SIMILAR PATTERNS OF AMINO ACIDS FOR 6H7L_A_Y00A406

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 THR A 213
ASP A 194
SER A  45
ASN A 200
VAL A 158
 None
 1.48A 6h7lA-1azzA:
undetectable		 6h7lA-1azzA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyg CYCLODEXTRIN
GLUCANOTRANSFERASE

(Geobacillus
stearothermophilus) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 VAL A 351
ASP A 514
SER A 536
ASN A   3
ASN A   5
 None
 1.13A 6h7lA-1cygA:
undetectable		 6h7lA-1cygA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gvf TAGATOSE-BISPHOSPHAT
E ALDOLASE AGAY

(Escherichia
coli) 		PF01116
(F_bP_aldolase) 		5 THR A  50
ASP A  82
SER A 106
VAL A 231
ASN A 230
 None
PGH  A 287 (-2.6A)
None
PGH  A 287 (-3.9A)
PGH  A 287 (-4.3A)
 1.39A 6h7lA-1gvfA:
undetectable		 6h7lA-1gvfA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7z ADENOVIRUS FIBRE
PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 VAL A 239
SER A 190
SER A 291
ASN A 192
TYR A 250
 SO4  A1320 ( 4.7A)
None
None
None
None
 1.36A 6h7lA-1h7zA:
undetectable		 6h7lA-1h7zA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6s METHANOL
DEHYDROGENASE
SUBUNIT 1

(Methylobacterium
extorquens) 		PF01011
(PQQ)
PF13360
(PQQ_2) 		5 VAL A 133
VAL A  15
SER A   8
ASN A   1
VAL A 169
 None
 1.36A 6h7lA-1w6sA:
undetectable		 6h7lA-1w6sA:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkh FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 VAL A 246
ASP A 178
SER A 810
SER A 778
VAL A 188
 None
 1.46A 6h7lA-1xkhA:
undetectable		 6h7lA-1xkhA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a4m TRYPTOPHANYL-TRNA
SYNTHETASE II

(Deinococcus
radiodurans) 		PF00579
(tRNA-synt_1b) 		5 ASP A  68
SER A 217
SER A 219
VAL A 130
TYR A 139
 None
 1.36A 6h7lA-2a4mA:
undetectable		 6h7lA-2a4mA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5v PYRANOSE 2-OXIDASE

(Peniophora sp.
SG) 		PF05199
(GMC_oxred_C) 		5 VAL A 323
ASP A  76
VAL A 161
SER A  82
VAL A 157
 None
FAD  A1625 (-2.9A)
None
None
None
 1.41A 6h7lA-2f5vA:
undetectable		 6h7lA-2f5vA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		5 VAL A 307
THR A 337
ASP A 338
SER A 461
SER A 168
 NAG  A 800 (-4.4A)
None
None
None
None
 1.21A 6h7lA-2gfiA:
undetectable		 6h7lA-2gfiA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qom SERINE PROTEASE ESPP

(Escherichia
coli) 		PF03797
(Autotransporter) 		5 VAL A1084
VAL A1178
ASN A1130
VAL A1103
TYR A1125
 None
 1.48A 6h7lA-2qomA:
undetectable		 6h7lA-2qomA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2f PENICILLIN BINDING
PROTEIN 1A

(Streptococcus
pneumoniae) 		PF00905
(Transpeptidase) 		5 VAL F 298
SER F 480
SER F 479
ASN F 359
VAL F 279
 None
 1.40A 6h7lA-2v2fF:
undetectable		 6h7lA-2v2fF:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3djc TYPE III
PANTOTHENATE KINASE

(Legionella
pneumophila) 		PF03309
(Pan_kinase) 		5 VAL A 103
ASP A  69
VAL A  68
SER A  30
ASN A   9
 None
 1.48A 6h7lA-3djcA:
undetectable		 6h7lA-3djcA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzh CHEMOTAXIS RESPONSE
REGULATOR (CHEY-3)
CHEMOTAXIS OPERON
PROTEIN (CHEX)

(Borreliella
burgdorferi;
Borreliella
burgdorferi) 		PF00072
(Response_reg)
PF13690
(CheX) 		5 VAL A  31
THR B  95
VAL B  97
ASN B  74
VAL A  38
 None
 1.45A 6h7lA-3hzhA:
undetectable		 6h7lA-3hzhA:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		5 VAL A 362
THR A  78
VAL A  75
SER A 477
VAL A 466
 None
 1.35A 6h7lA-3izkA:
undetectable		 6h7lA-3izkA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-SPLICING
FACTOR CWF17

