SIMILAR PATTERNS OF AMINO ACIDS FOR 6H0G_B_Y70B502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyj ALR0039 PROTEIN

(Nostoc sp. PCC
7120) 		PF00561
(Abhydrolase_1) 		5 PRO A 273
HIS A 103
GLU A 274
PHE A   5
GLN A  36
 None
 1.43A 6h0gB-3qyjA:
0.0
6h0gC-3qyjA:
undetectable		 6h0gB-3qyjA:
14.06
6h0gC-3qyjA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1r MANNOSYL-6-PHOSPHATA
SE

(Bacteroides
thetaiotaomicron) 		PF03372
(Exo_endo_phos) 		5 ASN A 200
HIS A 165
HIS A 162
PHE A 211
GLY A 167
 None
 1.20A 6h0gB-4c1rA:
0.0
6h0gC-4c1rA:
undetectable		 6h0gB-4c1rA:
16.41
6h0gC-4c1rA:
8.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		8 ASN B 353
PRO B 354
HIS B 355
HIS B 380
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-4.5A)
LVY  B1429 (-4.0A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.45A 6h0gB-4ci2B:
50.7
6h0gC-4ci2B:
undetectable		 6h0gB-4ci2B:
46.28
6h0gC-4ci2B:
8.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu PREDICTED MEMBRANE
PROTEIN
ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT

(Lactobacillus
brevis;
Lactobacillus
brevis) 		PF07155
(ECF-ribofla_trS)
PF02361
(CbiQ) 		5 HIS S  84
GLU S  41
PHE T 209
GLN S  87
GLY S  88
 None
 1.50A 6h0gB-4hzuS:
undetectable
6h0gC-4hzuS:
undetectable		 6h0gB-4hzuS:
14.79
6h0gC-4hzuS:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 5 ASN A  50
PRO A  51
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.58A 6h0gB-4v30A:
0.0
6h0gC-4v30A:
undetectable		 6h0gB-4v30A:
21.09
6h0gC-4v30A:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5buv PUTATIVE EPIMERASE

(Yersinia
enterocolitica) 		PF00908
(dTDP_sugar_isom) 		5 ASN A 105
PRO A 106
HIS A 107
GLU A  79
PHE A 122
 None
 1.38A 6h0gB-5buvA:
0.0
6h0gC-5buvA:
undetectable		 6h0gB-5buvA:
16.29
6h0gC-5buvA:
14.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		10 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.60A 6h0gB-5hxbZ:
51.9
6h0gC-5hxbZ:
undetectable		 6h0gB-5hxbZ:
62.90
6h0gC-5hxbZ:
10.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		6 PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 386
GLN X 534
 85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.4A)
85C  Z 502 ( 4.0A)
 1.41A 6h0gB-5hxbZ:
51.9
6h0gC-5hxbZ:
undetectable		 6h0gB-5hxbZ:
62.90
6h0gC-5hxbZ:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5d GLUCANASE

(Trichoderma
atroviride) 		no annotation 5 ASN A 188
HIS A 206
GLU A 190
TRP A 192
GLN A 186
 None
NI  A 603 ( 3.1A)
BTB  A 605 ( 4.7A)
None
None
 1.44A 6h0gB-5o5dA:
0.0
6h0gC-5o5dA:
undetectable		 6h0gB-5o5dA:
17.98
6h0gC-5o5dA:
18.18