SIMILAR PATTERNS OF AMINO ACIDS FOR 6GNG_B_QPSB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 THR A 443
PRO A 506
VAL A 629
CYH A 159
GLY A 162
 None
 1.49A 6gngB-1cu1A:
undetectable		 6gngB-1cu1A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 THR A 262
HIS A 367
PRO A 257
GLU A 194
GLY A 183
 None
 1.44A 6gngB-1e4oA:
23.3		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 TYR A 256
HIS A 345
VAL A 420
GLU A 637
GLY A 640
 GLC  A 996 (-3.8A)
GLC  A 998 (-4.3A)
None
GLC  A 998 (-3.6A)
PLP  A 999 ( 3.2A)
 0.77A 6gngB-1e4oA:
23.3		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee2 ALCOHOL
DEHYDROGENASE

(Equus caballus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 289
THR A  56
PRO A 118
VAL A 185
GLY A 178
 None
 1.43A 6gngB-1ee2A:
3.8		 6gngB-1ee2A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcd FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(CYTOCHROME SUBUNIT)
FLAVOCYTOCHROME C
SULFIDE
DEHYDROGENASE
(FLAVIN-BINDING
SUBUNIT)

(Allochromatium
vinosum) 		PF07992
(Pyr_redox_2)
PF09242
(FCSD-flav_bind)
no annotation 		5 VAL C  22
TYR A 338
TYR A 306
PRO A 302
GLY C  19
 None
 1.40A 6gngB-1fcdC:
undetectable		 6gngB-1fcdC:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		5 THR A 131
VAL A 250
TRP A 125
PRO A 144
GLY A 323
 None
 1.44A 6gngB-1n76A:
undetectable		 6gngB-1n76A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qe0 HISTIDINE--TRNA
LIGASE

(Staphylococcus
aureus) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		5 THR A 224
VAL A 147
GLU A 268
CYH A 284
GLY A 285
 None
 1.23A 6gngB-1qe0A:
2.7		 6gngB-1qe0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rwr FILAMENTOUS
HEMAGGLUTININ

(Bordetella
pertussis) 		PF05860
(Haemagg_act) 		5 VAL A 131
THR A 116
HIS A  33
PRO A  19
GLY A  30
 None
 0.94A 6gngB-1rwrA:
undetectable		 6gngB-1rwrA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 THR A  16
VAL A  22
TYR A  96
TRP A 139
HIS A 163
VAL A 213
 None
 0.48A 6gngB-1rzvA:
40.5		 6gngB-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A  22
HIS A 163
VAL A 213
GLU A 376
CYH A 378
 None
 0.72A 6gngB-1rzvA:
40.5		 6gngB-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A  22
TRP A 139
HIS A 163
VAL A 213
CYH A 378
 None
 0.79A 6gngB-1rzvA:
40.5		 6gngB-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A  22
VAL A 213
GLU A 376
CYH A 378
GLY A 379
 None
 0.65A 6gngB-1rzvA:
40.5		 6gngB-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de2 DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME B

(Rhodococcus sp.
IGTS8) 		no annotation 5 TYR A  24
HIS A 294
PRO A  76
VAL A 305
GLY A 299
 GOL  A 507 (-4.6A)
None
None
None
None
 1.45A 6gngB-2de2A:
undetectable		 6gngB-2de2A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		5 TYR A 229
THR A  98
TYR A 203
VAL A 291
GLY A  39
 None
PLP  A 400 (-3.0A)
PLP  A 400 (-4.2A)
None
None
 1.49A 6gngB-2o1bA:
undetectable		 6gngB-2o1bA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3b NUCLEASE
SUGAR-NON-SPECIFIC
NUCLEASE INHIBITOR

(Nostoc sp. PCC
7120) 		PF01223
(Endonuclease_NS)
PF07924
(NuiA) 		5 THR A  75
PRO A  99
VAL B 110
GLU A 163
GLY A 160
 None
None
MES  A 901 (-4.6A)
MG  A 303 ( 3.9A)
MES  A 901 (-3.4A)
 1.47A 6gngB-2o3bA:
undetectable		 6gngB-2o3bA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 TYR A 290
TRP A  14
HIS A 325
VAL A  55
GLY A 339
 None
None
ZN  A1515 ( 3.2A)
None
None
 1.47A 6gngB-2w8sA:
undetectable		 6gngB-2w8sA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 THR A  16
VAL A  22
TYR A  95
TRP A 138
HIS A 161
TYR A 165
VAL A 211
 None
 0.71A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 VAL A  22
HIS A 161
VAL A 211
GLU A 377
GLY A 380
 None
 0.93A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 VAL A  22
TRP A 138
HIS A 161
TYR A 165
VAL A 211
GLY A 380
 None
 1.00A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		5 THR A  96
THR A 126
HIS A 306
PRO A 176
GLY A 323
 None
None
None
None
FLC  A 424 (-3.2A)
 1.30A 6gngB-3d6nA:
undetectable		 6gngB-3d6nA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ewb 2-ISOPROPYLMALATE
SYNTHASE

