SIMILAR PATTERNS OF AMINO ACIDS FOR 6H1L_A_FJQA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 ALA A 213
VAL A 215
ILE A 224
ALA A 275
LEU A 227
 None
 1.10A 6h1lA-13pkA:
0.0		 6h1lA-13pkA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)

(Hordeum vulgare) 		PF01373
(Glyco_hydro_14) 		5 ALA A  86
LEU A  84
PHE A 166
VAL A  77
ALA A  20
 None
 1.40A 6h1lA-1b1yA:
0.0		 6h1lA-1b1yA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhy P64K

(Neisseria
meningitidis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 401
VAL A 416
ALA A 409
ALA A 272
LEU A 406
 None
None
None
FAD  A 600 (-3.8A)
None
 1.29A 6h1lA-1bhyA:
0.0		 6h1lA-1bhyA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 5 ALA A 104
LEU A 108
PHE A  65
ILE A 152
LEU A 156
 None
FOH  A 402 (-4.2A)
None
None
None
 1.42A 6h1lA-1dgpA:
1.2		 6h1lA-1dgpA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0r NUSA

(Mycobacterium
tuberculosis) 		PF08529
(NusA_N)
PF13184
(KH_5) 		5 ALA A 290
VAL A 280
VAL A 294
ALA A 275
ALA A 310
 None
 1.09A 6h1lA-1k0rA:
0.0		 6h1lA-1k0rA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k26 NUDIX HOMOLOG

(Pyrobaculum
aerophilum) 		PF00293
(NUDIX) 		5 ALA A 132
LEU A 133
VAL A   9
ILE A 111
THR A 121
 None
 1.35A 6h1lA-1k26A:
undetectable		 6h1lA-1k26A:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3v CAPSID PROTEIN VP2

(Ungulate
protoparvovirus
1) 		PF00740
(Parvo_coat) 		5 ALA A 176
LEU A 177
VAL A 251
THR A 186
LEU A 183
 None
 1.44A 6h1lA-1k3vA:
undetectable		 6h1lA-1k3vA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kl7 THREONINE SYNTHASE

(Saccharomyces
cerevisiae) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 ALA A 127
LEU A 128
VAL A 131
PHE A 135
ALA A 238
 None
 1.05A 6h1lA-1kl7A:
0.0		 6h1lA-1kl7A:
23.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4z STREPTOKINASE

(Streptococcus
dysgalactiae) 		PF02821
(Staphylokinase) 		5 ALA B 107
VAL B 141
VAL B  20
ALA B  82
LEU B  80
 None
 1.25A 6h1lA-1l4zB:
undetectable		 6h1lA-1l4zB:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1php 3-PHOSPHOGLYCERATE
KINASE

(Geobacillus
stearothermophilus) 		PF00162
(PGK) 		5 ALA A  77
LEU A 113
VAL A  88
ILE A  48
ALA A  40
 None
 1.25A 6h1lA-1phpA:
undetectable		 6h1lA-1phpA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0z ACLACINOMYCIN
METHYLESTERASE

(Streptomyces
purpurascens) 		PF00561
(Abhydrolase_1) 		5 ALA A  96
LEU A 119
VAL A  98
ILE A 107
ALA A  81
 None
 1.30A 6h1lA-1q0zA:
undetectable		 6h1lA-1q0zA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rdu CONSERVED
HYPOTHETICAL PROTEIN

(Thermotoga
maritima) 		PF02579
(Nitro_FeMo-Co) 		5 LEU A  58
VAL A  63
ILE A  67
ALA A  68
ALA A  24
 None
 1.38A 6h1lA-1rduA:
undetectable		 6h1lA-1rduA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 LEU A 365
VAL A 361
ILE A 342
THR A  56
ALA A  49
 None
 1.00A 6h1lA-1urjA:
undetectable		 6h1lA-1urjA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql IRON-SULFUR PROTEIN
LARGE SUBUNIT OF
CUMENE DIOXYGENASE
ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT

(Pseudomonas
fluorescens;
Pseudomonas
fluorescens) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		5 LEU A 254
VAL A 257
ILE A 288
THR A 383
ALA B  93
 None
 1.38A 6h1lA-1wqlA:
undetectable		 6h1lA-1wqlA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zfj INOSINE
MONOPHOSPHATE
DEHYDROGENASE

