SIMILAR PATTERNS OF AMINO ACIDS FOR 6GNG_B_QPSB601_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 GLY A 398
GLY A 375
GLY A 412
HIS A  62
PRO A 181
 ADP  A 421 ( 4.3A)
ADP  A 421 (-3.3A)
None
3PG  A 423 (-4.1A)
None
 0.95A 6gngB-13pkA:
3.6		 6gngB-13pkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		5 GLY B 470
GLY B 471
LEU B 472
GLY B  25
PRO B 367
 None
None
FNE  B 543 (-3.4A)
None
None
 1.05A 6gngB-1e3dB:
undetectable		 6gngB-1e3dB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		6 GLU A  67
GLY A 113
GLY A 114
LEU A 115
HIS A 309
ARG A 534
 GLC  A 997 (-3.3A)
GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
 0.65A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 GLU A  67
GLY A 114
LEU A 115
HIS A 309
ARG A 534
 GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
 1.07A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		5 GLU A 340
GLY A 343
LEU A 342
GLY A 357
PRO A 375
 None
 1.11A 6gngB-1fp9A:
undetectable		 6gngB-1fp9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		6 GLY A  21
GLY A  22
LEU A  23
GLY A 301
HIS A 132
ARG A 262
 UDP  A 900 (-3.4A)
IMD  A 902 (-3.0A)
G6P  A 901 ( 3.7A)
None
G6P  A 901 (-4.5A)
UDP  A 900 ( 3.8A)
 1.16A 6gngB-1gz5A:
22.1		 6gngB-1gz5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 GLY A 413
GLY A 415
GLY A 398
ASN A  94
ARG A 412
 IMP  A1331 (-3.5A)
IMP  A1331 ( 3.1A)
None
None
None
 1.07A 6gngB-1jr1A:
undetectable		 6gngB-1jr1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLU A   9
GLY A  17
GLY A  18
LEU A  19
PRO A 377
 None
 0.68A 6gngB-1rzvA:
40.5		 6gngB-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 GLY A 254
GLY A 302
GLY A 290
ASN A 310
PRO A 283
 None
None
None
None
SO4  A1406 (-4.4A)
 0.94A 6gngB-1uz5A:
undetectable		 6gngB-1uz5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 GLY A  71
GLY A  70
LEU A  69
GLY B 322
GLN A 256
 None
 1.04A 6gngB-1wytA:
2.2		 6gngB-1wytA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ARG A 569
 None
PO4  A1900 (-3.7A)
PLP  A 860 ( 3.3A)
None
None
PO4  A1900 (-3.7A)
 0.50A 6gngB-1ygpA:
20.8		 6gngB-1ygpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 GLY A 226
LEU A 225
HIS A  51
ARG A 232
GLN A 242
 None
 1.09A 6gngB-1yx2A:
undetectable		 6gngB-1yx2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 GLY A 218
GLY A 219
LEU A 222
GLY A 164
PRO A 115
 None
 1.06A 6gngB-1yzyA:
2.3		 6gngB-1yzyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLU A 221
GLY A 502
LEU A 501
GLY A 214
GLU A 180
 None
 1.10A 6gngB-1zj9A:
undetectable		 6gngB-1zj9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 GLU A  67
GLY A 113
GLY A 114
LEU A 115
HIS A 298
 None
PO4  A1794 (-3.5A)
PO4  A1794 (-3.4A)
None
None
 0.38A 6gngB-2c4mA:
22.2		 6gngB-2c4mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 161
GLY A 160
GLY A  81
HIS A 247
PRO A 202
 None
None
None
HMG  A 500 (-3.3A)
None
 1.06A 6gngB-2fa0A:
undetectable		 6gngB-2fa0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		5 GLY B 213
GLY B 212
GLY B 229
HIS A   9
PRO A 105
 CL  B 406 (-3.7A)
None
None
None
None
 1.02A 6gngB-2gezB:
undetectable		 6gngB-2gezB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 GLU A  88
GLY A 134
GLY A 135
GLY A 612
ASN A 284
 None
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
 1.03A 6gngB-2gj4A:
21.8		 6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ASN A 284
 None
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
