SIMILAR PATTERNS OF AMINO ACIDS FOR 6GNR_B_6J3B201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aog TRYPANOTHIONE
REDUCTASE

(Trypanosoma
cruzi) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LYS A 414
LEU A 235
ALA A 413
LEU A 430
 None
 1.48A 6gnrB-1aogA:
undetectable		 6gnrB-1aogA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dly HEMOGLOBIN

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 LYS A   5
LEU A   2
ALA A   4
LEU A  53
 SO4  A 123 ( 4.0A)
SO4  A 123 (-4.5A)
None
None
 1.41A 6gnrB-1dlyA:
undetectable		 6gnrB-1dlyA:
22.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gke TRANSTHYRETIN

(Rattus
norvegicus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.60A 6gnrB-1gkeA:
19.9		 6gnrB-1gkeA:
54.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		4 LYS A 139
LEU A 134
ALA A 142
LEU A 109
 None
 1.07A 6gnrB-1gz0A:
undetectable		 6gnrB-1gz0A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjo PROTEIN (HEAT-SHOCK
70KD PROTEIN)

(Homo sapiens) 		PF00012
(HSP70) 		4 LYS A 220
LEU A 326
ALA A 221
LEU A 321
 None
 1.49A 6gnrB-1hjoA:
undetectable		 6gnrB-1hjoA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jne IMAGINAL DISC GROWTH
FACTOR-2

(Drosophila
melanogaster) 		PF00704
(Glyco_hydro_18) 		4 LYS A 379
LEU A 274
ALA A 380
LEU A 388
 None
 1.43A 6gnrB-1jneA:
0.0		 6gnrB-1jneA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p99 HYPOTHETICAL PROTEIN
PG110

(Staphylococcus
aureus) 		PF03180
(Lipoprotein_9) 		4 LYS A  55
LEU A  59
ALA A 264
LEU A 258
 None
 1.30A 6gnrB-1p99A:
0.0		 6gnrB-1p99A:
21.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1sn2 TRANSTHYRETIN

(Sparus aurata) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.13A 6gnrB-1sn2A:
23.4		 6gnrB-1sn2A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tfp TRANSTHYRETIN

(Gallus gallus) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 None
 0.21A 6gnrB-1tfpA:
18.9		 6gnrB-1tfpA:
61.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uvx GLOBIN LI637

(Chlamydomonas
moewusii) 		PF01152
(Bac_globin) 		4 LYS A   5
LEU A   2
ALA A   4
LEU A  53
 None
 1.43A 6gnrB-1uvxA:
undetectable		 6gnrB-1uvxA:
23.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbg PYRUVATE,ORTHOPHOSPH
ATE DIKINASE

(Zea mays) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		4 LYS A 347
LEU A 379
ALA A 349
LEU A 376
 SO4  A3002 ( 4.3A)
None
None
None
 1.39A 6gnrB-1vbgA:
0.4		 6gnrB-1vbgA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wjt TRANSCRIPTION
ELONGATION FACTOR
S-II PROTEIN 3

(Mus musculus) 		PF08711
(Med26) 		4 LYS A  19
LEU A  15
ALA A  18
LEU A  14
 None
 1.32A 6gnrB-1wjtA:
undetectable		 6gnrB-1wjtA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 LYS A  43
LEU A  39
ALA A  42
LEU A  38
 None
 1.07A 6gnrB-1xmbA:
undetectable		 6gnrB-1xmbA:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1v STE50 PROTEIN

(Saccharomyces
cerevisiae) 		PF09235
(Ste50p-SAM) 		4 LYS A  88
LEU A  56
ALA A  89
LEU A  81
 None
 1.49A 6gnrB-1z1vA:
undetectable		 6gnrB-1z1vA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckx TELOMERE BINDING
PROTEIN TBP1

(Nicotiana
tabacum) 		PF00249
(Myb_DNA-binding) 		4 LYS A 604
LEU A 619
ALA A 607
LEU A 588
 None
 1.24A 6gnrB-2ckxA:
undetectable		 6gnrB-2ckxA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2esr METHYLTRANSFERASE

(Streptococcus
pyogenes) 		PF03602
(Cons_hypoth95) 		4 LYS A 135
LEU A 137
ALA A 134
LEU A 138
 None
 1.37A 6gnrB-2esrA:
undetectable		 6gnrB-2esrA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fkn UROCANATE HYDRATASE