(Streptococcus
pyogenes) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 ALA A 295
LEU A 292
VAL A 297
ILE A 250
THR A 235
 None
 1.16A 6h1lA-1zfjA:
undetectable		 6h1lA-1zfjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csu 457AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF13380
(CoA_binding_2)
PF13607
(Succ_CoA_lig) 		5 ALA A 440
VAL A 437
ILE A 298
ALA A 297
LEU A 313
 None
 1.34A 6h1lA-2csuA:
undetectable		 6h1lA-2csuA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9y CARBAMATE KINASE

(Aeropyrum
pernix) 		PF00696
(AA_kinase) 		5 ALA A 258
LEU A 261
VAL A 313
VAL A 241
ILE A 234
 None
 1.28A 6h1lA-2e9yA:
undetectable		 6h1lA-2e9yA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew2 2-DEHYDROPANTOATE
2-REDUCTASE,
PUTATIVE

(Enterococcus
faecalis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A  10
LEU A 134
VAL A 140
ALA A  38
LEU A  44
 None
 1.34A 6h1lA-2ew2A:
undetectable		 6h1lA-2ew2A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gs9 HYPOTHETICAL PROTEIN
TT1324

(Thermus
thermophilus) 		PF08241
(Methyltransf_11) 		5 LEU A 182
VAL A 180
ILE A  24
ALA A  21
THR A  17
 None
 1.22A 6h1lA-2gs9A:
undetectable		 6h1lA-2gs9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		5 VAL A  24
VAL A  62
ILE A  99
ALA A  95
ALA A 136
 None
 1.14A 6h1lA-2is3A:
undetectable		 6h1lA-2is3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iz7 MOCO CARRIER PROTEIN

(Chlamydomonas
reinhardtii) 		no annotation 5 LEU A 120
VAL A 126
ALA A 105
THR A 131
ALA A 135
 None
 1.40A 6h1lA-2iz7A:
undetectable		 6h1lA-2iz7A:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgr YEGS

(Escherichia
coli) 		PF00781
(DAGK_cat) 		5 ALA A  53
VAL A  58
ILE A 117
ALA A 116
ALA A  63
 None
 1.06A 6h1lA-2jgrA:
undetectable		 6h1lA-2jgrA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nrr UVRABC SYSTEM
PROTEIN C

(Thermotoga
maritima) 		PF08459
(UvrC_HhH_N) 		5 ALA A 455
VAL A 462
VAL A 428
ILE A 439
ALA A 438
 None
 1.08A 6h1lA-2nrrA:
undetectable		 6h1lA-2nrrA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pc6 PROBABLE
ACETOLACTATE
SYNTHASE ISOZYME III
(SMALL SUBUNIT)

(Nitrosomonas
europaea) 		PF10369
(ALS_ss_C)
PF13710
(ACT_5) 		5 ALA A  15
LEU A  16
VAL A  19
ILE A   5
LEU A   7
 None
 0.87A 6h1lA-2pc6A:
undetectable		 6h1lA-2pc6A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		6 PHE A 121
VAL A 126
ILE A 301
ALA A 302
THR A 306
ALA A 367
 None
HEM  A 505 ( 3.8A)
None
HEM  A 505 (-3.7A)
HEM  A 505 (-3.7A)
HEM  A 505 (-3.5A)
 0.41A 6h1lA-2q9gA:
42.3		 6h1lA-2q9gA:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkx BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 192
VAL A 108
VAL A  93
ILE A  53
LEU A 100
 None
 1.20A 6h1lA-2qkxA:
undetectable		 6h1lA-2qkxA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r87 PURP PROTEIN PF1517

(Pyrococcus
furiosus) 		PF06849
(DUF1246)
PF06973
(DUF1297) 		5 LEU A 329
VAL A 332
PHE A  89
ILE A 316
ALA A 317
 None
 1.33A 6h1lA-2r87A:
undetectable		 6h1lA-2r87A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rag DIPEPTIDASE

