SIMILAR PATTERNS OF AMINO ACIDS FOR 6HD4_B_STIB602

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
LEU A 321
 None
 0.67A 6hd4B-1k9aA:
26.8		 6hd4B-1k9aA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
 None
 0.63A 6hd4B-1k9aA:
26.8		 6hd4B-1k9aA:
16.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 606
LYS A 608
MET A 629
VAL A 638
LEU A 731
ALA A 741
ASP A 742
 None
 1.18A 6hd4B-1lufA:
34.0		 6hd4B-1lufA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
LYS A 608
VAL A 638
LEU A 731
ALA A 741
ASP A 742
 None
 0.89A 6hd4B-1lufA:
34.0		 6hd4B-1lufA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 VAL A 275
ALA A 288
GLU A 305
MET A 309
ILE A 312
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.64A 6hd4B-1opkA:
36.9		 6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 312
VAL A 318
ILE A 332
THR A 334
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-3.5A)
 0.70A 6hd4B-1opkA:
36.9		 6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.55A 6hd4B-1t46A:
28.2		 6hd4B-1t46A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.56A 6hd4B-1u59A:
29.5		 6hd4B-1u59A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
ALA X 147
ASP X 148
 STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.97A 6hd4B-2dq7X:
31.6		 6hd4B-2dq7X:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL X  25
ALA X  37
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.64A 6hd4B-2dq7X:
31.6		 6hd4B-2dq7X:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
 0.52A 6hd4B-2dq7X:
31.6		 6hd4B-2dq7X:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 170
ALA A 184
GLU A 201
VAL A 220
ILE A 234
LEU A 290
ALA A 319
 None
 0.60A 6hd4B-2eu9A:
21.1		 6hd4B-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 170
ALA A 184
LYS A 186
GLU A 201
ILE A 208
ILE A 234
LEU A 290
ALA A 319
 None
 0.82A 6hd4B-2eu9A:
21.1		 6hd4B-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.89A 6hd4B-2h8hA:
30.0		 6hd4B-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.93A 6hd4B-2hckA:
29.4		 6hd4B-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.01A 6hd4B-2hk5A:
26.5		 6hd4B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.64A 6hd4B-2hk5A:
26.5		 6hd4B-2hk5A:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
MET A 290
ILE A 293
VAL A 299
ILE A 313
THR A 315
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.79A 6hd4B-2hz0A:
33.9		 6hd4B-2hz0A:
92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 256
ALA A 269
GLU A 286
MET A 290
ILE A 293
VAL A 299
ILE A 313
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.56A 6hd4B-2hz0A:
33.9		 6hd4B-2hz0A:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.71A 6hd4B-2j0jA:
31.6		 6hd4B-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
ASP A 564
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
None
None
None
None
 0.94A 6hd4B-2jkmA:
31.4		 6hd4B-2jkmA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
None
None
None
None
BII  A1687 (-4.2A)
 0.82A 6hd4B-2jkmA:
31.4		 6hd4B-2jkmA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.60A 6hd4B-2og8A:
15.4		 6hd4B-2og8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
ASP A 796
 None
 0.91A 6hd4B-2ogvA:
22.2		 6hd4B-2ogvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
LEU A 785
 None
 0.83A 6hd4B-2ogvA:
22.2		 6hd4B-2ogvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
ALA A 853
LYS A 855
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.6A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.56A 6hd4B-2p4iA:
23.9		 6hd4B-2p4iA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.62A 6hd4B-2psqA:
31.0		 6hd4B-2psqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.02A 6hd4B-2qobA:
26.2		 6hd4B-2qobA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
ASP A 818
 None
 0.99A 6hd4B-2r2pA:
25.7		 6hd4B-2r2pA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.79A 6hd4B-2xikA:
18.3		 6hd4B-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.3A)
None
 0.78A 6hd4B-2xyuA:
32.1		 6hd4B-2xyuA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
MET A 294
VAL A 303
THR A 319
ASP A 385
 None
 1.08A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
VAL A 303
ILE A 317
THR A 319
ASP A 385
 None
 0.88A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
MET A 294
VAL A 303
THR A 319
ALA A 384
ASP A 385
 None
 1.09A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
MET A 294
VAL A 303
THR A 319
LEU A 374
ALA A 384
 None
 1.09A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
VAL A 303
ILE A 317
THR A 319
ALA A 384
ASP A 385
 None
 0.70A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
VAL A 303
ILE A 317
THR A 319
LEU A 374
ALA A 384
 None
 0.82A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.68A 6hd4B-3c4fA:
30.9		 6hd4B-3c4fA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 492
ALA A 512
LYS A 514
GLU A 531
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.59A 6hd4B-3c4fA:
30.9		 6hd4B-3c4fA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
LEU A 321
 None
 0.67A 6hd4B-3d7uA:
26.8		 6hd4B-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
 None
 0.63A 6hd4B-3d7uA:
26.8		 6hd4B-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.77A 6hd4B-3dkoA:
30.3		 6hd4B-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
LYS A 665
VAL A 695
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.72A 6hd4B-3dkoA:
30.3		 6hd4B-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  67
ALA A  80
LYS A  82
VAL A 113
ILE A 127
LEU A 186
 None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
None
None
STU  A   1 (-4.4A)
 0.58A 6hd4B-3fmeA:
16.7		 6hd4B-3fmeA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
LYS A  53
GLU A  71
THR A 106
ASP A 168
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
 0.58A 6hd4B-3gp0A:
21.8		 6hd4B-3gp0A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.88A 6hd4B-3hngA:
32.6		 6hd4B-3hngA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.74A 6hd4B-3iecA:
22.1		 6hd4B-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
LEU A 182
ALA A 192
 None
 0.77A 6hd4B-3iecA:
22.1		 6hd4B-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
LEU A 767
 None
 0.67A 6hd4B-3kulA:
31.1		 6hd4B-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
 None
 0.85A 6hd4B-3kulA:
