SIMILAR PATTERNS OF AMINO ACIDS FOR 6H7M_B_68HB405_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cl7 PROTEIN (IGG1
ANTIBODY 1696
(CONSTANT HEAVY
CHAIN))

(Mus musculus) 		PF07654
(C1-set) 		5 VAL I 170
VAL I 188
SER I 186
ASN I 203
ASN I 162
 None
 1.44A 6h7mB-1cl7I:
undetectable		 6h7mB-1cl7I:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clz IGG FAB (IGG3,
KAPPA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.45A 6h7mB-1clzH:
undetectable		 6h7mB-1clzH:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.45A 6h7mB-1fskC:
undetectable		 6h7mB-1fskC:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gy9 ALPHA-KETOGLUTARATE-
DEPENDENT TAURINE
DIOXYGENASE

(Escherichia
coli) 		PF02668
(TauD) 		5 TRP A 248
ASP A 101
VAL A 102
PHE A 159
ASN A  95
 None
FE  A 300 (-2.3A)
TAU  A 350 (-3.8A)
TAU  A 350 (-4.3A)
AKG  A 351 ( 3.5A)
 1.20A 6h7mB-1gy9A:
undetectable		 6h7mB-1gy9A:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3p ANTIBODY FAB
FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 164
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 6h7mB-1h3pH:
undetectable		 6h7mB-1h3pH:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASP A 113
VAL A 101
SER A 152
PHE A 139
PHE A 149
 None
 1.43A 6h7mB-1hbzA:
undetectable		 6h7mB-1hbzA:
11.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.44A 6h7mB-1i9iH:
undetectable		 6h7mB-1i9iH:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.43A 6h7mB-1jnhB:
undetectable		 6h7mB-1jnhB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfa MONOCLONAL ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 176
VAL H 194
SER H 192
ASN H 209
ASN H 168
 None
 1.46A 6h7mB-1kfaH:
undetectable		 6h7mB-1kfaH:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ngq N1G9 (IGG1-LAMBDA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.46A 6h7mB-1ngqH:
undetectable		 6h7mB-1ngqH:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nj9 IMMUNOGLOBULIN HEAVY
CHAIN

(Mus musculus) 		no annotation 5 VAL H 162
VAL H 180
SER H 178
ASN H 195
ASN H 154
 None
 1.47A 6h7mB-1nj9H:
undetectable		 6h7mB-1nj9H:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.46A 6h7mB-1pz5B:
undetectable		 6h7mB-1pz5B:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qx6 NPQTN SPECIFIC
SORTASE B

(Staphylococcus
aureus) 		PF04203
(Sortase) 		5 VAL A 235
VAL A 237
PHE A 195
ASN A 180
ASN A 124
 None
 1.43A 6h7mB-1qx6A:
undetectable		 6h7mB-1qx6A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yuh 88C6/12 FAB (HEAVY
CHAIN)

(Mus musculus) 		no annotation 5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.45A 6h7mB-1yuhH:
undetectable		 6h7mB-1yuhH:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		5 ASP A 244
VAL A 188
SER A 247
PHE A 178
TYR A 169
 None
 1.38A 6h7mB-2drwA:
undetectable		 6h7mB-2drwA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2edm 22KDA STRUCTURAL
PROTEIN VP22

(White spot
syndrome virus) 		PF12175
(WSS_VP) 		5 VAL A 135
SER A 114
SER A 173
PHE A 181
PHE A 175
 None
 1.37A 6h7mB-2edmA:
undetectable		 6h7mB-2edmA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fl5 IMMUNOGLOBULIN IGG1
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.40A 6h7mB-2fl5H:
undetectable		 6h7mB-2fl5H:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2op4 MURINE ANTIBODY FAB
RS2-1G9 IGG1 HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.46A 6h7mB-2op4H:
undetectable		 6h7mB-2op4H:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 ASP A 327
PHE A 256
PHE A 164
PHE A 145
TYR A  64
 None
 1.33A 6h7mB-2pwhA:
undetectable		 6h7mB-2pwhA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.46A 6h7mB-2w9dH:
undetectable		 6h7mB-2w9dH:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhf PEROXIREDOXIN 5