(Caulobacter
vibrioides) 		PF01244
(Peptidase_M19) 		5 ALA A 193
LEU A 192
VAL A 164
ILE A  99
ALA A 182
 None
 1.08A 6h1lA-2ragA:
undetectable		 6h1lA-2ragA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		5 LEU A 164
VAL A 281
VAL A 236
ILE A 248
ALA A 247
 None
 1.26A 6h1lA-2rjoA:
undetectable		 6h1lA-2rjoA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vjt ALLOPHYCOCYANIN
ALPHA SUBUNIT
ALLOPHYCOCYANIN BETA
SUBUNIT

(Gloeobacter
violaceus;
Gloeobacter
violaceus) 		PF00502
(Phycobilisome)
PF00502
(Phycobilisome) 		5 ALA B  35
VAL A  30
PHE B  31
ILE B   5
ALA B   4
 None
 1.49A 6h1lA-2vjtB:
undetectable		 6h1lA-2vjtB:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yvt HYPOTHETICAL PROTEIN
AQ_1956

(Aquifex
aeolicus) 		PF14582
(Metallophos_3) 		5 LEU A 165
VAL A 168
THR A 231
ALA A 216
LEU A 176
 None
 1.07A 6h1lA-2yvtA:
undetectable		 6h1lA-2yvtA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zu8 MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Pyrococcus
horikoshii) 		PF09488
(Osmo_MPGsynth) 		5 ALA A 169
VAL A  55
ILE A 112
ALA A  73
LEU A  71
 GDD  A 395 (-3.6A)
None
None
None
None
 1.25A 6h1lA-2zu8A:
undetectable		 6h1lA-2zu8A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zw4 BLEOMYCIN
ACETYLTRANSFERASE

(Streptomyces
verticillus) 		PF13302
(Acetyltransf_3) 		5 ALA A 144
LEU A 149
VAL A 147
VAL A 129
ALA A 120
 None
 1.37A 6h1lA-2zw4A:
undetectable		 6h1lA-2zw4A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxj RAS
GTPASE-ACTIVATING
PROTEIN SYNGAP

(Rattus
norvegicus) 		PF00168
(C2)
PF00616
(RasGAP) 		5 ALA A 535
LEU A 536
VAL A 539
PHE A 648
LEU A 583
 None
 1.00A 6h1lA-3bxjA:
undetectable		 6h1lA-3bxjA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dj4 BIFUNCTIONAL PROTEIN
GLMU

(Mycobacterium
tuberculosis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 192
VAL A 108
VAL A  93
ILE A  53
LEU A 100
 None
 1.17A 6h1lA-3dj4A:
undetectable		 6h1lA-3dj4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		5 ALA A 299
LEU A 304
VAL A 267
VAL A 306
ALA A 319
 None
 1.43A 6h1lA-3f8tA:
undetectable		 6h1lA-3f8tA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5j PUTATIVE ATP/GTP
BINDING PROTEIN

(Clostridioides
difficile) 		PF00581
(Rhodanese) 		5 ALA A  83
LEU A  82
VAL A  18
ILE A 103
LEU A 107
 None
 1.45A 6h1lA-3g5jA:
undetectable		 6h1lA-3g5jA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h6e CARBOHYDRATE KINASE,
FGGY

(Novosphingobium
aromaticivorans) 		PF00370
(FGGY_N) 		5 VAL A 223
ILE A 213
ALA A 214
ALA A  63
LEU A  59
 None
 0.95A 6h1lA-3h6eA:
undetectable		 6h1lA-3h6eA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7f SERINE
HYDROXYMETHYLTRANSFE
RASE 1

(Mycobacterium
tuberculosis) 		PF00464
(SHMT) 		5 ALA A 387
LEU A 297
VAL A 302
VAL A 321
ALA A 333
 None
 1.43A 6h1lA-3h7fA:
undetectable		 6h1lA-3h7fA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A  90
LEU A  91
VAL A  65
VAL A  97
ILE A   5
 None
 1.47A 6h1lA-3hwrA:
undetectable		 6h1lA-3hwrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hwr 2-DEHYDROPANTOATE
2-REDUCTASE

(Cupriavidus
pinatubonensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A  90
LEU A  91
VAL A  97
ILE A   5
ALA A  83
 None
None
None
None
NDP  A 300 ( 4.2A)
 1.02A 6h1lA-3hwrA:
undetectable		 6h1lA-3hwrA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ALA A 240
PHE A 244
VAL A 177
ILE A 162
LEU A 169
 None
 1.31A 6h1lA-3jv7A:
undetectable		 6h1lA-3jv7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN

(Corynebacterium
diphtheriae) 		PF04326
(AlbA_2)
PF13749
(HATPase_c_4) 		5 LEU A 439
VAL A 435
ILE A 447
ALA A 481
LEU A 465
 None
 1.37A 6h1lA-3lmmA:
undetectable		 6h1lA-3lmmA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nrn UNCHARACTERIZED
PROTEIN PF1083

(Pyrococcus
furiosus) 		PF01593
(Amino_oxidase) 		5 LEU A  10
VAL A 191
ALA A  74
ALA A  17
LEU A  68
 None
 1.38A 6h1lA-3nrnA:
undetectable		 6h1lA-3nrnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyg 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacterium
tuberculosis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 ALA A 144
VAL A 141
ALA A  76
ALA A 116
LEU A 114
 None
 1.20A 6h1lA-3pygA:
undetectable		 6h1lA-3pygA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pyz BIFUNCTIONAL
FOLYLPOLYGLUTAMATE
SYNTHASE/DIHYDROFOLA
TE SYNTHASE

(Yersinia pestis) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A 192
ILE A 166
ALA A 165
THR A 272
ALA A 275
 None
 1.23A 6h1lA-3pyzA:
undetectable		 6h1lA-3pyzA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		5 ALA A  32
LEU A  28
ALA A 175
THR A  83
LEU A  90
 None
 1.02A 6h1lA-3qtaA:
undetectable		 6h1lA-3qtaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qta CHEMOTAXIS PROTEIN
CHEC

(Haloarcula
marismortui) 		PF13690
(CheX) 		5 ALA A  32
VAL A  34
ALA A 175
THR A  83
LEU A  90
 None
 1.18A 6h1lA-3qtaA:
undetectable		 6h1lA-3qtaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5b TETRAHYDRODIPICOLINA
TE
N-SUCCINYLETRANSFERA
SE

(Pseudomonas
aeruginosa) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M)
PF14790
(THDPS_N) 		5 ALA A 266
LEU A 282
VAL A 278
PHE A 316
ALA A 305
 None
 1.11A 6h1lA-3r5bA:
undetectable		 6h1lA-3r5bA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r75 ANTHRANILATE/PARA-AM
INOBENZOATE
SYNTHASES COMPONENT
I

(Burkholderia
lata) 		PF00117
(GATase)
PF00425
(Chorismate_bind) 		5 ALA A 168
LEU A 169
VAL A 187
VAL A  13
ALA A  41
 None
 1.30A 6h1lA-3r75A:
undetectable		 6h1lA-3r75A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 LEU A 762
VAL A 744
PHE A 725
ILE A 708
THR A 734
 None
 1.03A 6h1lA-3szeA:
undetectable		 6h1lA-3szeA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t5t PUTATIVE
GLYCOSYLTRANSFERASE

(Streptomyces
hygroscopicus) 		PF00982
(Glyco_transf_20) 		5 VAL A 227
PHE A 223
ILE A 212
ALA A 166
LEU A 207
 None
 1.45A 6h1lA-3t5tA:
undetectable		 6h1lA-3t5tA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv3 DESEASIN MCP-01

(Pseudoalteromonas
sp. SM9913) 		PF00082
(Peptidase_S8) 		5 ALA A  30
VAL A 125
ALA A 271
THR A 227
LEU A 318
 None
 1.49A 6h1lA-3vv3A:
undetectable		 6h1lA-3vv3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdb PROTEIN XNI

(Escherichia
coli) 		PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N) 		5 ALA A  10
LEU A  13
VAL A   8
ILE A  37
ALA A  87
 None
 1.17A 6h1lA-3zdbA:
undetectable		 6h1lA-3zdbA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjc GTPASE IMAP FAMILY
MEMBER 7

(Homo sapiens) 		PF04548
(AIG1) 		5 ALA A  94
VAL A 128
VAL A  98
THR A  27
LEU A 185
 None
 1.12A 6h1lA-3zjcA:
undetectable		 6h1lA-3zjcA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlb PHOSPHOGLYCERATE
KINASE