(Bacillus
subtilis) 		PF01175
(Urocanase)
PF17391
(Urocanase_N)
PF17392
(Urocanase_C) 		4 LYS A 396
LEU A 180
ALA A 393
LEU A 142
 None
 1.42A 6gnrB-2fknA:
undetectable		 6gnrB-2fknA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1

(Homo sapiens) 		PF00018
(SH3_1) 		4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.26A 6gnrB-2gqiA:
undetectable		 6gnrB-2gqiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8o GERANYLTRANSTRANSFER
ASE

(Agrobacterium
fabrum) 		PF00348
(polyprenyl_synt) 		4 LYS A 319
LEU A  99
ALA A 321
LEU A 323
 None
 1.19A 6gnrB-2h8oA:
undetectable		 6gnrB-2h8oA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p31 GLUTATHIONE
PEROXIDASE 7

(Homo sapiens) 		PF00255
(GSHPx) 		4 LYS A 146
LEU A  49
ALA A 158
LEU A 148
 None
 1.39A 6gnrB-2p31A:
undetectable		 6gnrB-2p31A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 LYS A  85
LEU A  81
ALA A  84
LEU A  69
 None
 1.42A 6gnrB-2pcqA:
undetectable		 6gnrB-2pcqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pcq PUTATIVE
DIHYDRODIPICOLINATE
SYNTHASE

(Thermus
thermophilus) 		PF00701
(DHDPS) 		4 LYS A 118
LEU A  81
ALA A 116
LEU A  92
 None
 1.44A 6gnrB-2pcqA:
undetectable		 6gnrB-2pcqA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7y CHAPERONE PROTEIN
DNAK

(Geobacillus
kaustophilus) 		PF00012
(HSP70) 		4 LYS A 188
LEU A 298
ALA A 189
LEU A 293
 None
 1.47A 6gnrB-2v7yA:
1.9		 6gnrB-2v7yA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x49 INVASION PROTEIN
INVA

(Salmonella
enterica) 		PF00771
(FHIPEP) 		4 LYS A 512
LEU A 509
ALA A 511
LEU A 517
 None
 1.41A 6gnrB-2x49A:
undetectable		 6gnrB-2x49A:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnx M PROTEIN

(Streptococcus
pyogenes) 		no annotation 4 LYS M 211
LEU M 207
ALA M 210
LEU M 206
 None
 1.16A 6gnrB-2xnxM:
undetectable		 6gnrB-2xnxM:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LYS A  25
LEU A  51
ALA A  28
LEU A  50
 None
 1.46A 6gnrB-2xsjA:
undetectable		 6gnrB-2xsjA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z99 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF04079
(SMC_ScpB) 		4 LYS A  62
LEU A  32
ALA A  60
LEU A  48
 None
 1.45A 6gnrB-2z99A:
undetectable		 6gnrB-2z99A:
21.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		4 LYS A  15
LEU A  17
ALA A 108
LEU A 110
 IFA  A3000 (-3.0A)
IFA  A3000 ( 4.7A)
IFA  A3000 (-3.1A)
IFA  A3000 (-4.1A)
 1.01A 6gnrB-3fc8A:
20.9		 6gnrB-3fc8A:
54.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe1 HEAT SHOCK 70 KDA
PROTEIN 6

(Homo sapiens) 		PF00012
(HSP70) 		4 LYS A 222
LEU A 328
ALA A 223
LEU A 323
 None
 1.45A 6gnrB-3fe1A:
undetectable		 6gnrB-3fe1A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fmq METHIONINE
AMINOPEPTIDASE 2

(Encephalitozoon
cuniculi) 		PF00557
(Peptidase_M24) 		4 LYS A 149
LEU A 152
ALA A 147
LEU A 155
 None
 1.44A 6gnrB-3fmqA:
undetectable		 6gnrB-3fmqA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihk THIAMIN
PYROPHOSPHOKINASE

(Streptococcus
mutans) 		PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding) 		4 LYS A  60
LEU A  33
ALA A  61
LEU A  32
 None
 1.47A 6gnrB-3ihkA:
undetectable		 6gnrB-3ihkA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3izk CHAPERONIN

(Methanococcus
maripaludis) 		PF00118
(Cpn60_TCP1) 		4 LYS A 124
LEU A 128
ALA A 121
LEU A 383
 None
 1.39A 6gnrB-3izkA:
undetectable		 6gnrB-3izkA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		4 LYS A 159
LEU A 220
ALA A 162
LEU A 174
 None
 1.40A 6gnrB-3jzjA:
undetectable		 6gnrB-3jzjA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k49 MRNA-BINDING PROTEIN
PUF3