None
 1.12A 6gngB-2gj4A:
21.8		 6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 GLU A  88
GLY A 134
LEU A 136
HIS A 341
ASN A 284
 None
PLR  A 940 (-3.6A)
None
None
None
 1.07A 6gngB-2gj4A:
21.8		 6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		5 GLY A 121
GLY A 247
PRO A 282
ARG A 156
GLN A 125
 None
None
None
ADE  A1114 (-4.3A)
ADE  A1114 (-3.3A)
 1.11A 6gngB-2icsA:
undetectable		 6gngB-2icsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		5 GLY A 548
LEU A 547
GLY A 463
PRO A  74
PRO A 166
 None
 1.04A 6gngB-2o5pA:
undetectable		 6gngB-2o5pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 173
GLY A 172
GLY A  93
HIS A 264
PRO A 214
 None
None
None
SCY  A 129 ( 3.7A)
None
 1.06A 6gngB-2p8uA:
undetectable		 6gngB-2p8uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 210
GLY A 209
GLY A 130
HIS A 301
PRO A 251
 None
None
None
HMG  A1509 (-4.1A)
None
 1.11A 6gngB-2wyaA:
undetectable		 6gngB-2wyaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		5 GLU A 340
GLY A 343
LEU A 342
GLY A 357
PRO A 375
 None
 1.11A 6gngB-2x1iA:
undetectable		 6gngB-2x1iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 245
GLY A 246
GLY A 227
GLU A 228
PRO A 217
 None
 1.08A 6gngB-3b9gA:
4.3		 6gngB-3b9gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE

(Lactobacillus
plantarum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A  16
GLY A  19
HIS A  83
GLU A 221
ARG A  17
 NAD  A 400 (-3.3A)
NAD  A 400 ( 4.9A)
NAD  A 400 (-3.8A)
None
NAD  A 400 (-3.2A)
 1.04A 6gngB-3ceaA:
4.1		 6gngB-3ceaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ARG A 569
 None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
None
 1.47A 6gngB-3cemA:
22.2		 6gngB-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ASN A 284
 None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
NBG  A   1 (-3.5A)
 1.30A 6gngB-3cemA:
22.2		 6gngB-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLU A   9
GLY A  17
GLY A  18
LEU A  19
HIS A 139
 None
 0.78A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		5 GLY A 422
GLY A 325
ASN A 408
PRO A 256
ARG A  81
 None
 0.89A 6gngB-3griA:
2.1		 6gngB-3griA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hin PUTATIVE
3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Rhodopseudomonas
palustris) 		PF00378
(ECH_1) 		5 GLY A 120
GLY A  74
LEU A  75
HIS A  91
ASN A  41
 None
 1.04A 6gngB-3hinA:
2.5		 6gngB-3hinA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 GLY A 164
GLY A 140
GLY A 340
HIS A  61
PRO A 221
 None
None
SO4  A 447 (-3.3A)
ZN  A 453 (-3.4A)
None
 1.09A 6gngB-3ie1A:
2.4		 6gngB-3ie1A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 GLU A   9
GLY A  16
GLY A  17
LEU A  18
HIS A 130
PRO A 340
 None
CL  A5703 ( 3.9A)
CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6502 ( 3.8A)
K  A5600 ( 4.8A)
 0.84A 6gngB-3l01A:
34.5		 6gngB-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLU A   9
GLY A  17
LEU A  18
HIS A 130
PRO A 340
 None
CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6502 ( 3.8A)
K  A5600 ( 4.8A)
 0.85A 6gngB-3l01A:
34.5		 6gngB-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		5 GLY A 276
GLY A 262
LEU A 263
GLN A 270
PRO A  32
 None
 1.11A 6gngB-3lm6A:
undetectable		 6gngB-3lm6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A 102
GLY A  97
LEU A  98
GLY A 188
ASN A  32
 None
 1.09A 6gngB-3om8A:
5.6		 6gngB-3om8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox5 CALCIUM-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 GLY A  76