(Streptococcus
pneumoniae) 		PF00162
(PGK) 		5 ALA A  78
LEU A 114
VAL A  89
ILE A  48
ALA A  40
 GOL  A1405 ( 3.9A)
None
GOL  A1405 (-4.1A)
None
None
 1.22A 6h1lA-3zlbA:
undetectable		 6h1lA-3zlbA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 LEU B 133
VAL B 129
VAL B 139
ILE B 152
LEU B 161
 None
 1.12A 6h1lA-3zu7B:
undetectable		 6h1lA-3zu7B:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aty TEREPHTHALATE
1,2-CIS-DIHYDRODIOL
DEHYDROGENASE

(Paraburkholderia
xenovorans) 		PF04166
(PdxA) 		5 ALA A 254
LEU A 229
VAL A 264
VAL A 283
ALA A 213
 None
 1.23A 6h1lA-4atyA:
undetectable		 6h1lA-4atyA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg5 PHOSPHOGLYCERATE
KINASE

(Staphylococcus
aureus) 		PF00162
(PGK) 		5 ALA A  78
LEU A 114
VAL A  89
ILE A  48
ALA A  40
 None
 1.24A 6h1lA-4dg5A:
undetectable		 6h1lA-4dg5A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus
subtilis) 		PF00268
(Ribonuc_red_sm) 		5 ALA A  78
LEU A  90
VAL A 205
ILE A 212
LEU A 153
 None
 1.35A 6h1lA-4dr0A:
undetectable		 6h1lA-4dr0A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e04 BACTERIOPHYTOCHROME
(LIGHT-REGULATED
SIGNAL TRANSDUCTION
HISTIDINE KINASE),
PHYB1

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 ALA A  64
VAL A  67
PHE A  95
VAL A  93
LEU A  33
 None
 0.82A 6h1lA-4e04A:
undetectable		 6h1lA-4e04A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5k PHOSPHITE
DEHYDROGENASE
(THERMOSTABLE
VARIANT)

(Pseudomonas
stutzeri) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 LEU A  62
VAL A  91
VAL A  57
ALA A  51
THR A   8
 None
 1.32A 6h1lA-4e5kA:
undetectable		 6h1lA-4e5kA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		5 LEU A 312
VAL A 358
ILE A 354
ALA A 325
LEU A 330
 None
 0.85A 6h1lA-4fwgA:
undetectable		 6h1lA-4fwgA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 ALA A 114
LEU A 194
ALA A  34
THR A  32
ALA A 162
 None
 1.31A 6h1lA-4g4pA:
undetectable		 6h1lA-4g4pA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrn DESIGNED ANKYRIN
REPEAT PROTEIN
H10-2-G

(synthetic
construct) 		PF12796
(Ank_2) 		5 ALA A  56
PHE A  81
ILE A 119
ALA A 116
ALA A  96
 None
 1.19A 6h1lA-4hrnA:
undetectable		 6h1lA-4hrnA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxt DE NOVO PROTEIN
OR329

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A 149
VAL A 130
ILE A 163
ALA A 162
ALA A 114
 None
 1.10A 6h1lA-4hxtA:
undetectable		 6h1lA-4hxtA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k22 PROTEIN VISC

(Escherichia
coli) 		PF01494
(FAD_binding_3) 		5 LEU A  22
VAL A  29
VAL A  18
ALA A 163
ALA A 285
 None
 1.09A 6h1lA-4k22A:
undetectable		 6h1lA-4k22A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4koa 1,5-ANHYDRO-D-FRUCTO
SE REDUCTASE

(Sinorhizobium
meliloti) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A 147
VAL A 224
ILE A 194
THR A 313
ALA A 182
 None
 1.22A 6h1lA-4koaA:
undetectable		 6h1lA-4koaA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4li3 CYSTEINE SYNTHASE

(Haemophilus
influenzae) 		PF00291
(PALP) 		5 ALA X  76
LEU X  77
VAL X  80
ALA X  53
ALA X 148
 LLP  X  42 ( 3.2A)
None
None
None
None
 1.09A 6h1lA-4li3X:
undetectable		 6h1lA-4li3X:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mcj UNCHARACTERIZED
PROTEIN