(Saccharomyces
cerevisiae) 		PF00806
(PUF) 		4 LYS A 802
LEU A 841
ALA A 805
LEU A 798
 None
 1.47A 6gnrB-3k49A:
undetectable		 6gnrB-3k49A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kae POSSIBLE PROTEIN OF
NUCLEAR SCAFFOLD

(Encephalitozoon
cuniculi) 		no annotation 4 LYS A  73
LEU A 119
ALA A  81
LEU A  85
 None
 1.27A 6gnrB-3kaeA:
undetectable		 6gnrB-3kaeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldr FRUCTOSYLTRANSFERASE

(Aspergillus
japonicus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 LYS A 351
LEU A 265
ALA A 350
LEU A 248
 None
 1.43A 6gnrB-3ldrA:
undetectable		 6gnrB-3ldrA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnn MEMBRANE FUSION
PROTEIN (MFP) HEAVY
METAL CATION EFFLUX
ZNEB (CZCB-LIKE)

(Cupriavidus
metallidurans) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		4 LYS A 158
LEU A 155
ALA A 157
LEU A 152
 None
 1.29A 6gnrB-3lnnA:
undetectable		 6gnrB-3lnnA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp8 PHOSPHORIBOSYLAMINE-
GLYCINE LIGASE

(Ehrlichia
chaffeensis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 LYS A 313
LEU A 310
ALA A 312
LEU A 316
 None
 1.48A 6gnrB-3lp8A:
undetectable		 6gnrB-3lp8A:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mm5 SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT ALPHA

(Archaeoglobus
fulgidus) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LYS A  22
LEU A  48
ALA A  25
LEU A  47
 None
 1.39A 6gnrB-3mm5A:
undetectable		 6gnrB-3mm5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqw PUTATIVE CITRATE
LYASE

(Cupriavidus
pinatubonensis) 		PF03328
(HpcH_HpaI) 		4 LYS A 207
LEU A 203
ALA A 206
LEU A 202
 None
 1.30A 6gnrB-3qqwA:
undetectable		 6gnrB-3qqwA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwo MOTAVIZUMAB EPITOPE
SCAFFOLD

(Staphylococcus
aureus) 		PF02216
(B) 		4 LYS C  49
LEU C  45
ALA C  48
LEU C  44
 None
 1.41A 6gnrB-3qwoC:
undetectable		 6gnrB-3qwoC:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rb5 NA/CA EXCHANGE
PROTEIN

(Drosophila
melanogaster) 		PF03160
(Calx-beta) 		4 LYS A 656
LEU A 653
ALA A 655
LEU A 647
 None
 1.49A 6gnrB-3rb5A:
undetectable		 6gnrB-3rb5A:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s29 SUCROSE SYNTHASE 1

(Arabidopsis
thaliana) 		PF00534
(Glycos_transf_1)
PF00862
(Sucrose_synth) 		4 LYS A 169
LEU A 166
ALA A 168
LEU A 268
 None
 1.31A 6gnrB-3s29A:
undetectable		 6gnrB-3s29A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE

(Bartonella
henselae) 		PF00701
(DHDPS) 		4 LYS A 263
LEU A 296
ALA A 260
LEU A 295
 None
 1.40A 6gnrB-3si9A:
undetectable		 6gnrB-3si9A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq8 BETA-GLUCOSIDASE

(Pyrococcus
furiosus) 		PF00232
(Glyco_hydro_1) 		4 LYS A 315
LEU A 322
ALA A 314
LEU A 271
 None
 1.43A 6gnrB-3wq8A:
undetectable		 6gnrB-3wq8A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 LYS A 143
LEU A  83
ALA A 142
LEU A  82
 None
 1.22A 6gnrB-4a1oA:
undetectable		 6gnrB-4a1oA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 LYS A 475
LEU A 413
ALA A 473
LEU A 412
 None
 1.48A 6gnrB-4cj0A:
3.7		 6gnrB-4cj0A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 LYS A1040
LEU A 855
ALA A1051
LEU A1042
 None
 1.36A 6gnrB-4fxdA:
undetectable		 6gnrB-4fxdA:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gqo LMO0859 PROTEIN