GLY A  75
LEU A  74
GLY A  48
GLN A  68
 None
 1.01A 6gngB-3ox5A:
undetectable		 6gngB-3ox5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 728
GLY A 729
LEU A 730
GLY A 616
PRO A 720
 None
None
None
AMP  A 747 ( 4.0A)
None
 0.91A 6gngB-3ttfA:
undetectable		 6gngB-3ttfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		5 GLY A 112
GLY A 133
ASN A 107
PRO A  79
GLU A 176
 None
BGC  A 324 ( 3.9A)
NA  A 323 (-3.2A)
BGC  A 324 (-3.9A)
BGC  A 324 (-2.8A)
 1.08A 6gngB-3vglA:
undetectable		 6gngB-3vglA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 GLY B  24
GLY B  25
LEU B  28
GLU B 131
PRO A 119
 None
 1.06A 6gngB-3vreB:
undetectable		 6gngB-3vreB:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
GLY A 100
HIS A 236
ARG A 408
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
SO4  A 704 (-4.1A)
None
SO4  A 704 (-3.7A)
SO4  A 704 ( 3.7A)
None
 0.83A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
GLY A 100
LEU A 101
HIS A 236
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
SO4  A 704 (-4.1A)
None
None
SO4  A 704 ( 3.7A)
None
 0.78A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
HIS A 236
ASN A 265
ARG A 408
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
None
SO4  A 704 ( 4.2A)
SO4  A 704 (-3.7A)
SO4  A 704 ( 3.7A)
None
 1.16A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
LEU A 101
HIS A 236
ASN A 265
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
None
None
SO4  A 704 ( 4.2A)
SO4  A 704 ( 3.7A)
None
 1.23A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A 100
HIS A 236
ASN A 265
ARG A 408
GLN A 412
PRO A 486
 None
SO4  A 704 (-4.1A)
None
SO4  A 704 ( 4.2A)
SO4  A 704 (-3.7A)
SO4  A 704 ( 3.7A)
None
 0.83A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A 100
LEU A 101
HIS A 236
ASN A 265
GLN A 412
PRO A 486
 None
SO4  A 704 (-4.1A)
None
None
SO4  A 704 ( 4.2A)
SO4  A 704 ( 3.7A)
None
 0.78A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 GLY A 420
GLY A 419
GLY A 509
PRO A 206
GLU A 526
 None
 1.05A 6gngB-4bbwA:
undetectable		 6gngB-4bbwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		6 GLU A  91
GLY A 137
GLY A 138
LEU A 139
GLY A 287
HIS A 343
 None
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
 1.04A 6gngB-4bqiA:
22.3		 6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		6 GLU A  91
GLY A 137
GLY A 138
LEU A 139
HIS A 343
ARG A 573
 None
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
 0.60A 6gngB-4bqiA:
22.3		 6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		5 GLU A  91
GLY A 137
LEU A 139
GLY A 287
HIS A 343
 None
PLP  A 901 ( 4.2A)
None
None
None
 1.09A 6gngB-4bqiA:
22.3		 6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 GLY A 332
GLY A 333
LEU A 334
GLY A  98
ASN A 114
 None
 0.98A 6gngB-4fl0A:
undetectable		 6gngB-4fl0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 GLY A 332
GLY A 333
LEU A 334
GLY A 104
ASN A 114
 None
 0.93A 6gngB-4fl0A:
undetectable		 6gngB-4fl0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		5 GLY A 354
GLY A 355
GLY A 430
ASN A 450
GLN A 367
 None
None
None
None
TRH  A 502 (-4.1A)
 0.97A 6gngB-4j7hA:
undetectable		 6gngB-4j7hA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		6 GLU A  58
GLY A 104
GLY A 105
LEU A 106
HIS A 281
ARG A 498
 None
 0.67A 6gngB-4l22A:
23.1		 6gngB-4l22A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Bacillus sp.
