SIMILAR PATTERNS OF AMINO ACIDS FOR 6HD4_A_STIA604

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gng GLYCOGEN SYNTHASE
KINASE-3 BETA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  70
ALA A  83
LYS A  85
GLU A  97
VAL A 110
LEU A 188
 None
 0.59A 6hd4A-1gngA:
20.4		 6hd4A-1gngA:
12.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
LEU A 321
 None
 0.70A 6hd4A-1k9aA:
26.8		 6hd4A-1k9aA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
 None
 0.59A 6hd4A-1k9aA:
26.8		 6hd4A-1k9aA:
16.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 ALA A 606
LYS A 608
MET A 629
VAL A 638
LEU A 731
ALA A 741
ASP A 742
 None
 1.16A 6hd4A-1lufA:
34.0		 6hd4A-1lufA:
31.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 588
ALA A 606
LYS A 608
VAL A 638
LEU A 731
ALA A 741
ASP A 742
 None
 0.86A 6hd4A-1lufA:
34.0		 6hd4A-1lufA:
31.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		11 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
ILE A 312
VAL A 318
ILE A 332
THR A 334
LEU A 389
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
None
P16  A   2 ( 4.7A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.70A 6hd4A-1opkA:
36.8		 6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 603
ALA A 621
GLU A 640
VAL A 654
THR A 670
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
STI  A   3 (-4.3A)
STI  A   3 (-3.2A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.54A 6hd4A-1t46A:
33.7		 6hd4A-1t46A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
VAL A 399
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
None
STU  A 100 (-4.5A)
 0.60A 6hd4A-1u59A:
29.8		 6hd4A-1u59A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zrz PROTEIN KINASE C,
IOTA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 259
ALA A 272
LYS A 274
GLU A 293
VAL A 307
LEU A 376
ASP A 387
 BI1  A1000 (-4.2A)
BI1  A1000 (-3.4A)
BI1  A1000 (-3.5A)
BI1  A1000 ( 4.9A)
BI1  A1000 (-4.4A)
BI1  A1000 (-4.8A)
BI1  A1000 (-4.5A)
 1.06A 6hd4A-1zrzA:
20.0		 6hd4A-1zrzA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
ALA X 147
ASP X 148
 STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 ( 4.1A)
STU  X 902 (-3.6A)
 0.99A 6hd4A-2dq7X:
31.5		 6hd4A-2dq7X:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
VAL X  67
ILE X  80
THR X  82
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.73A 6hd4A-2dq7X:
31.5		 6hd4A-2dq7X:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 170
ALA A 184
GLU A 201
ILE A 208
VAL A 220
ILE A 234
LEU A 290
ALA A 319
 None
 0.72A 6hd4A-2eu9A:
21.1		 6hd4A-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 170
ALA A 184
LYS A 186
GLU A 201
ILE A 208
ILE A 234
LEU A 290
ALA A 319
 None
 0.79A 6hd4A-2eu9A:
21.1		 6hd4A-2eu9A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
 0.58A 6hd4A-2h8hA:
29.7		 6hd4A-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
None
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.92A 6hd4A-2h8hA:
29.7		 6hd4A-2h8hA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
VAL A 323
ILE A 336
THR A 338
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
None
QUE  A   1 (-3.3A)
QUE  A   1 ( 4.5A)
 0.95A 6hd4A-2hckA:
29.2		 6hd4A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
VAL A 323
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.95A 6hd4A-2hckA:
29.2		 6hd4A-2hckA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 1.01A 6hd4A-2hk5A:
26.5		 6hd4A-2hk5A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
None
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
 0.62A 6hd4A-2hk5A:
26.5		 6hd4A-2hk5A:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 269
GLU A 286
MET A 290
ILE A 293
VAL A 299
ILE A 313
THR A 315
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.78A 6hd4A-2hz0A:
34.3		 6hd4A-2hz0A:
92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 256
ALA A 269
GLU A 286
MET A 290
ILE A 293
VAL A 299
ILE A 313
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-4.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.59A 6hd4A-2hz0A:
34.3		 6hd4A-2hz0A:
92.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 256
ALA A 269
LYS A 271
GLU A 286
MET A 290
ILE A 293
ILE A 313
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-4.5A)
GIN  A 600 (-3.8A)
 0.78A 6hd4A-2hz0A:
34.3		 6hd4A-2hz0A:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
ASP A 564
 4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.7A)
 0.83A 6hd4A-2j0jA:
31.7		 6hd4A-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		8 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
VAL A 484
ILE A 497
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
None
4ST  A1687 (-4.4A)
 0.70A 6hd4A-2j0jA:
31.7		 6hd4A-2j0jA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 259
ALA A 271
GLU A 288
MET A 292
VAL A 301
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
None
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.57A 6hd4A-2og8A:
26.1		 6hd4A-2og8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.79A 6hd4A-2og8A:
26.1		 6hd4A-2og8A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
ASP A 796
 None
 0.93A 6hd4A-2ogvA:
22.1		 6hd4A-2ogvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
GLU A 633
MET A 637
VAL A 647
THR A 663
LEU A 785
 None
 0.86A 6hd4A-2ogvA:
22.1		 6hd4A-2ogvA:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 838
ALA A 853
LYS A 855
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.6A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.58A 6hd4A-2p4iA:
12.2		 6hd4A-2p4iA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 541
LEU A 633
ALA A 643
 None
 0.63A 6hd4A-2psqA:
31.4		 6hd4A-2psqA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
GLU A 670
MET A 674
ILE A 697
THR A 699
ASP A 764
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
 1.04A 6hd4A-2qobA:
26.1		 6hd4A-2qobA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd5 DMPK PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  85
ALA A  98
LYS A 100
GLU A 119
LEU A 202
ALA A 212
 BI8  A1417 ( 4.7A)
BI8  A1417 ( 3.8A)
BI8  A1417 (-4.2A)
BI8  A1417 ( 4.9A)
BI8  A1417 (-4.8A)
BI8  A1417 ( 4.1A)
 0.59A 6hd4A-2vd5A:
19.3		 6hd4A-2vd5A:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
LYS A  49
GLU A  66
ILE A  93
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.82A 6hd4A-2xikA:
18.3		 6hd4A-2xikA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.3A)
None
 0.77A 6hd4A-2xyuA:
32.4		 6hd4A-2xyuA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
MET A 294
VAL A 303
THR A 319
ASP A 385
 None
 1.06A 6hd4A-2zv7A:
30.8		 6hd4A-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
GLU A 290
VAL A 303
ILE A 317
THR A 319
ASP A 385
 None
 0.87A 6hd4A-2zv7A:
30.8		 6hd4A-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
MET A 294
VAL A 303
THR A 319
ALA A 384
ASP A 385
 None
 1.08A 6hd4A-2zv7A:
30.8		 6hd4A-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
MET A 294
VAL A 303
THR A 319
LEU A 374
ALA A 384
 None
 1.11A 6hd4A-2zv7A:
30.8		 6hd4A-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
VAL A 303
ILE A 317
THR A 319
ALA A 384
ASP A 385
 None
 0.70A 6hd4A-2zv7A:
30.8		 6hd4A-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
VAL A 303
ILE A 317
THR A 319
LEU A 374
ALA A 384
 None
 0.86A 6hd4A-2zv7A:
30.8		 6hd4A-2zv7A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.68A 6hd4A-3c4fA:
24.7		 6hd4A-3c4fA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
LEU A 321
 None
 0.70A 6hd4A-3d7uA:
26.8		 6hd4A-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
VAL A 249
ILE A 264
THR A 266
 None
 0.59A 6hd4A-3d7uA:
26.8		 6hd4A-3d7uA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
VAL A 695
ILE A 709
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.8A)
 0.73A 6hd4A-3dkoA:
30.4		 6hd4A-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
LYS A 665
VAL A 695
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 ( 4.9A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.70A 6hd4A-3dkoA:
30.4		 6hd4A-3dkoA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fme DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 6