(Listeria
monocytogenes) 		PF00682
(HMGL-like) 		5 VAL X 134
THR X 101
VAL X  41
GLU X  43
GLY X  71
 None
 1.45A 6gngB-3ewbX:
undetectable		 6gngB-3ewbX:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN

(Bacteroides
fragilis) 		PF12985
(DUF3869) 		5 VAL A  81
THR A 175
TYR A 232
PRO A 162
VAL A 104
 None
 1.36A 6gngB-3g3lA:
undetectable		 6gngB-3g3lA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		5 THR X  46
VAL X  60
TYR X  98
PRO X 125
VAL X  89
 NDP  X 207 (-3.2A)
None
None
None
None
 1.38A 6gngB-3i8aX:
undetectable		 6gngB-3i8aX:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 TYR A  89
TRP A 129
HIS A 151
VAL A 193
GLU A 339
GLY A 342
 GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
K  A5600 (-4.0A)
K  A5600 (-4.4A)
 0.83A 6gngB-3l01A:
34.6		 6gngB-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1w UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF03372
(Exo_endo_phos) 		5 THR A   5
THR A 198
VAL A  49
GLU A  72
GLY A  73
 None
 1.43A 6gngB-3l1wA:
undetectable		 6gngB-3l1wA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3u LIGNIN PEROXIDASE

(Trametopsis
cervina) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 THR A  90
THR A  79
HIS A  39
PRO A 145
VAL A 336
 None
None
HEM  A 338 (-4.6A)
HEM  A 338 ( 4.6A)
None
 1.42A 6gngB-3q3uA:
undetectable		 6gngB-3q3uA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qki GLUCOSE-6-PHOSPHATE
ISOMERASE

(Plasmodium
falciparum) 		PF00342
(PGI) 		5 VAL A 297
TYR A 312
VAL A 166
CYH A 508
GLY A 509
 None
 1.43A 6gngB-3qkiA:
2.7		 6gngB-3qkiA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3us8 ISOCITRATE
DEHYDROGENASE [NADP]

(Sinorhizobium
meliloti) 		PF00180
(Iso_dh) 		5 THR A 290
VAL A 279
TYR A 197
CYH A 267
GLY A 272
 None
 1.43A 6gngB-3us8A:
2.8		 6gngB-3us8A:
23.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		8 THR A  98
VAL A 104
TRP A 235
HIS A 264
TYR A 268
VAL A 321
CYH A 487
GLY A 488
 None
None
SO4  A 701 ( 4.8A)
None
SO4  A 701 (-4.8A)
None
None
None
 0.66A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		8 THR A  98
VAL A 104
TRP A 235
HIS A 264
VAL A 321
GLU A 485
CYH A 487
GLY A 488
 None
None
SO4  A 701 ( 4.8A)
None
None
None
None
None
 0.49A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 THR A1268
VAL A1292
TYR A1264
VAL A1278
GLY A1318
 None
 1.43A 6gngB-4acqA:
undetectable		 6gngB-4acqA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bzi SEC23P

(Saccharomyces
cerevisiae) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 VAL A 507
THR A 516
VAL A  12
CYH A  35
GLY A  34
 None
 1.37A 6gngB-4bziA:
4.9		 6gngB-4bziA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlo BRAIN-SPECIFIC
ANGIOGENESIS
INHIBITOR 3

(Homo sapiens) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		5 THR A 627
THR A 599
HIS A 683
VAL A 761
GLY A 688
 None
 1.31A 6gngB-4dloA:
undetectable		 6gngB-4dloA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jos ADENOSYLHOMOCYSTEINE
NUCLEOSIDASE

