SIMILAR PATTERNS OF AMINO ACIDS FOR 6H7L_A_Y00A406_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 THR A 213
ASP A 194
SER A  45
ASN A 200
VAL A 158
 None
 1.48A 6h7lA-1azzA:
undetectable		 6h7lA-1azzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 VAL A 351
ASP A 514
SER A 536
ASN A   3
ASN A   5
 None
 1.13A 6h7lA-1cygA:
undetectable		 6h7lA-1cygA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 THR A  50
ASP A  82
SER A 106
VAL A 231
ASN A 230
 None
PGH  A 287 (-2.6A)
None
PGH  A 287 (-3.9A)
PGH  A 287 (-4.3A)
 1.39A 6h7lA-1gvfA:
undetectable		 6h7lA-1gvfA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 VAL A 239
SER A 190
SER A 291
ASN A 192
TYR A 250
 SO4  A1320 ( 4.7A)
None
None
None
None
 1.36A 6h7lA-1h7zA:
undetectable		 6h7lA-1h7zA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 VAL A 133
VAL A  15
SER A   8
ASN A   1
VAL A 169
 None
 1.36A 6h7lA-1w6sA:
undetectable		 6h7lA-1w6sA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 246
ASP A 178
SER A 810
SER A 778
VAL A 188
 None
 1.46A 6h7lA-1xkhA:
undetectable		 6h7lA-1xkhA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		5 ASP A  68
SER A 217
SER A 219
VAL A 130
TYR A 139
 None
 1.36A 6h7lA-2a4mA:
undetectable		 6h7lA-2a4mA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		5 VAL A 323
ASP A  76
VAL A 161
SER A  82
VAL A 157
 None
FAD  A1625 (-2.9A)
None
None
None
 1.41A 6h7lA-2f5vA:
undetectable		 6h7lA-2f5vA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 VAL A 307
THR A 337
ASP A 338
SER A 461
SER A 168
 NAG  A 800 (-4.4A)
None
None
None
None
 1.21A 6h7lA-2gfiA:
undetectable		 6h7lA-2gfiA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qom SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		5 VAL A1084
VAL A1178
ASN A1130
VAL A1103
TYR A1125
 None
 1.48A 6h7lA-2qomA:
undetectable		 6h7lA-2qomA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 VAL F 298
SER F 480
SER F 479
ASN F 359
VAL F 279
 None
 1.40A 6h7lA-2v2fF:
undetectable		 6h7lA-2v2fF:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 VAL A 103
ASP A  69
VAL A  68
SER A  30
ASN A   9
 None
 1.48A 6h7lA-3djcA:
undetectable		 6h7lA-3djcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)
CHEMOTAXIS OPERON
PROTEIN (CHEX)

(Borreliella
burgdorferi;
Borreliella
burgdorferi) 		PF00072
(Response_reg)
PF13690
(CheX) 		5 VAL A  31
THR B  95
VAL B  97
ASN B  74
VAL A  38
 None
 1.45A 6h7lA-3hzhA:
undetectable		 6h7lA-3hzhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 VAL A 362
THR A  78
VAL A  75
SER A 477
VAL A 466
 None
 1.35A 6h7lA-3izkA:
undetectable		 6h7lA-3izkA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF17

