SIMILAR PATTERNS OF AMINO ACIDS FOR 6H1L_B_FJQB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a80 2,5-DIKETO-D-GLUCONI
C ACID REDUCTASE A


(Corynebacterium
sp.)
PF00248
(Aldo_ket_red)
5 ALA A  91
LEU A  94
VAL A 102
ILE A 136
LEU A 127
None
1.29A 6h1lB-1a80A:
undetectable
6h1lB-1a80A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 401
VAL A 416
ALA A 409
ALA A 272
LEU A 406
None
None
None
FAD  A 600 (-3.8A)
None
1.23A 6h1lB-1bhyA:
0.0
6h1lB-1bhyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ez4 LACTATE
DEHYDROGENASE


(Lactobacillus
pentosus)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ALA A 227
LEU A 226
VAL A 211
ALA A 187
ALA A 173
None
1.18A 6h1lB-1ez4A:
0.0
6h1lB-1ez4A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ffv CUTL, MOLYBDOPROTEIN
OF CARBON MONOXIDE
DEHYDROGENASE


(Hydrogenophaga
pseudoflava)
PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2)
5 VAL B 372
VAL B 143
THR B 374
ALA B 154
LEU B 150
None
1.23A 6h1lB-1ffvB:
0.0
6h1lB-1ffvB:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvf SEC1

(Doryteuthis
pealeii)
PF00995
(Sec1)
5 VAL A 186
ILE A 173
ALA A 170
ALA A 208
LEU A 206
None
1.22A 6h1lB-1fvfA:
0.0
6h1lB-1fvfA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghs 1,3-BETA-GLUCANASE

(Hordeum vulgare)
PF00332
(Glyco_hydro_17)
5 ALA A 268
LEU A 269
VAL A 258
VAL A 229
ILE A 273
None
1.27A 6h1lB-1ghsA:
0.0
6h1lB-1ghsA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0r NUSA

(Mycobacterium
tuberculosis)
PF08529
(NusA_N)
PF13184
(KH_5)
5 ALA A 290
VAL A 280
VAL A 294
ALA A 275
ALA A 310
None
1.00A 6h1lB-1k0rA:
undetectable
6h1lB-1k0rA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae)
PF00291
(PALP)
PF14821
(Thr_synth_N)
5 ALA A 127
LEU A 128
VAL A 131
PHE A 135
ALA A 238
None
1.00A 6h1lB-1kl7A:
0.0
6h1lB-1kl7A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5p FERREDOXIN

(Trichomonas
vaginalis)
PF00111
(Fer2)
5 LEU A  14
PHE A  91
ILE A  80
ALA A  77
LEU A  82
None
1.01A 6h1lB-1l5pA:
undetectable
6h1lB-1l5pA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzj BETA-KETOACYLSYNTHAS
E III


(Streptomyces
sp. R1128)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 ALA A 313
LEU A 251
VAL A 273
ILE A 264
ALA A 237
None
1.28A 6h1lB-1mzjA:
undetectable
6h1lB-1mzjA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7k DEOXYRIBOSE-PHOSPHAT
E ALDOLASE


(Aeropyrum
pernix)
PF01791
(DeoC)
5 ALA A 186
LEU A 185
VAL A 182
THR A 168
ILE A 219
None
0.91A 6h1lB-1n7kA:
undetectable
6h1lB-1n7kA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olx 2-OXOISOVALERATE
DEHYDROGENASE BETA
SUBUNIT


(Homo sapiens)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ALA B  87
LEU B 130
THR B 131
ILE B  43
THR B  72
None
None
K  B 502 (-4.4A)
None
None
1.19A 6h1lB-1olxB:
undetectable
6h1lB-1olxB:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE


(Streptomyces
purpurascens)
PF00561
(Abhydrolase_1)
5 ALA A  96
VAL A  98
ILE A 107
ALA A  81
ALA A  86
None
1.15A 6h1lB-1q0zA:
undetectable
6h1lB-1q0zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1re5 3-CARBOXY-CIS,CIS-MU
CONATE
CYCLOISOMERASE


