SIMILAR PATTERNS OF AMINO ACIDS FOR 6GP2_B_DAHB126_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a7j PHOSPHORIBULOKINASE

(Rhodobacter
sphaeroides)
PF00485
(PRK)
5 PHE A  84
GLY A  88
ILE A   7
PHE A  44
ILE A  39
None
0.90A 6gp2B-1a7jA:
undetectable
6gp2B-1a7jA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecx AMINOTRANSFERASE

(Thermotoga
maritima)
PF00266
(Aminotran_5)
5 PHE A 299
GLY A 304
ILE A 349
ILE A 369
ILE A 372
None
0.97A 6gp2B-1ecxA:
undetectable
6gp2B-1ecxA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eww ANTIFREEZE PROTEIN

(Choristoneura
fumiferana)
PF05264
(CfAFP)
5 PHE A  87
SER A  52
GLY A  54
ILE A  82
ILE A  64
None
0.95A 6gp2B-1ewwA:
undetectable
6gp2B-1ewwA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8r L-AMINO ACID OXIDASE

(Calloselasma
rhodostoma)
PF01593
(Amino_oxidase)
5 PHE A 381
LEU A 384
ASP A 385
ILE A 327
ILE A 392
None
0.98A 6gp2B-1f8rA:
undetectable
6gp2B-1f8rA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g0d PROTEIN-GLUTAMINE
GAMMA-GLUTAMYLTRANSF
ERASE


(Pagrus major)
PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core)
5 PHE A 189
LEU A 192
ASP A 205
GLY A  63
ILE A 105
None
0.94A 6gp2B-1g0dA:
undetectable
6gp2B-1g0dA:
7.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g71 DNA PRIMASE

(Pyrococcus
furiosus)
PF01896
(DNA_primase_S)
5 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
None
1.03A 6gp2B-1g71A:
undetectable
6gp2B-1g71A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N)
5 LEU A 529
ASP A 530
GLY A 519
ILE A 517
PHE A 466
None
0.92A 6gp2B-1g8xA:
undetectable
6gp2B-1g8xA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A


(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 LEU A 540
ASP A 541
GLY A 530
ILE A 528
PHE A 477
None
0.87A 6gp2B-1jx2A:
undetectable
6gp2B-1jx2A:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
9 PHE A  70
LEU A  73
THR A  74
ASP A  77
ILE A 118
PHE A 119
PHE A 176
ILE A 195
ILE A 198
None
None
None
MN  A1001 (-2.7A)
None
None
None
None
None
0.75A 6gp2B-1kgpA:
41.1
6gp2B-1kgpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
8 PHE A  70
LEU A  73
THR A  74
ASP A  77
SER A 114
ILE A 118
ILE A 195
ILE A 198
None
None
None
MN  A1001 (-2.7A)
None
None
None
None
0.66A 6gp2B-1kgpA:
41.1
6gp2B-1kgpA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kru GALACTOSIDE
O-ACETYLTRANSFERASE


(Escherichia
coli)
PF00132
(Hexapep)
PF12464
(Mac)
PF14602
(Hexapep_2)
5 LEU A  88
ILE A  51
PHE A  36
ILE A  78
ILE A  76
None
1.07A 6gp2B-1kruA:
undetectable
6gp2B-1kruA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogq POLYGALACTURONASE
INHIBITING PROTEIN


(Phaseolus
vulgaris)
PF08263
(LRRNT_2)
6 LEU A 141
GLY A 170
PHE A 194
PHE A 156
ILE A 154
ILE A 145
None
1.11A 6gp2B-1ogqA:
undetectable
6gp2B-1ogqA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE


(Escherichia
coli)
PF00696
(AA_kinase)
5 PHE A  24
LEU A  23
ILE A  97
ILE A  40
ILE A   7
None
1.05A 6gp2B-1oh9A:
undetectable
6gp2B-1oh9A:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN


(Escherichia
coli)
PF00268
(Ribonuc_red_sm)
5 THR A  81
SER A 121
ILE A 125
ILE A 231
ILE A 234
None
0.55A 6gp2B-1pm2A:
29.2
6gp2B-1pm2A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pm2 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
BETA CHAIN


(Escherichia
coli)
PF00268
(Ribonuc_red_sm)
5 THR A  81
SER A 121
PHE A 212
ILE A 231
ILE A 234
None
0.84A 6gp2B-1pm2A:
29.2
6gp2B-1pm2A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)