H-257) 		PF12146
(Hydrolase_4) 		5 GLY A  99
GLY A  95
LEU A  96
GLY A  57
GLU A   3
 None
None
SO4  A 302 ( 4.9A)
None
None
 0.94A 6gngB-4lheA:
5.8		 6gngB-4lheA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 GLY A 380
GLY A 379
GLY A 308
GLU A  87
PRO A 247
 None
 1.10A 6gngB-4lz6A:
undetectable		 6gngB-4lz6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 186
GLY A 185
LEU A 227
GLY A 222
PRO A 251
 SEP  A 184 ( 3.2A)
SEP  A 184 ( 2.4A)
None
None
None
 1.05A 6gngB-4m69A:
undetectable		 6gngB-4m69A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 GLY A 383
GLY A 385
GLY A 368
ASN A  72
ARG A 382
 IMP  A 500 (-3.3A)
IMP  A 500 ( 3.3A)
None
None
None
 1.00A 6gngB-4mz1A:
undetectable		 6gngB-4mz1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 GLY A 184
GLY A 183
LEU A 182
HIS A 230
PRO A  92
 None
 1.04A 6gngB-4ovqA:
undetectable		 6gngB-4ovqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 GLY A 181
LEU A 184
GLY A 312
GLN A 496
PRO A 497
 None
None
AER  A 601 ( 3.7A)
None
None
 1.05A 6gngB-4r1zA:
undetectable		 6gngB-4r1zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 GLY A 257
GLY A 256
GLY A 176
HIS A 226
GLU A 112
 None
None
None
3YN  A 503 (-4.5A)
None
 0.99A 6gngB-4rvhA:
2.8		 6gngB-4rvhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1k POLYHEDRIN

(Uranotaenia
sapphirina
cypovirus) 		PF17515
(CPV_Polyhedrin) 		5 GLU A 131
GLY A 121
GLY A 124
LEU A 125
GLN A  76
 None
 1.00A 6gngB-4s1kA:
undetectable		 6gngB-4s1kA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 GLY L 480
GLY L 481
LEU L 482
GLY L  35
PRO L 376
 None
None
NWN  L 601 (-3.4A)
None
None
 1.05A 6gngB-4u9iL:
undetectable		 6gngB-4u9iL:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		5 GLY A 393
LEU A 394
GLY A 238
ASN A 367
GLU A 246
 None
 0.93A 6gngB-4wk4A:
undetectable		 6gngB-4wk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xij SHIKIMATE
5-DEHYDROGENASE

(Mycolicibacterium
fortuitum) 		PF08501
(Shikimate_dh_N) 		5 GLY A 175
GLY A 176
LEU A 179
GLY A 127
PRO A 131
 None
None
None
EDO  A 303 ( 3.7A)
None
 1.10A 6gngB-4xijA:
5.2		 6gngB-4xijA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		5 GLY A  64
GLY A 116
LEU A 119
GLY A 364
ASN A  33
 None
None
CLM  A 500 ( 4.7A)
None
CLM  A 500 (-3.5A)
 0.99A 6gngB-4zowA:
undetectable		 6gngB-4zowA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		5 GLY A 386
GLY A 388
GLY A 371
ASN A  73
ARG A 385
 IMP  A 501 (-3.1A)
IMP  A 501 (-3.1A)
None
None
None
 0.99A 6gngB-5ahmA:
undetectable		 6gngB-5ahmA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 GLU B 262
GLY B 135
GLY B 278
GLU B 101
GLN B 286
 None
 0.87A 6gngB-5b3vB:
3.9		 6gngB-5b3vB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 342
LEU A 341
GLY A 465
HIS A 358
ARG A 429
 None
None
None
FAD  A3004 (-4.0A)
FAD  A3004 (-4.1A)
 1.06A 6gngB-5epgA:
undetectable		 6gngB-5epgA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 GLY A 269
GLY A 268
LEU A 267
GLY A 364
PRO A 168
 None
 0.94A 6gngB-5htpA:
undetectable		 6gngB-5htpA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
 None
PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
 0.59A 6gngB-5ikpA:
21.6		 6gngB-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		6 GLU A 135
GLY A 181
GLY A 182
LEU A 183
GLY A 331
HIS A 385
 None
PLP  A1002 ( 4.3A)
GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
None
 1.18A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 GLU A 135
GLY A 181
LEU A 183
GLY A 331
HIS A 385
 None
PLP  A1002 ( 4.3A)
GLC  A1001 (-4.3A)
None
None
 1.10A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 GLU A 135
GLY A 182
LEU A 183
HIS A 385
ARG A 699
 None
GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
GLC  A1001 ( 4.9A)
 0.75A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		5 GLY A 211
GLY A 212
LEU A 213
PRO A 260
PRO A 170
 None
 1.10A 6gngB-5m49A:
undetectable		 6gngB-5m49A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 GLY A 485
