 S91  A   1 ( 4.1A)
None
None
S91  A   1 (-3.3A)
 0.71A 6hd4B-2z8cA:
22.2		 6hd4B-2z8cA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 253
PHE A 321
MET A 322
GLY A 325
 None
 0.76A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU C 163
TYR C 164
PHE C 130
GLY C 160
 None
 1.05A 6hd4B-3aizC:
undetectable		 6hd4B-3aizC:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 165
PHE A  93
MET A  94
GLY A  96
 None
3AM  A 338 ( 4.6A)
None
None
 0.64A 6hd4B-3c0iA:
23.2		 6hd4B-3c0iA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 LEU A 300
TYR A 200
VAL A 267
GLY A 377
 None
 1.01A 6hd4B-3caiA:
undetectable		 6hd4B-3caiA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 LEU A 116
VAL A 278
PHE A  67
GLY A  33
 None
 1.03A 6hd4B-3d45A:
undetectable		 6hd4B-3d45A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 LEU A 344
TYR A   4
VAL A 323
MET A 136
GLY A 139
 None
 1.20A 6hd4B-3hfwA:
undetectable		 6hd4B-3hfwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 LEU A   3
VAL A 600
PHE A 247
GLY A 218
 None
 0.98A 6hd4B-3hjeA:
undetectable		 6hd4B-3hjeA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		4 LEU A 341
TYR A 313
VAL A 289
GLY A 224
 None
 0.99A 6hd4B-3i32A:
undetectable		 6hd4B-3i32A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 258
TYR A 254
VAL A 162
GLY A 155
 None
 1.02A 6hd4B-3iayA:
undetectable		 6hd4B-3iayA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kys TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-1

(Homo sapiens) 		no annotation 4 LEU A 258
TYR A 248
PHE A 270
GLY A 263
 None
 0.98A 6hd4B-3kysA:
undetectable		 6hd4B-3kysA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1005
VAL A1053
MET A1082
GLY A1085
 None
 0.52A 6hd4B-3lw0A:
31.4		 6hd4B-3lw0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		4 LEU B 349
VAL B 227
PHE B 336
GLY B 380
 None
 0.97A 6hd4B-3pr2B:
undetectable		 6hd4B-3pr2B:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A  84
TYR A  81
VAL A  12
GLY A  91
 None
None
NAP  A 372 (-3.7A)
None
 1.04A 6hd4B-3pzrA:
undetectable		 6hd4B-3pzrA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ray PR DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		PF00856
(SET) 		4 LEU A 154
VAL A 120
PHE A  98
GLY A  95
 None
 0.96A 6hd4B-3rayA:
undetectable		 6hd4B-3rayA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 LEU A 293
TYR A 297
VAL A  66
GLY A 286
 None
 0.83A 6hd4B-3rc0A:
undetectable		 6hd4B-3rc0A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 LEU L 321
VAL L 502
MET L 407
GLY L 405
 None
 0.98A 6hd4B-3rkoL:
2.6		 6hd4B-3rkoL:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  89
VAL A 157
PHE A 292
MET A 135
GLY A 134
 None
 1.43A 6hd4B-3sszA:
undetectable		 6hd4B-3sszA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  66
VAL A 134
PHE A 269
MET A 112
GLY A 111
 None
 1.43A 6hd4B-3stpA:
undetectable		 6hd4B-3stpA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A  77
VAL A  63
PHE A 418
GLY A 131
 None
 0.89A 6hd4B-3szbA:
undetectable		 6hd4B-3szbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 LEU B  90
VAL B 140
MET B 132
GLY B 124
 None
 0.94A 6hd4B-3u9rB:
undetectable		 6hd4B-3u9rB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 250
VAL A 286
PHE A 332
GLY A 329
 None
 0.99A 6hd4B-3u9sA:
undetectable		 6hd4B-3u9sA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 298
VAL A 286
PHE A 331
GLY A 303
 None
 0.93A 6hd4B-3u9sA:
undetectable		 6hd4B-3u9sA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 427
TYR A  11
VAL A 135
GLY A  61
 None
 0.94A 6hd4B-3v4pA:
undetectable		 6hd4B-3v4pA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A 646
VAL A 522
PHE A 622
GLY A 618
 None
 0.95A 6hd4B-3wdjA:
undetectable		 6hd4B-3wdjA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		4 TYR A 149
VAL A  41
PHE A  60
GLY A 205
 None
 1.06A 6hd4B-3zbmA:
undetectable		 6hd4B-3zbmA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 LEU A 314
VAL A 348
PHE A 262
GLY A 259
 None
 1.07A 6hd4B-4e4jA:
undetectable		 6hd4B-4e4jA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU A 369
VAL A 297
PHE A 395
GLY A 458
 None
 0.97A 6hd4B-4eqvA:
undetectable		 6hd4B-4eqvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.57A 6hd4B-4eutA:
18.6		 6hd4B-4eutA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.53A 6hd4B-4euuA:
15.0		 6hd4B-4euuA:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 514
PHE A 595
MET A 596
GLY A 599
 0T8  A 901 (-3.6A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
 0.62A 6hd4B-4feqA:
22.2		 6hd4B-4feqA:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 428
TYR A 429
PHE A 367
GLY A 111
 None
 0.89A 6hd4B-4h7uA:
undetectable		 6hd4B-4h7uA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		4 LEU A   7
VAL A 223
MET A 164
GLY A 138
 None
None
None
CA  A 401 ( 4.2A)
 1.06A 6hd4B-4i70A:
undetectable		 6hd4B-4i70A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 LEU A1210
VAL A1048
PHE A1177
GLY A1156
 None
 0.93A 6hd4B-4igiA:
undetectable		 6hd4B-4igiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 145
TYR A 142
VAL A 172
PHE A  36
 None
 1.02A 6hd4B-4ki9A:
undetectable		 6hd4B-4ki9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9z MALYL-COA LYASE