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  67
ALA A  80
LYS A  82
VAL A 113
ILE A 127
LEU A 186
 None
STU  A   1 (-3.4A)
STU  A   1 ( 4.2A)
None
None
STU  A   1 (-4.4A)
 0.60A 6hd4A-3fmeA:
16.9		 6hd4A-3fmeA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
LYS A  53
GLU A  71
THR A 106
ASP A 168
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.6A)
 0.53A 6hd4A-3gp0A:
21.9		 6hd4A-3gp0A:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
GLU A 878
ILE A 885
VAL A 892
LEU A1029
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
None
 0.87A 6hd4A-3hngA:
32.7		 6hd4A-3hngA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
LYS A 861
GLU A 878
ILE A 885
VAL A 892
ASP A1040
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
None
8ST  A2001 ( 4.7A)
None
 0.91A 6hd4A-3hngA:
32.7		 6hd4A-3hngA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
ALA A 192
ASP A 193
 None
 0.68A 6hd4A-3iecA:
22.3		 6hd4A-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  67
ALA A  80
LYS A  82
MET A 104
VAL A 113
LEU A 182
ALA A 192
 None
 0.73A 6hd4A-3iecA:
22.3		 6hd4A-3iecA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
LEU A 767
 None
 0.65A 6hd4A-3kulA:
31.4		 6hd4A-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 711
THR A 713
 None
 0.77A 6hd4A-3kulA:
31.4		 6hd4A-3kulA:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		7 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.77A 6hd4A-3mdyA:
24.4		 6hd4A-3mdyA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
GLU A 596
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.73A 6hd4A-3ppzA:
28.3		 6hd4A-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 VAL A 565
ALA A 576
LYS A 578
MET A 600
VAL A 609
ILE A 623
THR A 625
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.3A)
 0.75A 6hd4A-3ppzA:
28.3		 6hd4A-3ppzA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 431
ALA A 443
MET A 464
VAL A 473
ILE A 487
THR A 489
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
None
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 (-4.6A)
 0.68A 6hd4A-3sxsA:
25.0		 6hd4A-3sxsA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
None
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.69A 6hd4A-3tt0A:
30.4		 6hd4A-3tt0A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vid VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 4TT  A2001 ( 4.5A)
4TT  A2001 (-3.5A)
None
None
None
None
4TT  A2001 (-4.8A)
None
 0.77A 6hd4A-3vidA:
29.9		 6hd4A-3vidA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wzd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
LYS A 868
GLU A 885
ILE A 892
VAL A 899
LEU A1035
 LEV  A1201 ( 4.9A)
LEV  A1201 (-3.5A)
None
LEV  A1201 (-3.7A)
None
None
LEV  A1201 (-4.8A)
 0.61A 6hd4A-3wzdA:
30.7		 6hd4A-3wzdA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agd VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 848
ALA A 866
GLU A 885
ILE A 892
VAL A 899
LEU A1035
ASP A1046
 None
B49  A2000 (-3.5A)
None
None
B49  A2000 ( 4.6A)
B49  A2000 (-4.5A)
None
 0.80A 6hd4A-4agdA:
32.5		 6hd4A-4agdA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
GLU A  81
VAL A  94
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.70A 6hd4A-4bc6A:
21.2		 6hd4A-4bc6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
LYS A  65
ILE A  84
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
None
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 1.11A 6hd4A-4bc6A:
21.2		 6hd4A-4bc6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
LYS A  65
VAL A  94
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.78A 6hd4A-4bc6A:
21.2		 6hd4A-4bc6A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
THR A 701
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.70A 6hd4A-4ckrA:
32.1		 6hd4A-4ckrA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 836
ALA A 853
LYS A 855
GLU A 871
VAL A 884
LEU A 956
ALA A 966
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
None
19S  A1201 (-4.5A)
19S  A1201 ( 4.1A)
 0.66A 6hd4A-4hviA:
29.0		 6hd4A-4hviA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 486
ALA A 506
GLU A 525
MET A 529
ILE A 532
LEU A 624
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
 0.81A 6hd4A-4k33A:
30.8		 6hd4A-4k33A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
ILE A 532
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
 0.50A 6hd4A-4k33A:
30.8		 6hd4A-4k33A:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
GLU A  70
MET A  74
VAL A  83
LEU A 153
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
None
None
GOL  A 403 (-4.1A)
GOL  A 403 ( 4.4A)
GOL  A 403 ( 3.0A)
 1.13A 6hd4A-4lg4A:
17.0		 6hd4A-4lg4A:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
GLU A  85
MET A  89
VAL A  99
THR A 123
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 ( 4.5A)
 0.85A 6hd4A-4o38A:
19.1		 6hd4A-4o38A:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
VAL A  99
THR A 123
 None
SIN  A 401 ( 3.7A)
None
None
None
None
None
 0.78A 6hd4A-4o38A:
19.1		 6hd4A-4o38A:
14.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
GLU A  52
MET A  56
VAL A  65
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.07A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
GLU A  52
VAL A  65
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.88A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
ILE A  55
ILE A  79
THR A  81
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.8A)
None
None
 1.17A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
