SIMILAR PATTERNS OF AMINO ACIDS FOR 6HD4_A_STIA604_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 4 TYR A  47
VAL A 129
PHE A  99
GLY A 117
 PO4  A 400 (-4.4A)
None
None
None
 1.36A 6hd4A-1aqzA:
undetectable		 6hd4A-1aqzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		4 TYR A 190
VAL A   7
PHE A 136
GLY A 145
 None
 1.35A 6hd4A-1bs9A:
undetectable		 6hd4A-1bs9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 TYR A 273
VAL A  12
MET A 212
GLY A 211
 None
 1.03A 6hd4A-1fi4A:
undetectable		 6hd4A-1fi4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 TYR A 273
VAL A  37
MET A 212
GLY A 211
 None
 1.43A 6hd4A-1fi4A:
undetectable		 6hd4A-1fi4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 VAL A  36
PHE A 277
MET A 294
GLY A 293
 None
 1.42A 6hd4A-1k0fA:
undetectable		 6hd4A-1k0fA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		4 TYR A 107
VAL A 175
PHE A 219
GLY A 214
 None
 1.33A 6hd4A-1mn6A:
undetectable		 6hd4A-1mn6A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		4 TYR A 363
VAL A 357
PHE A 531
GLY A 527
 None
 1.18A 6hd4A-1n7uA:
undetectable		 6hd4A-1n7uA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 TYR A 272
VAL A 308
MET A 337
GLY A 340
 P16  A   2 (-3.6A)
None
None
P16  A   2 (-3.4A)
 0.76A 6hd4A-1opkA:
36.8		 6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 308
PHE A 336
MET A 337
GLY A 340
 None
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
 0.47A 6hd4A-1opkA:
36.8		 6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4y RIBONUCLEASE
ALPHA-SARCIN

(Aspergillus
giganteus) 		no annotation 4 TYR A  34
VAL A 116
PHE A  86
GLY A 104
 None
 1.11A 6hd4A-1r4yA:
undetectable		 6hd4A-1r4yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		4 TYR A  52
VAL A  43
MET A  78
GLY A 185
 None
 1.32A 6hd4A-1sawA:
undetectable		 6hd4A-1sawA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 409
PHE A 437
MET A 438
GLY A 441
 None
 0.72A 6hd4A-1snxA:
29.5		 6hd4A-1snxA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 VAL A 193
PHE A 208
MET A 502
GLY A 500
 None
 1.35A 6hd4A-1sy7A:
undetectable		 6hd4A-1sy7A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida;
Pseudomonas
putida) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A 133
PHE A 109
MET B 201
GLY A  47
 None
None
None
FES  A4908 (-4.2A)
 1.33A 6hd4A-1t3qA:
undetectable		 6hd4A-1t3qA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		4 VAL A  60
PHE A  22
MET A  23
GLY A  27
 None
None
NH3  A 402 (-4.4A)
None
 1.41A 6hd4A-1u7gA:
undetectable		 6hd4A-1u7gA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 TYR A 278
VAL A 267
PHE A 311
GLY A 275
 TYR  A 278 ( 1.3A)
VAL  A 267 ( 0.5A)
PHE  A 311 ( 1.3A)
GLY  A 275 ( 0.0A)
 1.32A 6hd4A-1v0fA:
undetectable		 6hd4A-1v0fA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc2 ENDOGLUCANASE

(Mytilus edulis) 		no annotation 4 TYR A 173
VAL A 140
PHE A  41
GLY A  31
 None
 1.03A 6hd4A-1wc2A:
undetectable		 6hd4A-1wc2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		4 TYR A 208
VAL A 176
PHE A  23
GLY A 225
 None
 1.13A 6hd4A-1y1pA:
undetectable		 6hd4A-1y1pA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 VAL A 526
PHE A 385
MET A 384
GLY A 473
 None
 1.35A 6hd4A-1z26A:
undetectable		 6hd4A-1z26A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxx PROBABLE GTP-BINDING
PROTEIN ENGB