31.1		 6hd4B-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.63A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
 0.67A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 628
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.5A)
 1.15A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
 0.64A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 VAL A 565
ALA A 576
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.75A 6hd4B-3ppzA:
28.4		 6hd4B-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.66A 6hd4B-3sxsA:
24.9		 6hd4B-3sxsA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.73A 6hd4B-3tt0A:
30.1		 6hd4B-3tt0A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.76A 6hd4B-3vidA:
29.7		 6hd4B-3vidA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.8A)
 0.62A 6hd4B-3wzdA:
30.5		 6hd4B-3wzdA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.79A 6hd4B-4agdA:
26.1		 6hd4B-4agdA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
GLU A  81
VAL A  94
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.69A 6hd4B-4bc6A:
21.1		 6hd4B-4bc6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
LYS A  65
ILE A  84
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
None
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 1.14A 6hd4B-4bc6A:
21.1		 6hd4B-4bc6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
LYS A  65
VAL A  94
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.78A 6hd4B-4bc6A:
21.1		 6hd4B-4bc6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.73A 6hd4B-4ckrA:
32.0		 6hd4B-4ckrA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 836
ALA A 853
LYS A 855
GLU A 871
VAL A 884
LEU A 956
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.66A 6hd4B-4hviA:
29.1		 6hd4B-4hviA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 486
ALA A 506
GLU A 525
MET A 529
ILE A 532
LEU A 624
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
 0.80A 6hd4B-4k33A:
25.4		 6hd4B-4k33A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
ILE A 532
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
 0.56A 6hd4B-4k33A:
25.4		 6hd4B-4k33A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  50
ALA A  61
LYS A  63
GLU A  77
VAL A  90
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
None
1UL  A 501 (-4.3A)
 0.57A 6hd4B-4l52A:
19.9		 6hd4B-4l52A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
GLU A  70
MET A  74
VAL A  83
LEU A 153
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 1.12A 6hd4B-4lg4A:
17.0		 6hd4B-4lg4A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
MET A 314
VAL A 323
ILE A 336
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 ( 3.6A)
VGG  A 601 ( 4.8A)
VGG  A 601 (-4.2A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 1.01A 6hd4B-4lggA:
29.7		 6hd4B-4lggA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
GLU B  70
ILE B  97
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
None
None
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 0.90A 6hd4B-4o27B:
17.5		 6hd4B-4o27B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.81A 6hd4B-4o38A:
19.0		 6hd4B-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
 None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.80A 6hd4B-4o38A:
19.0		 6hd4B-4o38A:
14.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.10A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.91A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
ILE A  55
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.19A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
 0.95A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		7 VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
 0.80A 6hd4B-4ueuA:
32.2		 6hd4B-4ueuA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  72
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 1.00A 6hd4B-4wsqA:
22.0		 6hd4B-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
None
KSA  A 405 (-4.6A)
 0.74A 6hd4B-4wsqA:
22.0		 6hd4B-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 481
ALA A 501
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.73A 6hd4B-4xcuA:
30.5		 6hd4B-4xcuA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 527
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-3.0A)
 0.78A 6hd4B-4xcuA:
30.5		 6hd4B-4xcuA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 275
ALA B 288
LYS B 290
MET B 309
ILE B 312
VAL B 318
ILE B 332
THR B 334
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
 0.73A 6hd4B-4xeyB:
34.1		 6hd4B-4xeyB:
40.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 VAL B 275
ALA B 288
MET B 309
ILE B 312
VAL B 318
ILE B 332
THR B 334
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.74A 6hd4B-4xeyB:
34.1		 6hd4B-4xeyB:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.63A 6hd4B-4xufA:
33.4		 6hd4B-4xufA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
LYS A 490
GLU A 509
ILE A 537
THR A 539
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.76A 6hd4B-4yffA:
18.9		 6hd4B-4yffA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.74A 6hd4B-5a46A:
30.2		 6hd4B-5a46A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.62A 6hd4B-5grnA:
28.3		 6hd4B-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
 0.85A 6hd4B-5grnA:
28.3		 6hd4B-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A  94
ALA A 105
VAL A 134
ILE A 146
THR A 148
LEU A 215
ASP A 226
 None
 0.89A 6hd4B-5gz8A:
18.7		 6hd4B-5gz8A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.74A 6hd4B-5i3oA:
21.8		 6hd4B-5i3oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.71A 6hd4B-5j5tA:
20.8		 6hd4B-5j5tA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
GLU A 315
MET A 319
VAL A 328
LEU A 396
ASP A 407
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
None
IPW  A 601 (-4.5A)
None
 1.08A 6hd4B-5kbrA:
21.3		 6hd4B-5kbrA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 647
ALA A 663
LYS A 665
ILE A 694
ILE A 709
THR A 711
ASP A 776
 None
6P6  A1001 (-3.3A)
None
DIO  A1002 ( 4.5A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
None
 1.49A 6hd4B-5l6oA:
33.0		 6hd4B-5l6oA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 709
THR A 711
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
None
 0.74A 6hd4B-5l6oA:
33.0		 6hd4B-5l6oA:
12.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vil MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 5