VAL A  65
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
None
None
 1.04A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
LYS A  37
GLU A  52
VAL A  65
ILE A  79
THR A  81
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
None
None
 0.86A 6hd4A-4ueuA:
32.2		 6hd4A-4ueuA:
30.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 ALA A  72
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
ASP A 194
 KSA  A 405 (-3.2A)
None
None
None
None
KSA  A 405 (-4.6A)
ZN  A 403 ( 2.6A)
 1.02A 6hd4A-4wsqA:
22.1		 6hd4A-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsq AP2-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  60
ALA A  72
LYS A  74
GLU A  90
MET A  94
VAL A 104
ILE A 124
LEU A 183
 KSA  A 405 ( 4.9A)
KSA  A 405 (-3.2A)
None
None
None
None
None
KSA  A 405 (-4.6A)
 0.78A 6hd4A-4wsqA:
22.1		 6hd4A-4wsqA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 527
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
None
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 6hd4A-4xcuA:
30.9		 6hd4A-4xcuA:
18.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 275
ALA B 288
LYS B 290
MET B 309
ILE B 312
VAL B 318
ILE B 332
THR B 334
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
 0.67A 6hd4A-4xeyB:
27.9		 6hd4A-4xeyB:
40.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 VAL B 275
ALA B 288
MET B 309
ILE B 312
VAL B 318
ILE B 332
THR B 334
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
None
1N1  B 601 ( 4.3A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.75A 6hd4A-4xeyB:
27.9		 6hd4A-4xeyB:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
LYS A 644
GLU A 661
VAL A 675
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
None
P30  A1001 (-4.3A)
None
 0.62A 6hd4A-4xufA:
27.6		 6hd4A-4xufA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
LYS A 490
GLU A 509
ILE A 537
THR A 539
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.72A 6hd4A-4yffA:
19.0		 6hd4A-4yffA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 538
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
None
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.72A 6hd4A-5a46A:
30.4		 6hd4A-5a46A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
LYS A  85
GLU A 103
VAL A 116
LEU A 185
ALA A 195
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
None
None
5RC  A4000 ( 3.9A)
 1.07A 6hd4A-5es1A:
17.0		 6hd4A-5es1A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 607
ALA A 625
GLU A 644
MET A 648
VAL A 658
ILE A 672
THR A 674
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 ( 4.8A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.62A 6hd4A-5grnA:
28.3		 6hd4A-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.8A)
 0.78A 6hd4A-5grnA:
28.3		 6hd4A-5grnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gz8 PROTEIN O-MANNOSE
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A  94
ALA A 105
VAL A 134
ILE A 146
THR A 148
LEU A 215
ASP A 226
 None
 0.88A 6hd4A-5gz8A:
19.0		 6hd4A-5gz8A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
VAL A 109
ILE A 128
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
None
IDV  A 401 (-4.4A)
 0.74A 6hd4A-5i3oA:
21.9		 6hd4A-5i3oA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
VAL A  74
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.72A 6hd4A-5j5tA:
20.8		 6hd4A-5j5tA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 647
ALA A 663
LYS A 665
ILE A 709
THR A 711
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
None
 0.63A 6hd4A-5l6oA:
33.3		 6hd4A-5l6oA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 709
THR A 711
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
None
 0.67A 6hd4A-5l6oA:
33.3		 6hd4A-5l6oA:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
LYS A 121
GLU A 136
VAL A 157
LEU A 232
ALA A 540
 W4A  A 716 ( 4.7A)
W4A  A 716 ( 3.9A)
SO4  A 702 (-3.3A)
DMS  A 717 (-4.0A)
DMS  A 717 (-4.3A)
None
DMS  A 717 ( 4.5A)
 0.99A 6hd4A-5myvA:
19.7		 6hd4A-5myvA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.7A)
 0.61A 6hd4A-5wnoA:
27.8		 6hd4A-5wnoA:
28.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 6 VAL A 741
ALA A 754
GLU A 774
VAL A 787
LEU A 866
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.56A 6hd4A-6b3eA:
22.6		 6hd4A-6b3eA:
32.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
VAL A 120
LEU A 189
ALA A 199
 None
 0.99A 6hd4A-6c9dA:
21.0		 6hd4A-6c9dA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 VAL A 179
ALA A 192
LYS A 194
GLU A 236
VAL A 249
LEU A 319
ALA A 329
 F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
F6J  A 501 ( 4.7A)
None
F6J  A 501 (-4.5A)
F6J  A 501 ( 4.0A)
 0.89A 6hd4A-6cmjA:
22.0		 6hd4A-6cmjA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 VAL A 177
ALA A 191
GLU A 208
ILE A 215
ILE A 241
LEU A 297
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
 1.20A 6hd4A-6fylA:
7.3		 6hd4A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 VAL A 177
ALA A 191
GLU A 208
VAL A 227
ILE A 241
LEU A 297
ASP A 327
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 ( 4.9A)
None
None
None
3NG  A 501 (-4.5A)
 1.03A 6hd4A-6fylA:
7.3		 6hd4A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 7 VAL A 177
ALA A 191
LYS A 193
GLU A 208
ILE A 215
ILE A 241
LEU A 297
 3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
3NG  A 501 ( 4.9A)
None
None
None
 1.01A 6hd4A-6fylA:
7.3		 6hd4A-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aqz RESTRICTOCIN