(Listeria
monocytogenes) 		PF13416
(SBP_bac_8) 		4 LYS A 198
LEU A 201
ALA A 197
LEU A 255
 None
 1.11A 6gnrB-4gqoA:
undetectable		 6gnrB-4gqoA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4idm DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00171
(Aldedh) 		4 LYS A 121
LEU A  35
ALA A 123
LEU A 128
 None
 1.49A 6gnrB-4idmA:
undetectable		 6gnrB-4idmA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iwm UPF0135 PROTEIN
MJ0927

(Methanocaldococcus
jannaschii) 		PF01784
(NIF3) 		4 LYS A 206
LEU A 201
ALA A 209
LEU A 181
 None
 1.28A 6gnrB-4iwmA:
undetectable		 6gnrB-4iwmA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		4 LYS A 390
LEU A 464
ALA A 388
LEU A 465
 None
 1.33A 6gnrB-4jclA:
undetectable		 6gnrB-4jclA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe3 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 LYS A 280
LEU A 277
ALA A 279
LEU A 273
 None
 1.48A 6gnrB-4pe3A:
undetectable		 6gnrB-4pe3A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfk ABC TRANSPORTER
PERIPLASMIC
PEPTIDE-BINDING
PROTEIN

(Pseudoalteromonas
sp. SM9913) 		no annotation 4 LYS H 457
LEU H 447
ALA H 452
LEU H 448
 None
 1.30A 6gnrB-4qfkH:
undetectable		 6gnrB-4qfkH:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhm ARGINASE

(Trypanosoma
brucei) 		PF00491
(Arginase) 		4 LYS A 290
LEU A 250
ALA A 287
LEU A 249
 None
 1.46A 6gnrB-4rhmA:
undetectable		 6gnrB-4rhmA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wau CENTROMERE PROTEIN M

(Homo sapiens) 		PF11111
(CENP-M) 		4 LYS A  50
LEU A  28
ALA A  49
LEU A  20
 None
 1.46A 6gnrB-4wauA:
undetectable		 6gnrB-4wauA:
24.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr2 PYRIMIDINE-SPECIFIC
RIBONUCLEOSIDE
HYDROLASE RIHA

(Shewanella
loihica) 		PF01156
(IU_nuc_hydro) 		4 LYS A 296
LEU A 299
ALA A 292
LEU A 340
 None
 1.32A 6gnrB-4wr2A:
undetectable		 6gnrB-4wr2A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvx ACYL-[ACYL-CARRIER-P
ROTEIN]
DEHYDROGENASE MBTN

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LYS A 312
LEU A 362
ALA A 308
LEU A 365
 None
 1.02A 6gnrB-4xvxA:
undetectable		 6gnrB-4xvxA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xym BETA SUBUNIT OF
ACYL-COA SYNTHETASE
(NDP FORMING)

(Candidatus
Korarchaeum
cryptofilum) 		PF13549
(ATP-grasp_5) 		4 LYS B  11
LEU B   7
ALA B  10
LEU B   6
 None
 1.46A 6gnrB-4xymB:
undetectable		 6gnrB-4xymB:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymr PROTEIN SNX21

(Mus musculus) 		no annotation 4 LYS A 298
LEU A 276
ALA A 294
LEU A 279
 None
 1.47A 6gnrB-4ymrA:
undetectable		 6gnrB-4ymrA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yod THIOREDOXIN-LIKE
PROTEIN

(Bacteroides
caccae) 		PF13905
(Thioredoxin_8)
PF17127
(DUF5106) 		4 LYS A 292
LEU A 202
ALA A 179
LEU A 204
 None
 1.31A 6gnrB-4yodA:
undetectable		 6gnrB-4yodA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yqz PUTATIVE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF13561
(adh_short_C2) 		4 LYS A 101
LEU A  97
ALA A 100
LEU A  98
 None
 1.44A 6gnrB-4yqzA:
undetectable		 6gnrB-4yqzA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 4 LYS A  11
LEU A   7
ALA A  10
LEU A  43
 None
 1.27A 6gnrB-5cwnA:
undetectable		 6gnrB-5cwnA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dse TETRATRICOPEPTIDE
REPEAT PROTEIN 7B

(Homo sapiens) 		PF12895
(ANAPC3)
PF13181
(TPR_8)
PF13424
(TPR_12) 		4 LYS A 439
LEU A 436
ALA A 438
LEU A 420
 None
 1.33A 6gnrB-5dseA:
undetectable		 6gnrB-5dseA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e01 UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR HI_0186

(Haemophilus
influenzae) 		PF13411
(MerR_1) 		4 LYS A  66
LEU A  27
ALA A  69
LEU A  52
 None
 1.49A 6gnrB-5e01A:
undetectable		 6gnrB-5e01A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2v IMPORTIN SUBUNIT
BETA-3