GLY A 516
GLY A 560
ASN A 511
GLU A 559
 None
 1.08A 6gngB-5o3wA:
2.5		 6gngB-5o3wA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 5 GLY A 283
GLY A 285
GLY A 268
ASN A  94
ARG A 282
 IMP  A 400 (-3.3A)
AUN  A 401 ( 3.2A)
None
None
None
 1.11A 6gngB-5ou3A:
undetectable		 6gngB-5ou3A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 GLY A  30
GLY A  31
LEU A  32
HIS A 142
ARG A 277
 UDP  A 501 (-3.4A)
UDP  A 501 ( 3.1A)
G6P  A 502 (-3.9A)
G6P  A 502 (-4.7A)
UDP  A 501 ( 3.9A)
 0.88A 6gngB-5v0tA:
21.9		 6gngB-5v0tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		5 GLY A 226
GLY A 225
GLY A 182
HIS A   6
GLU A 148
 None
None
None
ZN  A 400 (-3.3A)
None
 1.00A 6gngB-5vn5A:
undetectable		 6gngB-5vn5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 5 GLY A  99
GLY A  95
LEU A  96
GLY A  57
GLU A   3
 None
 0.97A 6gngB-5xksA:
6.0		 6gngB-5xksA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avw CARBOXYLESTERASE
SOBER1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 109
GLY A 108
LEU A 111
GLY A 124
PRO A  39
 None
 0.94A 6gngB-6avwA:
5.6		 6gngB-6avwA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 5 GLY A  56
GLY A  57
LEU A  60
GLY A 111
PRO A  35
 None
 1.06A 6gngB-6co9A:
undetectable		 6gngB-6co9A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A  53
GLY A  54
LEU A  57
GLY A 108
PRO A  32
 None
 1.09A 6gngB-6conA:
2.1		 6gngB-6conA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 GLY A 545
GLY A 544
LEU A 328
GLY A 439
PRO A 512
 None
 1.00A 6gngB-6etzA:
undetectable		 6gngB-6etzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 GLY A 193
GLY A 147
LEU A 146
GLY A 442
ASN A 456
 None
None
FAD  A 600 (-4.9A)
None
None
 0.91A 6gngB-6fydA:
undetectable		 6gngB-6fydA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1i -

(-) 		no annotation 5 GLY A 198
GLY A 318
LEU A 317
GLY A 293
PRO A 345
 None
 1.03A 6gngB-6g1iA:
undetectable		 6gngB-6g1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 8 GLU A  33
GLY A  41
GLY A  42
LEU A  43
ASN A 191
ARG A 332
GLN A 336
PRO A 413
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.5A)
 0.51A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 6 GLU A  33
GLY A  42
LEU A  43
ASN A 191
GLN A 336
PRO A 413
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.5A)
 0.98A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 6 GLY A  41
GLY A  42
GLY A 128
ASN A 191
ARG A 332
PRO A 413
 ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.9A)
ACR  A 602 (-4.9A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.5A)
 1.34A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 10 GLU A  10
GLY A  18
GLY A  19
LEU A  20
HIS A 153
ASN A 182
PRO A 216
ARG A 338
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.3A)
QPS  A 602 (-3.9A)
QPS  A 602 (-4.4A)
None
ADP  A 601 ( 4.1A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.39A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 8 GLU A  10
GLY A  18
GLY A  19
LEU A  20
PRO A 215
ARG A 338
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.3A)
SO4  A 606 (-4.7A)
ADP  A 601 ( 4.1A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.92A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 6 GLU A  10
GLY A  19
GLY A 368
ASN A 182
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.3A)
None
QPS  A 602 (-4.4A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 1.36A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 7 GLU A  10
GLY A  19
LEU A  20
HIS A 153
ASN A 182
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.3A)
QPS  A 602 (-3.9A)
QPS  A 602 (-4.4A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.97A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 7 GLY A  18
GLY A  19
ASN A 182
PRO A 225
ARG A 338
GLN A 342
PRO A 415
 ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.4A)
None
ADP  A 601 ( 4.1A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.74A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable