SIMILAR PATTERNS OF AMINO ACIDS FOR 6GSD_A_STRA401_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bpo | PROTEIN (CLATHRIN) (Rattusnorvegicus) |
PF01394(Clathrin_propel)PF09268(Clathrin-link)PF13838(Clathrin_H_link) | 5 | PHE A 37ILE A 52SER A 97VAL A 79ILE A 80 | None | 1.38A | 6gsdA-1bpoA:undetectable | 6gsdA-1bpoA:10.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c9l | CLATHRIN (Rattusnorvegicus) |
PF01394(Clathrin_propel)PF09268(Clathrin-link) | 5 | PHE A 37ILE A 52SER A 97VAL A 79ILE A 80 | None | 1.23A | 6gsdA-1c9lA:undetectable | 6gsdA-1c9lA:13.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cnv | CONCANAVALIN B (Canavaliaensiformis) |
PF00704(Glyco_hydro_18) | 5 | ARG A 187VAL A 186ILE A 184TRP A 139ILE A 176 | None | 1.30A | 6gsdA-1cnvA:undetectable | 6gsdA-1cnvA:12.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dci | DIENOYL-COAISOMERASE (Rattusnorvegicus) |
PF00378(ECH_1) | 5 | VAL A 69PHE A 84ILE A 57SER A 96VAL A 89 | None | 1.25A | 6gsdA-1dciA:undetectable | 6gsdA-1dciA:16.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dd5 | RIBOSOME RECYCLINGFACTOR (Thermotogamaritima) |
PF01765(RRF) | 5 | VAL A 51ILE A 78SER A 58VAL A 97ILE A 98 | None | 1.41A | 6gsdA-1dd5A:undetectable | 6gsdA-1dd5A:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I ALPHASUBUNIT (Methanopyruskandleri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | PHE A 516ILE A 512ASN A 279VAL A 108ILE A 109 | None | 1.39A | 6gsdA-1e6vA:undetectable | 6gsdA-1e6vA:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I ALPHASUBUNIT (Methanopyruskandleri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | PHE A 516ILE A 512ASN A 279VAL A 108ILE A 264 | None | 1.07A | 6gsdA-1e6vA:undetectable | 6gsdA-1e6vA:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6v | METHYL-COENZYME MREDUCTASE I ALPHASUBUNIT (Methanopyruskandleri) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | VAL A 288ILE A 512ASN A 279VAL A 108ILE A 264 | None | 0.94A | 6gsdA-1e6vA:undetectable | 6gsdA-1e6vA:10.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ezr | NUCLEOSIDE HYDROLASE (Leishmaniamajor) |
PF01156(IU_nuc_hydro) | 5 | LYS A 147VAL A 146ILE A 121VAL A 124ILE A 6 | None | 1.38A | 6gsdA-1ezrA:6.3 | 6gsdA-1ezrA:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1j32 | ASPARTATEAMINOTRANSFERASE (Phormidiumlapideum) |
PF00155(Aminotran_1_2) | 5 | LYS A 150VAL A 151SER A 201VAL A 185ILE A 188 | None | 1.47A | 6gsdA-1j32A:undetectable | 6gsdA-1j32A:11.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o9j | ALDEHYDEDEHYDROGENASE,CYTOSOLIC 1 (Elephantulusedwardii) |
PF00171(Aldedh) | 5 | VAL A 63ILE A 190SER A 260VAL A 241ILE A 232 | None | 1.24A | 6gsdA-1o9jA:2.9 | 6gsdA-1o9jA:10.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgj | 6-PHOSPHOGLUCONATEDEHYDROGENASE (Trypanosomabrucei) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | VAL A 202ILE A 205SER A 431VAL A 414ILE A 425 | None | 1.45A | 6gsdA-1pgjA:6.9 | 6gsdA-1pgjA:10.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pw5 | NAGD PROTEIN,PUTATIVE (Thermotogamaritima) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 5 | ARG A 202VAL A 198PHE A 8VAL A 223ILE A 222 | None | 1.46A | 6gsdA-1pw5A:3.5 | 6gsdA-1pw5A:14.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qgz | PROTEIN(FERREDOXIN:NADP+REDUCTASE) (Nostoc sp. PCC7119) |
