SIMILAR PATTERNS OF AMINO ACIDS FOR 6H3D_A_DHIA601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0h FORMATE
DEHYDROGENASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 TYR A 266
ASN A 739
TYR A 738
PHE A 788
 None
 1.43A 6h3dA-1h0hA:
2.5		 6h3dA-1h0hA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqf FORMATE
DEHYDROGENASE,
NITRATE-INDUCIBLE,
MAJOR SUBUNIT

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 TYR A 305
ASN A 780
TYR A 779
PHE A 825
 None
 1.50A 6h3dA-1kqfA:
1.3		 6h3dA-1kqfA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE

(Streptomyces
sp. 11AG8) 		PF01670
(Glyco_hydro_12) 		4 TYR A  93
ASN A 214
ARG A  92
PHE A 202
 None
 1.45A 6h3dA-1oa4A:
undetectable		 6h3dA-1oa4A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		4 TYR A 744
ASN A 749
TYR A 750
PHE A 685
 None
 1.40A 6h3dA-2henA:
undetectable		 6h3dA-2henA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n53 MAJOR PRION PROTEIN

(Ovis aries) 		PF00377
(Prion) 		4 TYR A 148
ASN A 156
TYR A 153
PHE A 144
 None
 1.00A 6h3dA-2n53A:
undetectable		 6h3dA-2n53A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nnu REGULATORY PROTEIN
E2

(Alphapapillomavirus
9) 		PF00508
(PPV_E2_N) 		4 TYR A 167
ASN A 133
TYR A 131
PHE A 171
 None
 1.49A 6h3dA-2nnuA:
undetectable		 6h3dA-2nnuA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1y BISPECIFIC
ALPHA/BETA TCR

(Mus musculus) 		PF07686
(V-set) 		4 TYR A  33
ASN A  30
TYR A  50
ARG A  69
 None
 1.28A 6h3dA-2p1yA:
undetectable		 6h3dA-2p1yA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w38 SIALIDASE

(Pseudomonas
aeruginosa) 		PF13088
(BNR_2) 		4 TYR A 185
ASN A 181
TYR A 180
PHE A 210
 None
 1.46A 6h3dA-2w38A:
undetectable		 6h3dA-2w38A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3y VIRULENCE FACTOR

(Pectobacterium
carotovorum) 		no annotation 4 TYR A 277
ASN A 135
ARG A 190
PHE A 178
 None
 1.19A 6h3dA-2w3yA:
0.0		 6h3dA-2w3yA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w6d DYNAMIN FAMILY
PROTEIN

(Nostoc
punctiforme) 		PF00350
(Dynamin_N) 		4 TYR A 274
ASN A 224
TYR A 221
PHE A 206
 None
 1.47A 6h3dA-2w6dA:
2.0		 6h3dA-2w6dA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xhc TRANSCRIPTION
ANTITERMINATION
PROTEIN NUSG

(Thermotoga
maritima) 		PF00467
(KOW)
PF02357
(NusG) 		4 TYR A   6
ASN A 243
TYR A 247
PHE A 259
 None
 1.41A 6h3dA-2xhcA:
undetectable		 6h3dA-2xhcA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0h PHOTOSYSTEM II CP43
PROTEIN

(Thermosynechococcus
vulcanus) 		PF00421
(PSII) 		4 ASN C 294
TYR C 297
ARG C 423
PHE C 289
 None
None
None
CLA  C1025 ( 4.3A)
 1.45A 6h3dA-3a0hC:
undetectable		 6h3dA-3a0hC:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ah5 THYMIDYLATE SYNTHASE
THYX

(Helicobacter
pylori) 		PF02511
(Thy1) 		4 TYR A 183
ASN A 186
TYR A  80
PHE A  82
 None
 1.23A 6h3dA-3ah5A:
undetectable		 6h3dA-3ah5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e1t HALOGENASE

(Chondromyces
crocatus) 		PF04820
(Trp_halogenase) 		4 TYR A 351
ASN A 290
ARG A 352
PHE A 347
 None
 1.47A 6h3dA-3e1tA:
undetectable		 6h3dA-3e1tA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7y ASPARTATE
AMINOTRANSFERASE

(Plasmodium
falciparum) 		PF00155
(Aminotran_1_2) 		4 TYR A 161
ASN A 190
TYR A 184
PHE A 151
 None
 1.10A 6h3dA-3k7yA:
2.2		 6h3dA-3k7yA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4k D-AMINO-ACID OXIDASE

(Homo sapiens) 		PF01266
(DAO) 		4 TYR A 128
ASN A  96
TYR A  95
PHE A 125
 None
 1.10A 6h3dA-3w4kA:
4.1		 6h3dA-3w4kA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f53 SUSD HOMOLOG

(Bacteroides
ovatus) 		PF12741
(SusD-like) 		4 TYR A  95
ASN A  99
TYR A  98
PHE A  78
 None
 1.48A 6h3dA-4f53A:
0.6		 6h3dA-4f53A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfh DNA TOPOISOMERASE 2

(Saccharomyces
cerevisiae) 		PF00204
(DNA_gyraseB)
PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF02518
(HATPase_c)
PF16898
(TOPRIM_C) 		4 TYR A 803
ASN A 694
ARG A 704
PHE A 795
 None
 1.44A 6h3dA-4gfhA:
undetectable		 6h3dA-4gfhA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n17 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Burkholderia
ambifaria) 		PF03480
(DctP) 		4 TYR A 267
ASN A  91
ARG A  89
PHE A  39
 None
GTR  A 401 (-4.1A)
GTR  A 401 (-2.7A)
None
 1.31A 6h3dA-4n17A:
undetectable		 6h3dA-4n17A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpv UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07901
(DUF1672) 		4 TYR A  49
ASN A 297
TYR A 298
PHE A 248
 None
 1.41A 6h3dA-4qpvA:
undetectable		 6h3dA-4qpvA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		4 TYR B 128
ASN B  96
TYR B  95
PHE B 125
 None
 1.07A 6h3dA-4yjfB:
2.9		 6h3dA-4yjfB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i68 ALCOHOL OXIDASE 1

(Komagataella
pastoris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ASN A  58
TYR A  55
ARG A 201
PHE A  98
 None
None
None
FAD  A 702 (-3.8A)
 1.41A 6h3dA-5i68A:
undetectable		 6h3dA-5i68A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i93 1,2-DIHYDROXY-3-KETO
-5-METHYLTHIOPENTENE
DIOXYGENASE

(Mus musculus) 		PF03079
(ARD) 		4 TYR A 104
ASN A 141
ARG A  15
PHE A 135
 None
None
None
69O  A 202 (-3.1A)
 1.39A 6h3dA-5i93A:
undetectable		 6h3dA-5i93A:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 TYR A 748
ASN A 753
TYR A 754
PHE A 689
 None
None
DIO  A1002 (-4.5A)
DIO  A1002 (-4.7A)
 1.35A 6h3dA-5l6oA:
undetectable		 6h3dA-5l6oA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nx2 GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR

(Homo sapiens) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 TYR A 250
ASN A 177
TYR A 178
PHE A 266
 None
 1.20A 6h3dA-5nx2A:
undetectable		 6h3dA-5nx2A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcm UNCHARACTERIZED
PROTEIN

(Leishmania
donovani) 		PF00439
(Bromodomain) 		4 TYR A  65
ASN A   6
TYR A   5
PHE A   2
 None
 1.42A 6h3dA-5tcmA:
undetectable		 6h3dA-5tcmA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vai UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF00002
(7tm_2)
PF02793
(HRM) 		4 TYR R 250
ASN R 177
TYR R 178
PHE R 266
 None
 1.15A 6h3dA-5vaiR:
2.3		 6h3dA-5vaiR:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3j GLUCAGON-LIKE
PEPTIDE 1 RECEPTOR

(Homo sapiens) 		no annotation 4 TYR R 250
ASN R 177
TYR R 178
PHE R 266
 None
 1.29A 6h3dA-6b3jR:
undetectable		 6h3dA-6b3jR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byw GOXA

(Pseudoalteromonas
luteoviolacea) 		no annotation 4 TYR B  45
ASN B 700
TYR B 361
ARG B  16
 None
MG  B 901 (-3.4A)
None
None
 1.45A 6h3dA-6bywB:
undetectable		 6h3dA-6bywB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4n PSEUDOPALINE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		no annotation 4 TYR A 243
ASN A 288
TYR A 289
ARG A 319
 None
 0.77A 6h3dA-6c4nA:
47.9		 6h3dA-6c4nA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 4 ASN A 284
TYR A 285
ARG A 315
PHE A 336
 SO4  A 506 (-3.4A)
None
SO4  A 506 (-3.3A)
None
 0.80A 6h3dA-6c4rA:
63.9		 6h3dA-6c4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4r STAPHYLOPINE
DEHYDROGENASE

(Staphylococcus
aureus) 		no annotation 4 TYR A 239
ASN A 284
TYR A 285
PHE A 336
 None
SO4  A 506 (-3.4A)
None
None
 0.27A 6h3dA-6c4rA:
63.9		 6h3dA-6c4rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8z ALPHA-1,2-MANNOSIDAS
E, PUTATIVE

(Bacteroides
thetaiotaomicron) 		no annotation 4 TYR A 125
ASN A 135
TYR A 149
PHE A  83
 None
 1.31A 6h3dA-6f8zA:
undetectable		 6h3dA-6f8zA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE

(metagenome) 		no annotation 4 TYR C  93
ASN C 228
TYR C 227
PHE C 210
 None
 1.41A 6h3dA-6fkxC:
undetectable		 6h3dA-6fkxC:
undetectable