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1) 		4 VAL A  73
PHE A  56
MET A  57
GLY A  59
 None
 1.37A 6hd4A-2cxxA:
undetectable		 6hd4A-2cxxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		4 VAL A  41
PHE A 298
MET A 297
GLY A 296
 None
 1.31A 6hd4A-2ek8A:
undetectable		 6hd4A-2ek8A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		4 VAL A  57
PHE A 298
MET A 297
GLY A 296
 None
 1.39A 6hd4A-2ek8A:
undetectable		 6hd4A-2ek8A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erx GTP-BINDING PROTEIN
DI-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 174
PHE A 147
MET A 148
GLY A 120
 None
 1.31A 6hd4A-2erxA:
undetectable		 6hd4A-2erxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 VAL A 503
PHE A  88
MET A  87
GLY A  86
 None
 1.23A 6hd4A-2fknA:
undetectable		 6hd4A-2fknA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 291
PHE A 318
MET A 319
GLY A 322
 None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 0.70A 6hd4A-2hk5A:
26.5		 6hd4A-2hk5A:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 289
PHE A 317
MET A 318
GLY A 321
 None
GIN  A 600 (-4.3A)
None
None
 0.34A 6hd4A-2hz0A:
34.3		 6hd4A-2hz0A:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 TYR A 342
VAL A 316
PHE A 337
GLY A 122
 None
 0.92A 6hd4A-2hzkA:
undetectable		 6hd4A-2hzkA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 TYR A 120
VAL A  29
PHE A  80
GLY A 263
 None
 1.09A 6hd4A-2p3xA:
undetectable		 6hd4A-2p3xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 TYR A 253
VAL A 248
MET A 324
GLY A 322
 None
 1.23A 6hd4A-2quaA:
undetectable		 6hd4A-2quaA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w18 PARTNER AND
LOCALIZER OF BRCA2

(Homo sapiens) 		PF16756
(PALB2_WD40) 		4 VAL A 991
PHE A 876
MET A 875
GLY A1166
 None
 1.35A 6hd4A-2w18A:
undetectable		 6hd4A-2w18A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		4 TYR A 350
VAL A 385
MET A 307
GLY A 311
 None
 1.32A 6hd4A-2w3cA:
undetectable		 6hd4A-2w3cA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 121
PHE B 149
MET B 150
GLY B 153
 None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
 0.85A 6hd4A-2wtkB:
21.8		 6hd4A-2wtkB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		4 TYR A 181
VAL A 190
PHE A  11
GLY A   9
 None
 1.42A 6hd4A-2x66A:
undetectable		 6hd4A-2x66A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 TYR A 496
VAL A 478
MET A 583
GLY A 580
 PO4  A1793 (-3.1A)
None
None
None
 1.14A 6hd4A-2xe4A:
undetectable		 6hd4A-2xe4A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvr MAJOR CAPSID PROTEIN
10A

(Escherichia
virus T7) 		no annotation 4 VAL A 271
PHE A 245
MET A 243
GLY A 237
 None
 1.25A 6hd4A-2xvrA:
undetectable		 6hd4A-2xvrA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 VAL A 176
PHE A  46
MET A  45
GLY A  44
 None
 1.07A 6hd4A-3a8kA:
undetectable		 6hd4A-3a8kA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 165
PHE A  93
MET A  94
GLY A  96
 None
3AM  A 338 ( 4.6A)
None
None
 0.61A 6hd4A-3c0iA:
23.0		 6hd4A-3c0iA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		4 TYR A 276
VAL A  16
MET A 215
GLY A 214
 None
None
SO4  A 401 ( 4.7A)
None
 1.10A 6hd4A-3d4jA:
undetectable		 6hd4A-3d4jA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 TYR A 199
VAL A 178
MET A 139
GLY A 143
 None
SO4  A 611 ( 3.7A)
None
None
 1.37A 6hd4A-3e2dA:
undetectable		 6hd4A-3e2dA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 VAL B 421
PHE A 563
MET A 560
GLY A 310
 None
 1.41A 6hd4A-3egwB:
undetectable		 6hd4A-3egwB:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 TYR A 276
VAL A  16
MET A 215
GLY A 214
 None
None
PO4  A 401 (-4.7A)
None
 1.17A 6hd4A-3f0nA:
undetectable		 6hd4A-3f0nA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		4 TYR A   4
VAL A 323
MET A 136
GLY A 139
 None
 1.33A 6hd4A-3hfwA:
undetectable		 6hd4A-3hfwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxt 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE

(Homo sapiens) 		PF01812
(5-FTHF_cyc-lig) 		4 TYR A 156
VAL A 195
PHE A  79
GLY A 128
 NI  A 204 (-4.8A)
None
None
None
 1.19A 6hd4A-3hxtA:
undetectable		 6hd4A-3hxtA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 VAL A  81
PHE A 142
MET A 143
GLY A 144
 None
 1.40A 6hd4A-3j4uA:
undetectable		 6hd4A-3j4uA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki6 CHOLIX TOXIN

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly) 		4 TYR A 626
VAL A 593
PHE A 570
GLY A 572
 None
 1.34A 6hd4A-3ki6A:
undetectable		 6hd4A-3ki6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 269
PHE A 290
MET A 282
GLY A 318
 None
 1.36A 6hd4A-3oc4A:
undetectable		 6hd4A-3oc4A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		4 TYR A  75
VAL A 138
MET A 209
GLY A 207
 None
 1.40A 6hd4A-3p0lA:
undetectable		 6hd4A-3p0lA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 TYR A 423
VAL A  33
PHE A 313
GLY A 318
 None
 1.32A 6hd4A-3p1vA:
undetectable		 6hd4A-3p1vA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 296
PHE A 376
MET A 375
GLY A 374
 None
 1.10A 6hd4A-3peiA:
undetectable		 6hd4A-3peiA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 297
PHE A 376
MET A 375
GLY A 374
 SO4  A 513 ( 4.9A)
None
None
None
 1.31A 6hd4A-3peiA:
undetectable		 6hd4A-3peiA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Shewanella
denitrificans) 		PF00465
(Fe-ADH) 		4 TYR A 207
VAL A 169
MET A 328
GLY A 329
 None
 1.25A 6hd4A-3rf7A:
undetectable		 6hd4A-3rf7A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 TYR A 366
VAL A 150
PHE A 394
GLY A 392
 None
 1.29A 6hd4A-3syjA:
undetectable		 6hd4A-3syjA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		4 TYR A 264
VAL A 250
PHE A 161
GLY A 284
 None
 1.25A 6hd4A-3vxcA:
undetectable		 6hd4A-3vxcA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 TYR A 123
VAL A 340
PHE A 273
GLY A 278
 EDO  A 408 (-4.8A)
None
None
EDO  A 408 ( 3.9A)
 1.20A 6hd4A-3vzbA:
undetectable		 6hd4A-3vzbA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR A 150
VAL A 104
PHE A 146
GLY A 136
 None
 1.40A 6hd4A-3wa1A:
undetectable		 6hd4A-3wa1A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		4 TYR A 149
VAL A  41
PHE A  60
GLY A 205
 None
 1.03A 6hd4A-3zbmA:
undetectable		 6hd4A-3zbmA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfn ALLYL ALCOHOL
DEHYDROGENASE