(Parabacteroides
distasonis) 		PF15891
(Nuc_deoxyri_tr2) 		5 ALA A  63
PHE A  68
VAL A  26
ILE A  46
LEU A  48
 None
 1.42A 6h1lA-4mcjA:
undetectable		 6h1lA-4mcjA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oec GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Thermococcus
kodakarensis) 		PF03009
(GDPD) 		5 ALA A 232
VAL A 230
PHE A 227
ALA A 221
LEU A 242
 None
 1.00A 6h1lA-4oecA:
undetectable		 6h1lA-4oecA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q76 CYSTEINE DESULFURASE
2, CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00266
(Aminotran_5) 		5 ALA A 184
LEU A 133
ILE A 147
THR A 152
ALA A 154
 None
 1.45A 6h1lA-4q76A:
undetectable		 6h1lA-4q76A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r14 COP9 SIGNALOSOME
COMPLEX SUBUNIT 6

(Homo sapiens) 		PF01398
(JAB) 		5 ALA A  42
LEU A  43
VAL A  47
ILE A  73
LEU A 122
 None
 1.33A 6h1lA-4r14A:
undetectable		 6h1lA-4r14A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497

(synthetic
construct) 		PF00514
(Arm) 		5 ALA A  65
VAL A  46
ILE A  79
ALA A  78
ALA A  30
 None
 1.10A 6h1lA-4rv1A:
undetectable		 6h1lA-4rv1A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wl2 PUTATIVE EXPORTED
CHOLOYLGLYCINE
HYDROLASE

(Pectobacterium
atrosepticum) 		PF02275
(CBAH) 		5 ALA A 332
VAL A 301
ILE A  59
ALA A  60
THR A  29
 None
 1.30A 6h1lA-4wl2A:
undetectable		 6h1lA-4wl2A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woy MITOCHONDRIAL
DYNAMICS PROTEIN
MID49

(Mus musculus) 		PF03281
(Mab-21) 		5 ALA A 261
LEU A 262
VAL A 266
ALA A 157
ALA A 198
 None
 0.85A 6h1lA-4woyA:
undetectable		 6h1lA-4woyA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNH
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05845
(PhnH)
PF06007
(PhnJ) 		5 LEU D 202
ILE D  30
ALA D  29
THR B 188
ALA B 141
 None
 1.40A 6h1lA-4xb6D:
undetectable		 6h1lA-4xb6D:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yr1 ALKALINE PHOSPHATASE

(Escherichia
coli) 		PF00245
(Alk_phosphatase) 		5 ALA A  77
LEU A  78
VAL A 364
THR A 303
ALA A 348
 None
 1.20A 6h1lA-4yr1A:
undetectable		 6h1lA-4yr1A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8q PUTATIVE RETAINING
B-GLYCOSIDASE

(Saccharophagus
degradans) 		PF00150
(Cellulase) 		5 ALA A 289
PHE A  58
ILE A 224
ALA A 182
LEU A 226
 None
 1.18A 6h1lA-5a8qA:
undetectable		 6h1lA-5a8qA:
22.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 ALA A  74
LEU A  75
VAL A  78
THR A 268
ALA A 328
 None
None
None
HEM  A 501 (-3.4A)
HEM  A 501 ( 3.8A)
 0.49A 6h1lA-5e78A:
57.1		 6h1lA-5e78A:
99.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ez3 ACYL-COA
DEHYDROGENASE

(Brucella
melitensis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M) 		5 LEU A 498
VAL A 389
VAL A 458
ALA A 505
LEU A 362
 None
 1.22A 6h1lA-5ez3A:
undetectable		 6h1lA-5ez3A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 ALA A 110
LEU A 111
ILE A 130
ALA A 127
LEU A 298
 None
 1.39A 6h1lA-5g4iA:
undetectable		 6h1lA-5g4iA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gwj DNA TOPOISOMERASE
2-BETA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		5 ALA A 999
VAL A1004
PHE A1005
ILE A 970
THR A 989
 None
 1.36A 6h1lA-5gwjA:
undetectable		 6h1lA-5gwjA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 5 LEU A  67
VAL A  31
PHE A  36
ALA A 105
LEU A  57
 None
 1.17A 6h1lA-5h2tA:
undetectable		 6h1lA-5h2tA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l7d SMOOTHENED
HOMOLOG,SOLUBLE
CYTOCHROME
B562,SMOOTHENED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF01392
(Fz)
PF01534
(Frizzled)
PF07361
(Cytochrom_B562) 		5 ALA A1050
LEU A1053
PHE A1080
ILE A1117
LEU A1025
 None
 1.42A 6h1lA-5l7dA:
undetectable		 6h1lA-5l7dA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6q UNCHARACTERIZED
PROTEIN

