SIMILAR PATTERNS OF AMINO ACIDS FOR 6GS4_A_F9EA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 ASN B 770
SER B 771
PHE B 216
ASN B 773
PRO B 774
 None
 1.44A 6gs4A-3ohmB:
0.0		 6gs4A-3ohmB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		5 TYR A 345
SER A 206
PHE A  54
ASN A 202
GLU A 416
 None
 1.31A 6gs4A-3wq4A:
0.0		 6gs4A-3wq4A:
24.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		5 TYR A  40
LYS A 136
ASN A 166
ASN A 342
PRO A 343
 None
 0.93A 6gs4A-4ikvA:
39.6		 6gs4A-4ikvA:
31.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4q65 DIPEPTIDE PERMEASE D

(Escherichia
coli) 		PF00854
(PTR2) 		6 TYR A  26
LYS A 118
ASN A 148
SER A 151
ASN A 317
GLU A 391
 None
 1.14A 6gs4A-4q65A:
43.5		 6gs4A-4q65A:
31.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		6 TYR A  29
LYS A 121
MET A 158
PHE A 288
ASN A 329
GLU A 402
 None
 1.22A 6gs4A-4tpgA:
49.5		 6gs4A-4tpgA:
39.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tpg PROTON:OLIGOPEPTIDE
SYMPORTER POT FAMILY

(Shewanella
oneidensis) 		PF00854
(PTR2) 		9 TYR A  29
TYR A 147
ASN A 151
SER A 154
MET A 158
PHE A 288
ASN A 329
PRO A 330
GLU A 402
 None
 0.67A 6gs4A-4tpgA:
49.5		 6gs4A-4tpgA:
39.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4w6v DI-/TRIPEPTIDE
TRANSPORTER

(Yersinia
enterocolitica) 		PF00854
(PTR2) 		6 TYR A  35
LYS A 133
ASN A 163
SER A 166
ASN A 344
GLU A 420
 None
 1.01A 6gs4A-4w6vA:
41.4		 6gs4A-4w6vA:
31.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		6 TYR A  30
LYS A 126
ASN A 156
ASN A 328
PRO A 329
GLU A 400
 None
 1.01A 6gs4A-4xniA:
38.5		 6gs4A-4xniA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xni DI-OR TRIPEPTIDE:H+
SYMPORTER

(Streptococcus
thermophilus) 		PF00854
(PTR2) 		5 TYR A  30
LYS A 126
ASN A 328
PRO A 329
GLU A 299
 None
 1.40A 6gs4A-4xniA:
38.5		 6gs4A-4xniA:
28.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ei3 PROTON-DEPENDENT
OLIGOPEPTIDE
TRANSPORTER FAMILY
PROTEIN

(Xanthomonas
campestris) 		no annotation 6 TYR A  34
ASN A 164
SER A 167
ASN A 350
PRO A 351
GLU A 425
 None
 0.89A 6gs4A-6ei3A:
34.9		 6gs4A-6ei3A:
25.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exs PEPTIDE ABC
TRANSPORTER PERMEASE

(Staphylococcus
hominis) 		no annotation 5 TYR A  41
ASN A 167
ASN A 347
PRO A 348
GLU A 418
 C3H  A 514 (-4.0A)
C3H  A 514 (-3.6A)
C3H  A 514 (-4.0A)
C3H  A 514 (-4.1A)
None
 0.61A 6gs4A-6exsA:
37.1		 6gs4A-6exsA:
undetectable