(Salmonella
enterica)
PF00268
(Ribonuc_red_sm)
9 PHE A  60
LEU A  63
THR A  64
ASP A  67
ILE A 108
PHE A 109
PHE A 166
ILE A 185
ILE A 188
None
None
None
FE  A 400 (-3.0A)
None
None
None
None
None
0.66A 6gp2B-1r2fA:
41.1
6gp2B-1r2fA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)


(Salmonella
enterica)
PF00268
(Ribonuc_red_sm)
9 PHE A  60
LEU A  63
THR A  64
ASP A  67
SER A 104
ILE A 108
PHE A 109
ILE A 185
ILE A 188
None
None
None
FE  A 400 (-3.0A)
None
None
None
None
None
0.63A 6gp2B-1r2fA:
41.1
6gp2B-1r2fA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdk L-AMINO ACID OXIDASE

(Gloydius halys)
PF01593
(Amino_oxidase)
5 PHE A 381
LEU A 384
ASP A 385
ILE A 327
ILE A 392
None
0.91A 6gp2B-1tdkA:
undetectable
6gp2B-1tdkA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
7 LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
PHE A 171
ILE A 193
None
None
FE  A1292 (-2.5A)
None
None
None
None
0.66A 6gp2B-1uzrA:
40.3
6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
7 LEU A  68
THR A  69
SER A 109
ILE A 113
PHE A 114
PHE A 171
ILE A 193
None
0.59A 6gp2B-1uzrA:
40.3
6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
6 PHE A  65
LEU A  68
THR A  66
ILE A 113
PHE A 114
ILE A 190
None
1.48A 6gp2B-1uzrA:
40.3
6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
8 PHE A  65
LEU A  68
THR A  69
ASP A  72
SER A 109
ILE A 113
ILE A 190
ILE A 193
None
None
None
FE  A1292 (-2.5A)
None
None
None
None
0.53A 6gp2B-1uzrA:
40.3
6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
8 PHE A  65
LEU A  68
THR A  69
SER A 109
ILE A 113
PHE A 114
ILE A 190
ILE A 193
None
0.42A 6gp2B-1uzrA:
40.3
6gp2B-1uzrA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v33 DNA PRIMASE SMALL
SUBUNIT


(Pyrococcus
horikoshii)
PF01896
(DNA_primase_S)
5 SER A  73
GLY A  38
PHE A  39
ILE A  24
ILE A  28
None
1.04A 6gp2B-1v33A:
undetectable
6gp2B-1v33A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana)
PF01937
(DUF89)
5 LEU A 237
GLY A 229
ILE A 159
ILE A 316
ILE A 217
None
0.97A 6gp2B-1xfiA:
undetectable
6gp2B-1xfiA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6o ISHP608 TRANSPOSASE

(Helicobacter
pylori)
PF01797
(Y1_Tnp)
5 PHE A  80
GLY A  76
ILE A  71
PHE A  75
ILE A  21
None
1.04A 6gp2B-2a6oA:
undetectable
6gp2B-2a6oA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bm3 SCAFFOLDING DOCKERIN
BINDING PROTEIN A


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
5 LEU A  73
GLY A  69
ILE A 116
PHE A  36
ILE A  30
None
0.87A 6gp2B-2bm3A:
undetectable
6gp2B-2bm3A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwg PROTEIN RUFY3

(Mus musculus)
PF02759
(RUN)
5 PHE A 122
LEU A 119
GLY A 100
ILE A  98
ILE A 236
None
0.99A 6gp2B-2dwgA:
undetectable
6gp2B-2dwgA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g28 PYRUVATE
DEHYDROGENASE E1
COMPONENT


(Escherichia
coli)
PF00456
(Transketolase_N)
5 PHE A 532
LEU A 531
GLY A 562
ILE A 537
ILE A 519
None
0.99A 6gp2B-2g28A:
undetectable
6gp2B-2g28A:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggq 401AA LONG
HYPOTHETICAL
GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Sulfurisphaera
tokodaii)
PF00132
(Hexapep)
PF00483
(NTP_transferase)
5 LEU A 277
GLY A 243
ILE A 241
ILE A 253
ILE A 265
None
1.07A 6gp2B-2ggqA:
undetectable
6gp2B-2ggqA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwm 65 KDA VIRULENCE
PROTEIN


