SIMILAR PATTERNS OF AMINO ACIDS FOR 6H0G_E_Y70E502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p49 STERYL-SULFATASE

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 ASN A 371
HIS A 444
GLU A 511
PHE A 473
GLY A 375
 None
 1.33A 6h0gE-1p49A:
0.0
6h0gF-1p49A:
undetectable		 6h0gE-1p49A:
9.66
6h0gF-1p49A:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE

(Bacteroides
thetaiotaomicron) 		PF03372
(Exo_endo_phos) 		5 ASN A 200
HIS A 165
HIS A 162
PHE A 211
GLY A 167
 None
 1.17A 6h0gE-4c1rA:
0.0
6h0gF-4c1rA:
undetectable		 6h0gE-4c1rA:
16.41
6h0gF-4c1rA:
8.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		9 ASN B 353
PRO B 354
HIS B 355
HIS B 380
SER B 381
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-4.5A)
LVY  B1429 (-4.0A)
LVY  B1429 (-3.8A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.34A 6h0gE-4ci2B:
50.4
6h0gF-4ci2B:
undetectable		 6h0gE-4ci2B:
46.28
6h0gF-4ci2B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbf PHIKZ131

(Pseudomonas
virus phiKZ) 		no annotation 5 HIS A 462
SER A 458
TRP A 459
PHE A 421
GLY A 414
 None
 1.31A 6h0gE-4gbfA:
0.0
6h0gF-4gbfA:
undetectable		 6h0gE-4gbfA:
14.08
6h0gF-4gbfA:
5.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq9 BETA-1,3-GLUCANASE

(Mycobacterium
marinum) 		PF00722
(Glyco_hydro_16) 		5 PRO A 131
GLU A 147
SER A 156
TRP A 148
GLY A 237
 None
BTB  A 303 (-2.7A)
None
None
None
 1.45A 6h0gE-4pq9A:
0.0
6h0gF-4pq9A:
undetectable		 6h0gE-4pq9A:
18.11
6h0gF-4pq9A:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 5 HIS C 380
SER C 381
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 ( 4.9A)
EF2  C 502 (-4.1A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.89A 6h0gE-4tzcC:
9.2
6h0gF-4tzcC:
undetectable		 6h0gE-4tzcC:
17.43
6h0gF-4tzcC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tzc PROTEIN CEREBLON

(Mus musculus) 		no annotation 5 SER C 381
TRP C 382
TRP C 388
TRP C 402
PHE C 404
 EF2  C 502 (-4.1A)
EF2  C 502 ( 3.2A)
EF2  C 502 (-3.5A)
EF2  C 502 (-3.8A)
EF2  C 502 (-4.5A)
 0.27A 6h0gE-4tzcC:
9.2
6h0gF-4tzcC:
undetectable		 6h0gE-4tzcC:
17.43
6h0gF-4tzcC:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 6 ASN A  50
PRO A  51
SER A  78
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-4.0A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.53A 6h0gE-4v30A:
0.0
6h0gF-4v30A:
undetectable		 6h0gE-4v30A:
21.09
6h0gF-4v30A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzf 1,3-BETA-GLUCANASE

(Mycobacterium
tuberculosis) 		PF00722
(Glyco_hydro_16) 		5 PRO A 157
GLU A 176
SER A 185
TRP A 177
GLY A 273
 None
EDO  A 402 (-3.5A)
None
None
None
 1.42A 6h0gE-4wzfA:
0.0
6h0gF-4wzfA:
undetectable		 6h0gE-4wzfA:
13.07
6h0gF-4wzfA:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		5 PRO A 129
GLU A 148
SER A 157
TRP A 149
GLY A 238
 None
EDO  A 307 (-3.4A)
EDO  A 308 (-3.4A)
EDO  A 308 (-3.6A)
None
 1.46A 6h0gE-4xdqA:
0.0
6h0gF-4xdqA:
undetectable		 6h0gE-4xdqA:
16.35
6h0gF-4xdqA:
7.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buv PUTATIVE EPIMERASE

(Yersinia
enterocolitica) 		PF00908
(dTDP_sugar_isom) 		5 ASN A 105
PRO A 106
HIS A 107
GLU A  79
PHE A 122
 None
 1.42A 6h0gE-5buvA:
undetectable
6h0gF-5buvA:
undetectable		 6h0gE-5buvA:
16.29
6h0gF-5buvA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb PROTEIN CEREBLON

(Homo sapiens) 		no annotation 5 ASN Z 351
PRO Z 352
HIS Z 378
SER Z 379
PHE Z 381
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
None
 1.33A 6h0gE-5hxbZ:
51.7
6h0gF-5hxbZ:
undetectable		 6h0gE-5hxbZ:
62.90
6h0gF-5hxbZ:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		11 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
SER Z 379
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.55A 6h0gE-5hxbZ:
51.7
6h0gF-5hxbZ:
undetectable		 6h0gE-5hxbZ:
62.90
6h0gF-5hxbZ:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		7 PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
SER Z 379
TRP Z 386
GLN X 534
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 ( 4.0A)
 1.26A 6h0gE-5hxbZ:
51.7
6h0gF-5hxbZ:
undetectable		 6h0gE-5hxbZ:
62.90
6h0gF-5hxbZ:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 ASN A 426
GLU A 360
HIS A 425
PHE A  76
GLY A  99
 None
 1.49A 6h0gE-5uqcA:
undetectable
6h0gF-5uqcA:
undetectable		 6h0gE-5uqcA:
10.43
6h0gF-5uqcA:
5.10