PF00175(NAD_binding_1)PF00970(FAD_binding_6) | 5 | VAL A 130PHE A 21ILE A 132SER A 27ILE A 95 | None | 1.39A | 6gsdA-1qgzA:4.2 | 6gsdA-1qgzA:16.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qvz | YDR533C PROTEIN (Saccharomycescerevisiae) |
PF01965(DJ-1_PfpI) | 5 | VAL A 133PHE A 43ILE A 101SER A 209VAL A 229 | None | 1.33A | 6gsdA-1qvzA:5.6 | 6gsdA-1qvzA:16.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r1a | HUMAN RHINOVIRUS 1ACOAT PROTEIN(SUBUNIT VP1) (Rhinovirus A) |
PF00073(Rhv) | 5 | ARG 1 158VAL 1 84ILE 1 235VAL 1 142ILE 1 141 | None | 1.30A | 6gsdA-1r1a1:undetectable | 6gsdA-1r1a1:12.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpl | ABC TRANSPORTER,ATP-BINDING PROTEIN (Thermotogamaritima) |
PF00005(ABC_tran) | 5 | ARG A 224LYS A 222VAL A 233ILE A 230ILE A 204 | None | 1.18A | 6gsdA-1vplA:undetectable | 6gsdA-1vplA:15.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eyn | ALPHA-ACTININ 1 (Homo sapiens) |
PF00307(CH) | 5 | LYS A 103VAL A 105PHE A 99ILE A 100ILE A 130 | None | 1.01A | 6gsdA-2eynA:undetectable | 6gsdA-2eynA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ghi | TRANSPORT PROTEIN (Plasmodiumyoelii) |
PF00005(ABC_tran) | 5 | PHE A 20ILE A 18SER A 90VAL A 83ILE A 78 | None | 1.38A | 6gsdA-2ghiA:undetectable | 6gsdA-2ghiA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kbs | HARMONIN (Homo sapiens) |
PF00595(PDZ) | 5 | LYS A 12VAL A 13ILE A 87VAL A 60ILE A 59 | None | 1.38A | 6gsdA-2kbsA:undetectable | 6gsdA-2kbsA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2l6g | FOCAL ADHESIONKINASE 1, LINKER,PAXILLIN (Gallus gallus;unidentified) |
PF03535(Paxillin)PF03623(Focal_AT) | 5 | VAL A 58ILE A 73ASN A 123VAL A 127ILE A 128 | None | 1.47A | 6gsdA-2l6gA:undetectable | 6gsdA-2l6gA:17.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3j | UDP-GLUCOSE6-DEHYDROGENASE (Caenorhabditiselegans) |
PF00984(UDPG_MGDP_dh)PF03720(UDPG_MGDP_dh_C)PF03721(UDPG_MGDP_dh_N) | 5 | VAL A 117ILE A 121VAL A 132ILE A 90CYH A 14 | None | 1.17A | 6gsdA-2o3jA:5.8 | 6gsdA-2o3jA:10.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qfr | PURPLE ACIDPHOSPHATASE (Phaseolusvulgaris) |
PF00149(Metallophos)PF14008(Metallophos_C)PF16656(Pur_ac_phosph_N) | 5 | ARG A 112VAL A 105ILE A 44VAL A 190ILE A 32 | None | 1.49A | 6gsdA-2qfrA:2.5 | 6gsdA-2qfrA:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qgy | ENOLASE FROM THEENVIRONMENTAL GENOMESHOTGUN SEQUENCINGOF THE SARGASSO SEA (-) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | VAL A 189PHE A 158ILE A 155TRP A 222ILE A 168 | None | 1.43A | 6gsdA-2qgyA:undetectable | 6gsdA-2qgyA:13.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v6b | L-LACTATEDEHYDROGENASE (Deinococcusradiodurans) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | VAL A 166ILE A 257SER A 286VAL A 137ILE A 161 | None | 1.35A | 6gsdA-2v6bA:7.6 | 6gsdA-2v6bA:14.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2v6g | PROGESTERONE5-BETA-REDUCTASE (Digitalislanata) |