(Aspergillus
restrictus) 		no annotation 4 TYR A  47
VAL A 129
PHE A  99
GLY A 117
 PO4  A 400 (-4.4A)
None
None
None
 1.36A 6hd4A-1aqzA:
undetectable		 6hd4A-1aqzA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		4 TYR A 190
VAL A   7
PHE A 136
GLY A 145
 None
 1.35A 6hd4A-1bs9A:
undetectable		 6hd4A-1bs9A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 TYR A 273
VAL A  12
MET A 212
GLY A 211
 None
 1.03A 6hd4A-1fi4A:
undetectable		 6hd4A-1fi4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fi4 MEVALONATE
5-DIPHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N) 		4 TYR A 273
VAL A  37
MET A 212
GLY A 211
 None
 1.43A 6hd4A-1fi4A:
undetectable		 6hd4A-1fi4A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		4 VAL A  36
PHE A 277
MET A 294
GLY A 293
 None
 1.42A 6hd4A-1k0fA:
undetectable		 6hd4A-1k0fA:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mn6 POLYKETIDE SYNTHASE
IV

(Streptomyces
venezuelae) 		PF00975
(Thioesterase) 		4 TYR A 107
VAL A 175
PHE A 219
GLY A 214
 None
 1.33A 6hd4A-1mn6A:
undetectable		 6hd4A-1mn6A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7u ADSORPTION PROTEIN
P2

(Salmonella
virus PRD1) 		PF09214
(Prd1-P2) 		4 TYR A 363
VAL A 357
PHE A 531
GLY A 527
 None
 1.18A 6hd4A-1n7uA:
undetectable		 6hd4A-1n7uA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 TYR A 272
VAL A 308
MET A 337
GLY A 340
 P16  A   2 (-3.6A)
None
None
P16  A   2 (-3.4A)
 0.76A 6hd4A-1opkA:
36.8		 6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		4 VAL A 308
PHE A 336
MET A 337
GLY A 340
 None
P16  A   2 ( 4.4A)
None
P16  A   2 (-3.4A)
 0.47A 6hd4A-1opkA:
36.8		 6hd4A-1opkA:
28.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4y RIBONUCLEASE
ALPHA-SARCIN

(Aspergillus
giganteus) 		no annotation 4 TYR A  34
VAL A 116
PHE A  86
GLY A 104
 None
 1.11A 6hd4A-1r4yA:
undetectable		 6hd4A-1r4yA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1saw HYPOTHETICAL PROTEIN
FLJ36880

(Homo sapiens) 		PF01557
(FAA_hydrolase) 		4 TYR A  52
VAL A  43
MET A  78
GLY A 185
 None
 1.32A 6hd4A-1sawA:
undetectable		 6hd4A-1sawA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 409
PHE A 437
MET A 438
GLY A 441
 None
 0.72A 6hd4A-1snxA:
29.5		 6hd4A-1snxA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sy7 CATALASE 1

(Neurospora
crassa) 		PF00199
(Catalase)
PF01965
(DJ-1_PfpI)
PF06628
(Catalase-rel) 		4 VAL A 193
PHE A 208
MET A 502
GLY A 500
 None
 1.35A 6hd4A-1sy7A:
undetectable		 6hd4A-1sy7A:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
SMALL SUBUNIT
QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida;
Pseudomonas
putida) 		PF00111
(Fer2)
PF01799
(Fer2_2)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A 133
PHE A 109
MET B 201
GLY A  47
 None
None
None
FES  A4908 (-4.2A)
 1.33A 6hd4A-1t3qA:
undetectable		 6hd4A-1t3qA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7g PROBABLE AMMONIUM
TRANSPORTER

(Escherichia
coli) 		PF00909
(Ammonium_transp) 		4 VAL A  60
PHE A  22
MET A  23
GLY A  27
 None
None
NH3  A 402 (-4.4A)
None
 1.41A 6hd4A-1u7gA:
undetectable		 6hd4A-1u7gA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 TYR A 278
VAL A 267
PHE A 311
GLY A 275
 TYR  A 278 ( 1.3A)
VAL  A 267 ( 0.5A)
PHE  A 311 ( 1.3A)
GLY  A 275 ( 0.0A)
 1.32A 6hd4A-1v0fA:
undetectable		 6hd4A-1v0fA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wc2 ENDOGLUCANASE