(Homo sapiens) 		no annotation 6 VAL A 694
ALA A 707
GLU A 725
VAL A 738
ILE A 752
LEU A 810
 9E1  A1001 ( 4.0A)
9E1  A1001 (-3.5A)
None
9E1  A1001 (-4.1A)
None
9E1  A1001 (-4.5A)
 0.58A 6hd4B-5vilA:
12.5		 6hd4B-5vilA:
30.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
ALA A  87
GLU A 107
MET A 111
VAL A 120
LEU A 189
ALA A 199
 None
 0.94A 6hd4B-6c9dA:
20.7		 6hd4B-6c9dA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 7 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
VAL A 120
LEU A 189
 None
 0.95A 6hd4B-6c9dA:
20.7		 6hd4B-6c9dA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 VAL A 179
ALA A 192
LYS A 194
GLU A 236
VAL A 249
LEU A 319
ALA A 329
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.88A 6hd4B-6cmjA:
21.8		 6hd4B-6cmjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 VAL A 177
ALA A 191
GLU A 208
ILE A 215
ILE A 241
LEU A 297
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
 1.18A 6hd4B-6fylA:
21.2		 6hd4B-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad3 ALDEHYDE
DEHYDROGENASE (CLASS
3)

(Rattus
norvegicus) 		PF00171
(Aldedh) 		4 LEU A  77
VAL A  63
PHE A 418
GLY A 131
 None
 0.98A 6hd4B-1ad3A:
undetectable		 6hd4B-1ad3A:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efy POLY (ADP-RIBOSE)
POLYMERASE

(Gallus gallus) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 LEU A 797
VAL A 833
PHE A 677
GLY A 871
 None
 0.99A 6hd4B-1efyA:
undetectable		 6hd4B-1efyA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 LEU A 103
TYR A 364
VAL A 205
PHE A 355
 None
 1.02A 6hd4B-1f82A:
undetectable		 6hd4B-1f82A:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g55 DNA CYTOSINE
METHYLTRANSFERASE
DNMT2

(Homo sapiens) 		PF00145
(DNA_methylase) 		4 LEU A 373
VAL A 250
PHE A 358
GLY A  15
 None
None
None
SAH  A 392 (-3.1A)
 0.90A 6hd4B-1g55A:
undetectable		 6hd4B-1g55A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jjf ENDO-1,4-BETA-XYLANA
SE Z

(Ruminiclostridium
thermocellum) 		PF00756
(Esterase) 		4 LEU A  84
VAL A  42
PHE A 272
GLY A 170
 None
 1.01A 6hd4B-1jjfA:
undetectable		 6hd4B-1jjfA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2