PF01370(Epimerase) | 8 | ARG A 146LYS A 147PHE A 153ASN A 205MET A 215SER A 248TRP A 284CYH A 352 | NoneNAP A1390 (-4.5A)NoneNoneNoneNoneNoneNone | 0.72A | 6gsdA-2v6gA:58.9 | 6gsdA-2v6gA:89.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xh1 | KYNURENINE/ALPHA-AMINOADIPATEAMINOTRANSFERASE,MITOCHONDRIAL (Homo sapiens) |
PF00155(Aminotran_1_2) | 5 | ARG A 321VAL A 322PHE A 235ILE A 264ILE A 265 | None | 1.30A | 6gsdA-2xh1A:3.8 | 6gsdA-2xh1A:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xka | FTSZ/TUBULIN-RELATEDPROTEIN (Bacillusthuringiensis) |
PF00091(Tubulin) | 5 | VAL A 208PHE A 189ILE A 186TRP A 145VAL A 149 | None | 1.43A | 6gsdA-2xkaA:6.0 | 6gsdA-2xkaA:13.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xq1 | PEROXISOMAL CATALASE (Ogataea angusta) |
PF00199(Catalase)PF06628(Catalase-rel) | 5 | ARG A 344VAL A 340PHE A 154ILE A 145ASN A 138 | None | 1.45A | 6gsdA-2xq1A:undetectable | 6gsdA-2xq1A:9.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bbh | RIBOSOME BIOGENESISPROTEIN NEP1-LIKE (Methanocaldococcusjannaschii) |
PF03587(EMG1) | 5 | ILE A 185SER A 61TRP A 193ILE A 198CYH A 196 | SFG A 206 (-4.5A)NoneNoneNoneNone | 1.24A | 6gsdA-3bbhA:undetectable | 6gsdA-3bbhA:17.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bzm | MENAQUINONE-SPECIFICISOCHORISMATESYNTHASE (Escherichiacoli) |
PF00425(Chorismate_bind) | 5 | VAL A 305ILE A 323ASN A 285VAL A 288ILE A 292 | None | 1.48A | 6gsdA-3bzmA:undetectable | 6gsdA-3bzmA:10.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fdd | L-ASPARTATE-BETA-DECARBOXYLASE (Comamonastestosteroni) |
PF00155(Aminotran_1_2) | 5 | ILE A 511ASN A 29MET A 32VAL A 482ILE A 475 | None | 1.10A | 6gsdA-3fddA:2.1 | 6gsdA-3fddA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fhh | OUTER MEMBRANE HEMERECEPTOR SHUA (Shigelladysenteriae) |
PF00593(TonB_dep_Rec)PF07715(Plug) | 5 | ARG A 99ILE A 120SER A 15VAL A 103ILE A 102 | None | 1.47A | 6gsdA-3fhhA:undetectable | 6gsdA-3fhhA:8.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fo8 | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF17481(Phage_sheath_1N) | 5 | ARG D 284VAL D 283ILE D 281VAL D 239ILE D 238 | ACT D 601 (-3.8A)NoneNoneNoneNone | 1.48A | 6gsdA-3fo8D:undetectable | 6gsdA-3fo8D:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i44 | ALDEHYDEDEHYDROGENASE (Bartonellahenselae) |
PF00171(Aldedh) | 5 | VAL A 434ILE A 414ASN A 404VAL A 400ILE A 257 | None | 1.37A | 6gsdA-3i44A:3.5 | 6gsdA-3i44A:12.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j0o | RIBOSOMAL PROTEINS15 (Oryctolaguscuniculus) |
PF00203(Ribosomal_S19) | 5 | ARG S 49VAL S 50ILE S 34VAL S 90ILE S 91 | None | 1.19A | 6gsdA-3j0oS:undetectable | 6gsdA-3j0oS:18.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jur | EXO-POLY-ALPHA-D-GALACTURONOSIDASE (Thermotogamaritima) |
PF00295(Glyco_hydro_28)PF12708(Pectate_lyase_3) | 5 | VAL A 203ILE A 226SER A 191TRP A 214ILE A 241 | None | 1.48A | 6gsdA-3jurA:undetectable | 6gsdA-3jurA:11.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ll5 | GAMMA-GLUTAMYLKINASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00696(AA_kinase) | 5 | LYS A 213VAL A 210ILE A 244ASN A 188ILE A 185 | None | 1.45A | 6gsdA-3ll5A:2.7 | 6gsdA-3ll5A:15.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3num | SERINE PROTEASEHTRA1 (Homo sapiens) |