(Salmonella
enterica)
PF03496
(ADPrib_exo_Tox)
5 LEU A 427
THR A 426
GLY A 405
ILE A 409
PHE A 443
None
0.93A 6gp2B-2gwmA:
undetectable
6gp2B-2gwmA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifa HYPOTHETICAL PROTEIN
SMU.260


(Streptococcus
mutans)
PF00881
(Nitroreductase)
5 PHE A 176
GLY A 144
ILE A 143
ILE A  32
ILE A 134
None
0.94A 6gp2B-2ifaA:
undetectable
6gp2B-2ifaA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jdx PROTEIN
(L-ARGININE:GLYCINE
AMIDINOTRANSFERASE)


(Homo sapiens)
no annotation 5 PHE A 383
GLY A 387
ILE A 388
ILE A 311
ILE A 315
None
1.05A 6gp2B-2jdxA:
undetectable
6gp2B-2jdxA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mjp PYROPHOSPHATASE

(Methanocaldococcus
jannaschii)
PF01725
(Ham1p_like)
5 LEU A  28
ILE A  21
PHE A 185
ILE A  70
ILE A  11
None
0.84A 6gp2B-2mjpA:
undetectable
6gp2B-2mjpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oda HYPOTHETICAL PROTEIN
PSPTO_2114


(Pseudomonas
syringae group
genomosp. 3)
no annotation 5 SER A 171
GLY A 130
ILE A 173
PHE A   6
ILE A 186
None
1.01A 6gp2B-2odaA:
undetectable
6gp2B-2odaA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcc RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus
halodurans)
PF00268
(Ribonuc_red_sm)
5 LEU A  84
SER A 124
PHE A 193
ILE A 212
ILE A 215
None
0.90A 6gp2B-2rccA:
27.4
6gp2B-2rccA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
6 LEU A 700
THR A 701
PHE A 780
PHE A 659
ILE A 654
ILE A 597
None
1.15A 6gp2B-2vdwA:
undetectable
6gp2B-2vdwA:
13.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9e MYOSIN-2

(Dictyostelium
discoideum)
PF00063
(Myosin_head)
PF02736
(Myosin_N)
5 LEU X 529
ASP X 530
GLY X 519
ILE X 517
PHE X 466
None
0.98A 6gp2B-2y9eX:
2.8
6gp2B-2y9eX:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yhe SEC-ALKYL SULFATASE

(Pseudomonas sp.
DSM 6611)
PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C)
5 LEU A 261
THR A 260
GLY A 190
ILE A 192
PHE A 210
None
0.86A 6gp2B-2yheA:
undetectable
6gp2B-2yheA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yr1 3-DEHYDROQUINATE
DEHYDRATASE


(Geobacillus
kaustophilus)
PF01487
(DHquinase_I)
5 THR A 205
GLY A 223
ILE A   3
ILE A  15
ILE A 172
None
1.05A 6gp2B-2yr1A:
undetectable
6gp2B-2yr1A:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0r UBIQUITIN
THIOESTERASE OTU1


(Saccharomyces
cerevisiae)
PF02338
(OTU)
5 LEU A 138
GLY A 182
ILE A 192
PHE A 130
ILE A 129
None
0.97A 6gp2B-3c0rA:
undetectable
6gp2B-3c0rA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9k KYNURENINASE

(Homo sapiens)
PF00266
(Aminotran_5)
5 LEU A 368
THR A 365
GLY A 400
ILE A 405
ILE A 390
None
1.00A 6gp2B-3e9kA:
undetectable
6gp2B-3e9kA:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ege PUTATIVE
METHYLTRANSFERASE
FROM ANTIBIOTIC
BIOSYNTHESIS PATHWAY


(Trichormus
variabilis)
PF08241
(Methyltransf_11)
5 LEU A 101
SER A 208
GLY A 206
ILE A 207
PHE A 130
None
1.02A 6gp2B-3egeA:
undetectable
6gp2B-3egeA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5o TRANSCRIPTIONAL
REGULATOR GNTR


(Chromobacterium
violaceum)
PF13377
(Peripla_BP_3)
5 LEU A  86
GLY A 306
ILE A  92
ILE A 105
ILE A  77
None
0.97A 6gp2B-3h5oA:
undetectable
6gp2B-3h5oA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i04 CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT BETA