(Mytilus edulis) 		no annotation 4 TYR A 173
VAL A 140
PHE A  41
GLY A  31
 None
 1.03A 6hd4A-1wc2A:
undetectable		 6hd4A-1wc2A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		4 TYR A 208
VAL A 176
PHE A  23
GLY A 225
 None
 1.13A 6hd4A-1y1pA:
undetectable		 6hd4A-1y1pA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z26 ARGONAUTE

(Pyrococcus
furiosus) 		PF02171
(Piwi)
PF12212
(PAZ_siRNAbind) 		4 VAL A 526
PHE A 385
MET A 384
GLY A 473
 None
 1.35A 6hd4A-1z26A:
undetectable		 6hd4A-1z26A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxx PROBABLE GTP-BINDING
PROTEIN ENGB

(Pyrococcus
horikoshii) 		PF01926
(MMR_HSR1) 		4 VAL A  73
PHE A  56
MET A  57
GLY A  59
 None
 1.37A 6hd4A-2cxxA:
undetectable		 6hd4A-2cxxA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		4 VAL A  41
PHE A 298
MET A 297
GLY A 296
 None
 1.31A 6hd4A-2ek8A:
undetectable		 6hd4A-2ek8A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ek8 AMINOPEPTIDASE

(Aneurinibacillus
sp. AM-1) 		PF02225
(PA)
PF04389
(Peptidase_M28) 		4 VAL A  57
PHE A 298
MET A 297
GLY A 296
 None
 1.39A 6hd4A-2ek8A:
undetectable		 6hd4A-2ek8A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erx GTP-BINDING PROTEIN
DI-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 174
PHE A 147
MET A 148
GLY A 120
 None
 1.31A 6hd4A-2erxA:
undetectable		 6hd4A-2erxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 VAL A 503
PHE A  88
MET A  87
GLY A  86
 None
 1.23A 6hd4A-2fknA:
undetectable		 6hd4A-2fknA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 291
PHE A 318
MET A 319
GLY A 322
 None
1BM  A 499 (-4.1A)
None
1BM  A 499 (-3.5A)
 0.70A 6hd4A-2hk5A:
26.5		 6hd4A-2hk5A:
18.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 289
PHE A 317
MET A 318
GLY A 321
 None
GIN  A 600 (-4.3A)
None
None
 0.34A 6hd4A-2hz0A:
34.3		 6hd4A-2hz0A:
92.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 TYR A 342
VAL A 316
PHE A 337
GLY A 122
 None
 0.92A 6hd4A-2hzkA:
undetectable		 6hd4A-2hzkA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		4 TYR A 120
VAL A  29
PHE A  80
GLY A 263
 None
 1.09A 6hd4A-2p3xA:
undetectable		 6hd4A-2p3xA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qua EXTRACELLULAR LIPASE

(Serratia
marcescens) 		no annotation 4 TYR A 253
VAL A 248
MET A 324
GLY A 322
 None
 1.23A 6hd4A-2quaA:
undetectable		 6hd4A-2quaA:
8.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w18 PARTNER AND
LOCALIZER OF BRCA2

(Homo sapiens) 		PF16756
(PALB2_WD40) 		4 VAL A 991
PHE A 876
MET A 875
GLY A1166
 None
 1.35A 6hd4A-2w18A:
undetectable		 6hd4A-2w18A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3c GENERAL VESICULAR
TRANSPORT FACTOR
P115

(Homo sapiens) 		PF04869
(Uso1_p115_head) 		4 TYR A 350
VAL A 385
MET A 307
GLY A 311
 None
 1.32A 6hd4A-2w3cA:
undetectable		 6hd4A-2w3cA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk STE20-RELATED KINASE
ADAPTER PROTEIN
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL B 121
PHE B 149
MET B 150
GLY B 153
 None
ANP  B 432 ( 4.9A)
None
ANP  B 432 ( 4.2A)
 0.85A 6hd4A-2wtkB:
21.8		 6hd4A-2wtkB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x66 PRNB

(Pseudomonas
fluorescens) 		PF08933
(DUF1864) 		4 TYR A 181
VAL A 190
PHE A  11
GLY A   9
 None
 1.42A 6hd4A-2x66A:
undetectable		 6hd4A-2x66A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 TYR A 496
VAL A 478
MET A 583
GLY A 580
 PO4  A1793 (-3.1A)
None
None
None
 1.14A 6hd4A-2xe4A:
undetectable		 6hd4A-2xe4A:
7.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvr MAJOR CAPSID PROTEIN
10A

(Escherichia
virus T7) 		no annotation 4 VAL A 271
PHE A 245
MET A 243
GLY A 237
 None
 1.25A 6hd4A-2xvrA:
undetectable		 6hd4A-2xvrA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8k AMINOMETHYLTRANSFERA
SE

(Escherichia
coli) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 VAL A 176
PHE A  46
MET A  45
GLY A  44
 None
 1.07A 6hd4A-3a8kA:
undetectable		 6hd4A-3a8kA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0i PERIPHERAL PLASMA
MEMBRANE PROTEIN
CASK

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 165
PHE A  93
MET A  94
GLY A  96
 None
3AM  A 338 ( 4.6A)
None
None
 0.61A 6hd4A-3c0iA:
23.0		 6hd4A-3c0iA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d4j DIPHOSPHOMEVALONATE
DECARBOXYLASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N) 		4 TYR A 276
VAL A  16
MET A 215
GLY A 214
 None
None
SO4  A 401 ( 4.7A)
None
 1.10A 6hd4A-3d4jA:
undetectable		 6hd4A-3d4jA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2d ALKALINE PHOSPHATASE

(Vibrio sp.
G15-21) 		PF00245
(Alk_phosphatase) 		4 TYR A 199
VAL A 178
MET A 139
GLY A 143
 None
SO4  A 611 ( 3.7A)
None
None
 1.37A 6hd4A-3e2dA:
undetectable		 6hd4A-3e2dA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN
RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		4 VAL B 421
PHE A 563
MET A 560
GLY A 310
 None
 1.41A 6hd4A-3egwB:
undetectable		 6hd4A-3egwB:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 TYR A 276
VAL A  16
MET A 215
GLY A 214
 None
None
PO4  A 401 (-4.7A)
None
 1.17A 6hd4A-3f0nA:
undetectable		 6hd4A-3f0nA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hfw PROTEIN
ADP-RIBOSYLARGININE
HYDROLASE

(Homo sapiens) 		PF03747
(ADP_ribosyl_GH) 		4 TYR A   4
VAL A 323
MET A 136
GLY A 139
 None
 1.33A 6hd4A-3hfwA:
undetectable		 6hd4A-3hfwA:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxt 5-FORMYLTETRAHYDROFO
LATE CYCLO-LIGASE

(Homo sapiens) 		PF01812
(5-FTHF_cyc-lig) 		4 TYR A 156
VAL A 195
PHE A  79
GLY A 128
 NI  A 204 (-4.8A)
None
None
None
 1.19A 6hd4A-3hxtA:
undetectable		 6hd4A-3hxtA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4u MAJOR CAPSID PROTEIN

(Bordetella
virus BPP1) 		no annotation 4 VAL A  81
PHE A 142
MET A 143
GLY A 144
 None
 1.40A 6hd4A-3j4uA:
undetectable		 6hd4A-3j4uA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ki6 CHOLIX TOXIN

(Vibrio cholerae) 		PF09009
(Exotox-A_cataly) 		4 TYR A 626
VAL A 593
PHE A 570
GLY A 572
 None
 1.34A 6hd4A-3ki6A:
undetectable		 6hd4A-3ki6A:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 269
PHE A 290
MET A 282
GLY A 318
 None
 1.36A 6hd4A-3oc4A:
undetectable		 6hd4A-3oc4A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0l STEROIDOGENIC ACUTE
REGULATORY PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF01852
(START) 		4 TYR A  75
VAL A 138
MET A 209
GLY A 207
 None
 1.40A 6hd4A-3p0lA:
undetectable		 6hd4A-3p0lA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1v METALLO-ENDOPEPTIDAS
E

(Bacteroides
ovatus) 		PF09471
(Peptidase_M64)
PF16217
(M64_N) 		4 TYR A 423
VAL A  33
PHE A 313
GLY A 318
 None
 1.32A 6hd4A-3p1vA:
undetectable		 6hd4A-3p1vA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 296
PHE A 376
MET A 375
GLY A 374
 None
 1.10A 6hd4A-3peiA:
undetectable		 6hd4A-3peiA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pei CYTOSOL
AMINOPEPTIDASE

(Francisella
tularensis) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 VAL A 297
PHE A 376
MET A 375
GLY A 374
 SO4  A 513 ( 4.9A)
None
None
None
 1.31A 6hd4A-3peiA:
undetectable		 6hd4A-3peiA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Shewanella
denitrificans) 		PF00465
(Fe-ADH) 		4 TYR A 207
VAL A 169
MET A 328
GLY A 329
 None
 1.25A 6hd4A-3rf7A:
undetectable		 6hd4A-3rf7A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 TYR A 366
VAL A 150
PHE A 394
GLY A 392
 None
 1.29A 6hd4A-3syjA:
undetectable		 6hd4A-3syjA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vxc PUTATIVE
SUGAR-BINDING
LIPOPROTEIN

(Streptomyces
thermoviolaceus) 		PF01547
(SBP_bac_1) 		4 TYR A 264
VAL A 250
PHE A 161
GLY A 284
 None
 1.25A 6hd4A-3vxcA:
undetectable		 6hd4A-3vxcA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzb SPHINGOSINE KINASE 1

(Homo sapiens) 		PF00781
(DAGK_cat) 		4 TYR A 123
VAL A 340
PHE A 273
GLY A 278
 EDO  A 408 (-4.8A)
None
None
EDO  A 408 ( 3.9A)
 1.20A 6hd4A-3vzbA:
undetectable		 6hd4A-3vzbA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR A 150
VAL A 104
PHE A 146
GLY A 136
 None
 1.40A 6hd4A-3wa1A:
undetectable		 6hd4A-3wa1A:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zbm COPPER-CONTAINING
NITRITE REDUCTASE

(Ralstonia
pickettii) 		PF07732
(Cu-oxidase_3)
PF13442
(Cytochrome_CBB3) 		4 TYR A 149
VAL A  41
PHE A  60
GLY A 205
 None
 1.03A 6hd4A-3zbmA:
undetectable		 6hd4A-3zbmA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfn ALLYL ALCOHOL
DEHYDROGENASE

(Nicotiana
tabacum) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		4 TYR A 309
VAL A 325
MET A 136
GLY A 138
 None
None
NAP  A 400 (-3.4A)
None
 1.37A 6hd4A-4hfnA:
undetectable		 6hd4A-4hfnA:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4imd N-ACETYLNEURAMINATE
LYASE