(Escherichia
coli) 		PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N) 		4 LEU A 347
VAL A 375
PHE A 369
GLY A 352
 None
 0.85A 6hd4B-1l5jA:
undetectable		 6hd4B-1l5jA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 LEU A  32
TYR A   4
VAL A   9
GLY A 387
 None
None
FAD  A2457 ( 4.7A)
None
 0.96A 6hd4B-1lqtA:
undetectable		 6hd4B-1lqtA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		4 LEU A 206
VAL A 263
PHE A 185
GLY A 182
 None
 1.01A 6hd4B-1lwhA:
undetectable		 6hd4B-1lwhA:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
TYR A 272
VAL A 308
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
P16  A   2 (-3.6A)
None
None
P16  A   2 (-3.4A)
 0.84A 6hd4B-1opkA:
36.9		 6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 267
VAL A 308
PHE A 336
MET A 337
GLY A 340
 P16  A   2 ( 4.2A)
None
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
 0.56A 6hd4B-1opkA:
36.9		 6hd4B-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgz PROTEIN
(FERREDOXIN:NADP+
REDUCTASE)

(Nostoc sp. PCC
7119) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A  14
TYR A  15
VAL A  99
GLY A  50
 None
None
FAD  A 304 (-3.8A)
None
 0.97A 6hd4B-1qgzA:
undetectable		 6hd4B-1qgzA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 409
PHE A 437
MET A 438
GLY A 441
 None
 0.76A 6hd4B-1snxA:
29.5		 6hd4B-1snxA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 LEU A 334
VAL A 242
PHE A 327
GLY A 255
 None
 0.96A 6hd4B-1vbgA:
2.3		 6hd4B-1vbgA:
7.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc2 ENDOGLUCANASE

(Mytilus edulis) 		no annotation 4 TYR A 173
VAL A 140
PHE A  41
GLY A  31
 None
 1.01A 6hd4B-1wc2A:
undetectable		 6hd4B-1wc2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wm6 PHENYLACETIC ACID
DEGRADATION PROTEIN
PAAI

(Thermus
thermophilus) 		PF03061
(4HBT) 		4 LEU A   9
VAL A 114
PHE A  42
GLY A  25
 None
 0.99A 6hd4B-1wm6A:
undetectable		 6hd4B-1wm6A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 LEU A 163
VAL A  77
PHE A 181
MET A 182
GLY A 151
 None
 1.45A 6hd4B-2bb0A:
undetectable		 6hd4B-2bb0A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cu0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pyrococcus
horikoshii) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 219
VAL A 225
MET A  67
GLY A  71
 None
 0.97A 6hd4B-2cu0A:
undetectable		 6hd4B-2cu0A:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Streptococcus
pneumoniae) 		PF13419
(HAD_2) 		4 LEU A  93
VAL A 169
MET A  86
GLY A  88
 None
 1.02A 6hd4B-2go7A:
undetectable		 6hd4B-2go7A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 LEU A 273
PHE A 340
MET A 341
GLY A 344
 QUE  A   1 (-3.9A)
QUE  A   1 (-4.2A)
None
QUE  A   1 (-3.0A)
 0.75A 6hd4B-2hckA:
29.4		 6hd4B-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 251
VAL A 291
PHE A 318
MET A 319
GLY A 322
 1BM  A 499 ( 3.7A)
None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 0.95A 6hd4B-2hk5A:
26.5		 6hd4B-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hpi DNA POLYMERASE III
ALPHA SUBUNIT

(Thermus
aquaticus) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 LEU A  18
VAL A  32
PHE A  51
GLY A  48
 None
 1.03A 6hd4B-2hpiA:
undetectable		 6hd4B-2hpiA:
5.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 LEU A 248
VAL A 289
PHE A 317
MET A 318
GLY A 321
 GIN  A 600 ( 4.6A)
None
GIN  A 600 (-4.3A)
None
None
 0.54A 6hd4B-2hz0A:
33.9		 6hd4B-2hz0A:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ihf SINGLE-STRANDED
DNA-BINDING PROTEIN

(Thermus
aquaticus) 		PF00436
(SSB) 		4 LEU A 196
VAL A  78
MET A   1
GLY A   4
 None
 1.05A 6hd4B-2ihfA:
undetectable		 6hd4B-2ihfA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obm ESCN

(Escherichia
coli) 		PF00006
(ATP-synt_ab) 		4 LEU A 339
VAL A 229
PHE A 176
GLY A 332
 None
 0.98A 6hd4B-2obmA:
undetectable		 6hd4B-2obmA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 TYR A 120
VAL A  29
PHE A  80
GLY A 263
 None
 1.04A 6hd4B-2p3xA:
undetectable		 6hd4B-2p3xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		4 LEU A  25
TYR A  10
VAL A  44
GLY A  20
 None
NAD  A 601 (-4.6A)
None
None
 1.04A 6hd4B-2qjoA:
undetectable		 6hd4B-2qjoA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qpq PROTEIN BUG27