(Kutzneria
albida) 		PF09017
(Transglut_prok) 		5 LEU A 107
VAL A 110
ILE A  84
ALA A  76
LEU A  81
 None
 1.10A 6h1lA-5m6qA:
undetectable		 6h1lA-5m6qA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN3

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF08375
(Rpn3_C) 		5 ALA S 195
LEU S 194
VAL S 156
ILE S 187
LEU S 210
 None
 1.37A 6h1lA-5mpdS:
undetectable		 6h1lA-5mpdS:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 5 VAL A  93
PHE A 240
ILE A  26
ALA A  22
ALA A 522
 None
 1.31A 6h1lA-5odoA:
undetectable		 6h1lA-5odoA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veu CYTOCHROME P450 3A5

(Homo sapiens) 		no annotation 5 LEU A 236
VAL A 238
VAL A 232
ILE A 223
LEU A 219
 None
 1.31A 6h1lA-5veuA:
38.2		 6h1lA-5veuA:
29.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 5 ALA A 134
VAL A  88
ILE A  73
ALA A  74
ALA A  79
 None
 1.30A 6h1lA-5wmmA:
undetectable		 6h1lA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A) 		no annotation 5 ALA A 676
LEU A 677
VAL A 680
VAL A 479
ILE A 567
 None
 1.02A 6h1lA-5wsoA:
undetectable		 6h1lA-5wsoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wso NS3 HELICASE

(Pestivirus A) 		no annotation 5 ALA A 676
LEU A 677
VAL A 680
VAL A 479
THR A 547
 None
 0.90A 6h1lA-5wsoA:
undetectable		 6h1lA-5wsoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 ALA A 340
VAL A 373
ILE A 365
ALA A 364
ALA A 331
 None
 1.13A 6h1lA-5xyaA:
undetectable		 6h1lA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpz PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,MOUSE
PIEZO1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT
1,PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 5 VAL A2447
PHE A2449
VAL A2387
ILE A2273
LEU A2259
 None
 1.30A 6h1lA-6bpzA:
undetectable		 6h1lA-6bpzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8

(Homo sapiens) 		no annotation 5 ALA E1302
VAL E1298
ILE E1177
ALA E1184
LEU E1247
 None
 1.28A 6h1lA-6c3pE:
undetectable		 6h1lA-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5b METHYLTRANSFERASE

(Lysobacter
antibioticus) 		no annotation 5 LEU A 193
PHE A 172
VAL A 178
ALA A 183
LEU A 188
 None
None
None
FMT  A 502 ( 3.9A)
FMT  A 502 (-4.4A)
 0.97A 6h1lA-6c5bA:
undetectable		 6h1lA-6c5bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9k DARP14 - SUBUNIT A
WITH DARPIN

(synthetic
construct) 		no annotation 5 LEU A 283
VAL A 279
VAL A 289
ILE A 302
LEU A 311
 None
 1.25A 6h1lA-6c9kA:
undetectable		 6h1lA-6c9kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d35 SMOOTHENED,SOLUBLE
CYTOCHROME
B562,SMOOTHENED

(Escherichia
coli;
Xenopus laevis) 		no annotation 5 ALA A1050
LEU A1053
PHE A1080
ILE A1117
LEU A1025
 None
 1.42A 6h1lA-6d35A:
undetectable		 6h1lA-6d35A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyu BACTERIORHODOPSIN

(Candidatus
Nanosalina sp.
J07AB43) 		no annotation 5 ALA A 110
LEU A 114
VAL A 140
ILE A 170
LEU A  85
 MUN  A 319 ( 4.2A)
RET  A 301 ( 4.5A)
None
None
None
 1.05A 6h1lA-6eyuA:
undetectable		 6h1lA-6eyuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 5 ALA A 575
ILE A 638
ALA A 640
ALA A 389
LEU A 387
 None
 1.09A 6h1lA-6fikA:
undetectable		 6h1lA-6fikA:
undetectable