SIMILAR PATTERNS OF AMINO ACIDS FOR 6H0F_H_Y70H502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		5 ASN A 268
HIS A 273
TRP A 271
ASN A 245
GLY A 265
 None
None
SO4  A 593 (-4.4A)
None
None
 1.49A 6h0fH-1qonA:
0.0
6h0fI-1qonA:
0.0		 6h0fH-1qonA:
9.34
6h0fI-1qonA:
4.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		5 GLU A 563
TRP A 566
TRP A 399
ASN A 393
GLY A 395
 None
 1.47A 6h0fH-1ut9A:
0.0
6h0fI-1ut9A:
0.0		 6h0fH-1ut9A:
8.05
6h0fI-1ut9A:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ay0 UNCHARACTERIZED
PROTEIN MJ0883

(Methanocaldococcus
jannaschii) 		PF02475
(Met_10) 		5 HIS A 151
GLU A 122
PHE A  76
ASN A 156
GLY A 132
 None
 1.48A 6h0fH-3ay0A:
0.0
6h0fI-3ay0A:
0.0		 6h0fH-3ay0A:
12.39
6h0fI-3ay0A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doj DEHYDROGENASE-LIKE
PROTEIN

(Arabidopsis
thaliana) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 ASN A 182
PHE A 215
GLN A 236
ASN A 261
GLY A 178
 None
 1.46A 6h0fH-3dojA:
0.0
6h0fI-3dojA:
0.0		 6h0fH-3dojA:
16.16
6h0fI-3dojA:
8.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		8 ASN B 353
PRO B 354
HIS B 355
HIS B 380
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 LVY  B1429 (-4.1A)
LVY  B1429 (-4.7A)
LVY  B1429 (-4.5A)
LVY  B1429 (-4.0A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.42A 6h0fH-4ci2B:
29.9
6h0fI-4ci2B:
undetectable		 6h0fH-4ci2B:
46.28
6h0fI-4ci2B:
4.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ci2 PROTEIN CEREBLON

(Gallus gallus) 		PF02190
(LON_substr_bdg)
PF03226
(Yippee-Mis18) 		6 GLU B 379
HIS B 380
TRP B 382
TRP B 388
TRP B 402
PHE B 404
 None
LVY  B1429 (-4.0A)
LVY  B1429 (-3.1A)
LVY  B1429 (-3.5A)
LVY  B1429 (-3.7A)
LVY  B1429 (-4.5A)
 0.93A 6h0fH-4ci2B:
29.9
6h0fI-4ci2B:
undetectable		 6h0fH-4ci2B:
46.28
6h0fI-4ci2B:
4.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v30 CEREBLON ISOFORM 4

(Magnetospirillum
gryphiswaldense) 		no annotation 5 ASN A  50
PRO A  51
TRP A  79
TRP A  85
TRP A  99
 LVY  A 151 (-3.8A)
LVY  A 151 (-4.4A)
LVY  A 151 (-3.2A)
LVY  A 151 (-3.4A)
LVY  A 151 (-3.7A)
 0.57A 6h0fH-4v30A:
0.0
6h0fI-4v30A:
undetectable		 6h0fH-4v30A:
21.09
6h0fI-4v30A:
16.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		9 ASN Z 351
PRO Z 352
HIS Z 353
GLU Z 377
HIS Z 378
TRP Z 380
TRP Z 386
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
None
85C  Z 502 (-3.7A)
 0.62A 6h0fH-5hxbZ:
30.7
6h0fI-5hxbZ:
0.0		 6h0fH-5hxbZ:
62.90
6h0fI-5hxbZ:
6.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A
PROTEIN CEREBLON

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		9 ASN Z 351
PRO Z 352
HIS Z 353
HIS Z 378
TRP Z 380
TRP Z 386
TRP Z 400
PHE Z 402
GLY X 575
 85C  Z 502 (-3.6A)
85C  Z 502 (-4.4A)
85C  Z 502 (-3.9A)
85C  Z 502 (-3.8A)
85C  Z 502 (-3.2A)
85C  Z 502 (-3.4A)
85C  Z 502 (-3.7A)
None
85C  Z 502 (-3.7A)
 0.40A 6h0fH-5hxbZ:
30.7
6h0fI-5hxbZ:
0.0		 6h0fH-5hxbZ:
62.90
6h0fI-5hxbZ:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01493
(GXGXG) 		5 ASN C  75
PRO C  15
GLU C  17
PHE C  52
ASN B 332
 None
 1.44A 6h0fH-5t5iC:
undetectable
6h0fI-5t5iC:
undetectable		 6h0fH-5t5iC:
11.85
6h0fI-5t5iC:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bsu XYLOGLUCAN
6-XYLOSYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 5 ASN A 408
HIS A 418
TRP A 372
ASN A 404
GLY A 406
 None
 1.18A 6h0fH-6bsuA:
0.9
6h0fI-6bsuA:
undetectable		 6h0fH-6bsuA:
22.47
6h0fI-6bsuA:
15.79