(Pseudomonas
putida)
PF00206
(Lyase_1)
PF10397
(ADSL_C)
5 ALA A 337
LEU A 247
ALA A 133
THR A 135
ALA A 345
None
1.31A 6h1lB-1re5A:
undetectable
6h1lB-1re5A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis)
PF00067
(p450)
5 ALA A 346
LEU A  53
VAL A  51
VAL A 334
ALA A  65
None
1.24A 6h1lB-1x8vA:
31.1
6h1lB-1x8vA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH


(Thermotoga
maritima)
PF01808
(AICARFT_IMPCHas)
PF02142
(MGS)
5 ALA A 243
VAL A 240
ALA A 279
ALA A 207
LEU A 256
None
1.17A 6h1lB-1zczA:
undetectable
6h1lB-1zczA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asb TRANSCRIPTION
ELONGATION PROTEIN
NUSA


(Mycobacterium
tuberculosis)
PF13184
(KH_5)
5 ALA A 290
VAL A 280
VAL A 294
ALA A 275
ALA A 310
None
None
None
None
A  B   8 ( 3.6A)
0.95A 6h1lB-2asbA:
undetectable
6h1lB-2asbA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewm (S)-1-PHENYLETHANOL
DEHYDROGENASE


(Azoarcus)
PF13561
(adh_short_C2)
5 ALA A  10
VAL A  87
THR A  13
ILE A  19
ALA A  45
None
None
None
NAD  A 257 (-3.9A)
None
1.16A 6h1lB-2ewmA:
undetectable
6h1lB-2ewmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324


(Thermus
thermophilus)
PF08241
(Methyltransf_11)
5 LEU A 182
VAL A 180
ILE A  24
ALA A  21
THR A  17
None
1.18A 6h1lB-2gs9A:
undetectable
6h1lB-2gs9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hls PROTEIN DISULFIDE
OXIDOREDUCTASE


(Aeropyrum
pernix)
PF13192
(Thioredoxin_3)
5 VAL A  90
PHE A  92
VAL A  97
ILE A 115
LEU A 111
None
1.13A 6h1lB-2hlsA:
undetectable
6h1lB-2hlsA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C


(Thermotoga
maritima)
PF08459
(UvrC_HhH_N)
5 ALA A 455
VAL A 462
VAL A 428
ILE A 439
ALA A 438
None
1.15A 6h1lB-2nrrA:
undetectable
6h1lB-2nrrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA


(Azotobacter
vinelandii)
PF00696
(AA_kinase)
5 ALA A 231
LEU A 232
ALA A 178
ALA A 151
LEU A 176
None
0.98A 6h1lB-2ogxA:
undetectable
6h1lB-2ogxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogx MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA


(Azotobacter
vinelandii)
PF00696
(AA_kinase)
5 ALA A 231
LEU A 232
VAL A 235
ALA A 178
ALA A 151
None
0.95A 6h1lB-2ogxA:
undetectable
6h1lB-2ogxA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pig PUTATIVE TRANSFERASE

(Salmonella
enterica)
no annotation 5 ALA A 101
VAL A  96
ILE A  74
ALA A 107
LEU A  86
None
1.12A 6h1lB-2pigA:
undetectable
6h1lB-2pigA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens)
PF00067
(p450)
6 PHE A 121
VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
0.40A 6h1lB-2q9gA:
41.9
6h1lB-2q9gA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qym PHOSPHODIESTERASE 4C

(Homo sapiens)
PF00233
(PDEase_I)
5 LEU A 405
VAL A 409
THR A 505
ALA A 514
THR A 300
None
1.28A 6h1lB-2qymA:
undetectable
6h1lB-2qymA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides)
PF01244
(Peptidase_M19)
5 ALA A 193
LEU A 192
VAL A 164
ILE A  99
ALA A 182
None
1.06A 6h1lB-2ragA:
undetectable
6h1lB-2ragA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN


(Paraburkholderia
phytofirmans)
PF13407
(Peripla_BP_4)
5 LEU A 164
VAL A 281
VAL A 236
ILE A 248
ALA A 247
None
1.27A 6h1lB-2rjoA:
undetectable
6h1lB-2rjoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z06 PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0625


