SIMILAR PATTERNS OF AMINO ACIDS FOR 6GTQ_A_ACTA205_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3p POLLEN ALLERGEN PHL
P 5B

(Phleum pratense) 		PF01620
(Pollen_allerg_2) 		4 ALA A 168
ALA A 171
ALA A 187
ALA A 191
 None
 0.81A 6gtqA-1l3pA:
undetectable
6gtqB-1l3pA:
undetectable		 6gtqA-1l3pA:
22.47
6gtqB-1l3pA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3p POLLEN ALLERGEN PHL
P 5B

(Phleum pratense) 		PF01620
(Pollen_allerg_2) 		4 ALA A 187
ALA A 191
ALA A 168
ALA A 171
 None
 0.80A 6gtqA-1l3pA:
undetectable
6gtqB-1l3pA:
undetectable		 6gtqA-1l3pA:
22.47
6gtqB-1l3pA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3p POLLEN ALLERGEN PHL
P 5B

(Phleum pratense) 		PF01620
(Pollen_allerg_2) 		4 ALA A 216
ALA A 219
ALA A 235
ALA A 239
 None
 0.80A 6gtqA-1l3pA:
undetectable
6gtqB-1l3pA:
undetectable		 6gtqA-1l3pA:
22.47
6gtqB-1l3pA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l3p POLLEN ALLERGEN PHL
P 5B

(Phleum pratense) 		PF01620
(Pollen_allerg_2) 		4 ALA A 235
ALA A 239
ALA A 216
ALA A 219
 None
 0.80A 6gtqA-1l3pA:
undetectable
6gtqB-1l3pA:
undetectable		 6gtqA-1l3pA:
22.47
6gtqB-1l3pA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1me5 ALKYLHYDROPEROXIDASE
D

(Mycobacterium
tuberculosis) 		PF02627
(CMD) 		4 ALA A  41
ALA A  44
ALA A  75
ALA A  74
 None
 0.85A 6gtqA-1me5A:
0.0
6gtqB-1me5A:
0.0		 6gtqA-1me5A:
25.70
6gtqB-1me5A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1me5 ALKYLHYDROPEROXIDASE
D

(Mycobacterium
tuberculosis) 		PF02627
(CMD) 		4 ALA A  75
ALA A  74
ALA A  41
ALA A  44
 None
 0.84A 6gtqA-1me5A:
0.0
6gtqB-1me5A:
0.0		 6gtqA-1me5A:
25.70
6gtqB-1me5A:
25.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		4 ALA A 394
ALA A 397
ALA A 424
ALA A 434
 None
 0.68A 6gtqA-1nbwA:
0.4
6gtqB-1nbwA:
0.4		 6gtqA-1nbwA:
15.32
6gtqB-1nbwA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT

(Klebsiella
pneumoniae) 		PF08841
(DDR) 		4 ALA A 424
ALA A 434
ALA A 394
ALA A 397
 None
 0.68A 6gtqA-1nbwA:
0.4
6gtqB-1nbwA:
0.4		 6gtqA-1nbwA:
15.32
6gtqB-1nbwA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE

(Methanopyrus
kandleri) 		PF01993
(MTD) 		4 ALA A 203
ALA A 206
ALA A 248
ALA A 251
 None
 0.82A 6gtqA-1qv9A:
0.0
6gtqB-1qv9A:
0.0		 6gtqA-1qv9A:
22.07
6gtqB-1qv9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv9 F420-DEPENDENT
METHYLENETETRAHYDROM
ETHANOPTERIN
DEHYDROGENASE

(Methanopyrus
kandleri) 		PF01993
(MTD) 		4 ALA A 248
ALA A 251
ALA A 203
ALA A 206
 None
 0.83A 6gtqA-1qv9A:
0.0
6gtqB-1qv9A:
0.0		 6gtqA-1qv9A:
22.07
6gtqB-1qv9A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9u PUTATIVE COMPONENT
OF ANAEROBIC
DEHYDROGENASES