(Bordetella
pertussis) 		PF03401
(TctC) 		4 LEU A 173
VAL A 216
PHE A 190
GLY A 166
 None
 1.06A 6hd4B-2qpqA:
undetectable		 6hd4B-2qpqA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 121
PHE B 149
MET B 150
GLY B 153
 None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
 0.87A 6hd4B-2wtkB:
21.7		 6hd4B-2wtkB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		4 LEU A 263
VAL A 349
MET A 271
GLY A 268
 None
 1.03A 6hd4B-2z6hA:
undetectable		 6hd4B-2z6hA:
8.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8c INSULIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1002
VAL A1050
MET A1079
GLY A1082
 S91  A   1 ( 4.1A)
None
None
S91  A   1 (-3.3A)
 0.71A 6hd4B-2z8cA:
22.2		 6hd4B-2z8cA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 253
PHE A 321
MET A 322
GLY A 325
 None
 0.76A 6hd4B-2zv7A:
31.0		 6hd4B-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aiz DNA POLYMERASE
SLIDING CLAMP C

(Sulfurisphaera
tokodaii) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 LEU C 163
TYR C 164
PHE C 130
GLY C 160
 None
 1.05A 6hd4B-3aizC:
undetectable		 6hd4B-3aizC:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 165
PHE A  93
MET A  94
GLY A  96
 None
3AM  A 338 ( 4.6A)
None
None
 0.64A 6hd4B-3c0iA:
23.2		 6hd4B-3c0iA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00266
(Aminotran_5) 		4 LEU A 300
TYR A 200
VAL A 267
GLY A 377
 None
 1.01A 6hd4B-3caiA:
undetectable		 6hd4B-3caiA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d45 POLY(A)-SPECIFIC
RIBONUCLEASE PARN

(Mus musculus) 		PF01424
(R3H)
PF04857
(CAF1)
PF08675
(RNA_bind) 		4 LEU A 116
VAL A 278
PHE A  67
GLY A  33
 None
 1.03A 6hd4B-3d45A:
undetectable		 6hd4B-3d45A:
10.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		5 LEU A 344
TYR A   4
VAL A 323
MET A 136
GLY A 139
 None
 1.20A 6hd4B-3hfwA:
undetectable		 6hd4B-3hfwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hje 704AA LONG
HYPOTHETICAL
GLYCOSYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF00128
(Alpha-amylase)
PF09196
(DUF1953) 		4 LEU A   3
VAL A 600
PHE A 247
GLY A 218
 None
 0.98A 6hd4B-3hjeA:
undetectable		 6hd4B-3hjeA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i32 HEAT RESISTANT RNA
DEPENDENT ATPASE

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		4 LEU A 341
TYR A 313
VAL A 289
GLY A 224
 None
 0.99A 6hd4B-3i32A:
undetectable		 6hd4B-3i32A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iay DNA POLYMERASE DELTA
CATALYTIC SUBUNIT

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LEU A 258
TYR A 254
VAL A 162
GLY A 155
 None
 1.02A 6hd4B-3iayA:
undetectable		 6hd4B-3iayA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kys TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-1

(Homo sapiens) 		no annotation 4 LEU A 258
TYR A 248
PHE A 270
GLY A 263
 None
 0.98A 6hd4B-3kysA:
undetectable		 6hd4B-3kysA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lw0 INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1005
VAL A1053
MET A1082
GLY A1085
 None
 0.52A 6hd4B-3lw0A:
31.4		 6hd4B-3lw0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		4 LEU B 349
VAL B 227
PHE B 336
GLY B 380
 None
 0.97A 6hd4B-3pr2B:
undetectable		 6hd4B-3pr2B:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzr ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Vibrio cholerae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 LEU A  84
TYR A  81
VAL A  12
GLY A  91
 None
None
NAP  A 372 (-3.7A)
None
 1.04A 6hd4B-3pzrA:
undetectable		 6hd4B-3pzrA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ray PR DOMAIN-CONTAINING
PROTEIN 11

(Homo sapiens) 		PF00856
(SET) 		4 LEU A 154
VAL A 120
PHE A  98
GLY A  95
 None
 0.96A 6hd4B-3rayA:
undetectable		 6hd4B-3rayA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 LEU A 293
TYR A 297
VAL A  66
GLY A 286
 None
 0.83A 6hd4B-3rc0A:
undetectable		 6hd4B-3rc0A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L

(Escherichia
coli) 		no annotation 4 LEU L 321
VAL L 502
MET L 407
GLY L 405
 None
 0.98A 6hd4B-3rkoL:
2.6		 6hd4B-3rkoL:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssz MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
N-TERMINAL DOMAIN
PROTEIN