PF13365(Trypsin_2) | 5 | VAL A 230ILE A 186SER A 210VAL A 216ILE A 254 | None | 1.40A | 6gsdA-3numA:undetectable | 6gsdA-3numA:15.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nv9 | MALIC ENZYME (Entamoebahistolytica) |
PF00390(malic)PF03949(Malic_M) | 5 | VAL A 155ILE A 158SER A 99VAL A 95ILE A 135 | None | 1.47A | 6gsdA-3nv9A:2.7 | 6gsdA-3nv9A:9.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nva | CTP SYNTHASE (Sulfolobussolfataricus) |
PF00117(GATase)PF06418(CTP_synth_N) | 5 | PHE A 173ILE A 172SER A 131VAL A 141ILE A 6 | None | 1.48A | 6gsdA-3nvaA:3.4 | 6gsdA-3nvaA:9.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nwu | SERINE PROTEASEHTRA1 (Homo sapiens) |
PF13365(Trypsin_2) | 5 | VAL A 230ILE A 186SER A 210VAL A 216ILE A 254 | None | 1.39A | 6gsdA-3nwuA:undetectable | 6gsdA-3nwuA:17.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ot5 | UDP-N-ACETYLGLUCOSAMINE 2-EPIMERASE (Listeriamonocytogenes) |
PF02350(Epimerase_2) | 5 | VAL A 78ILE A 82MET A 145VAL A 96ILE A 9 | None | 1.07A | 6gsdA-3ot5A:8.4 | 6gsdA-3ot5A:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3poh | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE F1 (Bacteroidesthetaiotaomicron) |
PF08522(DUF1735) | 5 | VAL A 225MET A 358SER A 399VAL A 376ILE A 375 | None | 1.26A | 6gsdA-3pohA:undetectable | 6gsdA-3pohA:11.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q3q | ALKALINE PHOSPHATASE (Sphingomonassp. BSAR-1) |
PF01663(Phosphodiest) | 5 | VAL A 501ILE A 503SER A 94VAL A 522ILE A 524 | None | 1.43A | 6gsdA-3q3qA:undetectable | 6gsdA-3q3qA:10.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rim | TRANSKETOLASE (Mycobacteriumtuberculosis) |
PF00456(Transketolase_N)PF02779(Transket_pyr)PF02780(Transketolase_C) | 5 | PHE A 680ILE A 494SER A 510TRP A 654ILE A 667 | None | 1.24A | 6gsdA-3rimA:undetectable | 6gsdA-3rimA:8.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s46 | ALANINE RACEMASE (Streptococcuspneumoniae) |
PF00842(Ala_racemase_C)PF01168(Ala_racemase_N) | 5 | VAL A 278ILE A 313VAL A 305ILE A 304CYH A 302 | None | 1.25A | 6gsdA-3s46A:undetectable | 6gsdA-3s46A:13.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3txv | PROBABLE TAGATOSE6-PHOSPHATE KINASE (Sinorhizobiummeliloti) |
PF08013(Tagatose_6_P_K) | 5 | VAL A 33PHE A 74ILE A 34ILE A 50CYH A 27 | None | 1.36A | 6gsdA-3txvA:3.5 | 6gsdA-3txvA:11.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubm | FORMYL-COA:OXALATECOA-TRANSFERASE (Acetobacteraceti) |
PF02515(CoA_transf_3) | 5 | ARG A 74VAL A 76ILE A 42VAL A 16ILE A 17 | None | 1.49A | 6gsdA-3ubmA:5.7 | 6gsdA-3ubmA:10.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uyu | ANTIFREEZE PROTEIN (Leucosporidiumsp. AY30) |
PF11999(DUF3494) | 5 | VAL A 83PHE A 34ILE A 54VAL A 56ILE A 42 | None | 1.49A | 6gsdA-3uyuA:undetectable | 6gsdA-3uyuA:15.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wgh | REDOX-SENSINGTRANSCRIPTIONALREPRESSOR REX (Thermoanaerobacterethanolicus) |
PF02629(CoA_binding)PF06971(Put_DNA-bind_N) | 5 | ARG A 168VAL A 167ILE A 171VAL A 138ILE A 142 | None | 1.48A | 6gsdA-3wghA:6.8 | 6gsdA-3wghA:16.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zif | PENTON PROTEIN (BovinemastadenovirusB) |