(Salmonella
enterica) 		PF02613
(Nitrate_red_del) 		4 ALA A  11
ALA A  14
ALA A 136
ALA A 139
 None
None
None
PEG  A 304 ( 4.3A)
 0.77A 6gtqA-1s9uA:
undetectable
6gtqB-1s9uA:
undetectable		 6gtqA-1s9uA:
20.35
6gtqB-1s9uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9u PUTATIVE COMPONENT
OF ANAEROBIC
DEHYDROGENASES

(Salmonella
enterica) 		PF02613
(Nitrate_red_del) 		4 ALA A 136
ALA A 139
ALA A  11
ALA A  14
 None
PEG  A 304 ( 4.3A)
None
None
 0.77A 6gtqA-1s9uA:
undetectable
6gtqB-1s9uA:
undetectable		 6gtqA-1s9uA:
20.35
6gtqB-1s9uA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3

(Pseudomonas
savastanoi) 		PF03543
(Peptidase_C58) 		4 ALA A 141
ALA A 145
ALA A 157
ALA A 160
 None
 0.84A 6gtqA-1ukfA:
0.3
6gtqB-1ukfA:
0.4		 6gtqA-1ukfA:
21.43
6gtqB-1ukfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukf AVIRULENCE PROTEIN
AVRPPH3

(Pseudomonas
savastanoi) 		PF03543
(Peptidase_C58) 		4 ALA A 157
ALA A 160
ALA A 141
ALA A 145
 None
 0.85A 6gtqA-1ukfA:
0.3
6gtqB-1ukfA:
0.4		 6gtqA-1ukfA:
21.43
6gtqB-1ukfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 ALA A  39
ALA A  47
ALA A 460
ALA A 463
 None
 0.83A 6gtqA-1urjA:
0.3
6gtqB-1urjA:
0.2		 6gtqA-1urjA:
10.11
6gtqB-1urjA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		4 ALA A 460
ALA A 463
ALA A  39
ALA A  47
 None
 0.82A 6gtqA-1urjA:
0.3
6gtqB-1urjA:
0.2		 6gtqA-1urjA:
10.11
6gtqB-1urjA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 ALA A 262
ALA A 267
ALA A 270
ALA A 250
 None
 0.83A 6gtqA-2bb0A:
1.9
6gtqB-2bb0A:
0.8		 6gtqA-2bb0A:
20.37
6gtqB-2bb0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		4 ALA A 270
ALA A 250
ALA A 262
ALA A 267
 None
 0.85A 6gtqA-2bb0A:
1.9
6gtqB-2bb0A:
0.8		 6gtqA-2bb0A:
20.37
6gtqB-2bb0A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ALA A 169
ALA A 172
ALA A 189
ALA A 192
 None
 0.81A 6gtqA-2hyjA:
0.2
6gtqB-2hyjA:
0.2		 6gtqA-2hyjA:
23.77
6gtqB-2hyjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyj PUTATIVE TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N) 		4 ALA A 189
ALA A 192
ALA A 169
ALA A 172
 None
 0.81A 6gtqA-2hyjA:
0.2
6gtqB-2hyjA:
0.2		 6gtqA-2hyjA:
23.77
6gtqB-2hyjA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00120
(Gln-synt_C) 		4 ALA A 280
ALA A 283
ALA A 324
ALA A 326
 None
 0.61A 6gtqA-2j9iA:
0.0
6gtqB-2j9iA:
0.0		 6gtqA-2j9iA:
15.70
6gtqB-2j9iA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j9i GLUTAMATE-AMMONIA
LIGASE
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus) 		PF00120
(Gln-synt_C) 		4 ALA A 324
ALA A 326
ALA A 280
ALA A 283
 None
 0.62A 6gtqA-2j9iA:
0.0
6gtqB-2j9iA:
0.0		 6gtqA-2j9iA:
15.70
6gtqB-2j9iA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus) 		PF01608
(I_LWEQ) 		4 ALA A2355
ALA A2358
ALA A2459
ALA A2462
 None
 0.81A 6gtqA-2jswA:
undetectable
6gtqB-2jswA:
undetectable		 6gtqA-2jswA:
23.76
6gtqB-2jswA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsw TALIN-1

(Mus musculus) 		PF01608
(I_LWEQ) 		4 ALA A2459
ALA A2462
ALA A2355
ALA A2358
 None
 0.81A 6gtqA-2jswA:
undetectable
6gtqB-2jswA:
undetectable		 6gtqA-2jswA:
23.76
6gtqB-2jswA:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9a ACETATE OPERON
REPRESSOR

(Escherichia
coli) 		PF01614
(IclR) 		4 ALA A  67
ALA A 130
ALA A 143
ALA A  29
 PYR  A 905 (-4.0A)
PYR  A 905 ( 4.9A)
None
None
 0.79A 6gtqA-2o9aA:
0.5
6gtqB-2o9aA:
0.2		 6gtqA-2o9aA:
18.23
6gtqB-2o9aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o9a ACETATE OPERON
REPRESSOR

(Escherichia
coli) 		PF01614
(IclR) 		4 ALA A 143
ALA A  29
ALA A  67
ALA A 130
 None
None
PYR  A 905 (-4.0A)
PYR  A 905 ( 4.9A)
 0.81A 6gtqA-2o9aA:
0.5
6gtqB-2o9aA:
0.2		 6gtqA-2o9aA:
18.23
6gtqB-2o9aA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		4 ALA A 128
ALA A 131
ALA A 156
ALA A 159
 None
 0.73A 6gtqA-2oewA:
0.0
6gtqB-2oewA:
0.0		 6gtqA-2oewA:
20.42
6gtqB-2oewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oew PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1) 		4 ALA A 156
ALA A 159
ALA A 128
ALA A 131
 None
 0.73A 6gtqA-2oewA:
0.0
6gtqB-2oewA:
0.0		 6gtqA-2oewA:
20.42
6gtqB-2oewA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 ALA A 128
ALA A 131
ALA A 156
ALA A 159
 None
 0.76A 6gtqA-2r05A:
undetectable
6gtqB-2r05A:
undetectable		 6gtqA-2r05A:
12.55
6gtqB-2r05A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 ALA A 156
ALA A 159
ALA A 128
ALA A 131
 None
 0.76A 6gtqA-2r05A:
undetectable
6gtqB-2r05A:
undetectable		 6gtqA-2r05A:
12.55
6gtqB-2r05A:
12.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		4 ALA A  60
ALA A  63
ALA A  86
ALA A  89
 L2P  A 280 ( 4.8A)
L2P  A 280 ( 4.1A)
L2P  A 280 ( 4.8A)
L2P  A 280 (-3.5A)
 0.51A 6gtqA-2z55A:
undetectable
6gtqB-2z55A:
undetectable		 6gtqA-2z55A:
23.19
6gtqB-2z55A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z55 ARCHAERHODOPSIN-2

(Halobacterium
sp. AUS-2) 		PF01036
(Bac_rhodopsin) 		4 ALA A  86
ALA A  89
ALA A  60
ALA A  63
 L2P  A 280 ( 4.8A)
L2P  A 280 (-3.5A)
L2P  A 280 ( 4.8A)
L2P  A 280 ( 4.1A)
 0.50A 6gtqA-2z55A:
undetectable
6gtqB-2z55A:
undetectable		 6gtqA-2z55A:
23.19
6gtqB-2z55A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		4 ALA A 249
ALA A 252
ALA A 360
ALA A 359
 None
 0.82A 6gtqA-3b2zA:
undetectable
6gtqB-3b2zA:
undetectable		 6gtqA-3b2zA:
20.90
6gtqB-3b2zA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2z ADAMTS-4