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF00400
(WD40) 		5 VAL L 154
TRP A  58
SER L 312
SER L 289
ASN L 314
 None
 1.29A 6h7lA-3jb9L:
undetectable		 6h7lA-3jb9L:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 204
ASN A 293
ASN A 312
TRP A 313
TYR A 316
 ERC  A1201 ( 4.1A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
None
 1.09A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 SER A 204
SER A 207
ASN A 293
ASN A 312
TRP A 313
 ERC  A1201 ( 4.1A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
 1.44A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
ASN A 293
ASN A 312
TRP A 313
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
None
 0.76A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
SER A 207
ASN A 293
ASN A 312
TRP A 313
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
 0.79A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		8 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
ASN A 312
TRP A 313
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-3.0A)
ERC  A1201 (-4.4A)
None
 1.12A 6h7lA-3pdsA:
32.2		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pv4 DEGQ

(Legionella
fallonii) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 VAL A 274
ASP A 232
SER A 133
VAL A 277
ASN A 278
 None
 1.35A 6h7lA-3pv4A:
undetectable		 6h7lA-3pv4A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		5 VAL A1529
ASP A1570
VAL A1571
ASN A1583
TYR A1588
 None
 1.49A 6h7lA-3rytA:
undetectable		 6h7lA-3rytA:
9.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 VAL A 386
ASN A 539
VAL A 566
ASN A 565
TYR A 563
 None
 1.32A 6h7lA-3txaA:
undetectable		 6h7lA-3txaA:
6.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
ASP A 113
VAL A 114
SER A 207
TRP A 285
TYR A 288
 None
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
None
CAU  A 500 (-4.6A)
 1.26A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		8 TRP A 109
THR A 110
ASP A 113
VAL A 114
ASN A 265
ASN A 284
TRP A 285
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
None
CAU  A 500 (-4.6A)
 0.73A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
SER A 207
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
 0.87A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		7 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
TRP A 285
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
None
CAU  A 500 (-4.6A)
 0.76A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		6 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 207
ASN A 265
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.1A)
CAU  A 500 (-3.4A)
 0.94A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkv ALCOHOL
DEHYDROGENASE,
PROPANOL-PREFERRING

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 THR A 101
VAL A 106
SER A 112
VAL A 129
TYR A 127
 None
 1.35A 6h7lA-4gkvA:
undetectable		 6h7lA-4gkvA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hk1 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Drosophila
melanogaster) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 VAL A 137
THR A 206
SER A 172
ASN A 179
VAL A 167
 None
 1.39A 6h7lA-4hk1A:
undetectable		 6h7lA-4hk1A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 TRP A 131
ASP A 135
SER A 222
ASN A 344
TRP A 367
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 ( 4.6A)
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.8A)
 1.20A 6h7lA-4ib4A:
28.0		 6h7lA-4ib4A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		6 TRP A 131
ASP A 135
VAL A 136
ASN A 344
TRP A 367
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
None
ERM  A2001 ( 4.8A)
 0.54A 6h7lA-4ib4A:
28.0		 6h7lA-4ib4A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j6f PUTATIVE ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 113
THR A  53
ASP A  54
VAL A  55
TYR A 139
 None
GOL  A 501 ( 4.0A)
None
None
None
 1.47A 6h7lA-4j6fA:
undetectable		 6h7lA-4j6fA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 325
VAL A 161
SER A 244
VAL A  42
ASN A  43
 None
None
None
EDO  A 402 (-4.8A)
EDO  A 401 (-4.5A)
 1.46A 6h7lA-4jxkA:
undetectable		 6h7lA-4jxkA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A1113
SER A1204
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 P0G  A1401 (-2.9A)
P0G  A1401 ( 3.7A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 1.15A 6h7lA-4ldeA:
40.9		 6h7lA-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A1109
THR A1110
ASP A1113
VAL A1114
SER A1203
SER A1207
ASN A1293
ASN A1312
TRP A1313
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 (-2.8A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
1WV  A1403 ( 4.3A)
None
 0.47A 6h7lA-4ldeA:
40.9		 6h7lA-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4liy FIBER PROTEIN

(Human
mastadenovirus
B) 		PF00541
(Adeno_knob) 		5 VAL A 239
SER A 190
SER A 291
ASN A 192
TYR A 250
 None
 1.42A 6h7lA-4liyA:
undetectable		 6h7lA-4liyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dgk ACTIVE HELICASE

(Staphylococcus
aureus) 		PF06048
(DUF927) 		5 VAL A 359
THR A 303
VAL A 305
SER A 307
VAL A 226
 None
 1.50A 6h7lA-5dgkA:
undetectable		 6h7lA-5dgkA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f05 PHI CLASS
GLUTATHIONE
TRANSFERASE GSTF5