(Rhodobacteraceae
bacterium KLH11) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  89
VAL A 157
PHE A 292
MET A 135
GLY A 134
 None
 1.43A 6hd4B-3sszA:
undetectable		 6hd4B-3sszA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stp GALACTONATE
DEHYDRATASE,
PUTATIVE

(Labrenzia
aggregata) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  66
VAL A 134
PHE A 269
MET A 112
GLY A 111
 None
 1.43A 6hd4B-3stpA:
undetectable		 6hd4B-3stpA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3szb ALDEHYDE
DEHYDROGENASE

(Homo sapiens) 		PF00171
(Aldedh) 		4 LEU A  77
VAL A  63
PHE A 418
GLY A 131
 None
 0.89A 6hd4B-3szbA:
undetectable		 6hd4B-3szbA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9r METHYLCROTONYL-COA
CARBOXYLASE,
BETA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF01039
(Carboxyl_trans) 		4 LEU B  90
VAL B 140
MET B 132
GLY B 124
 None
 0.94A 6hd4B-3u9rB:
undetectable		 6hd4B-3u9rB:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 250
VAL A 286
PHE A 332
GLY A 329
 None
 0.99A 6hd4B-3u9sA:
undetectable		 6hd4B-3u9sA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9s METHYLCROTONYL-COA
CARBOXYLASE,
ALPHA-SUBUNIT

(Pseudomonas
aeruginosa) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 298
VAL A 286
PHE A 331
GLY A 303
 None
 0.93A 6hd4B-3u9sA:
undetectable		 6hd4B-3u9sA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4p INTEGRIN ALPHA-4

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 427
TYR A  11
VAL A 135
GLY A  61
 None
 0.94A 6hd4B-3v4pA:
undetectable		 6hd4B-3v4pA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 LEU A 646
VAL A 522
PHE A 622
GLY A 618
 None
 0.95A 6hd4B-3wdjA:
undetectable		 6hd4B-3wdjA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		4 TYR A 149
VAL A  41
PHE A  60
GLY A 205
 None
 1.06A 6hd4B-3zbmA:
undetectable		 6hd4B-3zbmA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4j ARGININE DEIMINASE

(Mycoplasma
penetrans) 		PF02274
(Amidinotransf) 		4 LEU A 314
VAL A 348
PHE A 262
GLY A 259
 None
 1.07A 6hd4B-4e4jA:
undetectable		 6hd4B-4e4jA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqv INVERTASE 2

(Saccharomyces
cerevisiae) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LEU A 369
VAL A 297
PHE A 395
GLY A 458
 None
 0.97A 6hd4B-4eqvA:
undetectable		 6hd4B-4eqvA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eut SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.7A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.5A)
 0.57A 6hd4B-4eutA:
18.6		 6hd4B-4eutA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A  15
VAL A  58
PHE A  88
GLY A  92
 BX7  A 401 (-3.9A)
None
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.3A)
 0.53A 6hd4B-4euuA:
15.0		 6hd4B-4euuA:
16.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4feq TYROSINE-PROTEIN
KINASE RECEPTOR
TYRO3

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 514
PHE A 595
MET A 596
GLY A 599
 0T8  A 901 (-3.6A)
0T8  A 901 (-3.9A)
None
0T8  A 901 ( 3.8A)
 0.62A 6hd4B-4feqA:
22.2		 6hd4B-4feqA:
30.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 LEU A 428
TYR A 429
PHE A 367
GLY A 111
 None
 0.89A 6hd4B-4h7uA:
undetectable		 6hd4B-4h7uA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i70 INOSINE-ADENOSINE-GU
ANOSINE-NUCLEOSIDE
HYDROLASE

(Trypanosoma
brucei) 		PF01156
(IU_nuc_hydro) 		4 LEU A   7
VAL A 223
MET A 164
GLY A 138
 None
None
None
CA  A 401 ( 4.2A)
 1.06A 6hd4B-4i70A:
undetectable		 6hd4B-4i70A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igi COLLAGEN ALPHA3(VI)

(Mus musculus) 		PF00092
(VWA) 		4 LEU A1210
VAL A1048
PHE A1177
GLY A1156
 None
 0.93A 6hd4B-4igiA:
undetectable		 6hd4B-4igiA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ki9 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
12

(Homo sapiens) 		PF00782
(DSPc) 		4 LEU A 145
TYR A 142
VAL A 172
PHE A  36
 None
 1.02A 6hd4B-4ki9A:
undetectable		 6hd4B-4ki9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9z MALYL-COA LYASE