(Homo sapiens) 		PF01421
(Reprolysin) 		4 ALA A 360
ALA A 359
ALA A 249
ALA A 252
 None
 0.81A 6gtqA-3b2zA:
undetectable
6gtqB-3b2zA:
undetectable		 6gtqA-3b2zA:
20.90
6gtqB-3b2zA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ALA A 203
ALA A 206
ALA A 220
ALA A 223
 None
 0.62A 6gtqA-3bfjA:
undetectable
6gtqB-3bfjA:
undetectable		 6gtqA-3bfjA:
19.02
6gtqB-3bfjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		4 ALA A 220
ALA A 223
ALA A 203
ALA A 206
 None
 0.62A 6gtqA-3bfjA:
undetectable
6gtqB-3bfjA:
undetectable		 6gtqA-3bfjA:
19.02
6gtqB-3bfjA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 ALA A  60
ALA A  63
ALA A 250
ALA A 249
 None
 0.84A 6gtqA-3go7A:
undetectable
6gtqB-3go7A:
undetectable		 6gtqA-3go7A:
21.26
6gtqB-3go7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 ALA A 250
ALA A 249
ALA A  60
ALA A  63
 None
 0.83A 6gtqA-3go7A:
undetectable
6gtqB-3go7A:
undetectable		 6gtqA-3go7A:
21.26
6gtqB-3go7A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		4 ALA A  72
ALA A  75
ALA A  84
ALA A  87
 None
 0.62A 6gtqA-3h0nA:
undetectable
6gtqB-3h0nA:
undetectable		 6gtqA-3h0nA:
21.29
6gtqB-3h0nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0n UNCHARACTERIZED
PROTEIN DUF1470

(Jannaschia sp.
CCS1) 		PF07336
(ABATE)
PF11706
(zf-CGNR) 		4 ALA A  84
ALA A  87
ALA A  72
ALA A  75
 None
 0.62A 6gtqA-3h0nA:
undetectable
6gtqB-3h0nA:
undetectable		 6gtqA-3h0nA:
21.29
6gtqB-3h0nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ALA A 450
ALA A 453
ALA A 473
ALA A 476
 None
 0.72A 6gtqA-3h7lA:
undetectable
6gtqB-3h7lA:
undetectable		 6gtqA-3h7lA:
15.55
6gtqB-3h7lA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7l ENDOGLUCANASE

(Vibrio
parahaemolyticus) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ALA A 473
ALA A 476
ALA A 450
ALA A 453
 None
 0.72A 6gtqA-3h7lA:
undetectable
6gtqB-3h7lA:
undetectable		 6gtqA-3h7lA:
15.55
6gtqB-3h7lA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
NA+/K+ ATPASE GAMMA
SUBUNIT TRANSCRIPT
VARIANT A

(Sus scrofa;
Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
no annotation 		4 ALA A 956
ALA A 959
ALA G  34
ALA G  37
 None
 0.76A 6gtqA-3n23A:
0.0
6gtqB-3n23A:
0.0		 6gtqA-3n23A:
10.46
6gtqB-3n23A:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n23 SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1
NA+/K+ ATPASE GAMMA
SUBUNIT TRANSCRIPT
VARIANT A

(Sus scrofa;
Sus scrofa) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF13246
(Cation_ATPase)
no annotation 		4 ALA G  34
ALA G  37
ALA A 956
ALA A 959
 None
 0.76A 6gtqA-3n23G:
undetectable
6gtqB-3n23G:
undetectable		 6gtqA-3n23G:
12.80
6gtqB-3n23G:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 ALA A 199
ALA A 202
ALA A 216
ALA A 219
 None
 0.52A 6gtqA-3ox4A:
undetectable
6gtqB-3ox4A:
undetectable		 6gtqA-3ox4A:
17.66
6gtqB-3ox4A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		4 ALA A 216
ALA A 219
ALA A 199
ALA A 202
 None
 0.52A 6gtqA-3ox4A:
undetectable
6gtqB-3ox4A:
undetectable		 6gtqA-3ox4A:
17.66
6gtqB-3ox4A:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		4 ALA A 304
ALA A 307
ALA A 327
ALA A 330
 None
 0.49A 6gtqA-3oyrA:
undetectable
6gtqB-3oyrA:
undetectable		 6gtqA-3oyrA:
19.77
6gtqB-3oyrA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		4 ALA A 327
ALA A 330
ALA A 304
ALA A 307
 None
 0.48A 6gtqA-3oyrA:
undetectable
6gtqB-3oyrA:
undetectable		 6gtqA-3oyrA:
19.77
6gtqB-3oyrA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 ALA A 805
ALA A 808
ALA A 819
ALA A 822
 None
 0.78A 6gtqA-3tzwA:
undetectable
6gtqB-3tzwA:
undetectable		 6gtqA-3tzwA:
16.91
6gtqB-3tzwA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzw POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		4 ALA A 819
ALA A 822
ALA A 805
ALA A 808
 None
 0.78A 6gtqA-3tzwA:
undetectable
6gtqB-3tzwA:
undetectable		 6gtqA-3tzwA:
16.91
6gtqB-3tzwA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8v METAL-BINDING
PROTEIN SMBP