(Populus
trichocarpa) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 VAL A 146
TRP A 194
ASP A 166
SER A  72
VAL A 102
 None
 1.24A 6h7lA-5f05A:
undetectable		 6h7lA-5f05A:
15.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 7 VAL B 102
TRP B 117
ASP B 121
VAL B 122
SER B 215
TRP B 330
TYR B 333
 None
P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.2A)
None
P32  B 400 (-4.6A)
 1.34A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 11 VAL B 102
TRP B 117
THR B 118
ASP B 121
VAL B 122
SER B 211
ASN B 310
VAL B 326
ASN B 329
TRP B 330
TYR B 333
 None
P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 (-3.5A)
None
P32  B 400 (-2.9A)
None
P32  B 400 (-4.6A)
 0.80A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 9 VAL B 102
TRP B 117
THR B 118
ASP B 121
VAL B 122
SER B 211
SER B 215
ASN B 310
TRP B 330
 None
P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
P32  B 400 (-3.5A)
None
 0.89A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5glg FUMARATE REDUCTASE 2

(Saccharomyces
cerevisiae) 		PF00890
(FAD_binding_2) 		5 VAL A  37
THR A 492
ASP A 495
SER A 127
TYR A  57
 None
 1.46A 6h7lA-5glgA:
undetectable		 6h7lA-5glgA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h82 HETEROYOHIMBINE
SYNTHASE THAS2

(Catharanthus
roseus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 173
ASP A  51
VAL A  52
VAL A 361
TYR A 149
 None
 1.28A 6h7lA-5h82A:
undetectable		 6h7lA-5h82A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp9 CMP
5-HYDROXYMETHYLASE

(Streptomyces
rimofaciens) 		PF00303
(Thymidylat_synt) 		5 VAL A 288
THR A 191
VAL A 187
VAL A  62
ASN A  65
 None
 1.42A 6h7lA-5jp9A:
undetectable		 6h7lA-5jp9A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5li4 TAIL SHEATH PROTEIN

(Staphylococcus
phage 812) 		no annotation 5 VAL A 437
VAL A 366
SER A 385
SER A 390
ASN A 455
 None
 1.13A 6h7lA-5li4A:
undetectable		 6h7lA-5li4A:
8.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9h C5A ANAPHYLATOXIN
CHEMOTACTIC RECEPTOR
1

(Homo sapiens) 		no annotation 5 VAL A  59
VAL A 248
ASN A 292
ASN A 296
TYR A 300
 None
OLA  A 417 ( 4.9A)
None
None
None
 1.49A 6h7lA-5o9hA:
20.7		 6h7lA-5o9hA:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 5 TRP A 125
ASP A 129
SER A 212
TRP A 356
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
None
None
 0.85A 6h7lA-5v54A:
28.2		 6h7lA-5v54A:
32.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xm3 GLUCOSE
DEHYDROGENASE

(Methylophaga
aminisulfidivorans) 		no annotation 5 VAL A 164
VAL A  46
SER A  39
ASN A  32
VAL A 200
 None
 1.28A 6h7lA-5xm3A:
undetectable		 6h7lA-5xm3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 5 THR A 407
ASP A 404
VAL A 403
SER A 335
SER A 365
 None
 1.09A 6h7lA-6bfnA:
undetectable		 6h7lA-6bfnA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 6 TRP A 130
ASP A 134
SER A 219
ASN A 331
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
None
 0.86A 6h7lA-6bqhA:
26.7		 6h7lA-6bqhA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
VAL A 135
TRP A 355
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
None
None
 0.59A 6h7lA-6bqhA:
26.7		 6h7lA-6bqhA:
17.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Homo sapiens;
Escherichia
virus T4) 		no annotation 5 ASP A 114
VAL A 115
SER A 193
SER A 197
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.9A)
 1.10A 6h7lA-6cm4A:
26.5		 6h7lA-6cm4A:
42.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 5 VAL M 392
THR M 413
VAL M 179
SER M 192
TYR M 267
 None
 1.20A 6h7lA-6criM:
undetectable		 6h7lA-6criM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		4 GLY 3 102
LEU 3 105
PHE 3  86
PHE 3  84
 None
 0.81A 6h7lA-1ev13:
undetectable		 6h7lA-1ev13:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gl6 ATPASE

(Escherichia
coli) 		PF10412
(TrwB_AAD_bind) 		4 GLY A 384
LEU A 358
VAL A 112
PHE A 479
 None
 0.91A 6h7lA-1gl6A:
0.0		 6h7lA-1gl6A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 GLY A 339
LEU A 374
VAL A 285
PHE A  28
 None
 1.04A 6h7lA-1h17A:
1.0		 6h7lA-1h17A:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 GLY A 119
LEU A 117
VAL A 136
PHE A  31
 None
 1.05A 6h7lA-1mppA:
undetectable		 6h7lA-1mppA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpp PEPSIN

(Rhizomucor
pusillus) 		PF00026
(Asp) 		4 GLY A 176
LEU A 175
VAL A 269
PHE A 322
 None
 1.03A 6h7lA-1mppA:
undetectable		 6h7lA-1mppA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpx ALPHA-AMINO ACID
ESTER HYDROLASE