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF00400
(WD40) 		5 VAL L 154
TRP A  58
SER L 312
SER L 289
ASN L 314
 None
 1.29A 6h7lA-3jb9L:
undetectable		 6h7lA-3jb9L:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 204
ASN A 293
ASN A 312
TRP A 313
TYR A 316
 ERC  A1201 ( 4.1A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
None
 1.09A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 204
SER A 207
ASN A 293
ASN A 312
TRP A 313
 ERC  A1201 ( 4.1A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
 1.44A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
ASN A 293
ASN A 312
TRP A 313
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
None
 0.76A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
SER A 207
ASN A 293
ASN A 312
TRP A 313
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
 0.79A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
ASN A 312
TRP A 313
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
None
 1.12A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A 274
ASP A 232
SER A 133
VAL A 277
ASN A 278
 None
 1.35A 6h7lA-3pv4A:
undetectable		 6h7lA-3pv4A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 VAL A1529
ASP A1570
VAL A1571
ASN A1583
TYR A1588
 None
 1.49A 6h7lA-3rytA:
undetectable		 6h7lA-3rytA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 VAL A 386
ASN A 539
VAL A 566
ASN A 565
TYR A 563
 None
 1.32A 6h7lA-3txaA:
undetectable		 6h7lA-3txaA:
6.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
ASP A 113
VAL A 114
SER A 207
TRP A 285
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
None
CAU  A 500 (-4.6A)
 1.26A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
THR A 110
ASP A 113
VAL A 114
ASN A 265
ASN A 284
TRP A 285
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
None
CAU  A 500 (-4.6A)
 0.73A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
SER A 207
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
 0.87A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		7 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
TRP A 285
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
None
CAU  A 500 (-4.6A)
 0.76A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
ASN A 265
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-3.4A)
 0.94A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 101
VAL A 106
SER A 112
VAL A 129
TYR A 127
 None
 1.35A 6h7lA-4gkvA:
undetectable		 6h7lA-4gkvA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 VAL A 137
THR A 206
SER A 172
ASN A 179
VAL A 167
 None
 1.39A 6h7lA-4hk1A:
undetectable		 6h7lA-4hk1A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 TRP A 131
ASP A 135
SER A 222
ASN A 344
TRP A 367
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 ( 4.6A)
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.8A)
 1.20A 6h7lA-4ib4A:
28.0		 6h7lA-4ib4A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 TRP A 131
ASP A 135
VAL A 136
ASN A 344
TRP A 367
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.8A)
 0.54A 6h7lA-4ib4A:
28.0		 6h7lA-4ib4A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 113
THR A  53
ASP A  54
VAL A  55
TYR A 139
 None
GOL  A 501 ( 4.0A)
None
None
None
 1.47A 6h7lA-4j6fA:
undetectable		 6h7lA-4j6fA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 325
VAL A 161
SER A 244
VAL A  42
ASN A  43
 None
None
None
EDO  A 402 (-4.8A)
EDO  A 401 (-4.5A)
 1.46A 6h7lA-4jxkA:
undetectable		 6h7lA-4jxkA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A1113
SER A1204
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 P0G  A1401 (-2.9A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 1.15A 6h7lA-4ldeA:
40.9		 6h7lA-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A1109
THR A1110
ASP A1113
VAL A1114
SER A1203
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 0.47A 6h7lA-4ldeA:
40.9		 6h7lA-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liy FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 VAL A 239
SER A 190
SER A 291
ASN A 192
TYR A 250
 None
 1.42A 6h7lA-4liyA:
undetectable		 6h7lA-4liyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 VAL A 359
THR A 303
VAL A 305
SER A 307
VAL A 226
 None
 1.50A 6h7lA-5dgkA:
undetectable		 6h7lA-5dgkA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 146
TRP A 194
ASP A 166
SER A  72
VAL A 102
 None
 1.24A 6h7lA-5f05A:
undetectable		 6h7lA-5f05A:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 7 VAL B 102
TRP B 117
ASP B 121
VAL B 122
SER B 215
TRP B 330
TYR B 333
 None
P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.2A)
None
P32  B 400 (-4.6A)
 1.34A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 11 VAL B 102
TRP B 117
THR B 118
ASP B 121
VAL B 122
SER B 211
ASN B 310
VAL B 326
ASN B 329
TRP B 330
TYR B 333
 None
P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 (-3.5A)
None
P32  B 400 (-2.9A)
None
P32  B 400 (-4.6A)
 0.80A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 9 VAL B 102
TRP B 117
THR B 118
ASP B 121
VAL B 122
SER B 211
SER B 215
ASN B 310
TRP B 330
 None
P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
P32  B 400 (-3.5A)
None
 0.89A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 VAL A  37
THR A 492
ASP A 495
SER A 127
TYR A  57
 None
 1.46A 6h7lA-5glgA:
undetectable		 6h7lA-5glgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 173
ASP A  51
VAL A  52
VAL A 361
TYR A 149
 None
 1.28A 6h7lA-5h82A:
undetectable		 6h7lA-5h82A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		5 VAL A 288
THR A 191
VAL A 187
VAL A  62
ASN A  65
 None
 1.42A 6h7lA-5jp9A:
undetectable		 6h7lA-5jp9A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812) 		no annotation 5 VAL A 437
VAL A 366
SER A 385
SER A 390
ASN A 455
 None
 1.13A 6h7lA-5li4A:
undetectable		 6h7lA-5li4A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1

(Homo sapiens) 		no annotation 5 VAL A  59
VAL A 248
ASN A 292
ASN A 296
TYR A 300
 None
OLA  A 417 ( 4.9A)
None
None
None
 1.49A 6h7lA-5o9hA:
20.7		 6h7lA-5o9hA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 5 TRP A 125
ASP A 129
SER A 212
TRP A 356
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
None
None
 0.85A 6h7lA-5v54A:
28.2		 6h7lA-5v54A:
32.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 VAL A 164
VAL A  46
SER A  39
ASN A  32
VAL A 200
 None
 1.28A 6h7lA-5xm3A:
undetectable		 6h7lA-5xm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.09A 6h7lA-6bfnA:
undetectable		 6h7lA-6bfnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
SER A 219
ASN A 331
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
None
 0.86A 6h7lA-6bqhA:
26.7		 6h7lA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
VAL A 135
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
None
None
 0.59A 6h7lA-6bqhA:
26.7		 6h7lA-6bqhA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 ASP A 114
VAL A 115
SER A 193
SER A 197
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.9A)
 1.10A 6h7lA-6cm4A:
26.5		 6h7lA-6cm4A:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 VAL M 392
THR M 413
VAL M 179
SER M 192
TYR M 267
 None
 1.20A 6h7lA-6criM:
undetectable		 6h7lA-6criM:
undetectable