SIMILAR PATTERNS OF AMINO ACIDS FOR 6HAU_B_ACTB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zkj CRISPR-ASSOCIATED
PROTEIN CAS1

(Streptococcus
pyogenes) 		PF01867
(Cas_Cas1) 		4 LEU A 177
TYR A 156
ARG A 223
ASP A 227
 None
 1.35A 6hauA-4zkjA:
0.0
6hauB-4zkjA:
0.4		 6hauA-4zkjA:
21.81
6hauB-4zkjA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 4 LEU A 219
TYR A  23
ARG A 253
ASP A 257
 None
 1.31A 6hauA-5od2A:
0.0
6hauB-5od2A:
0.0		 6hauA-5od2A:
undetectable
6hauB-5od2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u0k GLUTAMINASE LIVER
ISOFORM,
MITOCHONDRIAL

(Homo sapiens) 		PF12796
(Ank_2) 		4 LEU A 491
TYR A 517
ARG A 520
ASP A 516
 None
 1.50A 6hauA-5u0kA:
0.0
6hauB-5u0kA:
undetectable		 6hauA-5u0kA:
20.16
6hauB-5u0kA:
20.16