(Nitrosomonas
europaea) 		PF16785
(SMBP) 		4 ALA A  14
ALA A  17
ALA A  78
ALA A  81
 None
 0.72A 6gtqA-3u8vA:
undetectable
6gtqB-3u8vA:
0.2		 6gtqA-3u8vA:
20.99
6gtqB-3u8vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u8v METAL-BINDING
PROTEIN SMBP

(Nitrosomonas
europaea) 		PF16785
(SMBP) 		4 ALA A  78
ALA A  81
ALA A  14
ALA A  17
 None
 0.72A 6gtqA-3u8vA:
undetectable
6gtqB-3u8vA:
0.2		 6gtqA-3u8vA:
20.99
6gtqB-3u8vA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ALA A 292
ALA A 295
ALA A 315
ALA A 318
 None
 0.31A 6gtqA-3wjoA:
undetectable
6gtqB-3wjoA:
undetectable		 6gtqA-3wjoA:
20.24
6gtqB-3wjoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ALA A 315
ALA A 318
ALA A 292
ALA A 295
 None
 0.31A 6gtqA-3wjoA:
undetectable
6gtqB-3wjoA:
undetectable		 6gtqA-3wjoA:
20.24
6gtqB-3wjoA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 ALA A 666
ALA A 669
ALA A 683
ALA A 686
 None
 0.62A 6gtqA-3zdrA:
undetectable
6gtqB-3zdrA:
undetectable		 6gtqA-3zdrA:
16.55
6gtqB-3zdrA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdr ALCOHOL
DEHYDROGENASE DOMAIN
OF THE BIFUNCTIONAL
ACETALDEHYDE
DEHYDROGENASE

(Parageobacillus
thermoglucosidasius) 		PF00465
(Fe-ADH) 		4 ALA A 683
ALA A 686
ALA A 666
ALA A 669
 None
 0.62A 6gtqA-3zdrA:
undetectable
6gtqB-3zdrA:
undetectable		 6gtqA-3zdrA:
16.55
6gtqB-3zdrA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfi FLAGELLIN

(Burkholderia
pseudomallei) 		PF00669
(Flagellin_N)
PF12613
(FliC_SP) 		4 ALA A  95
ALA A  98
ALA A 298
ALA A 301
 None
 0.57A 6gtqA-4cfiA:
0.0
6gtqB-4cfiA:
0.0		 6gtqA-4cfiA:
23.05
6gtqB-4cfiA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfi FLAGELLIN

(Burkholderia
pseudomallei) 		PF00669
(Flagellin_N)
PF12613
(FliC_SP) 		4 ALA A 298
ALA A 301
ALA A  95
ALA A  98
 None
 0.57A 6gtqA-4cfiA:
0.0
6gtqB-4cfiA:
0.0		 6gtqA-4cfiA:
23.05
6gtqB-4cfiA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmt CHPT PROTEIN

(Caulobacter
vibrioides) 		PF10090
(HPTransfase) 		4 ALA A 136
ALA A 139
ALA A 163
ALA A 161
 None
 0.81A 6gtqA-4fmtA:
undetectable
6gtqB-4fmtA:
undetectable		 6gtqA-4fmtA:
20.47
6gtqB-4fmtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmt CHPT PROTEIN

