SIMILAR PATTERNS OF AMINO ACIDS FOR 6GZ9_A_TXCA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nap CAPSID PROTEIN
CAPSID PROTEIN

(Triatoma virus;
Triatoma virus) 		PF08762
(CRPV_capsid)
PF00073
(Rhv) 		5 TYR A 206
TYR A 178
VAL A 204
ALA A  72
ASN C  38
 None
 1.18A 6gz9A-3napA:
0.0		 6gz9A-3napA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxx ACRH
AOPB

(Aeromonas
hydrophila;
Aeromonas
hydrophila) 		no annotation
PF04888
(SseC) 		5 VAL B 241
ASN B  82
ALA B  83
GLN B  77
ASN A  27
 None
 1.32A 6gz9A-3wxxB:
0.0		 6gz9A-3wxxB:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		5 ASN A 727
GLN A 611
ASN A 730
PRO A 731
ASN B 452
 None
NAG  B3453 (-3.8A)
None
None
NAG  B3452 (-1.9A)
 1.50A 6gz9A-4cakA:
0.0		 6gz9A-4cakA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fvs PUTATIVE LIPOPROTEIN

(Parabacteroides
distasonis) 		no annotation 5 TYR A 206
VAL A 183
ALA A 181
ASN A 126
PRO A 127
 None
 1.38A 6gz9A-4fvsA:
undetectable		 6gz9A-4fvsA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		6 TYR A  40
ASN A 166
ALA A 169
GLN A 309
ASN A 342
PRO A 343
 None
 0.49A 6gz9A-4ikvA:
52.2		 6gz9A-4ikvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		6 TYR A  40
TYR A 162
ALA A 169
GLN A 309
ASN A 342
PRO A 343
 None
 0.69A 6gz9A-4ikvA:
52.2		 6gz9A-4ikvA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		5 TYR A  29
VAL A 150
ASN A 151
ASN A 329
PRO A 330
 None
 0.57A 6gz9A-4tpgA:
38.8		 6gz9A-4tpgA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		6 TYR A  30
TYR A  68
ASN A 156
ALA A 159
ASN A 328
PRO A 329
 None
 0.59A 6gz9A-4xniA:
46.0		 6gz9A-4xniA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohs -

(-) 		no annotation 5 TYR A 483
TYR A 237
TYR A 592
VAL A 569
ALA A 482
 None
 1.45A 6gz9A-5ohsA:
undetectable		 6gz9A-5ohsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wro ENOLASE

(Drosophila
melanogaster) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 TYR A 256
VAL A 219
ASN A 218
ALA A 465
ASN A 228
 None
 1.32A 6gz9A-5wroA:
undetectable		 6gz9A-5wroA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 ASN A   5
ALA A   6
GLN A 246
PRO A   7
ASN A 289
 None
 1.35A 6gz9A-6blgA:
undetectable		 6gz9A-6blgA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cau UDP-N-ACETYLMURAMATE
--L-ALANINE LIGASE

(Acinetobacter
baumannii) 		no annotation 5 VAL A  41
ASN A  44
ALA A  43
GLN A  62
ASN A  66
 None
 1.19A 6gz9A-6cauA:
undetectable		 6gz9A-6cauA:
17.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 10 TYR A  41
TYR A  79
TYR A 163
VAL A 166
ASN A 167
ALA A 170
GLN A 310
ASN A 347
PRO A 348
ASN A 426
 C3H  A 514 (-4.0A)
None
None
None
C3H  A 514 (-3.6A)
C3H  A 514 ( 3.7A)
C3H  A 514 (-3.5A)
C3H  A 514 (-4.0A)
C3H  A 514 (-4.1A)
None
 0.56A 6gz9A-6exsA:
60.6		 6gz9A-6exsA:
100.00