(Saccharomyces
cerevisiae) 		PF13513
(HEAT_EZ) 		4 LYS A 633
LEU A 629
ALA A 632
LEU A 628
 None
 1.46A 6gnrB-5h2vA:
undetectable		 6gnrB-5h2vA:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 4 LYS A 350
LEU A 346
ALA A 349
LEU A 345
 None
 1.42A 6gnrB-5hssA:
undetectable		 6gnrB-5hssA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		4 LYS A 248
LEU A 272
ALA A 237
LEU A 250
 None
 1.30A 6gnrB-5htpA:
undetectable		 6gnrB-5htpA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htv PUTATIVE XYLULOSE
KINASE

(Arabidopsis
thaliana) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LYS A 263
LEU A 287
ALA A 252
LEU A 265
 None
 1.16A 6gnrB-5htvA:
undetectable		 6gnrB-5htvA:
17.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ie6 ZEARALENONE
HYDROLASE

(Clonostachys
rosea) 		PF00561
(Abhydrolase_1) 		4 LYS A 230
LEU A 200
ALA A 228
LEU A 203
 None
 1.10A 6gnrB-5ie6A:
undetectable		 6gnrB-5ie6A:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kvr PYRUVATE
DEHYDROGENASE
COMPLEX REPRESSOR

(Escherichia
coli) 		PF00392
(GntR) 		4 LYS A  61
LEU A  58
ALA A  60
LEU A  64
 None
 1.34A 6gnrB-5kvrA:
undetectable		 6gnrB-5kvrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nf4 MINOR FIMBRIUM TIP
SUBUNIT MFA3

(Porphyromonas
gingivalis) 		no annotation 4 LYS A 304
LEU A 306
ALA A 303
LEU A 307
 None
 1.41A 6gnrB-5nf4A:
5.1		 6gnrB-5nf4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ng5 MULTIDRUG EFFLUX
PUMP SUBUNIT ACRA

(Escherichia
coli) 		no annotation 4 LYS E 346
LEU E 307
ALA E 342
LEU E 348
 None
 1.28A 6gnrB-5ng5E:
undetectable		 6gnrB-5ng5E:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5veh KYNURENINE
AMINOTRANSFERASE

(Aedes aegypti) 		no annotation 4 LYS A 417
LEU A  40
ALA A 419
LEU A 383
 None
 1.46A 6gnrB-5vehA:
undetectable		 6gnrB-5vehA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x8t PROTEIN L17

(Spinacia
oleracea) 		PF01196
(Ribosomal_L17) 		4 LYS O  50
LEU O  34
ALA O  51
LEU O  38
 A  A1298 ( 3.5A)
A  A1298 ( 3.8A)
None
None
 1.30A 6gnrB-5x8tO:
undetectable		 6gnrB-5x8tO:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yap SCYLLO-INOSITOL
DEHYDROGENASE WITH
L-GLUCOSE
DEHYDROGENASE
ACTIVITY

(Paracoccus
laeviglucosivorans) 		no annotation 4 LYS A  20
LEU A  54
ALA A  23
LEU A  43
 None
 1.40A 6gnrB-5yapA:
undetectable		 6gnrB-5yapA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yv5 ATPASE RIL

(Pyrococcus
furiosus) 		no annotation 4 LYS A 427
LEU A 469
ALA A 425
LEU A 420
 None
 1.44A 6gnrB-5yv5A:
undetectable		 6gnrB-5yv5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvt C-TERMINUS OF OUTER
CAPSID PROTEIN VP5

(Aquareovirus C) 		no annotation 4 LYS B 191
LEU B 187
ALA B 190
LEU B 186
 MYR  A 101 (-2.4A)
MYR  A 101 (-4.2A)
MYR  A 101 ( 3.7A)
None
 1.29A 6gnrB-5zvtB:
undetectable		 6gnrB-5zvtB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ave ACID-SENSING ION
CHANNEL 1

(Gallus gallus) 		no annotation 4 LYS A 142
LEU A 109
ALA A 143
LEU A 119
 None
 1.27A 6gnrB-6aveA:
2.3		 6gnrB-6aveA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bma INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Campylobacter
jejuni) 		no annotation 4 LYS A 176
LEU A 150
ALA A 177
LEU A 154
 None
 1.29A 6gnrB-6bmaA:
undetectable		 6gnrB-6bmaA:
19.40