(Xanthomonas
citri) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLY A 304
LEU A 305
VAL A 195
PHE A 371
 None
 1.02A 6h7lA-1mpxA:
undetectable		 6h7lA-1mpxA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpy CATECHOL
2,3-DIOXYGENASE

(Pseudomonas
putida) 		PF00903
(Glyoxalase) 		4 GLY A 210
PHE A 109
PHE A 168
PHE A 174
 None
 1.01A 6h7lA-1mpyA:
undetectable		 6h7lA-1mpyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mqt POLYPROTEIN CAPSID
PROTEIN

(Enterovirus B) 		PF00073
(Rhv) 		4 GLY C 101
LEU C 104
PHE C  85
PHE C  83
 None
 0.98A 6h7lA-1mqtC:
undetectable		 6h7lA-1mqtC:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN

(Nudaurelia
capensis omega
virus) 		PF03566
(Peptidase_A21) 		4 GLY A 543
LEU A 544
VAL A 235
PHE A 160
 None
 0.83A 6h7lA-1ohfA:
undetectable		 6h7lA-1ohfA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		4 GLY A1339
LEU A1374
VAL A1285
PHE A1028
 None
 0.92A 6h7lA-1qhmA:
3.3		 6h7lA-1qhmA:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmj BETA-GALACTOSIDE-BIN
DING LECTIN

(Gallus gallus) 		PF00337
(Gal-bind_lectin) 		4 GLY A  35
VAL A  19
PHE A  45
PHE A 126
 None
 0.94A 6h7lA-1qmjA:
undetectable		 6h7lA-1qmjA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3t ALCOHOL
DEHYDROGENASE ALPHA
CHAIN

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLY A 175
LEU A 171
PHE A 146
PHE A  21
 None
 0.99A 6h7lA-1u3tA:
0.1		 6h7lA-1u3tA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		4 GLY C1042
LEU C1046
PHE C1112
PHE C 840
 None
 0.77A 6h7lA-1w36C:
1.5		 6h7lA-1w36C:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be4 HYPOTHETICAL PROTEIN
LOC449832

(Danio rerio) 		PF13202
(EF-hand_5)
PF13499
(EF-hand_7) 		4 GLY A 119
LEU A 167
PHE A 198
PHE A 202
 None
 1.04A 6h7lA-2be4A:
undetectable		 6h7lA-2be4A:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		4 GLY A 217
LEU A 122
VAL A 239
PHE A 214
 None
 1.06A 6h7lA-2f9tA:
undetectable		 6h7lA-2f9tA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 LEU D 192
VAL D 120
PHE D 168
PHE D 206
 None
 1.06A 6h7lA-2g9hD:
undetectable		 6h7lA-2g9hD:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gas ISOFLAVONE REDUCTASE

(Medicago sativa) 		PF05368
(NmrA) 		4 GLY A  11
LEU A  10
VAL A 205
PHE A 120
 None
 0.85A 6h7lA-2gasA:
undetectable		 6h7lA-2gasA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ify 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Bacillus
anthracis) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 GLY A  52
LEU A  53
PHE A 342
PHE A 341
 None
 1.03A 6h7lA-2ifyA:
undetectable		 6h7lA-2ifyA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		4 LEU A 193
VAL A 120
PHE A 168
PHE A 207
 None
 1.05A 6h7lA-2nttA:
undetectable		 6h7lA-2nttA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 GLY A 414
LEU A 415
VAL A 361
PHE A 250
 None
 0.83A 6h7lA-2pqdA:
undetectable		 6h7lA-2pqdA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q22 UNCHARACTERIZED
PROTEIN

(Trichormus
variabilis) 		PF08854
(DUF1824) 		4 GLY A  64
LEU A  66
VAL A 115
PHE A 137
 None
 0.99A 6h7lA-2q22A:
undetectable		 6h7lA-2q22A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxr BOTULINUM NEUROTOXIN
TYPE G

(Clostridium
botulinum) 		PF07951
(Toxin_R_bind_C)
PF07953
(Toxin_R_bind_N) 		4 GLY A1148
VAL A1188
PHE A1288
PHE A1243
 None
 0.91A 6h7lA-2vxrA:
undetectable		 6h7lA-2vxrA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 GLY A 672
LEU A 671
PHE A 528
PHE A 678
 None
 1.05A 6h7lA-2wdaA:
undetectable		 6h7lA-2wdaA:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688

(Pyrococcus
horikoshii) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 GLY A  67
LEU A  69
VAL A 319
PHE A  75
 None
NAD  A1001 (-4.8A)
None
None
 0.95A 6h7lA-3abiA:
undetectable		 6h7lA-3abiA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0p TRNA-DIHYDROURIDINE
SYNTHASE

(Thermus
thermophilus) 		PF01207
(Dus) 		4 GLY A 136
LEU A 135
VAL A 114
PHE A 161
 None
 0.74A 6h7lA-3b0pA:
undetectable		 6h7lA-3b0pA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e61 PUTATIVE
TRANSCRIPTIONAL
REPRESSOR OF RIBOSE
OPERON