(Moorella
thermoacetica)
PF03063
(Prismane)
5 PHE A 174
LEU A 171
GLY A 207
ILE A 208
ILE A 247
None
0.96A 6gp2B-3i04A:
undetectable
6gp2B-3i04A:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E


(Lactobacillus
acidophilus)
PF01263
(Aldose_epim)
5 LEU A 273
THR A 295
GLY A 276
PHE A 217
ILE A 223
None
1.08A 6gp2B-3imhA:
undetectable
6gp2B-3imhA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw3 ALANINE RACEMASE

(Bartonella
henselae)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 LEU A 157
GLY A 148
PHE A 164
ILE A 169
ILE A 172
None
1.07A 6gp2B-3kw3A:
undetectable
6gp2B-3kw3A:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzp PUTATIVE DIGUANYLATE
CYCLASE/PHOSPHODIEST
ERASE


(Listeria
monocytogenes)
PF00563
(EAL)
5 LEU A  96
ILE A 137
PHE A  63
ILE A  77
ILE A 103
None
0.89A 6gp2B-3kzpA:
undetectable
6gp2B-3kzpA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
5 PHE A 604
THR A 471
GLY A 599
ILE A 603
ILE A 457
None
0.94A 6gp2B-3lk6A:
undetectable
6gp2B-3lk6A:
8.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkb PROBABLE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER, AMINO
ACID BINDING PROTEIN


(Thermus
thermophilus)
PF13458
(Peripla_BP_6)
5 PHE A  67
THR A  63
SER A  81
PHE A  11
ILE A  94
None
1.04A 6gp2B-3lkbA:
undetectable
6gp2B-3lkbA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3me5 CYTOSINE-SPECIFIC
METHYLTRANSFERASE


(Shigella
flexneri)
PF00145
(DNA_methylase)
5 PHE A 103
SER A 105
GLY A 107
ILE A 106
PHE A  87
None
1.06A 6gp2B-3me5A:
undetectable
6gp2B-3me5A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
5 LEU A  73
ASP A  77
PHE A 176
ILE A 195
ILE A 198
None
MN3  A1001 (-2.2A)
None
None
None
0.87A 6gp2B-3mjoA:
40.5
6gp2B-3mjoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
7 LEU A  73
THR A  74
ILE A 118
PHE A 119
PHE A 176
ILE A 195
ILE A 198
None
0.63A 6gp2B-3mjoA:
40.5
6gp2B-3mjoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
7 PHE A  70
LEU A  73
THR A  74
ILE A 118
PHE A 119
ILE A 195
ILE A 198
None
0.37A 6gp2B-3mjoA:
40.5
6gp2B-3mjoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
7 PHE A  70
LEU A  73
THR A  74
SER A 114
ILE A 118
ILE A 195
ILE A 198
None
0.55A 6gp2B-3mjoA:
40.5
6gp2B-3mjoA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n00 REV-ERBA-ALPHA

(Homo sapiens)
PF00104
(Hormone_recep)
5 LEU A 545
THR A 541
ILE A 299
PHE A 300
ILE A 457
None
1.02A 6gp2B-3n00A:
3.2
6gp2B-3n00A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA


(Escherichia
coli)
no annotation 8 PHE B  60
LEU B  63
ASP B  67
ILE B 108
PHE B 109
PHE B 166
ILE B 185
ILE B 188
None
None
MN  B 320 (-2.8A)
None
None
None
None
None
0.74A 6gp2B-3n3bB:
40.4
6gp2B-3n3bB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA


(Escherichia
coli)
no annotation 7 PHE B  60
LEU B  63
ASP B  67
SER B 104
ILE B 108
ILE B 185
ILE B 188
None
None
MN  B 320 (-2.8A)
None
None
None
None
0.77A 6gp2B-3n3bB:
40.4
6gp2B-3n3bB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3b RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 2
SUBUNIT BETA


(Escherichia
coli)
no annotation 8 PHE B  60
LEU B  63
THR B  64
ILE B 108
PHE B 109
PHE B 166
ILE B 185
ILE B 188
None
0.61A 6gp2B-3n3bB:
40.4
6gp2B-3n3bB:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdu 3-HYDROXYISOBUTYRATE
DEHYDROGENASE FAMILY
PROTEIN