(Alvinella
pompejana) 		PF08534
(Redoxin) 		5 VAL A  75
VAL A  79
SER A 148
ASN A 154
ASN A 110
 None
 1.23A 6h7mB-2xhfA:
undetectable		 6h7mB-2xhfA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		5 ASP A 238
VAL A 240
VAL A 264
SER A 109
SER A 276
 PLP  A 450 (-2.9A)
PLP  A 450 (-4.3A)
None
PLP  A 450 (-3.8A)
None
 1.44A 6h7mB-2zukA:
undetectable		 6h7mB-2zukA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.46A 6h7mB-3cvhH:
undetectable		 6h7mB-3cvhH:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
 None
 1.43A 6h7mB-3g04B:
undetectable		 6h7mB-3g04B:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnm JAA-F11 FAB ANTIBODY
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.46A 6h7mB-3gnmH:
undetectable		 6h7mB-3gnmH:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
 1.27A 6h7mB-3pblA:
16.5		 6h7mB-3pblA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.85A 6h7mB-3pblA:
16.5		 6h7mB-3pblA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 196
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.51A 6h7mB-3pblA:
16.5		 6h7mB-3pblA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 113
VAL A 117
SER A 204
ASN A 293
ASN A 312
TYR A 316
 ERC  A1201 (-3.7A)
None
ERC  A1201 ( 4.1A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 1.15A 6h7mB-3pdsA:
32.6		 6h7mB-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 113
VAL A 117
SER A 204
SER A 207
ASN A 293
ASN A 312
 ERC  A1201 (-3.7A)
None
ERC  A1201 ( 4.1A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
 1.48A 6h7mB-3pdsA:
32.6		 6h7mB-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 289
PHE A 290
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.0A)
None
 1.21A 6h7mB-3pdsA:
32.6		 6h7mB-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A 109
ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
PHE A 289
PHE A 290
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.4A)
ERC  A1201 (-2.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 0.60A 6h7mB-3pdsA:
32.6		 6h7mB-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A 109
ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
SER A 207
PHE A 289
PHE A 290
ASN A 293
ASN A 312
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.4A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
 0.59A 6h7mB-3pdsA:
32.6		 6h7mB-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6g HEAVY CHAIN OF FAB
OF RHESUS MAB 2.5B

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 6h7mB-3q6gH:
undetectable		 6h7mB-3q6gH:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhf HUMAN MONOCLONAL
ANTIBODY DEL2D1,
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.41A 6h7mB-3qhfH:
undetectable		 6h7mB-3qhfH:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		5 VAL A 404
VAL A 402
SER A 308
SER A 311
PHE A 343
 None
 1.38A 6h7mB-3s1sA:
undetectable		 6h7mB-3s1sA:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uji FAB REGION OF THE
HEAVY CHAIN OF
ANTI-HIV-1 V3
MONOCLONAL ANTIBODY
2558

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.43A 6h7mB-3ujiH:
undetectable		 6h7mB-3ujiH:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v34 RIBONUCLEASE ZC3H12A

(Homo sapiens) 		PF11977
(RNase_Zc3h12a) 		5 VAL A 139
VAL A 240
SER A 236
PHE A 259
TYR A 246
 None
 1.39A 6h7mB-3v34A:
undetectable		 6h7mB-3v34A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 ASP A 123
VAL A 111
SER A 162
PHE A 149
PHE A 159
 None
 1.46A 6h7mB-4b7gA:
undetectable		 6h7mB-4b7gA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edx HEAVY CHAIN OF FAB
OF MURINE ANTI-NGF

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 171
VAL B 191
SER B 189
ASN B 209
ASN B 162
 None
 1.45A 6h7mB-4edxB:
undetectable		 6h7mB-4edxB:
18.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 262
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.6A)
CAU  A 500 (-4.6A)
 1.29A 6h7mB-4gbrA:
32.8		 6h7mB-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		10 TRP A 109
ASP A 113
VAL A 114
VAL A 117
PHE A 193
PHE A 261
PHE A 262
ASN A 265
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.64A 6h7mB-4gbrA:
32.8		 6h7mB-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		10 TRP A 109
ASP A 113
VAL A 114
VAL A 117
PHE A 193
SER A 203
PHE A 261
PHE A 262
ASN A 284
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.75A 6h7mB-4gbrA:
32.8		 6h7mB-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
VAL A 114
VAL A 117
PHE A 193
SER A 207
PHE A 261
PHE A 262
ASN A 265
 None
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
 0.82A 6h7mB-4gbrA:
32.8		 6h7mB-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		5 VAL A 117
PHE A 261
ASN A 265
ASN A 284
TYR A 288
 CAU  A 500 (-4.2A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 1.38A 6h7mB-4gbrA:
32.8		 6h7mB-4gbrA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
ASP A 135
VAL A 136
PHE A 340
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.44A 6h7mB-4ib4A:
28.2		 6h7mB-4ib4A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.44A 6h7mB-4jo3H:
undetectable		 6h7mB-4jo3H:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3d BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.45A 6h7mB-4k3dH:
undetectable		 6h7mB-4k3dH:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.46A 6h7mB-4k3eH:
undetectable		 6h7mB-4k3eH:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ktd GE136 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 6h7mB-4ktdH:
undetectable		 6h7mB-4ktdH:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kte GE148 HEAVY CHAIN
FAB

(Macaca mulatta) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.45A 6h7mB-4kteH:
undetectable		 6h7mB-4kteH:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A1113
VAL A1117
SER A1204
SER A1207
ASN A1293
ASN A1312
TYR A1316
 P0G  A1401 (-2.9A)
P0G  A1401 ( 4.4A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 1.09A 6h7mB-4ldeA:
41.2		 6h7mB-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		12 TRP A1109
ASP A1113
VAL A1114
VAL A1117
PHE A1193
SER A1203
SER A1207
PHE A1289
PHE A1290
ASN A1293
ASN A1312
TYR A1316
 None
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-3.8A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 0.44A 6h7mB-4ldeA:
41.2		 6h7mB-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5y FAB 5J8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 6h7mB-4m5yH:
undetectable		 6h7mB-4m5yH:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6q VOSA

(Aspergillus
nidulans) 		PF11754
(Velvet) 		5 ASP A 109
VAL A 108
SER A 174
PHE A 115
PHE A 175
 None
 1.25A 6h7mB-4n6qA:
undetectable		 6h7mB-4n6qA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ocr CAP256-VRC26.01
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 6h7mB-4ocrH:
undetectable		 6h7mB-4ocrH:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ocs CAP256-VRC26.10
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.45A 6h7mB-4ocsH:
undetectable		 6h7mB-4ocsH:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ot1 SM5-1 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 181
VAL H 200
SER H 198
ASN H 215
ASN H 173
 None
 1.45A 6h7mB-4ot1H:
undetectable		 6h7mB-4ot1H:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py8 ANTIBODY 3.1 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.38A 6h7mB-4py8I:
undetectable		 6h7mB-4py8I:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py8 ANTIBODY 3.1 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL I 168
VAL I 187
SER I 185
ASN I 202
TYR I 199
 None
 1.46A 6h7mB-4py8I:
undetectable		 6h7mB-4py8I:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r90 ANTI CD70 LLAMA
GLAMA FAB 27B3 HEAVY
CHAIN

(Lama glama) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 172
VAL H 191
SER H 189
ASN H 206
ASN H 164
 None
 1.44A 6h7mB-4r90H:
undetectable		 6h7mB-4r90H:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfe FAB HEAVY CHAIN OF
ADCC-POTENT
ANTI-HIV-1 ANTIBODY
JR4

(Macaca mulatta) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 6h7mB-4rfeH:
undetectable		 6h7mB-4rfeH:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rld ASPARTIC PROTEASE
BLA G 2

(Blattella
germanica) 		PF00026
(Asp) 		5 VAL A   4
VAL A   2
PHE A  31
SER A  92
PHE A 140
 None
 1.39A 6h7mB-4rldA:
undetectable		 6h7mB-4rldA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.41A 6h7mB-4rnrA:
undetectable		 6h7mB-4rnrA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yaq PG9_N100FY FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
None
None
MES  H 301 (-3.2A)
None
 1.46A 6h7mB-4yaqH:
undetectable		 6h7mB-4yaqH:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zs6 FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.45A 6h7mB-4zs6H:
undetectable		 6h7mB-4zs6H:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anm IMMUNOGLOBULIN G

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 171
VAL B 190
SER B 188
ASN B 205
ASN B 163
 None
 1.45A 6h7mB-5anmB:
undetectable		 6h7mB-5anmB:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cck ANTIBODY 3BC315 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.41A 6h7mB-5cckH:
undetectable		 6h7mB-5cckH:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dur HEAVY CHAIN OF
ANTIBODY 100F4

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.44A 6h7mB-5durH:
undetectable		 6h7mB-5durH:
16.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 6 TRP B 117
ASP B 121
VAL B 122
SER B 215
PHE B 307
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.9A)
P32  B 400 (-4.6A)
 1.37A 6h7mB-5f8uB:
34.6		 6h7mB-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 11 TRP B 117
ASP B 121
VAL B 122
VAL B 125
PHE B 201
SER B 211
PHE B 306
PHE B 307
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
P32  B 400 (-4.0A)
P32  B 400 (-2.7A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.58A 6h7mB-5f8uB:
34.6		 6h7mB-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 9 TRP B 117
ASP B 121
VAL B 122
VAL B 125
PHE B 201
SER B 211
SER B 215
PHE B 306
ASN B 310
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
P32  B 400 (-4.0A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-3.5A)
 0.71A 6h7mB-5f8uB:
34.6		 6h7mB-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 VAL B 125
PHE B 306
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 ( 4.7A)
P32  B 400 (-4.1A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.32A 6h7mB-5f8uB:
34.6		 6h7mB-5f8uB:
86.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fuz 645 FAB, HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.44A 6h7mB-5fuzH:
undetectable		 6h7mB-5fuzH:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9v RIBONUCLEASE ZC3H12A

(Mus musculus) 		PF11977
(RNase_Zc3h12a) 		5 VAL A 139
VAL A 240
SER A 236
PHE A 259
TYR A 246
 None
 1.36A 6h7mB-5h9vA:
undetectable		 6h7mB-5h9vA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 218
VAL H 237
SER H 235
ASN H 251
ASN H 210
 None
 1.42A 6h7mB-5ihuH:
undetectable		 6h7mB-5ihuH:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijv BOVINE FAB E03 HEAVY
CHAIN

(Bos taurus) 		no annotation 5 VAL H 199
VAL H 218
SER H 216
ASN H 232
ASN H 191
 None
 1.42A 6h7mB-5ijvH:
undetectable		 6h7mB-5ijvH:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilt BOVINE FAB A01 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 216
VAL H 235
SER H 233
ASN H 249
ASN H 208
 None
 1.44A 6h7mB-5iltH:
undetectable		 6h7mB-5iltH:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t4z ANTIBODY DH501 FAB
HEAVY CHAIN

(Macaca mulatta) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 6h7mB-5t4zH:
undetectable		 6h7mB-5t4zH:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ukp DH522.1 FAB FRAGMENT
HEAVY CHAIN

(Macaca mulatta) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.44A 6h7mB-5ukpH:
undetectable		 6h7mB-5ukpH:
22.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.65A 6h7mB-5v54A:
28.5		 6h7mB-5v54A:
32.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6l HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A37

(Oryctolagus
cuniculus) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.45A 6h7mB-5v6lH:
undetectable		 6h7mB-5v6lH:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vk2 FAB 37.7H HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 174
VAL D 193
SER D 191
ASN D 208
ASN D 166
 None
 1.46A 6h7mB-5vk2D:
undetectable		 6h7mB-5vk2D:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vta FAB HEAVY CHAIN

(Mus musculus) 		no annotation 5 VAL H 166
VAL H 185
SER H 183
ASN H 200
ASN H 158
 None
 1.44A 6h7mB-5vtaH:
undetectable		 6h7mB-5vtaH:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w0x TIP41-LIKE PROTEIN

(Mus musculus) 		no annotation 5 TRP A 110
ASP A 109
VAL A  76
PHE A 185
ASN A 197
 None
 1.25A 6h7mB-5w0xA:
undetectable		 6h7mB-5w0xA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6g 6649 ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 VAL H 175
VAL H 194
SER H 192
ASN H 209
ASN H 167
 None
 1.42A 6h7mB-5w6gH:
undetectable		 6h7mB-5w6gH:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcc VRC 315 02-1F07 FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 6h7mB-5wccH:
undetectable		 6h7mB-5wccH:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcd VRC315 04-1D02 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 174
VAL H 193
SER H 191
ASN H 208
ASN H 166
 None
 1.45A 6h7mB-5wcdH:
undetectable		 6h7mB-5wcdH:
17.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ASP A 115
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.97A 6h7mB-5wivA:
27.2		 6h7mB-5wivA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
 1.32A 6h7mB-5wivA:
27.2		 6h7mB-5wivA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 200
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.72A 6h7mB-5wivA:
27.2		 6h7mB-5wivA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wl2 -

(-) 		no annotation 5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.46A 6h7mB-5wl2H:
undetectable		 6h7mB-5wl2H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
ASP A 134
SER A 219
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.87A 6h7mB-6bqhA:
27.1		 6h7mB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
 0.56A 6h7mB-6bqhA:
27.1		 6h7mB-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cbl NEAMINE TRANSAMINASE
NEON

(Streptomyces
fradiae) 		no annotation 5 ASP A 204
VAL A 206
VAL A 228
SER A 103
SER A 240
 DOW  A 501 (-2.7A)
DOW  A 501 (-4.0A)
None
DOW  A 501 ( 4.0A)
None
 1.33A 6h7mB-6cblA:
undetectable		 6h7mB-6cblA:
25.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 ASP A 114
VAL A 115
PHE A 189
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
None
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 1.12A 6h7mB-6cm4A:
26.6		 6h7mB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.48A 6h7mB-6cm4A:
26.6		 6h7mB-6cm4A:
42.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 ASP A 114
VAL A 115
SER A 197
PHE A 389
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.9A)
 0.73A 6h7mB-6cm4A:
26.6		 6h7mB-6cm4A:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.43A 6h7mB-6db6H:
undetectable		 6h7mB-6db6H:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.76A 6h7mB-6g79S:
33.0		 6h7mB-6g79S:
29.79