(Pasteurella
multocida) 		PF00701
(DHDPS) 		4 TYR A 121
VAL A 148
PHE A 109
GLY A  81
 None
 1.37A 6hd4A-4imdA:
undetectable		 6hd4A-4imdA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 TYR A  98
VAL A 166
PHE A 101
GLY A 110
 None
 1.35A 6hd4A-4kh8A:
undetectable		 6hd4A-4kh8A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kh8 HYPOTHETICAL PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 TYR A 264
VAL A 330
PHE A 267
GLY A 276
 None
 1.33A 6hd4A-4kh8A:
undetectable		 6hd4A-4kh8A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nw4 LIPOPROTEIN S-LAYER
PROTEIN

(Enterococcus
faecalis) 		PF16103
(DUF4822) 		4 TYR A 238
VAL A 304
PHE A 241
GLY A 250
 None
 1.41A 6hd4A-4nw4A:
undetectable		 6hd4A-4nw4A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qez 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Bacillus
anthracis) 		no annotation 4 VAL B 112
PHE B 152
MET B 153
GLY B  78
 None
ADE  B 301 (-3.9A)
None
ADE  B 301 (-3.2A)
 1.43A 6hd4A-4qezB:
undetectable		 6hd4A-4qezB:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qq1 TRANSFERRIN-BINDING
PROTEIN 2

(Neisseria
meningitidis) 		PF01298
(TbpB_B_D)
PF17483
(TbpB_C)
PF17484
(TbpB_A) 		4 TYR A 541
VAL A 370
PHE A 570
GLY A 538
 None
 1.43A 6hd4A-4qq1A:
undetectable		 6hd4A-4qq1A:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 VAL A 100
PHE A 194
MET A 195
GLY A 197
 None
 1.11A 6hd4A-4r12A:
undetectable		 6hd4A-4r12A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		4 VAL A 114
PHE A 194
MET A 195
GLY A 197
 None
 1.34A 6hd4A-4r12A:
undetectable		 6hd4A-4r12A:
9.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv2 MAOC FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01575
(MaoC_dehydratas) 		4 TYR B  83
VAL B  11
PHE B 104
GLY B  68
 None
 1.37A 6hd4A-4rv2B:
undetectable		 6hd4A-4rv2B:
22.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 4 VAL B 308
PHE B 336
MET B 337
GLY B 340
 None
1N1  B 601 ( 4.2A)
None
1N1  B 601 (-3.5A)
 0.35A 6hd4A-4xeyB:
27.9		 6hd4A-4xeyB:
40.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztc AMINOTRANSFERASE
HOMOLOG

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 TYR A 132
VAL A 109
PHE A 356
GLY A 359
 None
 1.41A 6hd4A-4ztcA:
undetectable		 6hd4A-4ztcA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 TYR A 257
VAL A 386
PHE A 227
GLY A 247
 None
 1.01A 6hd4A-5ahkA:
undetectable		 6hd4A-5ahkA:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 VAL A 127
PHE A 193
MET A 192
GLY A 190
 None
 1.01A 6hd4A-5aydA:
undetectable		 6hd4A-5aydA:
11.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		4 TYR A 268
VAL A 413
MET A 331
GLY A 332
 None
 1.37A 6hd4A-5aynA:
undetectable		 6hd4A-5aynA:
9.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cee NAD-DEPENDENT MALIC
ENZYME

(Aster yellows
witches'-broom
phytoplasma) 		PF00390
(malic)
PF03949
(Malic_M) 		4 TYR A  55
VAL A  40
MET A  63
GLY A 128
 None
 1.13A 6hd4A-5ceeA:
undetectable		 6hd4A-5ceeA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cyr RNA-DEPENDENT RNA
POLYMERASE

(Thosea asigna
virus) 		no annotation 4 TYR B 270
VAL B  64
PHE B 122
GLY B 160
 None
 1.25A 6hd4A-5cyrB:
undetectable		 6hd4A-5cyrB:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d3o GLUTAMINASE KIDNEY
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF04960
(Glutaminase) 		4 TYR A 419
VAL A 376
MET A 338
GLY A 342
 None
 1.43A 6hd4A-5d3oA:
undetectable		 6hd4A-5d3oA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		4 TYR A 134
VAL A  14
PHE A 318
GLY A 312
 None
 1.42A 6hd4A-5f1yA:
undetectable		 6hd4A-5f1yA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1y MCCC FAMILY PROTEIN

(Bacillus cereus) 		PF02016
(Peptidase_S66) 		4 TYR A 322
VAL A  14
PHE A 311
GLY A 215
 None
 1.41A 6hd4A-5f1yA:
undetectable		 6hd4A-5f1yA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foz LARVICIDAL TOXIN
PROTEIN

(Lysinibacillus
sphaericus) 		PF05431
(Toxin_10) 		4 TYR B 150
VAL B 104
PHE B 146
GLY B 136
 None
 1.43A 6hd4A-5fozB:
undetectable		 6hd4A-5fozB:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4e BETA 1-3 GLUCANASE

(Clostridium
beijerinckii) 		no annotation 4 TYR A 425
PHE A 354
MET A 353
GLY A 351
 None
 1.09A 6hd4A-5h4eA:
undetectable		 6hd4A-5h4eA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(uncultured
marine
bacterium) 		PF03480
(DctP) 		4 TYR A 235
VAL A 280
MET A 206
GLY A 170
 None
 1.34A 6hd4A-5i5pA:
undetectable		 6hd4A-5i5pA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 TYR A 284
VAL A 212
PHE A 304
GLY A 269
 None
 1.34A 6hd4A-5i7nA:
undetectable		 6hd4A-5i7nA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbw RIBOFLAVIN
TRANSPORTER RIBU