(Caulobacter
vibrioides) 		PF10090
(HPTransfase) 		4 ALA A 163
ALA A 161
ALA A 136
ALA A 139
 None
 0.82A 6gtqA-4fmtA:
undetectable
6gtqB-4fmtA:
undetectable		 6gtqA-4fmtA:
20.47
6gtqB-4fmtA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gi2 CROTONYL-COA
CARBOXYLASE/REDUCTAS
E

(Methylobacterium
extorquens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ALA A 194
ALA A 359
ALA A 364
ALA A 367
 None
 0.86A 6gtqA-4gi2A:
undetectable
6gtqB-4gi2A:
undetectable		 6gtqA-4gi2A:
16.10
6gtqB-4gi2A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzs BETA-KETOTHIOLASE
BKTB

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ALA A 322
ALA A 325
ALA A 179
ALA A 180
 None
 0.86A 6gtqA-4nzsA:
undetectable
6gtqB-4nzsA:
undetectable		 6gtqA-4nzsA:
18.58
6gtqB-4nzsA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ALA A 330
ALA A 333
ALA A 376
ALA A 375
 None
 0.76A 6gtqA-4o5hA:
0.0
6gtqB-4o5hA:
0.0		 6gtqA-4o5hA:
18.11
6gtqB-4o5hA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 ALA A 376
ALA A 375
ALA A 330
ALA A 333
 None
 0.75A 6gtqA-4o5hA:
0.0
6gtqB-4o5hA:
0.0		 6gtqA-4o5hA:
18.11
6gtqB-4o5hA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 249
ALA A 252
ALA A 254
ALA A 268
 None
 0.83A 6gtqA-4p52A:
undetectable
6gtqB-4p52A:
undetectable		 6gtqA-4p52A:
19.87
6gtqB-4p52A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p52 HOMOSERINE KINASE

(Cytophaga
hutchinsonii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		4 ALA A 254
ALA A 268
ALA A 249
ALA A 252
 None
 0.83A 6gtqA-4p52A:
undetectable
6gtqB-4p52A:
undetectable		 6gtqA-4p52A:
19.87
6gtqB-4p52A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		4 ALA A 205
ALA A 210
ALA A 220
ALA A 223
 None
 0.78A 6gtqA-4rjzA:
undetectable
6gtqB-4rjzA:
undetectable		 6gtqA-4rjzA:
19.75
6gtqB-4rjzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjz ABC TRANSPORTER,
SUBSTRATE BINDING
PROTEIN (SUGAR)