(Geobacter
sulfurreducens)
PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11)
5 PHE A 151
GLY A 155
ILE A 135
ILE A  92
ILE A  62
None
1.08A 6gp2B-3pduA:
undetectable
6gp2B-3pduA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69)
PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
5 PHE A 841
GLY A 807
ILE A 846
ILE A 858
ILE A 815
None
1.06A 6gp2B-3sunA:
undetectable
6gp2B-3sunA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2p RETINOIC ACID
INDUCIBLE PROTEIN I


(Anas
platyrhynchos)
PF00270
(DEAD)
PF00271
(Helicase_C)
6 PHE A 358
LEU A 354
GLY A 361
PHE A 369
ILE A 368
ILE A 341
None
1.38A 6gp2B-4a2pA:
undetectable
6gp2B-4a2pA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I


(Anas
platyrhynchos)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2)
6 PHE A 358
LEU A 354
GLY A 361
PHE A 369
ILE A 368
ILE A 341
None
1.30A 6gp2B-4a2qA:
undetectable
6gp2B-4a2qA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I


(Anas
platyrhynchos)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2)
6 PHE A 358
LEU A 354
GLY A 361
PHE A 369
ILE A 368
ILE A 341
None
1.24A 6gp2B-4a2wA:
undetectable
6gp2B-4a2wA:
5.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N


(Homo sapiens)
PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
5 PHE A 219
GLY A 201
PHE A 192
ILE A 167
ILE A 175
None
1.06A 6gp2B-4acqA:
undetectable
6gp2B-4acqA:
4.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus cereus)
PF00268
(Ribonuc_red_sm)
7 LEU A  58
THR A  59
ASP A  62
ILE A 103
PHE A 104
ILE A 188
ILE A 191
None
None
FE2  A1323 (-2.4A)
None
None
None
None
0.65A 6gp2B-4bmrA:
37.2
6gp2B-4bmrA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus cereus)
PF00268
(Ribonuc_red_sm)
7 LEU A  58
THR A  59
ASP A  62
ILE A 103
PHE A 104
PHE A 169
ILE A 191
None
None
FE2  A1323 (-2.4A)
None
None
None
None
0.82A 6gp2B-4bmrA:
37.2
6gp2B-4bmrA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus cereus)
PF00268
(Ribonuc_red_sm)
7 LEU A  58
THR A  59
ASP A  62
SER A  99
ILE A 103
ILE A 188
ILE A 191
None
None
FE2  A1323 (-2.4A)
None
None
None
None
0.77A 6gp2B-4bmrA:
37.2
6gp2B-4bmrA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT


(Vaccinia virus)
PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT)
6 LEU A 700
THR A 701
PHE A 780
PHE A 659
ILE A 654
ILE A 597
None
1.14A 6gp2B-4ckbA:
undetectable
6gp2B-4ckbA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dr0 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Bacillus
subtilis)
PF00268
(Ribonuc_red_sm)
9 LEU A  62
THR A  63
ASP A  66
SER A 104
ILE A 108
PHE A 109
PHE A 172
ILE A 191
ILE A 194
None
None
MN  A 402 (-2.3A)
None
None
None
None
None
None
0.77A 6gp2B-4dr0A:
37.7
6gp2B-4dr0A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fd0 LEUCINE RICH
HYPOTHETICAL PROTEIN


(Bacteroides
caccae)
PF07523
(Big_3)
PF13306
(LRR_5)
5 PHE A 294
GLY A 268
ILE A 267
PHE A 332
ILE A 318
None
SO4  A 512 ( 4.3A)
None
None
None
1.01A 6gp2B-4fd0A:
undetectable
6gp2B-4fd0A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
5 PHE A  87
GLY A 106
ILE A  82
ILE A  96
ILE A 119
None
0.98A 6gp2B-4fs7A:
undetectable
6gp2B-4fs7A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
5 PHE A 336
GLY A 355
ILE A 331
ILE A 345
ILE A 368
None
0.86A 6gp2B-4fs7A:
undetectable
6gp2B-4fs7A:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4s PROTEASOME CHAPERONE
1