(Thermotoga
maritima) 		PF12822
(ECF_trnsprt) 		4 TYR A  36
VAL A 127
PHE A  87
GLY A 154
 None
 1.20A 6hd4A-5kbwA:
undetectable		 6hd4A-5kbwA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kd5 METALLOPEPTIDASE

(Bacteroides
thetaiotaomicron) 		PF13402
(Peptidase_M60)
PF17291
(M60-like_N) 		4 VAL A 362
PHE A 482
MET A 481
GLY A 477
 None
 1.33A 6hd4A-5kd5A:
undetectable		 6hd4A-5kd5A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvu ISOCITRATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF03971
(IDH) 		4 VAL A 295
PHE A 228
MET A 229
GLY A 181
 None
 1.43A 6hd4A-5kvuA:
undetectable		 6hd4A-5kvuA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0v PROTEIN
O-GLUCOSYLTRANSFERAS
E 1

(Homo sapiens) 		PF05686
(Glyco_transf_90) 		4 TYR A 161
VAL A 374
PHE A 114
GLY A 110
 None
 1.31A 6hd4A-5l0vA:
undetectable		 6hd4A-5l0vA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 4 VAL A  35
PHE A  52
MET A  51
GLY A  49
 None
SO4  A1011 (-4.8A)
None
None
 1.35A 6hd4A-5lewA:
undetectable		 6hd4A-5lewA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8e ALPHA-N-ARABINOFURAN
OSIDASE

(Weissella
cibaria) 		PF04616
(Glyco_hydro_43) 		4 VAL A  29
PHE A 215
MET A 226
GLY A 217
 None
 1.40A 6hd4A-5m8eA:
undetectable		 6hd4A-5m8eA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc9 LAMININ SUBUNIT
ALPHA-1

(Mus musculus) 		PF00054
(Laminin_G_1)
PF06009
(Laminin_II) 		4 VAL A2225
PHE A2257
MET A2256
GLY A2167
 None
 1.11A 6hd4A-5mc9A:
undetectable		 6hd4A-5mc9A:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr4 GDNF FAMILY RECEPTOR
ALPHA-2

(Homo sapiens) 		no annotation 4 TYR C 128
PHE C 303
MET C 300
GLY C 299
 None
 1.41A 6hd4A-5mr4C:
undetectable		 6hd4A-5mr4C:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nks DIHYDROPYRIMIDINASE-
RELATED PROTEIN 4

(Homo sapiens) 		no annotation 4 VAL A  70
PHE A 460
MET A 459
GLY A 457
 VAL  A  70 ( 0.6A)
PHE  A 460 ( 1.3A)
MET  A 459 ( 0.0A)
GLY  A 457 ( 0.0A)
 1.40A 6hd4A-5nksA:
undetectable		 6hd4A-5nksA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sui RIBOSOME BIOGENESIS
PROTEIN NSA1

(Saccharomyces
cerevisiae) 		no annotation 4 VAL A  13
PHE A 194
MET A 254
GLY A 214
 None
 1.18A 6hd4A-5suiA:
undetectable		 6hd4A-5suiA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6b TYROSINE-PROTEIN
KINASE RECEPTOR UFO

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 529
PHE A 622
MET A 623
GLY A 626
 None
7YS  A9001 (-4.3A)
7YS  A9001 (-4.7A)
7YS  A9001 (-3.4A)
 1.34A 6hd4A-5u6bA:
29.5		 6hd4A-5u6bA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 TYR A 407
VAL A 443
MET A 323
GLY A 328
 None
 1.10A 6hd4A-5vanA:
undetectable		 6hd4A-5vanA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5van BETA-KLOTHO

(Homo sapiens) 		no annotation 4 TYR A 928
VAL A 685
PHE A 944
GLY A 891
 None
 1.37A 6hd4A-5vanA:
undetectable		 6hd4A-5vanA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wi9 -

(-) 		no annotation 4 TYR A 407
VAL A 443
MET A 323
GLY A 328
 None
 1.15A 6hd4A-5wi9A:
undetectable		 6hd4A-5wi9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 TYR A 605
VAL A  49
PHE A  36
GLY A 574
 None
 1.33A 6hd4A-5wugA:
undetectable		 6hd4A-5wugA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc4 ENDO-BETA-1,4-GLUCAN
ASE

(Ampullaria
crossean) 		no annotation 4 TYR A 170
VAL A  99
PHE A  44
GLY A  34
 None
 1.25A 6hd4A-5xc4A:
undetectable		 6hd4A-5xc4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xc4 ENDO-BETA-1,4-GLUCAN
ASE

(Ampullaria
crossean) 		no annotation 4 TYR A 170
VAL A 145
PHE A  44
GLY A  34
 None
 1.24A 6hd4A-5xc4A:
undetectable		 6hd4A-5xc4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmd EPOXIDE HYDROLASE A

(Vigna radiata) 		no annotation 4 TYR A 121
VAL A 296
PHE A 128
MET A 129
 None
 1.38A 6hd4A-5xmdA:
undetectable		 6hd4A-5xmdA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xr6 RAS-RELATED PROTEIN
RABA1A

(Arabidopsis
thaliana) 		no annotation 4 VAL A  87
PHE A 152
MET A 153
GLY A 125
 None
 1.43A 6hd4A-5xr6A:
undetectable		 6hd4A-5xr6A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cth CONCANAVALIN A-LIKE
LECTIN PROTEIN
KINASE FAMILY
PROTEIN

(Theobroma cacao) 		no annotation 4 VAL A 315
PHE A 345
MET A 346
GLY A 349
 None
FE7  A 601 (-4.5A)
FE7  A 601 (-4.7A)
FE7  A 601 ( 3.7A)
 1.24A 6hd4A-6cthA:
21.8		 6hd4A-6cthA:
28.74