(Agrobacterium
fabrum) 		PF01547
(SBP_bac_1) 		4 ALA A 220
ALA A 223
ALA A 205
ALA A 210
 None
 0.78A 6gtqA-4rjzA:
undetectable
6gtqB-4rjzA:
undetectable		 6gtqA-4rjzA:
19.75
6gtqB-4rjzA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 ALA A 211
ALA A 214
ALA A 223
ALA A 226
 None
 0.81A 6gtqA-4uj6A:
undetectable
6gtqB-4uj6A:
undetectable		 6gtqA-4uj6A:
10.95
6gtqB-4uj6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		4 ALA A 223
ALA A 226
ALA A 211
ALA A 214
 None
 0.81A 6gtqA-4uj6A:
undetectable
6gtqB-4uj6A:
undetectable		 6gtqA-4uj6A:
10.95
6gtqB-4uj6A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A  48
ALA A  45
ALA A  92
ALA A  95
 None
 0.84A 6gtqA-5cwcA:
undetectable
6gtqB-5cwcA:
undetectable		 6gtqA-5cwcA:
23.22
6gtqB-5cwcA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwc DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A  92
ALA A  95
ALA A  48
ALA A  45
 None
 0.83A 6gtqA-5cwcA:
undetectable
6gtqB-5cwcA:
undetectable		 6gtqA-5cwcA:
23.22
6gtqB-5cwcA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwd DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A  56
ALA A  59
ALA A  72
ALA A  75
 None
 0.57A 6gtqA-5cwdA:
0.0
6gtqB-5cwdA:
0.0		 6gtqA-5cwdA:
20.83
6gtqB-5cwdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwd DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A  72
ALA A  75
ALA A  56
ALA A  59
 None
 0.58A 6gtqA-5cwdA:
0.0
6gtqB-5cwdA:
0.0		 6gtqA-5cwdA:
20.83
6gtqB-5cwdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwd DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A  98
ALA A 101
ALA A 114
ALA A 117
 None
 0.71A 6gtqA-5cwdA:
0.0
6gtqB-5cwdA:
0.0		 6gtqA-5cwdA:
20.83
6gtqB-5cwdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwd DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A 114
ALA A 117
ALA A  98
ALA A 101
 None
 0.71A 6gtqA-5cwdA:
0.0
6gtqB-5cwdA:
0.0		 6gtqA-5cwdA:
20.83
6gtqB-5cwdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwd DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A 140
ALA A 143
ALA A 156
ALA A 159
 None
 0.74A 6gtqA-5cwdA:
0.0
6gtqB-5cwdA:
0.0		 6gtqA-5cwdA:
20.83
6gtqB-5cwdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwd DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 ALA A 156
ALA A 159
ALA A 140
ALA A 143
 None
 0.75A 6gtqA-5cwdA:
0.0
6gtqB-5cwdA:
0.0		 6gtqA-5cwdA:
20.83
6gtqB-5cwdA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 4 ALA A  24
ALA A  27
ALA A  96
ALA A 130
 None
 0.81A 6gtqA-5gufA:
undetectable
6gtqB-5gufA:
undetectable		 6gtqA-5gufA:
22.73
6gtqB-5gufA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5guf CDP-ARCHAEOL
SYNTHASE

(Aeropyrum
pernix) 		no annotation 4 ALA A  96
ALA A 130
ALA A  24
ALA A  27
 None
 0.81A 6gtqA-5gufA:
undetectable
6gtqB-5gufA:
undetectable		 6gtqA-5gufA:
22.73
6gtqB-5gufA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 4 ALA E 104
ALA E 129
ALA E 156
ALA E 184
 None
 0.81A 6gtqA-5h36E:
undetectable
6gtqB-5h36E:
undetectable		 6gtqA-5h36E:
24.22
6gtqB-5h36E:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h36 UNCHARACTERIZED
PROTEIN TRIC

(Rhodobacter
sphaeroides) 		no annotation 4 ALA E 156
ALA E 184
ALA E 104
ALA E 129
 None
 0.81A 6gtqA-5h36E:
undetectable
6gtqB-5h36E:
undetectable		 6gtqA-5h36E:
24.22
6gtqB-5h36E:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 ALA A 147
ALA A 150
ALA A 163
ALA A 166
 None
 0.73A 6gtqA-5hzgA:
0.8
6gtqB-5hzgA:
0.3		 6gtqA-5hzgA:
21.62
6gtqB-5hzgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzg STRIGOLACTONE
ESTERASE D14

(Arabidopsis
thaliana) 		PF12697
(Abhydrolase_6) 		4 ALA A 163
ALA A 166
ALA A 147
ALA A 150
 None
 0.72A 6gtqA-5hzgA:
0.8
6gtqB-5hzgA:
0.3		 6gtqA-5hzgA:
21.62
6gtqB-5hzgA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP

(Sphaerobacter
thermophilus) 		PF08443
(RimK) 		4 ALA A  63
ALA A  66
ALA A  83
ALA A  87
 None
 0.84A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP

(Sphaerobacter
thermophilus) 		PF08443
(RimK) 		4 ALA A  66
ALA A  70
ALA A  80
ALA A  83
 None
 0.85A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP

(Sphaerobacter
thermophilus) 		PF08443
(RimK) 		4 ALA A  80
ALA A  83
ALA A  66
ALA A  70
 None
 0.85A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i47 RIMK DOMAIN PROTEIN
ATP-GRASP