(Nicotiana
tabacum) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 309
VAL A 325
MET A 136
GLY A 138
 None
None
NAP  A 400 (-3.4A)
None
 1.37A 6hd4A-4hfnA:
undetectable		 6hd4A-4hfnA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 TYR A 121
VAL A 148
PHE A 109
GLY A  81
 None
 1.37A 6hd4A-4imdA:
undetectable		 6hd4A-4imdA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 TYR A  98
VAL A 166
PHE A 101
GLY A 110
 None
 1.35A 6hd4A-4kh8A:
undetectable		 6hd4A-4kh8A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 TYR A 264
VAL A 330
PHE A 267
GLY A 276
 None
 1.33A 6hd4A-4kh8A:
undetectable		 6hd4A-4kh8A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nw4 LIPOPROTEIN S-LAYER
PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 TYR A 238
VAL A 304
PHE A 241
GLY A 250
 None
 1.41A 6hd4A-4nw4A:
undetectable		 6hd4A-4nw4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 4 VAL B 112
PHE B 152
MET B 153
GLY B  78
 None
ADE  B 301 (-3.9A)
None
ADE  B 301 (-3.2A)
 1.43A 6hd4A-4qezB:
undetectable		 6hd4A-4qezB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 541
VAL A 370
PHE A 570
GLY A 538
 None
 1.43A 6hd4A-4qq1A:
undetectable		 6hd4A-4qq1A:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 VAL A 100
PHE A 194
MET A 195
GLY A 197
 None
 1.11A 6hd4A-4r12A:
undetectable		 6hd4A-4r12A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 VAL A 114
PHE A 194
MET A 195
GLY A 197
 None
 1.34A 6hd4A-4r12A:
undetectable		 6hd4A-4r12A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 MAOC FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01575
(MaoC_dehydratas) 		4 TYR B  83
VAL B  11
PHE B 104
GLY B  68
 None
 1.37A 6hd4A-4rv2B:
undetectable		 6hd4A-4rv2B:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 VAL B 308
PHE B 336
MET B 337
GLY B 340
 None
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
 0.35A 6hd4A-4xeyB:
27.9		 6hd4A-4xeyB:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 TYR A 132
VAL A 109
PHE A 356
GLY A 359
 None
 1.41A 6hd4A-4ztcA:
undetectable		 6hd4A-4ztcA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 257
VAL A 386
PHE A 227
GLY A 247
 None
 1.01A 6hd4A-5ahkA:
undetectable		 6hd4A-5ahkA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 VAL A 127
PHE A 193
MET A 192
GLY A 190
 None
 1.01A 6hd4A-5aydA:
undetectable		 6hd4A-5aydA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		4 TYR A 268
VAL A 413
MET A 331
GLY A 332
 None
 1.37A 6hd4A-5aynA:
undetectable		 6hd4A-5aynA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		4 TYR A  55
VAL A  40
MET A  63
GLY A 128
 None
 1.13A 6hd4A-5ceeA:
undetectable		 6hd4A-5ceeA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 4 TYR B 270
VAL B  64
PHE B 122
GLY B 160
 None
 1.25A 6hd4A-5cyrB:
undetectable		 6hd4A-5cyrB:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		4 TYR A 419
VAL A 376
MET A 338
GLY A 342
 None
 1.43A 6hd4A-5d3oA:
undetectable		 6hd4A-5d3oA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		4 TYR A 134
VAL A  14
PHE A 318
GLY A 312
 None
 1.42A 6hd4A-5f1yA:
undetectable		 6hd4A-5f1yA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		4 TYR A 322
VAL A  14
PHE A 311
GLY A 215
 None
 1.41A 6hd4A-5f1yA:
undetectable		 6hd4A-5f1yA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR B 150
VAL B 104
PHE B 146
GLY B 136
 None
 1.43A 6hd4A-5fozB:
undetectable		 6hd4A-5fozB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 TYR A 425
PHE A 354
MET A 353
GLY A 351
 None
 1.09A 6hd4A-5h4eA:
undetectable		 6hd4A-5h4eA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(uncultured
marine
bacterium) 		PF03480
(DctP) 		4 TYR A 235
VAL A 280
MET A 206
GLY A 170
 None
 1.34A 6hd4A-5i5pA:
undetectable		 6hd4A-5i5pA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 TYR A 284
VAL A 212
PHE A 304
GLY A 269
 None
 1.34A 6hd4A-5i7nA:
undetectable		 6hd4A-5i7nA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		4 TYR A  36
VAL A 127
PHE A  87
GLY A 154
 None
 1.20A 6hd4A-5kbwA:
undetectable		 6hd4A-5kbwA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 VAL A 362
PHE A 482
MET A 481
GLY A 477
 None
 1.33A 6hd4A-5kd5A:
undetectable		 6hd4A-5kd5A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 VAL A 295
PHE A 228
MET A 229
GLY A 181
 None
 1.43A 6hd4A-5kvuA:
undetectable		 6hd4A-5kvuA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0v PROTEIN
O-GLUCOSYLTRANSFERAS
E 1