(Staphylococcus
saprophyticus) 		PF13377
(Peripla_BP_3) 		4 GLY A 161
LEU A 163
PHE A  73
PHE A  74
 None
None
GOL  A   1 (-4.1A)
GOL  A   1 ( 4.5A)
 0.98A 6h7lA-3e61A:
undetectable		 6h7lA-3e61A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e79 HIGH AFFINITY
TRANSPORT SYSTEM
PROTEIN P37

(Mycoplasma
hyorhinis) 		PF06646
(Mycoplasma_p37) 		4 LEU A 379
VAL A 361
PHE A  48
PHE A 348
 None
 1.05A 6h7lA-3e79A:
undetectable		 6h7lA-3e79A:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 GLY A1164
LEU A1168
PHE A1034
PHE A1044
 None
 0.87A 6h7lA-3fq8A:
undetectable		 6h7lA-3fq8A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fq8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		4 GLY A1164
LEU A1168
VAL A1064
PHE A1034
 None
 0.79A 6h7lA-3fq8A:
undetectable		 6h7lA-3fq8A:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		4 GLY A 177
LEU A 179
VAL A 160
PHE A  58
 None
 0.83A 6h7lA-3gbrA:
undetectable		 6h7lA-3gbrA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gm8 GLYCOSIDE HYDROLASE
FAMILY 2, CANDIDATE
BETA-GLYCOSIDASE

(Bacteroides
vulgatus) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 GLY A 410
VAL A 362
PHE A 347
PHE A 351
 None
 0.81A 6h7lA-3gm8A:
undetectable		 6h7lA-3gm8A:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5l PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC TRANSPORTER

(Ruegeria
pomeroyi) 		PF13458
(Peripla_BP_6) 		4 GLY A 418
PHE A 431
PHE A 178
PHE A 175
 None
 1.04A 6h7lA-3h5lA:
undetectable		 6h7lA-3h5lA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 GLY A 333
LEU A 332
VAL A 362
PHE A 427
 None
 0.86A 6h7lA-3l44A:
undetectable		 6h7lA-3l44A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lv4 GLYCOSIDE HYDROLASE
YXIA

(Bacillus
licheniformis) 		PF04616
(Glyco_hydro_43)
PF16369
(GH43_C) 		4 GLY A 390
VAL A 362
PHE A 305
PHE A 334
 None
 1.02A 6h7lA-3lv4A:
undetectable		 6h7lA-3lv4A:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mkt MULTI ANTIMICROBIAL
EXTRUSION PROTEIN
(NA(+)/DRUG
ANTIPORTER)
MATE-LIKE MDR EFFLUX
PUMP

(Vibrio cholerae) 		PF01554
(MatE) 		4 GLY A 321
LEU A 322
VAL A  22
PHE A 153
 None
 1.05A 6h7lA-3mktA:
undetectable		 6h7lA-3mktA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		4 GLY A 243
VAL A 194
PHE A 330
PHE A 447
 None
 0.92A 6h7lA-3oflA:
undetectable		 6h7lA-3oflA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 GLY B 301
LEU B 300
PHE B 737
PHE B 179
 None
 0.74A 6h7lA-3ohmB:
undetectable		 6h7lA-3ohmB:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otr ENOLASE

(Toxoplasma
gondii) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLY A 112
LEU A 111
VAL A 356
PHE A 392
 None
 0.95A 6h7lA-3otrA:
undetectable		 6h7lA-3otrA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p91 PROLIFERATING CELL
NUCLEAR ANTIGEN

(Entamoeba
histolytica) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 GLY A 241
LEU A 221
PHE A  59
PHE A  62
 None
 1.03A 6h7lA-3p91A:
undetectable		 6h7lA-3p91A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 GLY A  90
VAL A 117
PHE A 193
PHE A 290
 ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.4A)
ERC  A1201 (-4.8A)
 0.63A 6h7lA-3pdsA:
32.3		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 GLY A  90
VAL A 117
PHE A 289
PHE A 290
 ERC  A1201 (-3.8A)
None
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
 0.49A 6h7lA-3pdsA:
32.3		 6h7lA-3pdsA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		4 GLY A 548
LEU A 549
VAL A 238
PHE A 163
 None
 0.89A 6h7lA-3s6pA:
undetectable		 6h7lA-3s6pA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 GLY A  45
LEU A  44
PHE A  39
PHE A  34
 None
 0.88A 6h7lA-3stoA:
undetectable		 6h7lA-3stoA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5b PROBABLE
CHAIN-FATTY-ACID-COA
LIGASE FADD13

(Mycobacterium
tuberculosis) 		PF00501
(AMP-binding) 		4 GLY A  78
LEU A  77
VAL A 181
PHE A  71
 None
 1.03A 6h7lA-3t5bA:
undetectable		 6h7lA-3t5bA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3taw HYPOTHETICAL
GLYCOSIDE HYDROLASE