PF01686(Adeno_Penton_B) | 5 | PHE M 239ILE M 262MET M 173VAL M 139CYH M 235 | None | 1.39A | 6gsdA-3zifM:undetectable | 6gsdA-3zifM:10.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ccd | GALACTOCEREBROSIDASE (Mus musculus) |
PF02057(Glyco_hydro_59)PF17387(Glyco_hydro_59M) | 5 | VAL A 534PHE A 579ILE A 532ASN A 566ILE A 572 | None | 1.25A | 6gsdA-4ccdA:3.0 | 6gsdA-4ccdA:9.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dqx | PROBABLEOXIDOREDUCTASEPROTEIN (Rhizobium etli) |
PF13561(adh_short_C2) | 5 | VAL A 143ILE A 144ASN A 157VAL A 198ILE A 196 | None | 1.35A | 6gsdA-4dqxA:18.2 | 6gsdA-4dqxA:13.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e4y | SHORT CHAINDEHYDROGENASE FAMILYPROTEIN (Francisellatularensis) |
PF13561(adh_short_C2) | 5 | VAL A 59ILE A 63SER A 10VAL A 6ILE A 30 | None | 1.43A | 6gsdA-4e4yA:18.1 | 6gsdA-4e4yA:15.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4huh | TAIL CONNECTORPROTEIN GP15 (Escherichiavirus T4) |
PF16724(T4-gp15_tss) | 5 | VAL A 39PHE A 21ILE A 75VAL A 134ILE A 122 | None | 1.32A | 6gsdA-4huhA:undetectable | 6gsdA-4huhA:14.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ilg | A1 CISTRON-SPLICINGFACTOR AAR2 (Saccharomycescerevisiae) |
PF05282(AAR2) | 5 | VAL A 4ILE A 36MET A 123VAL A 43ILE A 17 | None | 1.46A | 6gsdA-4ilgA:undetectable | 6gsdA-4ilgA:12.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j75 | TRYPTOPHANYL-TRNASYNTHETASE (Plasmodiumfalciparum) |
PF00579(tRNA-synt_1b) | 5 | VAL A 600ILE A 526MET A 483SER A 315VAL A 516 | None | 1.21A | 6gsdA-4j75A:2.3 | 6gsdA-4j75A:11.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jb3 | HALOACIDDEHALOGENASE-LIKEHYDROLASE (Bacteroidesthetaiotaomicron) |
PF13419(HAD_2) | 5 | VAL A 104ILE A 95SER A 108VAL A 12ILE A 13 | None | 1.31A | 6gsdA-4jb3A:3.3 | 6gsdA-4jb3A:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4k17 | LEUCINE-RICHREPEAT-CONTAININGPROTEIN 16A (Mus musculus) |
PF13516(LRR_6) | 5 | VAL A 580ILE A 582MET A 627SER A 573ILE A 568 | None | 1.01A | 6gsdA-4k17A:undetectable | 6gsdA-4k17A:9.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kw7 | ARSENICMETHYLTRANSFERASE (Cyanidioschyzonsp. 5508) |
PF13847(Methyltransf_31) | 5 | LYS A 110VAL A 105SER A 74VAL A 170ILE A 169 | NoneNone CA A 401 ( 4.3A)NoneNone | 1.35A | 6gsdA-4kw7A:4.9 | 6gsdA-4kw7A:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kyi | VIPD (Legionellapneumophila) |
PF01734(Patatin) | 5 | VAL A 124ILE A 170ASN A 178SER A 182ILE A 168 | None | 1.49A | 6gsdA-4kyiA:undetectable | 6gsdA-4kyiA:9.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lcb | CELL DIVISIONPROTEIN CDVC, VPS4 (Acidianushospitalis) |
PF00004(AAA)PF09336(Vps4_C) | 5 | ARG A 184VAL A 238ILE A 196VAL A 176ILE A 179 | None | 1.26A | 6gsdA-4lcbA:undetectable | 6gsdA-4lcbA:13.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m5t | ALPHA-CRYSTALLIN BCHAIN (Homo sapiens) |
PF00011(HSP20) | 5 | VAL A 128ILE A 124SER A 135VAL A 77ILE A 98 | None | 1.48A | 6gsdA-4m5tA:undetectable | 6gsdA-4m5tA:18.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n06 | CRISPR-ASSOCIATEDENDONUCLEASE CAS1 1 (Archaeoglobusfulgidus) |