(Homo sapiens) 		PF05686
(Glyco_transf_90) 		4 TYR A 161
VAL A 374
PHE A 114
GLY A 110
 None
 1.31A 6hd4A-5l0vA:
undetectable		 6hd4A-5l0vA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  35
PHE A  52
MET A  51
GLY A  49
 None
SO4  A1011 (-4.8A)
None
None
 1.35A 6hd4A-5lewA:
undetectable		 6hd4A-5lewA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8e ALPHA-N-ARABINOFURAN
OSIDASE

(Weissella
cibaria) 		PF04616
(Glyco_hydro_43) 		4 VAL A  29
PHE A 215
MET A 226
GLY A 217
 None
 1.40A 6hd4A-5m8eA:
undetectable		 6hd4A-5m8eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		4 VAL A2225
PHE A2257
MET A2256
GLY A2167
 None
 1.11A 6hd4A-5mc9A:
undetectable		 6hd4A-5mc9A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr4 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 4 TYR C 128
PHE C 303
MET C 300
GLY C 299
 None
 1.41A 6hd4A-5mr4C:
undetectable		 6hd4A-5mr4C:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 4 VAL A  70
PHE A 460
MET A 459
GLY A 457
 VAL  A  70 ( 0.6A)
PHE  A 460 ( 1.3A)
MET  A 459 ( 0.0A)
GLY  A 457 ( 0.0A)
 1.40A 6hd4A-5nksA:
undetectable		 6hd4A-5nksA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A  13
PHE A 194
MET A 254
GLY A 214
 None
 1.18A 6hd4A-5suiA:
undetectable		 6hd4A-5suiA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 529
PHE A 622
MET A 623
GLY A 626
 None
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 1.34A 6hd4A-5u6bA:
29.5		 6hd4A-5u6bA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 TYR A 407
VAL A 443
MET A 323
GLY A 328
 None
 1.10A 6hd4A-5vanA:
undetectable		 6hd4A-5vanA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 TYR A 928
VAL A 685
PHE A 944
GLY A 891
 None
 1.37A 6hd4A-5vanA:
undetectable		 6hd4A-5vanA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 4 TYR A 407
VAL A 443
MET A 323
GLY A 328
 None
 1.15A 6hd4A-5wi9A:
undetectable		 6hd4A-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 605
VAL A  49
PHE A  36
GLY A 574
 None
 1.33A 6hd4A-5wugA:
undetectable		 6hd4A-5wugA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc4 ENDO-BETA-1,4-GLUCAN
ASE

(Ampullaria
crossean) 		no annotation 4 TYR A 170
VAL A  99
PHE A  44
GLY A  34
 None
 1.25A 6hd4A-5xc4A:
undetectable		 6hd4A-5xc4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc4 ENDO-BETA-1,4-GLUCAN
ASE

(Ampullaria
crossean) 		no annotation 4 TYR A 170
VAL A 145
PHE A  44
GLY A  34
 None
 1.24A 6hd4A-5xc4A:
undetectable		 6hd4A-5xc4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 TYR A 121
VAL A 296
PHE A 128
MET A 129
 None
 1.38A 6hd4A-5xmdA:
undetectable		 6hd4A-5xmdA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 4 VAL A  87
PHE A 152
MET A 153
GLY A 125
 None
 1.43A 6hd4A-5xr6A:
undetectable		 6hd4A-5xr6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 4 VAL A 315
PHE A 345
MET A 346
GLY A 349
 None
FE7  A 601 (-4.5A)
FE7  A 601 (-4.7A)
FE7  A 601 ( 3.7A)
 1.24A 6hd4A-6cthA:
21.8		 6hd4A-6cthA:
28.74