(Parabacteroides
distasonis) 		PF04041
(Glyco_hydro_130) 		4 GLY A 350
VAL A 354
PHE A 270
PHE A 334
 None
 1.00A 6h7lA-3tawA:
undetectable		 6h7lA-3tawA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txy ISOCHORISMATASE
FAMILY PROTEIN
FAMILY

(Burkholderia
thailandensis) 		PF00857
(Isochorismatase) 		4 GLY A 177
LEU A 176
VAL A 185
PHE A  45
 None
 0.97A 6h7lA-3txyA:
undetectable		 6h7lA-3txyA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A  77
VAL A  64
PHE A  55
PHE A  31
 None
 1.02A 6h7lA-3wpeA:
undetectable		 6h7lA-3wpeA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ak9 CPFTSY

(Physcomitrella
patens) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 GLY A 313
LEU A 314
VAL A 360
PHE A 377
 None
 1.03A 6h7lA-4ak9A:
undetectable		 6h7lA-4ak9A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbl LIPS LIPOLYTIC
ENZYME

(unidentified) 		PF12146
(Hydrolase_4) 		4 GLY A 129
LEU A 131
VAL A 229
PHE A  58
 None
 0.86A 6h7lA-4fblA:
undetectable		 6h7lA-4fblA:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fo0 ACTIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF00022
(Actin) 		4 GLY A 109
VAL A 314
PHE A 393
PHE A 544
 None
None
None
ATP  A 702 (-4.0A)
 1.02A 6h7lA-4fo0A:
undetectable		 6h7lA-4fo0A:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbo E7

(Thermobifida
fusca) 		PF03067
(LPMO_10) 		4 GLY A  49
LEU A  52
VAL A 200
PHE A 134
 IOD  A 319 ( 4.4A)
None
None
None
 0.86A 6h7lA-4gboA:
undetectable		 6h7lA-4gboA:
16.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		4 GLY A  90
VAL A 117
PHE A 193
PHE A 262
 None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.5A)
CAU  A 500 (-4.6A)
 0.66A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		4 GLY A  90
VAL A 117
PHE A 261
PHE A 262
 None
CAU  A 500 (-4.2A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
 0.46A 6h7lA-4gbrA:
32.3		 6h7lA-4gbrA:
59.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 GLY B 301
LEU B 300
PHE B 737
PHE B 179
 None
 0.72A 6h7lA-4gnkB:
undetectable		 6h7lA-4gnkB:
4.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hva CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU A  74
VAL A 103
PHE A 118
PHE A 143
 None
 1.04A 6h7lA-4hvaA:
undetectable		 6h7lA-4hvaA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j05 PHOSPHATE
TRANSPORTER

(Serendipita
indica) 		PF00083
(Sugar_tr) 		4 GLY A 143
LEU A 142
PHE A  50
PHE A 174
 None
None
None
PO4  A 600 (-4.5A)
 0.90A 6h7lA-4j05A:
3.4		 6h7lA-4j05A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jhz BETA-GLUCURONIDASE

(Escherichia
coli) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 GLY A 247
VAL A 406
PHE A 288
PHE A 290
 None
 1.06A 6h7lA-4jhzA:
undetectable		 6h7lA-4jhzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kbm DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycobacterium
tuberculosis) 		PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1) 		4 VAL A 375
PHE A 151
PHE A 425
PHE A 424
 None
 0.92A 6h7lA-4kbmA:
undetectable		 6h7lA-4kbmA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 GLY A1090
VAL A1117
PHE A1193
PHE A1289
PHE A1290
 None
P0G  A1401 ( 4.4A)
P0G  A1401 (-3.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
 0.50A 6h7lA-4ldeA:
40.9		 6h7lA-4ldeA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 GLY B 301
LEU B 300
PHE B 737
PHE B 179
 None
 0.71A 6h7lA-4qj4B:
undetectable		 6h7lA-4qj4B:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1i AMINOBENZOYL-GLUTAMA
TE TRANSPORTER

(Neisseria
gonorrhoeae) 		PF03806
(ABG_transport) 		4 GLY A  44
LEU A  49
PHE A 371
PHE A 367
 None
 1.01A 6h7lA-4r1iA:
undetectable		 6h7lA-4r1iA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udj UHGB_MP

(uncultured
organism) 		PF04041
(Glyco_hydro_130) 		4 GLY A 102
VAL A 107
PHE A  58
PHE A 135
 None
 1.01A 6h7lA-4udjA:
undetectable		 6h7lA-4udjA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uvq THIAZOLINE
OXIDASE/SUBTILISIN-L
IKE PROTEASE

(Prochloron sp.) 		no annotation 4 GLY A1093
LEU A1092
VAL A1042
PHE A 998
 None
 0.78A 6h7lA-4uvqA:
undetectable		 6h7lA-4uvqA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd3 L-AMINO ACID LIGASE