PF01867(Cas_Cas1) | 5 | VAL A 182PHE A 189ILE A 183VAL A 265ILE A 269 | None | 1.10A | 6gsdA-4n06A:undetectable | 6gsdA-4n06A:13.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nbu | 3-OXOACYL-(ACYL-CARRIER-PROTEIN)REDUCTASE (Bacillus sp.SG-1) |
PF13561(adh_short_C2) | 5 | VAL A 128ASN A 142MET A 168VAL A 183ILE A 181 | None | 1.33A | 6gsdA-4nbuA:19.0 | 6gsdA-4nbuA:17.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nmu | THIOL-DISULFIDEOXIDOREDUCTASE RESA (Bacillusanthracis) |
PF00578(AhpC-TSA) | 5 | VAL A 35ILE A 69ASN A 14VAL A 16ILE A 25 | None | 1.06A | 6gsdA-4nmuA:2.3 | 6gsdA-4nmuA:19.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pc9 | C4-DICARBOXYLATETRANSPORT SYSTEM,SUBSTRATE-BINDINGPROTEIN, PUTATIVE (Roseobacterdenitrificans) |
PF03480(DctP) | 5 | VAL A 121ILE A 126SER A 324VAL A 319ILE A 318 | None | 1.50A | 6gsdA-4pc9A:undetectable | 6gsdA-4pc9A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pju | COHESIN SUBUNIT SA-2 (Homo sapiens) |
PF08514(STAG) | 5 | ARG A 184VAL A 183ILE A 191ASN A 236ILE A 281 | None | 1.42A | 6gsdA-4pjuA:undetectable | 6gsdA-4pjuA:5.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q3n | MGS-M5 (unidentified) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | VAL A 104PHE A 112ILE A 107SER A 120VAL A 76 | None | 1.38A | 6gsdA-4q3nA:9.4 | 6gsdA-4q3nA:14.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyi | HYPOXANTHINEPHOSPHORIBOSYLTRANSFERASE (Bacillusanthracis) |
PF00156(Pribosyltran) | 5 | VAL A 59ILE A 35SER A 44VAL A 96ILE A 95 | None | 1.49A | 6gsdA-4qyiA:3.6 | 6gsdA-4qyiA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qyj | ALDEHYDEDEHYDROGENASE (Pseudomonasputida) |
PF00171(Aldedh) | 5 | VAL A 452ILE A 432ASN A 422VAL A 418ILE A 275 | None | 1.39A | 6gsdA-4qyjA:3.2 | 6gsdA-4qyjA:10.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ywe | PUTATIVE ALDEHYDEDEHYDROGENASE (Burkholderiacenocepacia) |
PF00171(Aldedh) | 5 | VAL A 433ILE A 413ASN A 403VAL A 399ILE A 256 | None | 1.42A | 6gsdA-4yweA:3.4 | 6gsdA-4yweA:11.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z0z | AURONE SYNTHASE (Coreopsisgrandiflora) |
PF00264(Tyrosinase)PF12142(PPO1_DWL) | 5 | PHE A 108ILE A 111SER A 118TRP A 119VAL A 231 | None | 1.36A | 6gsdA-4z0zA:undetectable | 6gsdA-4z0zA:13.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITALPHA (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | PHE A 515ILE A 511ASN A 279VAL A 108ILE A 109 | None | 1.34A | 6gsdA-5a8rA:undetectable | 6gsdA-5a8rA:8.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II SUBUNITALPHA (Methanothermobactermarburgensis) |
PF02249(MCR_alpha)PF02745(MCR_alpha_N) | 5 | PHE A 515ILE A 511ASN A 279VAL A 108ILE A 264 | None | 1.21A | 6gsdA-5a8rA:undetectable | 6gsdA-5a8rA:8.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fxe | EUGENOL OXIDASE (Rhodococcusjostii) |
PF01565(FAD_binding_4)PF02913(FAD-oxidase_C) | 5 | ARG A 290VAL A 385ASN A 419MET A 455ILE A 445 | None | 1.43A | 6gsdA-5fxeA:undetectable | 6gsdA-5fxeA:10.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gaj | DE NOVO DESIGNEDPROTEIN OR258 (syntheticconstruct) |
no annotation | 5 | LYS A 37VAL A 40ILE A 69VAL A 8ILE A 6 | None | 1.33A | 6gsdA-5gajA:2.6 | 6gsdA-5gajA:17.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kha | GLUTAMINE-DEPENDENTNAD+ SYNTHETASE (Acinetobacterbaumannii) |