(Rhodobacter
sphaeroides) 		PF03328
(HpcH_HpaI) 		4 LEU A 164
VAL A  47
PHE A 169
GLY A 145
 None
 0.94A 6hd4B-4l9zA:
undetectable		 6hd4B-4l9zA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		4 LEU A 273
VAL A 313
MET A 341
GLY A 344
 VGG  A 601 (-3.2A)
None
None
VGG  A 601 ( 3.2A)
 1.06A 6hd4B-4lggA:
29.7		 6hd4B-4lggA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4neg TRYPTOPHAN SYNTHASE
BETA CHAIN

(Bacillus
anthracis) 		PF00291
(PALP) 		4 LEU A 353
VAL A 231
PHE A 340
GLY A 383
 None
 0.87A 6hd4B-4negA:
undetectable		 6hd4B-4negA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqa POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg)
PF05406
(WGR) 		4 LEU C 797
VAL C 833
PHE C 677
GLY C 871
 None
 0.88A 6hd4B-4oqaC:
undetectable		 6hd4B-4oqaC:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd4 CYTOCHROME B

(Saccharomyces
cerevisiae) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		4 LEU C 275
TYR C 274
VAL C 194
PHE C 129
 AOQ  C4003 (-3.8A)
None
HEM  C4002 (-4.4A)
AOQ  C4003 (-4.6A)
 0.88A 6hd4B-4pd4C:
undetectable		 6hd4B-4pd4C:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9o ISOPRENYL
TRANSFERASE

(Streptococcus
pneumoniae) 		PF01255
(Prenyltransf) 		4 TYR A  70
VAL A  64
PHE A 184
GLY A 149
 None
 0.96A 6hd4B-4q9oA:
undetectable		 6hd4B-4q9oA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uou FUCOSE-SPECIFIC
LECTIN FLEA

(Aspergillus
fumigatus) 		PF07938
(Fungal_lectin) 		4 LEU A 281
VAL A  74
PHE A 220
GLY A 272
 None
 1.06A 6hd4B-4uouA:
undetectable		 6hd4B-4uouA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 LEU A 490
TYR A 487
VAL A 471
PHE A 440
MET A 439
 None
 1.47A 6hd4B-4uplA:
undetectable		 6hd4B-4uplA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxp NS3-4 PROTEASE

(Hepacivirus C) 		PF07652
(Flavi_DEAD) 		4 LEU A 414
VAL A 331
PHE A 422
GLY A 420
 None
 1.00A 6hd4B-4wxpA:
undetectable		 6hd4B-4wxpA:
10.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 267
VAL B 308
PHE B 336
MET B 337
GLY B 340
 1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
 0.74A 6hd4B-4xeyB:
34.1		 6hd4B-4xeyB:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuv GLYCOSIDE HYDROLASE
FAMILY 105 PROTEIN

(Thielavia
terrestris) 		PF07470
(Glyco_hydro_88) 		4 LEU A  20
VAL A 108
MET A 365
GLY A 362
 None
 1.03A 6hd4B-4xuvA:
undetectable		 6hd4B-4xuvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		4 LEU A  37
PHE A 373
MET A 374
GLY A 376
 None
 1.05A 6hd4B-4xyiA:
undetectable		 6hd4B-4xyiA:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypt REPLICASE
POLYPROTEIN 1AB

(Murine
coronavirus) 		PF08715
(Viral_protease) 		4 LEU A1845
TYR A1906
PHE A1840
GLY A1818
 None
 0.91A 6hd4B-4yptA:
undetectable		 6hd4B-4yptA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 257
VAL A 386
PHE A 227
GLY A 247
 None
 1.05A 6hd4B-5ahkA:
undetectable		 6hd4B-5ahkA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		4 LEU A 217
VAL A 223
MET A  61
GLY A  65
 None
 1.01A 6hd4B-5ahmA:
undetectable		 6hd4B-5ahmA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahn INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH)
PF00571
(CBS) 		4 LEU A 217
VAL A 223
MET A  61
GLY A  65
 None
 1.02A 6hd4B-5ahnA:
undetectable		 6hd4B-5ahnA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 VAL A 127
PHE A 193
MET A 192
GLY A 190
 None
 0.98A 6hd4B-5aydA:
undetectable		 6hd4B-5aydA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 LEU A 247
VAL A  64
PHE A 163
GLY A 286
 None
HEM  A 502 (-4.0A)
None
None
 1.07A 6hd4B-5djqA:
undetectable		 6hd4B-5djqA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		4 LEU A 102
TYR A 106
VAL A  71
GLY A  81
 None
 0.85A 6hd4B-5dzqA:
undetectable		 6hd4B-5dzqA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqj TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
NON-CATALYTIC
SUBUNIT TRM6