(Bacillus
subtilis) 		PF13535
(ATP-grasp_4) 		4 LEU A 213
VAL A  78
PHE A  17
PHE A  18
 None
 0.97A 6h7lA-4wd3A:
undetectable		 6h7lA-4wd3A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 GLY A 290
LEU A 331
VAL A 181
PHE A 148
 None
 0.93A 6h7lA-4zgsA:
undetectable		 6h7lA-4zgsA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayd BETA-1,4-MANNOOLIGOS
ACCHARIDE
PHOSPHORYLASE

(Ruminococcus
albus) 		PF04041
(Glyco_hydro_130) 		4 GLY A 113
VAL A 118
PHE A  66
PHE A 147
 None
 0.91A 6h7lA-5aydA:
undetectable		 6h7lA-5aydA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1r RV1816
TRANSCRIPTIONAL
REGULATOR

(Mycobacterium
tuberculosis) 		PF00440
(TetR_N) 		4 LEU A 227
PHE A 190
PHE A 143
PHE A 177
 None
56S  A 305 (-3.0A)
56S  A 305 ( 3.5A)
None
 0.97A 6h7lA-5d1rA:
undetectable		 6h7lA-5d1rA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esv 2-C-METHYL-D-ERYTHRI
TOL
2,4-CYCLODIPHOSPHATE
SYNTHASE,ENVELOPE
GLYCOPROTEIN GP160

(Haemophilus
influenzae;
Human
immunodeficiency
virus 1) 		PF00516
(GP120)
PF02542
(YgbB) 		4 GLY E 215
LEU E 219
VAL E 259
PHE E 246
 None
 0.90A 6h7lA-5esvE:
undetectable		 6h7lA-5esvE:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		4 GLY A  49
VAL A  18
PHE A  11
PHE A   8
 None
 0.96A 6h7lA-5eyyA:
undetectable		 6h7lA-5eyyA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyy CENTROLOBIUM
TOMENTOSUM LECTIN

(Centrolobium
tomentosum) 		PF00139
(Lectin_legB) 		4 VAL A  18
PHE A 216
PHE A  11
PHE A   8
 None
 0.99A 6h7lA-5eyyA:
undetectable		 6h7lA-5eyyA:
16.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 4 GLY B  98
LEU B 101
PHE B 201
PHE B 307
 None
None
P32  B 400 (-4.0A)
P32  B 400 (-4.9A)
 0.75A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 5 GLY B  98
LEU B 101
VAL B 125
PHE B 306
PHE B 307
 None
None
P32  B 400 ( 4.7A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
 0.38A 6h7lA-5f8uB:
34.1		 6h7lA-5f8uB:
86.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fno MANGANESE
LIPOXYGENASE

(Magnaporthe
oryzae) 		PF00305
(Lipoxygenase) 		4 GLY A 482
PHE A 278
PHE A 338
PHE A 332
 None
 0.98A 6h7lA-5fnoA:
undetectable		 6h7lA-5fnoA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqr LEUCINE-RICH REPEAT
RECEPTOR-LIKE
PROTEIN KINASE TDR

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 GLY B 222
LEU B 247
VAL B 256
PHE B 285
 None
 1.02A 6h7lA-5gqrB:
undetectable		 6h7lA-5gqrB:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 4 GLY A 382
LEU A 384
PHE A 520
PHE A 524
 None
 0.97A 6h7lA-5h3kA:
undetectable		 6h7lA-5h3kA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE

(Thermotoga
neapolitana) 		PF00232
(Glyco_hydro_1) 		4 GLY A 289
VAL A 380
PHE A   8
PHE A   4
 None
 0.96A 6h7lA-5idiA:
undetectable		 6h7lA-5idiA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idv LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA

(Acinetobacter
baumannii) 		PF00005
(ABC_tran) 		4 GLY A  37
LEU A  35
PHE A  41
PHE A  58
 None
 0.94A 6h7lA-5idvA:
undetectable		 6h7lA-5idvA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5je8 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Bacillus cereus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLY A  10
LEU A   9
VAL A 121
PHE A  62
 NAD  A 401 (-3.3A)
None
None
None
 1.00A 6h7lA-5je8A:
undetectable		 6h7lA-5je8A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 GLY A 112
LEU A  42
VAL A 243
PHE A 173
 None
 0.95A 6h7lA-5jzbA:
undetectable		 6h7lA-5jzbA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		4 GLY A 215
LEU A 216
VAL A 250
PHE A 209
 None
 1.03A 6h7lA-5l25A:
undetectable		 6h7lA-5l25A:
8.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 GLY N 693
VAL N 701
PHE N 739
PHE N 736
 None
 0.87A 6h7lA-5mpdN:
undetectable		 6h7lA-5mpdN:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msw THIOESTER REDUCTASE
DOMAIN-CONTAINING
PROTEIN