PF00795(CN_hydrolase)PF02540(NAD_synthase) | 5 | VAL A 75ILE A 78SER A 46VAL A 81ILE A 40 | None | 1.36A | 6gsdA-5khaA:undetectable | 6gsdA-5khaA:10.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lt1 | KINESIN-LIKE PROTEIN (Homo sapiens) |
PF00225(Kinesin) | 5 | ARG A 321PHE A 82ILE A 298MET A 282ILE A 9 | None | 1.42A | 6gsdA-5lt1A:undetectable | 6gsdA-5lt1A:12.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlh | - (-) |
no annotation | 11 | ARG A 146LYS A 147VAL A 150PHE A 153ILE A 156ASN A 205MET A 215SER A 248TRP A 284VAL A 347ILE A 350 | NoneXOG A 402 ( 2.7A)NoneXOG A 402 (-3.9A)NoneXOG A 402 (-2.8A)XOG A 402 ( 4.2A)XOG A 402 ( 4.6A)NoneXOG A 402 (-3.6A)XOG A 402 (-4.8A) | 0.58A | 6gsdA-5mlhA:62.5 | 6gsdA-5mlhA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mlh | - (-) |
no annotation | 11 | ARG A 146VAL A 150PHE A 153ILE A 156ASN A 205MET A 215SER A 248TRP A 284VAL A 347ILE A 350CYH A 352 | NoneNoneXOG A 402 (-3.9A)NoneXOG A 402 (-2.8A)XOG A 402 ( 4.2A)XOG A 402 ( 4.6A)NoneXOG A 402 (-3.6A)XOG A 402 (-4.8A)XOG A 402 (-3.8A) | 0.57A | 6gsdA-5mlhA:62.5 | 6gsdA-5mlhA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mqp | GLYCOSIDE HYDROLASEBT_1002 (Bacteroidesthetaiotaomicron) |
no annotation | 5 | VAL A 104ILE A 317VAL A 95ILE A 96CYH A 68 | None | 1.19A | 6gsdA-5mqpA:undetectable | 6gsdA-5mqpA:8.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n7z | LIPOPOLYSACCHARIDE1,6-GALACTOSYLTRANSFERASE (Salmonellaenterica) |
no annotation | 5 | PHE A 115ILE A 91ASN A 350SER A 30ILE A 3 | None | 1.41A | 6gsdA-5n7zA:5.8 | 6gsdA-5n7zA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ttk | AMINE OXIDASE (Pseudomonasputida) |
PF01593(Amino_oxidase) | 5 | VAL A 396ILE A 388MET A 141SER A 379ILE A 382 | None | 0.94A | 6gsdA-5ttkA:3.3 | 6gsdA-5ttkA:10.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u81 | ACID CERAMIDASEISOFORM B (Heterocephalusglaber) |
no annotation | 5 | VAL A 177ILE A 178MET A 94VAL A 77ILE A 76 | CL A 417 (-4.4A) CL A 417 (-3.9A)NoneNoneNone | 1.34A | 6gsdA-5u81A:undetectable | 6gsdA-5u81A:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 5 | VAL A 718PHE A 721ILE A 720VAL A 824ILE A 782 | None | 1.43A | 6gsdA-5x7sA:undetectable | 6gsdA-5x7sA:5.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xxu | RIBOSOMAL PROTEINUS15 (Toxoplasmagondii) |
PF00312(Ribosomal_S15)PF08069(Ribosomal_S13_N) | 5 | VAL N 63ILE N 71SER N 57VAL N 52ILE N 50 | None U 2 958 ( 4.3A)None U 2 957 ( 4.5A)None | 1.29A | 6gsdA-5xxuN:undetectable | 6gsdA-5xxuN:24.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y28 | - (-) |
no annotation | 5 | VAL A 126ILE A 58SER A 106VAL A 112ILE A 151 | None | 1.44A | 6gsdA-5y28A:undetectable | 6gsdA-5y28A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4o | GLUTATHIONEREDUCTASE (Enterococcusfaecalis) |
no annotation | 5 | VAL A 124PHE A 116ILE A 122VAL A 8ILE A 7 | None | 1.44A | 6gsdA-6b4oA:6.4 | 6gsdA-6b4oA:11.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fb3 | TENEURIN-2 (Gallus gallus) |
no annotation | 5 | VAL A1532ILE A1518SER A1475VAL A1464ILE A1465 | None | 1.37A | 6gsdA-6fb3A:undetectable | 6gsdA-6fb3A:12.50 |