(Sphaerobacter
thermophilus) 		PF08443
(RimK) 		4 ALA A  83
ALA A  87
ALA A  63
ALA A  66
 None
 0.85A 6gtqA-5i47A:
undetectable
6gtqB-5i47A:
undetectable		 6gtqA-5i47A:
22.97
6gtqB-5i47A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 ALA A 176
ALA A 175
ALA A 228
ALA A 189
 None
 0.82A 6gtqA-5muxA:
0.0
6gtqB-5muxA:
0.0		 6gtqA-5muxA:
undetectable
6gtqB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mux 2-METHYLCITRATE
DEHYDRATASE

(Bacillus
subtilis) 		no annotation 4 ALA A 228
ALA A 189
ALA A 176
ALA A 175
 None
 0.82A 6gtqA-5muxA:
0.0
6gtqB-5muxA:
0.0		 6gtqA-5muxA:
undetectable
6gtqB-5muxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 ALA A 527
ALA A 530
ALA A 539
ALA A 542
 None
 0.75A 6gtqA-5v7vA:
undetectable
6gtqB-5v7vA:
undetectable		 6gtqA-5v7vA:
13.54
6gtqB-5v7vA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v7v ERAD-ASSOCIATED E3
UBIQUITIN-PROTEIN
LIGASE COMPONENT
HRD3

(Saccharomyces
cerevisiae) 		PF08238
(Sel1) 		4 ALA A 539
ALA A 542
ALA A 527
ALA A 530
 None
 0.75A 6gtqA-5v7vA:
undetectable
6gtqB-5v7vA:
undetectable		 6gtqA-5v7vA:
13.54
6gtqB-5v7vA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtl -

(-) 		no annotation 4 ALA A 104
ALA A 107
ALA A 212
ALA A 215
 None
 0.70A 6gtqA-5vtlA:
undetectable
6gtqB-5vtlA:
undetectable		 6gtqA-5vtlA:
undetectable
6gtqB-5vtlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtl -

(-) 		no annotation 4 ALA A 212
ALA A 215
ALA A 104
ALA A 107
 None
 0.70A 6gtqA-5vtlA:
undetectable
6gtqB-5vtlA:
undetectable		 6gtqA-5vtlA:
undetectable
6gtqB-5vtlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN

(Sulfolobus
acidocaldarius) 		PF03458
(UPF0126) 		4 ALA A  21
ALA A  46
ALA A  74
ALA A  77
 None
 0.77A 6gtqA-5wueA:
undetectable
6gtqB-5wueA:
0.0		 6gtqA-5wueA:
21.61
6gtqB-5wueA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wue UNCHARACTERIZED
PROTEIN

(Sulfolobus
acidocaldarius) 		PF03458
(UPF0126) 		4 ALA A  74
ALA A  77
ALA A  21
ALA A  46
 None
 0.79A 6gtqA-5wueA:
undetectable
6gtqB-5wueA:
0.0		 6gtqA-5wueA:
21.61
6gtqB-5wueA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 ALA A 205
ALA A 208
ALA A 246
ALA A 249
 None
 0.81A 6gtqA-5xa5A:
undetectable
6gtqB-5xa5A:
undetectable		 6gtqA-5xa5A:
20.57
6gtqB-5xa5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xa5 ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		4 ALA A 246
ALA A 249
ALA A 205
ALA A 208
 None
 0.81A 6gtqA-5xa5A:
undetectable
6gtqB-5xa5A:
undetectable		 6gtqA-5xa5A:
20.57
6gtqB-5xa5A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 805
ALA A 808
ALA A 819
ALA A 822
 None
 0.86A 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable		 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xuo POLYKETIDE SYNTHASE
PKS13

(Mycobacterium
tuberculosis) 		no annotation 4 ALA A 819
ALA A 822
ALA A 805
ALA A 808
 None
 0.86A 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable		 6gtqA-5xuoA:
undetectable
6gtqB-5xuoA:
undetectable