(Saccharomyces
cerevisiae)
PF10450
(POC1)
5 PHE O  38
GLY O  72
ILE O 124
ILE O 154
ILE O 150
None
0.98A 6gp2B-4g4sO:
undetectable
6gp2B-4g4sO:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdu AEROTOLERANCE-RELATE
D MEMBRANE PROTEIN


(Bacteroides
fragilis)
PF00092
(VWA)
5 ASP A 129
GLY A 132
ILE A  94
ILE A 283
ILE A 287
None
0.85A 6gp2B-4jduA:
undetectable
6gp2B-4jduA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n83 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA


(Streptococcus
sanguinis)
PF00268
(Ribonuc_red_sm)
10 PHE A  59
LEU A  62
THR A  63
ASP A  66
SER A 103
ILE A 107
PHE A 108
PHE A 165
ILE A 184
ILE A 187
None
None
None
MN  A 402 (-2.8A)
None
None
None
None
None
None
0.71A 6gp2B-4n83A:
37.5
6gp2B-4n83A:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfy D-3-PHOSPHOGLYCERATE
DEHYDROGENASE,
PUTATIVE


(Entamoeba
histolytica)
PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
5 GLY A 276
ILE A  19
PHE A  11
ILE A   3
ILE A 283
None
1.06A 6gp2B-4nfyA:
undetectable
6gp2B-4nfyA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ouq UNCHARACTERIZED
PROTEIN


(Bacteroides
fragilis)
PF16022
(DUF4783)
5 PHE A  71
THR A  67
PHE A  32
ILE A 107
ILE A 123
None
0.90A 6gp2B-4ouqA:
undetectable
6gp2B-4ouqA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5w CALCIUM-BINDING
MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2,CALCIUM-BIND
ING MITOCHONDRIAL
CARRIER PROTEIN
ARALAR2


(Homo sapiens)
no annotation 5 THR A 265
GLY A 222
ILE A 271
PHE A 254
ILE A 233
None
0.99A 6gp2B-4p5wA:
undetectable
6gp2B-4p5wA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9d BENZOYLFORMATE
DECARBOXYLASE


(Mycolicibacterium
smegmatis)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 LEU A 385
THR A 381
GLY A 433
ILE A 432
PHE A 397
None
None
FMT  A 603 (-3.3A)
None
None
0.92A 6gp2B-4q9dA:
undetectable
6gp2B-4q9dA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdf 3-KETOSTEROID
9ALPHA-HYDROXYLASE
OXYGENASE


(Rhodococcus
rhodochrous)
PF00355
(Rieske)
5 GLY B 149
ILE B 275
PHE B 238
ILE B 257
ILE B 240
None
1.05A 6gp2B-4qdfB:
undetectable
6gp2B-4qdfB:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis)
PF13561
(adh_short_C2)
5 PHE A 147
SER A 140
GLY A 143
ILE A 141
ILE A 185
None
NAP  A 300 ( 3.9A)
None
None
None
1.08A 6gp2B-4qedA:
undetectable
6gp2B-4qedA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qku HYDROLASE

(Burkholderia
cenocepacia)
PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N)
5 LEU A 245
GLY A 364
ILE A 366
PHE A 420
ILE A 312
None
1.07A 6gp2B-4qkuA:
undetectable
6gp2B-4qkuA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxs VIRION EGRESS
PROTEIN UL34


(Human
alphaherpesvirus
1)
PF04541
(Herpes_U34)
5 LEU A  85
GLY A 109
ILE A 111
ILE A 153
ILE A  87
None
1.03A 6gp2B-4zxsA:
undetectable
6gp2B-4zxsA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aex AMMONIUM TRANSPORTER
MEP2


(Saccharomyces
cerevisiae)
PF00909
(Ammonium_transp)
5 LEU A  56
GLY A 142
ILE A  49
ILE A 297
ILE A 347
None
1.01A 6gp2B-5aexA:
undetectable
6gp2B-5aexA:
10.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110)
5 LEU A 164
THR A 165
GLY A 423
ILE A 158
ILE A 149
None
1.06A 6gp2B-5djwA:
undetectable
6gp2B-5djwA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd4 COMR

(Streptococcus
suis)
PF13560
(HTH_31)
5 LEU A 215
THR A 214
ILE A 203
ILE A 200
ILE A 241
None
1.08A 6gp2B-5fd4A:
undetectable
6gp2B-5fd4A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE


(Caldicellulosiruptor
sp. F32)
PF00150
(Cellulase)
5 PHE A 307
LEU A 311
ILE A 304
ILE A 324
ILE A 355
None
1.08A 6gp2B-5h4rA:
undetectable
6gp2B-5h4rA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h80 CARBOXYLASE

(Deinococcus
radiodurans)
PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 PHE A 364
LEU A 382
GLY A 422
ILE A 420
PHE A 377
None
1.02A 6gp2B-5h80A:
undetectable
6gp2B-5h80A:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hiu GTPASE
ACTIVATOR-LIKE
PROTEIN


(Chaetomium
thermophilum)
PF11864
(DUF3384)
6 PHE A 207
LEU A 210
THR A 211
GLY A 276
ILE A 274
ILE A 262
PHE  A 207 ( 1.3A)
LEU  A 210 ( 0.5A)
THR  A 211 ( 0.8A)
GLY  A 276 ( 0.0A)
ILE  A 274 ( 0.7A)
ILE  A 262 ( 0.7A)
0.86A 6gp2B-5hiuA:
undetectable
6gp2B-5hiuA:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huq LACTATE RACEMIZATION
OPERON PROTEIN LARA


(Lactobacillus
plantarum)
PF09861
(DUF2088)
5 SER A 250
GLY A 249
ILE A 247
ILE A  82
ILE A 237
None
0.93A 6gp2B-5huqA:
undetectable
6gp2B-5huqA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy7 TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA


(Homo sapiens)
PF02186
(TFIIE_beta)
5 LEU R  97
THR R  98
GLY R 135
ILE R 133
ILE R 130
None
1.07A 6gp2B-5iy7R:
undetectable
6gp2B-5iy7R:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j4r WELO5

(Hapalosiphon
welwitschii)
no annotation 5 PHE A 120
ILE A 192
PHE A  47
PHE A 106
ILE A 152
None
0.99A 6gp2B-5j4rA:
undetectable
6gp2B-5j4rA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0y CELLULOSOME
ANCHORING PROTEIN
COHESIN REGION


(Ruminiclostridium
thermocellum)
PF00963
(Cohesin)
5 LEU A  85
GLY A  81
ILE A 128
PHE A  48
ILE A  42
None
P6G  A 205 (-3.6A)
P6G  A 205 (-4.9A)
None
None
0.85A 6gp2B-5m0yA:
undetectable
6gp2B-5m0yA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mso CARBOXYLIC ACID
REDUCTASE


(Mycobacterium
marinum)
PF07993
(NAD_binding_4)
5 LEU A1071
ILE A1085
PHE A1002
ILE A1006
ILE A1161
None
0.92A 6gp2B-5msoA:
undetectable
6gp2B-5msoA:
5.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1)
no annotation 5 ASP A 254
SER A 628
GLY A 727
ILE A 731
ILE A 626
None
1.03A 6gp2B-5nd1A:
undetectable
6gp2B-5nd1A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szs SPIKE GLYCOPROTEIN

(Human
coronavirus
NL63)
PF01600
(Corona_S1)
PF01601
(Corona_S2)
5 LEU A 151
THR A 159
ILE A 144
ILE A  89
ILE A 105
None
0.97A 6gp2B-5szsA:
undetectable
6gp2B-5szsA:
4.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ti1 FUMARYLACETOACETATE
HYDROLASE


(Paraburkholderia
xenovorans)
PF01557
(FAA_hydrolase)
PF09298
(FAA_hydrolase_N)
5 LEU A 249
GLY A 368
ILE A 370
PHE A 424
ILE A 316
None
MG  A 501 ( 4.7A)
None
None
None
1.04A 6gp2B-5ti1A:
undetectable
6gp2B-5ti1A:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2g L-AMINO ACID OXIDASE

(Naja atra)
no annotation 5 PHE A 398
LEU A 401
ASP A 402
ILE A 344
ILE A 409
None
0.96A 6gp2B-5z2gA:
undetectable
6gp2B-5z2gA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c1d UNCONVENTIONAL
MYOSIN-IB


(Rattus
norvegicus)
no annotation 5 LEU P 460
ASP P 461
ILE P 449
PHE P 399
ILE P 403
None
1.05A 6gp2B-6c1dP:
undetectable
6gp2B-6c1dP:
15.48