(Segniliparus
rugosus) 		PF00501
(AMP-binding)
PF00550
(PP-binding) 		4 GLY A 628
PHE A 357
PHE A 343
PHE A 344
 None
 0.78A 6h7lA-5mswA:
undetectable		 6h7lA-5mswA:
5.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncc FATTY ACID
PHOTODECARBOXYLASE

(Chlorella
variabilis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 530
LEU A 527
PHE A 437
PHE A 251
 None
 0.88A 6h7lA-5nccA:
undetectable		 6h7lA-5nccA:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9g CHROMO
DOMAIN-CONTAINING
PROTEIN 1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY W 728
LEU W 731
VAL W 745
PHE W 767
 None
 0.76A 6h7lA-5o9gW:
undetectable		 6h7lA-5o9gW:
4.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svd NUCLEOLAR PROTEIN 9

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 GLY A 348
LEU A 352
PHE A 291
PHE A 273
 GLY  A 348 ( 0.0A)
LEU  A 352 ( 0.6A)
PHE  A 291 ( 1.3A)
PHE  A 273 ( 1.3A)
 1.04A 6h7lA-5svdA:
undetectable		 6h7lA-5svdA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		4 GLY A  90
VAL A  52
PHE A  94
PHE A 197
 None
 1.04A 6h7lA-5tcbA:
undetectable		 6h7lA-5tcbA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4t PUTATIVE GENTAMICIN
METHYLTRANSFERASE

(Micromonospora
echinospora) 		no annotation 4 GLY A 292
VAL A 232
PHE A 219
PHE A 218
 None
 0.96A 6h7lA-5u4tA:
undetectable		 6h7lA-5u4tA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u5g 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Pseudomonas
syringae) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 GLY A  11
LEU A  10
VAL A 123
PHE A  63
 NAP  A 301 (-3.2A)
None
None
None
 0.97A 6h7lA-5u5gA:
undetectable		 6h7lA-5u5gA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uak CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Homo sapiens) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 GLY A 144
LEU A 145
VAL A  43
PHE A  77
 None
 0.93A 6h7lA-5uakA:
1.6		 6h7lA-5uakA:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz7 CALCITONIN RECEPTOR

(Homo sapiens) 		PF00002
(7tm_2) 		4 GLY R 241
LEU R 238
VAL R 320
PHE R 313
 None
 0.96A 6h7lA-5uz7R:
16.3		 6h7lA-5uz7R:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wu7 UNCHARACTERIZED
PROTEIN

(Pyrococcus
horikoshii) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 GLY A 331
LEU A 334
VAL A 271
PHE A 359
 None
 1.03A 6h7lA-5wu7A:
2.4		 6h7lA-5wu7A:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		4 LEU A  97
VAL A 175
PHE A  73
PHE A  72
 None
 0.96A 6h7lA-5x62A:
2.9		 6h7lA-5x62A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE

(unidentified) 		PF00465
(Fe-ADH) 		4 GLY A 359
LEU A 358
VAL A 314
PHE A 260
 None
 1.01A 6h7lA-5xn8A:
undetectable		 6h7lA-5xn8A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zxd -

(-) 		no annotation 4 GLY A 429
LEU A 428
PHE A 455
PHE A 316
 None
 0.86A 6h7lA-5zxdA:
undetectable		 6h7lA-5zxdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aq3 TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 3

(Naegleria
fowleri) 		PF04051
(TRAPP) 		4 GLY A  56
LEU A  59
VAL A 173
PHE A  89
 None
None
None
PLM  A 201 ( 4.9A)
 0.92A 6h7lA-6aq3A:
undetectable		 6h7lA-6aq3A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 4 GLY A 651
LEU A 386
VAL A 638
PHE A 360
 None
 0.88A 6h7lA-6cgmA:
undetectable		 6h7lA-6cgmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cuf


(;
) 		no annotation
no annotation 		4 GLY 8  44
LEU 7 100
PHE 7  97
PHE 8 100
 None
 1.05A 6h7lA-6cuf8:
undetectable		 6h7lA-6cuf8:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d4j PROTEIN PATCHED
HOMOLOG 1

(Homo sapiens) 		no annotation 4 GLY A1163
LEU A1162
VAL A 510
PHE A 559
 None
 0.94A 6h7lA-6d4jA:
2.0		 6h7lA-6d4jA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6du8 -

(-) 		no annotation 4 VAL A 548
PHE A 517
PHE A 488
PHE A 484
 None
 0.96A 6h7lA-6du8A:
3.6		 6h7lA-6du8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
5
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4

(Mus musculus;
Mus musculus) 		no annotation
no annotation 		4 GLY M 311
LEU M 315
VAL L  69
PHE L 138
 None
None
None
CDL  L 703 (-4.9A)
 1.01A 6h7lA-6g2jM:
undetectable		 6h7lA-6g2jM:
20.48