(Saccharomyces
cerevisiae) 		PF04189
(Gcd10p) 		4 LEU A 252
TYR A 249
PHE A 291
GLY A 258
 None
 0.97A 6hd4B-5eqjA:
undetectable		 6hd4B-5eqjA:
9.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		5 LEU A 320
TYR A 134
VAL A  14
PHE A 318
GLY A 312
 None
 1.43A 6hd4B-5f1yA:
undetectable		 6hd4B-5f1yA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip7 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB3
DNA-DIRECTED RNA
POLYMERASES I, II,
AND III SUBUNIT
RPABC5

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF01194
(RNA_pol_N) 		4 LEU J  24
TYR J  21
VAL C 235
GLY J  33
 None
 0.94A 6hd4B-5ip7J:
undetectable		 6hd4B-5ip7J:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kym 1-ACYL-SN-GLYCEROL-3
-PHOSPHATE
ACYLTRANSFERASE

(Thermotoga
maritima) 		PF01553
(Acyltransferase) 		4 LEU A  92
VAL A 181
PHE A  96
GLY A  53
 None
 1.06A 6hd4B-5kymA:
2.2		 6hd4B-5kymA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1t PENTALENOLACTONE
SYNTHASE

(Streptomyces
arenae) 		PF00067
(p450) 		4 LEU A 246
VAL A 148
PHE A 391
GLY A 278
 None
 0.87A 6hd4B-5l1tA:
undetectable		 6hd4B-5l1tA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		4 VAL A2225
PHE A2257
MET A2256
GLY A2167
 None
 1.07A 6hd4B-5mc9A:
undetectable		 6hd4B-5mc9A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5my0 FATTY ACID SYNTHASE

(Mus musculus) 		no annotation 4 LEU B 615
VAL B 585
PHE B 686
GLY B 618
 None
 0.98A 6hd4B-5my0B:
undetectable		 6hd4B-5my0B:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 4 LEU A 113
VAL A 119
MET A  82
GLY A  86
 None
 1.06A 6hd4B-5ou3A:
undetectable		 6hd4B-5ou3A:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5td2 TYROSINE-PROTEIN
KINASE MER

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 593
PHE A 673
MET A 674
GLY A 677
 7AE  A1000 ( 3.9A)
7AE  A1000 (-4.1A)
None
7AE  A1000 ( 3.7A)
 0.60A 6hd4B-5td2A:
28.4		 6hd4B-5td2A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A 542
PHE A 622
MET A 623
GLY A 626
 7YS  A9001 (-4.1A)
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 0.48A 6hd4B-5u6bA:
29.5		 6hd4B-5u6bA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wtf VP0

(Hepatovirus A) 		PF00073
(Rhv) 		4 LEU B 141
TYR B 144
VAL B  84
GLY B 136
 None
 0.85A 6hd4B-5wtfB:
undetectable		 6hd4B-5wtfB:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x0e FREE SERINE KINASE

(Thermococcus
kodakarensis) 		PF02195
(ParBc) 		4 LEU A 110
VAL A  33
PHE A 149
GLY A 145
 None
 1.05A 6hd4B-5x0eA:
undetectable		 6hd4B-5x0eA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xst POLY [ADP-RIBOSE]
POLYMERASE 1

(Homo sapiens) 		no annotation 4 LEU A 136
VAL A 172
PHE A  16
GLY A 210
 None
 0.95A 6hd4B-5xstA:
undetectable		 6hd4B-5xstA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bgd GLUCOSE/GALACTOSE-BI
NDING LIPOPROTEIN

(Treponema
pallidum) 		no annotation 4 LEU A 209
VAL A 130
MET A 175
GLY A 178
 None
 1.02A 6hd4B-6bgdA:
undetectable		 6hd4B-6bgdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 5 LEU A 275
VAL A 315
PHE A 345
MET A 346
GLY A 349
 FE7  A 601 (-3.8A)
None
FE7  A 601 (-4.5A)
FE7  A 601 (-4.7A)
FE7  A 601 ( 3.7A)
 1.22A 6hd4B-6cthA:
21.7		 6hd4B-6cthA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 LEU A2878
VAL A2776
MET A2854
GLY A2856
 None
 0.89A 6hd4B-6ez8A:
undetectable		 6hd4B-6ez8A:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 4 LEU A 247
TYR A   9
VAL A 204
GLY A  85
 None
None
PGE  A 401 (-4.5A)
None
 1.02A 6hd4B-6f9mA:
undetectable		 6hd4B-6f9mA:
12.35