(Rhodobacter
sphaeroides) 		PF03328
(HpcH_HpaI) 		4 LEU A 164
VAL A  47
PHE A 169
GLY A 145
 None
 0.94A 6hd4B-4l9zA:
undetectable		 6hd4B-4l9zA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 313
MET A 341
GLY A 344
 VGG  A 601 (-3.2A)
None
None
VGG  A 601 ( 3.2A)
 1.06A 6hd4B-4lggA:
29.7		 6hd4B-4lggA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4neg TRYPTOPHAN SYNTHASE
BETA CHAIN

(Bacillus
anthracis) 		PF00291
(PALP) 		4 LEU A 353
VAL A 231
PHE A 340
GLY A 383
 None
 0.87A 6hd4B-4negA:
undetectable		 6hd4B-4negA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR) 		4 LEU C 797
VAL C 833
PHE C 677
GLY C 871
 None
 0.88A 6hd4B-4oqaC:
undetectable		 6hd4B-4oqaC:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd4 CYTOCHROME B

(Saccharomyces
cerevisiae) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 LEU C 275
TYR C 274
VAL C 194
PHE C 129
 AOQ  C4003 (-3.8A)
None
HEM  C4002 (-4.4A)
AOQ  C4003 (-4.6A)
 0.88A 6hd4B-4pd4C:
undetectable		 6hd4B-4pd4C:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9o ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 TYR A  70
VAL A  64
PHE A 184
GLY A 149
 None
 0.96A 6hd4B-4q9oA:
undetectable		 6hd4B-4q9oA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA

(Aspergillus
fumigatus) 		PF07938
(Fungal_lectin) 		4 LEU A 281
VAL A  74
PHE A 220
GLY A 272
 None
 1.06A 6hd4B-4uouA:
undetectable		 6hd4B-4uouA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 LEU A 490
TYR A 487
VAL A 471
PHE A 440
MET A 439
 None
 1.47A 6hd4B-4uplA:
undetectable		 6hd4B-4uplA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C) 		PF07652
(Flavi_DEAD) 		4 LEU A 414
VAL A 331
PHE A 422
GLY A 420
 None
 1.00A 6hd4B-4wxpA:
undetectable		 6hd4B-4wxpA:
10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 267
VAL B 308
PHE B 336
MET B 337
GLY B 340
 1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
 0.74A 6hd4B-4xeyB:
34.1		 6hd4B-4xeyB:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		4 LEU A  20
VAL A 108
MET A 365
GLY A 362
 None
 1.03A 6hd4B-4xuvA:
undetectable		 6hd4B-4xuvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU A  37
PHE A 373
MET A 374
GLY A 376
 None
 1.05A 6hd4B-4xyiA:
undetectable		 6hd4B-4xyiA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypt REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF08715
(Viral_protease) 		4 LEU A1845
TYR A1906
PHE A1840
GLY A1818
 None
 0.91A 6hd4B-4yptA:
undetectable		 6hd4B-4yptA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 257
VAL A 386
PHE A 227
GLY A 247
 None
 1.05A 6hd4B-5ahkA:
undetectable		 6hd4B-5ahkA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		4 LEU A 217
VAL A 223
MET A  61
GLY A  65
 None
 1.01A 6hd4B-5ahmA:
undetectable		 6hd4B-5ahmA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 217
VAL A 223
MET A  61
GLY A  65
 None
 1.02A 6hd4B-5ahnA:
undetectable		 6hd4B-5ahnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 VAL A 127
PHE A 193
MET A 192
GLY A 190
 None
 0.98A 6hd4B-5aydA:
undetectable		 6hd4B-5aydA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 LEU A 247
VAL A  64
PHE A 163
GLY A 286
 None
HEM  A 502 (-4.0A)
None
None
 1.07A 6hd4B-5djqA:
undetectable		 6hd4B-5djqA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 102
TYR A 106
VAL A  71
GLY A  81
 None
 0.85A 6hd4B-5dzqA:
undetectable		 6hd4B-5dzqA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqj TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Saccharomyces
cerevisiae) 		PF04189
(Gcd10p) 		4 LEU A 252
TYR A 249
PHE A 291
GLY A 258
 None
 0.97A 6hd4B-5eqjA:
undetectable		 6hd4B-5eqjA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		5 LEU A 320
TYR A 134
VAL A  14
PHE A 318
GLY A 312
 None
 1.43A 6hd4B-5f1yA:
undetectable		 6hd4B-5f1yA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		4 LEU J  24
TYR J  21
VAL C 235
GLY J  33
 None
 0.94A 6hd4B-5ip7J:
undetectable		 6hd4B-5ip7J:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE

(Thermotoga
maritima) 		PF01553
(Acyltransferase) 		4 LEU A  92
VAL A 181
PHE A  96
GLY A  53
 None
 1.06A 6hd4B-5kymA:
2.2		 6hd4B-5kymA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		4 LEU A 246
VAL A 148
PHE A 391
GLY A 278
 None
 0.87A 6hd4B-5l1tA:
undetectable		 6hd4B-5l1tA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		4 VAL A2225
PHE A2257
MET A2256
GLY A2167
 None
 1.07A 6hd4B-5mc9A:
undetectable		 6hd4B-5mc9A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 4 LEU B 615
VAL B 585
PHE B 686
GLY B 618
 None
 0.98A 6hd4B-5my0B:
undetectable		 6hd4B-5my0B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 4 LEU A 113
VAL A 119
MET A  82
GLY A  86
 None
 1.06A 6hd4B-5ou3A:
undetectable		 6hd4B-5ou3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 593
PHE A 673
MET A 674
GLY A 677
 7AE  A1000 ( 3.9A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
 0.60A 6hd4B-5td2A:
28.4		 6hd4B-5td2A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 542
PHE A 622
MET A 623
GLY A 626
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 0.48A 6hd4B-5u6bA:
29.5		 6hd4B-5u6bA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP0

(Hepatovirus A) 		PF00073
(Rhv) 		4 LEU B 141
TYR B 144
VAL B  84
GLY B 136
 None
 0.85A 6hd4B-5wtfB:
undetectable		 6hd4B-5wtfB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0e FREE SERINE KINASE

(Thermococcus
kodakarensis) 		PF02195
(ParBc) 		4 LEU A 110
VAL A  33
PHE A 149
GLY A 145
 None
 1.05A 6hd4B-5x0eA:
undetectable		 6hd4B-5x0eA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xst POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 4 LEU A 136
VAL A 172
PHE A  16
GLY A 210
 None
 0.95A 6hd4B-5xstA:
undetectable		 6hd4B-5xstA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgd GLUCOSE/GALACTOSE-BI
NDING LIPOPROTEIN

(Treponema
pallidum) 		no annotation 4 LEU A 209
VAL A 130
MET A 175
GLY A 178
 None
 1.02A 6hd4B-6bgdA:
undetectable		 6hd4B-6bgdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 275
VAL A 315
PHE A 345
MET A 346
GLY A 349
 FE7  A 601 (-3.8A)
None
FE7  A 601 (-4.5A)
FE7  A 601 (-4.7A)
FE7  A 601 ( 3.7A)
 1.22A 6hd4B-6cthA:
21.7		 6hd4B-6cthA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 LEU A2878
VAL A2776
MET A2854
GLY A2856
 None
 0.89A 6hd4B-6ez8A:
undetectable		 6hd4B-6ez8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 4 LEU A 247
TYR A   9
VAL A 204
GLY A  85
 None
None
PGE  A 401 (-4.5A)
None
 1.02A 6hd4B-6f9mA:
undetectable		 6hd4B-6f9mA:
12.35