(Thermus
thermophilus)
PF13277
(YmdB)
5 ALA A  34
VAL A  32
ILE A  25
ALA A  17
LEU A  22
None
1.23A 6h1lB-2z06A:
undetectable
6h1lB-2z06A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Pyrococcus
horikoshii)
PF09488
(Osmo_MPGsynth)
5 ALA A 169
VAL A  55
ILE A 112
ALA A  73
LEU A  71
GDD  A 395 (-3.6A)
None
None
None
None
1.26A 6h1lB-2zu8A:
undetectable
6h1lB-2zu8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7y E3 UBIQUITIN-PROTEIN
LIGASE NEDD4


(Homo sapiens)
PF00168
(C2)
5 LEU A 231
VAL A 206
VAL A 191
ALA A 127
LEU A 246
None
1.10A 6h1lB-3b7yA:
undetectable
6h1lB-3b7yA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cai POSSIBLE
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00266
(Aminotran_5)
5 ALA A 131
VAL A 133
ILE A 119
ALA A 120
ALA A  95
None
1.05A 6h1lB-3caiA:
undetectable
6h1lB-3caiA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmm UBIQUITIN-ACTIVATING
ENZYME E1 1


(Saccharomyces
cerevisiae)
PF00899
(ThiF)
PF09358
(E1_UFD)
PF10585
(UBA_e1_thiolCys)
PF16190
(E1_FCCH)
PF16191
(E1_4HB)
5 LEU A 439
VAL A 437
PHE A 538
THR A 540
LEU A 458
None
1.15A 6h1lB-3cmmA:
undetectable
6h1lB-3cmmA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dla GLUTAMINE-DEPENDENT
NAD(+) SYNTHETASE


(Mycobacterium
tuberculosis)
PF00795
(CN_hydrolase)
PF02540
(NAD_synthase)
5 LEU A 116
VAL A 109
ALA A  46
ALA A 163
LEU A 171
None
1.14A 6h1lB-3dlaA:
undetectable
6h1lB-3dlaA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ep7 S-ADENOSYLMETHIONINE
DECARBOXYLASE ALPHA
CHAIN


(Homo sapiens)
PF01536
(SAM_decarbox)
5 VAL A 274
PHE A 275
ILE A 242
THR A 257
LEU A 212
None
1.02A 6h1lB-3ep7A:
undetectable
6h1lB-3ep7A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcr PUTATIVE
AMINOTRANSFERASE


(Ruegeria sp.
TM1040)
PF00202
(Aminotran_3)
5 ALA A 352
VAL A 262
THR A 263
ILE A 234
ALA A  56
None
LLP  A 288 (-4.4A)
None
None
None
1.10A 6h1lB-3fcrA:
undetectable
6h1lB-3fcrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gka N-ETHYLMALEIMIDE
REDUCTASE


(Burkholderia
pseudomallei)
PF00724
(Oxidored_FMN)
5 ALA A 211
LEU A 214
VAL A 180
ILE A 222
ALA A 221
None
1.27A 6h1lB-3gkaA:
undetectable
6h1lB-3gkaA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE


(Aeromonas
sobria)
PF00082
(Peptidase_S8)
PF01483
(P_proprotein)
5 ALA A  62
LEU A  59
ALA A 124
ALA A 347
LEU A  68
None
1.25A 6h1lB-3hjrA:
undetectable
6h1lB-3hjrA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i57 MUCUS BINDING
PROTEIN


(Lactobacillus
reuteri)
no annotation 5 VAL A   6
PHE A  53
THR A  34
ILE A  30
LEU A  22
None
1.20A 6h1lB-3i57A:
undetectable
6h1lB-3i57A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ikm DNA POLYMERASE
SUBUNIT GAMMA-1


(Homo sapiens)
PF00476
(DNA_pol_A)
5 ALA A 425
LEU A 428
VAL A 266
ALA A 153
LEU A 151
None
1.26A 6h1lB-3ikmA:
undetectable
6h1lB-3ikmA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN


(Klebsiella
pneumoniae)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 ALA A  51
LEU A  50
VAL A  98
PHE A 179
ALA A 161
None
1.32A 6h1lB-3io1A:
undetectable
6h1lB-3io1A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7f E3 UBIQUITIN-PROTEIN
LIGASE NEDD4


(Mus musculus)
PF00168
(C2)
5 LEU B 231
VAL B 206
VAL B 191
ALA B 127
LEU B 246
None
1.12A 6h1lB-3m7fB:
undetectable
6h1lB-3m7fB:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o90 NICOTINAMIDASE

(Streptococcus
pneumoniae)
PF00857
(Isochorismatase)
5 ALA A  54
PHE A  14
THR A  11
THR A 140
ALA A 108
None
1.13A 6h1lB-3o90A:
undetectable
6h1lB-3o90A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE


(Yersinia pestis)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M)
5 PHE A 192
ILE A 166
ALA A 165
THR A 272
ALA A 275
None
1.25A 6h1lB-3pyzA:
undetectable
6h1lB-3pyzA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC


(Haloarcula
marismortui)
PF13690
(CheX)
5 ALA A  32
LEU A  28
ALA A 175
THR A  83
LEU A  90
None
0.97A 6h1lB-3qtaA:
undetectable
6h1lB-3qtaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r38 UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE 1


(Listeria
monocytogenes)
PF00275
(EPSP_synthase)
5 VAL A 312
ILE A 377
THR A 387
ALA A 383
LEU A 381
None
1.00A 6h1lB-3r38A:
undetectable
6h1lB-3r38A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sc3 PUTATIVE DNA
REPLICATION
REGULATOR HDA


(Shewanella
amazonensis)
PF00308
(Bac_DnaA)
5 LEU A 241
VAL A 235
THR A 211
ALA A 206
LEU A 201
None
1.12A 6h1lB-3sc3A:
undetectable
6h1lB-3sc3A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli)
PF02395
(Peptidase_S6)
5 LEU A 762
VAL A 744
PHE A 725
ILE A 708
THR A 734
None
1.07A 6h1lB-3szeA:
undetectable
6h1lB-3szeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE


(Streptomyces
hygroscopicus)
PF00982
(Glyco_transf_20)
5 VAL A 227
PHE A 223
ILE A 212
ALA A 166
LEU A 207
None
1.32A 6h1lB-3t5tA:
undetectable
6h1lB-3t5tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Rhodobacter
sphaeroides)
PF13561
(adh_short_C2)
5 ALA A 223
VAL A 127
VAL A  11
ILE A  18
ALA A  25
None
1.07A 6h1lB-3uxyA:
undetectable
6h1lB-3uxyA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7


(Homo sapiens)
PF04548
(AIG1)
5 ALA A  94
VAL A 128
VAL A  98
THR A  27
LEU A 185
None
1.11A 6h1lB-3zjcA:
undetectable
6h1lB-3zjcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpm LATHERIN

(Equus caballus)
PF01273
(LBP_BPI_CETP)
5 ALA A 173
PHE A  24
THR A 178
ILE A  88
LEU A 135
None
1.27A 6h1lB-3zpmA:
undetectable
6h1lB-3zpmA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bru ATP-DEPENDENT RNA
HELICASE DHH1


(Saccharomyces
cerevisiae)
PF00270
(DEAD)
PF00271
(Helicase_C)
5 ALA A 179
VAL A 175
THR A 148
ILE A 119
LEU A 118
None
1.27A 6h1lB-4bruA:
undetectable
6h1lB-4bruA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima)
PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim)
5 ALA A 258
VAL A 278
PHE A 270
ILE A 215
LEU A 209
None
1.03A 6h1lB-4ddwA:
undetectable
6h1lB-4ddwA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1


(Caenorhabditis
elegans)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
5 ALA A 596
LEU A 597
ALA A 495
ALA A 564
LEU A 569
None
1.03A 6h1lB-4f4cA:
undetectable
6h1lB-4f4cA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN


(Staphylococcus
aureus)
PF07993
(NAD_binding_4)
5 ALA A2217
VAL A2214
VAL A2156
THR A2153
ILE A2168
None
1.28A 6h1lB-4f6cA:
undetectable
6h1lB-4f6cA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN


(Staphylococcus
aureus)
no annotation 5 ALA B2217
VAL B2214
VAL B2156
THR B2153
ALA B2165
None
1.26A 6h1lB-4f6lB:
undetectable
6h1lB-4f6lB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN


(Staphylococcus
aureus)
no annotation 5 ALA B2217
VAL B2214
VAL B2156
THR B2153
ILE B2168
None
1.24A 6h1lB-4f6lB:
undetectable
6h1lB-4f6lB:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA


(Azotobacter
vinelandii)
PF00696
(AA_kinase)
5 ALA A 231
LEU A 232
ALA A 178
ALA A 151
LEU A 176
None
0.98A 6h1lB-4f6tA:
undetectable
6h1lB-4f6tA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6t MOLYBDENUM STORAGE
PROTEIN SUBUNIT
ALPHA


(Azotobacter
vinelandii)
PF00696
(AA_kinase)
5 ALA A 231
LEU A 232
VAL A 235
ALA A 178
ALA A 151
None
0.95A 6h1lB-4f6tA:
undetectable
6h1lB-4f6tA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7z RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 4


(Mus musculus)
PF00027
(cNMP_binding)
PF00610
(DEP)
PF00617
(RasGEF)
PF00618
(RasGEF_N)
5 ALA A 940
VAL A 943
PHE A 770
VAL A 773
LEU A 909
None
1.29A 6h1lB-4f7zA:
undetectable
6h1lB-4f7zA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdg MINICHROMOSOME
MAINTENANCE PROTEIN
MCM


(Sulfolobus
solfataricus)
no annotation 5 ALA B 396
VAL B 426
ILE B 417
ALA B 416
ALA B 371
None
1.09A 6h1lB-4fdgB:
undetectable
6h1lB-4fdgB:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis)
PF05362
(Lon_C)
PF13654
(AAA_32)
5 LEU A 312
VAL A 358
ILE A 354
ALA A 325
LEU A 330
None
0.93A 6h1lB-4fwgA:
undetectable
6h1lB-4fwgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ggj MITOCHONDRIAL
CARDIOLIPIN
HYDROLASE


(Mus musculus)
PF13091
(PLDc_2)
5 VAL A 183
PHE A  43
ILE A 176
ALA A 175
ALA A  97
None
1.09A 6h1lB-4ggjA:
undetectable
6h1lB-4ggjA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpr UBIQUITIN-CONJUGATIN
G ENZYME FAMILY
PROTEIN


(Entamoeba
histolytica)
PF00179
(UQ_con)
5 VAL A  73
PHE A  69
THR A  71
ILE A 106
LEU A 110
None
1.27A 6h1lB-4gprA:
undetectable
6h1lB-4gprA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxt DE NOVO PROTEIN
OR329


(synthetic
construct)
PF00514
(Arm)
5 ALA A 191
VAL A 172
ILE A 205
ALA A 204
ALA A 156
None
1.12A 6h1lB-4hxtA:
undetectable
6h1lB-4hxtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw2 UNCHARACTERIZED
PROTEIN


(Parabacteroides
distasonis)
PF01261
(AP_endonuc_2)
5 VAL A 207
VAL A 127
THR A 128
ILE A  99
ALA A 124
None
1.17A 6h1lB-4kw2A:
undetectable
6h1lB-4kw2A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0p RIBOSE-PHOSPHATE
PYROPHOSPHOKINASE 1


(Homo sapiens)
PF13793
(Pribosyltran_N)
PF14572
(Pribosyl_synth)
5 ALA A 241
LEU A 237
VAL A 244
PHE A 266
ILE A 229
None
1.22A 6h1lB-4m0pA:
undetectable
6h1lB-4m0pA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Brucella suis)
PF13561
(adh_short_C2)
5 ALA A 225
VAL A 136
VAL A  10
ILE A  17
ALA A  24
None
0.99A 6h1lB-4ni5A:
undetectable
6h1lB-4ni5A:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB


(Cupriavidus
necator)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 ALA A  42
LEU A  39
VAL A  77
THR A 109
ALA A 112
None
1.04A 6h1lB-4nzsA:
undetectable
6h1lB-4nzsA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
5 ALA A 647
LEU A 648
THR A 601
ILE A 665
ALA A 612
None
1.24A 6h1lB-4oqjA:
undetectable
6h1lB-4oqjA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj6 LEUCYL-CYSTINYL
AMINOPEPTIDASE


(Homo sapiens)
PF01433
(Peptidase_M1)
PF11838
(ERAP1_C)
5 LEU A 251
VAL A 172
THR A 204
ALA A 244
ALA A 232
None
1.04A 6h1lB-4pj6A:
undetectable
6h1lB-4pj6A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE


(Pectobacterium
atrosepticum)
PF02275
(CBAH)
5 ALA A 332
VAL A 301
ILE A  59
ALA A  60
THR A  29
None
1.27A 6h1lB-4wl2A:
undetectable
6h1lB-4wl2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x57 UBIQUITIN-CONJUGATIN
G ENZYME E2 8


(Arabidopsis
thaliana)
PF00179
(UQ_con)
5 VAL A  73
PHE A  69
THR A  71
ILE A 106
LEU A 110
None
1.32A 6h1lB-4x57A:
undetectable
6h1lB-4x57A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE


(Escherichia
coli)
PF06007
(PhnJ)
5 PHE D  86
VAL D  89
THR D  90
ILE D  53
LEU D  12
None
1.17A 6h1lB-4xb6D:
undetectable
6h1lB-4xb6D:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcg THERMOSOME SUBUNIT
BETA


(Sulfolobus
solfataricus)
PF00118
(Cpn60_TCP1)
5 ALA B 375
VAL B 372
ILE B 301
ALA B 249
LEU B 333
None
1.13A 6h1lB-4xcgB:
undetectable
6h1lB-4xcgB:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xkm XYLOSE ISOMERASE

(Bacteroides
thetaiotaomicron)
no annotation 5 ALA A 357
THR A  53
ALA A  47
THR A 338
ALA A 299
None
1.32A 6h1lB-4xkmA:
undetectable
6h1lB-4xkmA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA


(Escherichia
coli)
PF07804
(HipA_C)
PF13657
(Couple_hipA)
5 LEU D 129
VAL D 128
ILE D 149
ALA D 232
LEU D 160
None
1.24A 6h1lB-4yg7D:
undetectable
6h1lB-4yg7D:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE


(Saccharophagus
degradans)
PF00150
(Cellulase)
5 ALA A 289
PHE A  58
ILE A 224
ALA A 182
LEU A 226
None
1.28A 6h1lB-5a8qA:
undetectable
6h1lB-5a8qA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6s EPOXYQUEUOSINE
REDUCTASE


(Streptococcus
thermophilus)
PF08331
(DUF1730)
PF13484
(Fer4_16)
5 LEU A 172
PHE A  21
THR A  66
ILE A  19
ALA A 113
None
1.06A 6h1lB-5d6sA:
undetectable
6h1lB-5d6sA:
23.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
6 ALA A  74
LEU A  75
VAL A  78
THR A  88
THR A 268
ALA A 328
None
None
None
None
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
0.40A 6h1lB-5e78A:
55.5
6h1lB-5e78A:
99.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
5 ILE A 263
ALA A 264
THR A 268
ALA A 328
LEU A 437
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
None
0.80A 6h1lB-5e78A:
55.5
6h1lB-5e78A:
99.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
5 THR A  88
ALA A 264
THR A 268
ALA A 328
LEU A 437
None
HEM  A 501 (-3.6A)
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
None
0.81A 6h1lB-5e78A:
55.5
6h1lB-5e78A:
99.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE


(Bacillus
megaterium)
PF00067
(p450)
5 VAL A  78
THR A  88
THR A 268
ALA A 328
LEU A 437
None
None
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
None
1.11A 6h1lB-5e78A:
55.5
6h1lB-5e78A:
99.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej2 CARVEOL
DEHYDROGENASE


(Mycobacterium
avium)
PF13561
(adh_short_C2)
5 ALA A 205
LEU A 162
VAL A 144
ILE A 201
ALA A 191
None
0.95A 6h1lB-5ej2A:
undetectable
6h1lB-5ej2A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA


(Moorella
thermoacetica)
PF00037
(Fer4)
PF01558
(POR)
5 ALA B  19
VAL B  17
VAL B 112
ALA B 173
ALA B 140
None
1.09A 6h1lB-5exeB:
undetectable
6h1lB-5exeB:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans)
PF01580
(FtsK_SpoIIIE)
5 ALA A1434
VAL A1283
THR A1438
ALA A1447
LEU A1445
None
1.04A 6h1lB-5fv0A:
undetectable
6h1lB-5fv0A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjl TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE


(Streptococcus
porcinus)
PF01791
(DeoC)
5 ALA A  22
LEU A  23
THR A  60
ILE A  77
ALA A  76
None
1.22A 6h1lB-5hjlA:
undetectable
6h1lB-5hjlA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5


(Homo sapiens)
PF00899
(ThiF)
5 LEU A 273
VAL A 269
ILE A  78
ALA A  77
LEU A  92
None
0.99A 6h1lB-5iaaA:
undetectable
6h1lB-5iaaA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ic9 PUTATIVE
UNCHARACTERIZED
PROTEIN


(Chaetomium
thermophilum)
PF08625
(Utp13)
5 VAL B 829
PHE B 774
VAL B 777
ILE B 758
LEU B 798
None
0.91A 6h1lB-5ic9B:
undetectable
6h1lB-5ic9B:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpe KALLIKREIN-10

(Homo sapiens)
PF00089
(Trypsin)
5 VAL A 217
THR A 144
ALA A  43
THR A  54
LEU A 213
SO4  A 301 (-4.1A)
None
None
None
None
1.21A 6h1lB-5lpeA:
undetectable
6h1lB-5lpeA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd5 TRANSKETOLASE

(Chlamydomonas
reinhardtii)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
5 ALA A 309
VAL A 314
ILE A  70
ALA A  66
LEU A 319
None
1.31A 6h1lB-5nd5A:
undetectable
6h1lB-5nd5A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u25 DIHYDROLIPOAMIDE
DEHYDROGENASE (E3
COMPONENT OF
PYRUVATE AND
2-OXOGLUTARATE
DEHYDROGENASE
COMPLEXES)


(Neisseria
gonorrhoeae)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
5 ALA A 396
VAL A 411
ALA A 404
ALA A 267
LEU A 401
None
None
None
FAD  A 601 (-3.8A)
None
1.32A 6h1lB-5u25A:
undetectable
6h1lB-5u25A:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v44 SACSIN

(Homo sapiens)
no annotation 5 ALA A 303
LEU A 307
VAL A 306
VAL A 313
ALA A 121
None
1.04A 6h1lB-5v44A:
undetectable
6h1lB-5v44A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K


(Pseudomonas
aeruginosa)
no annotation 5 LEU X 132
THR X 135
ILE X 233
ALA X 238
ALA X 222
None
1.02A 6h1lB-5vtmX:
undetectable
6h1lB-5vtmX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A)
no annotation 5 ALA A 676
LEU A 677
VAL A 680
VAL A 479
THR A 547
None
0.92A 6h1lB-5wsoA:
undetectable
6h1lB-5wsoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-)
no annotation 5 ALA A 340
VAL A 373
ILE A 365
ALA A 364
ALA A 331
None
1.16A 6h1lB-5xyaA:
undetectable
6h1lB-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5v TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5


(Oryctolagus
cuniculus)
no annotation 5 ALA A 498
PHE A 504
THR A 533
ILE A 565
ALA A 566
None
0.81A 6h1lB-6b5vA:
undetectable
6h1lB-6b5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR


(Chaetomium
thermophilum)
no annotation 5 LEU A 444
THR A 438
ILE A 448
THR A 349
ALA A 347
None
1.08A 6h1lB-6fa5A:
undetectable
6h1lB-6fa5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae)
no annotation 5 ALA A 122
LEU A 123
VAL A 126
VAL A 147
THR A 144
None
1.00A 6h1lB-6fikA:
undetectable
6h1lB-6fikA:
undetectable