(Francisella
philomiragia) 		PF01048
(PNP_UDP_1) 		5 THR A  95
VAL A 161
HIS A  98
VAL A 152
GLY A  79
 None
None
None
ADE  A 301 (-4.2A)
ADE  A 301 (-3.7A)
 1.32A 6gngB-4josA:
2.8		 6gngB-4josA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		5 VAL A 279
THR A 173
VAL A 228
GLU A 266
CYH A 342
 None
 1.32A 6gngB-4krfA:
2.0		 6gngB-4krfA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4maa PUTATIVE
BRANCHED-CHAIN AMINO
ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Pseudomonas
protegens) 		PF13458
(Peripla_BP_6) 		5 THR A 155
VAL A 252
TRP A 256
PRO A 126
GLY A 367
 None
None
GOL  A 503 (-4.6A)
None
None
 1.45A 6gngB-4maaA:
4.7		 6gngB-4maaA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 VAL A 188
TYR A 364
THR A 325
VAL A 204
GLY A 199
 None
 1.02A 6gngB-4nurA:
undetectable		 6gngB-4nurA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nur PSDSA

(Pseudomonas sp.
S9) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		5 VAL A 188
TYR A 364
THR A 325
VAL A 204
GLY A 200
 None
 1.27A 6gngB-4nurA:
undetectable		 6gngB-4nurA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz5 DEACETYLASE DA1

(Vibrio cholerae) 		PF01522
(Polysacc_deac_1) 		5 VAL A 351
TYR A  35
THR A  37
GLU A 163
GLY A 355
 None
None
None
None
NA  A 501 (-4.0A)
 1.39A 6gngB-4nz5A:
undetectable		 6gngB-4nz5A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 VAL A  63
HIS A 223
VAL A 276
GLU A 531
GLY A 534
 None
 1.06A 6gngB-4qlbA:
18.6		 6gngB-4qlbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qlb PROBABLE GLYCOGEN
[STARCH] SYNTHASE

(Caenorhabditis
elegans) 		PF05693
(Glycogen_syn) 		5 VAL A  63
TRP A 200
HIS A 223
VAL A 276
GLY A 534
 None
 0.75A 6gngB-4qlbA:
18.6		 6gngB-4qlbA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 VAL B 165
TYR A 221
THR A 249
PRO A 298
GLY B 192
 None
 1.49A 6gngB-4um8B:
2.8		 6gngB-4um8B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4um8 INTEGRIN ALPHA-V
INTEGRIN BETA-6

(Homo sapiens) 		PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 VAL B 169
TYR A 221
THR A 249
PRO A 298
GLY B 192
 None
 1.45A 6gngB-4um8B:
2.8		 6gngB-4um8B:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w91 AMINOTRANSFERASE

(Brucella suis) 		PF00266
(Aminotran_5) 		5 VAL A 218
HIS A 180
VAL A 207
CYH A 225
GLY A 224
 None
 1.12A 6gngB-4w91A:
undetectable		 6gngB-4w91A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgj NITRILE HYDRATASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02211
(NHase_beta) 		5 THR B 136
TYR B 201
PRO B 115
GLU B 166
GLY B 165
 None
 1.39A 6gngB-4zgjB:
undetectable		 6gngB-4zgjB:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 THR A 128
VAL A 333
PRO A   9
GLU A 293
GLY A 286
 None
 1.44A 6gngB-5giuA:
undetectable		 6gngB-5giuA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gt5 PECTATE LYASE

(Paenibacillus
sp. 0602) 		no annotation 5 TYR A 146
TRP A 138
HIS A  83
VAL A  85
GLY A  90
 None
 1.46A 6gngB-5gt5A:
undetectable		 6gngB-5gt5A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iai SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF01547
(SBP_bac_1) 		5 VAL A 377
THR A  97
PRO A 396
VAL A 157
GLY A 280
 None
 1.39A 6gngB-5iaiA:
undetectable		 6gngB-5iaiA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 TYR A 280
HIS A 377
VAL A 455
GLU A 672
GLY A 675
 None
None
None
None
PLP  A 901 (-3.3A)
 0.76A 6gngB-5ikpA:
21.5		 6gngB-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		5 THR B 693
VAL B 309
THR B 669
VAL B 444
GLY B 481
 None
 1.36A 6gngB-5l9wB:
undetectable		 6gngB-5l9wB:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 TYR A 329
HIS A 421
VAL A 584
GLU A 806
GLY A 809
 None
GLC  A1001 (-3.7A)
None
GLC  A1001 (-3.4A)
GLC  A1001 ( 3.6A)
 0.83A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqd ARSENITE OXIDASE
LARGE SUBUNIT AIOA
[3FE-4S] CLUSTER,
MO-MOLYBDOPTERIN
COFACTOR-BINDING
ACTIVE SITE

(Rhizobium sp.
NT-26) 		no annotation 5 VAL A 510
TYR A 490
THR A 493
HIS A 555
GLY A 480
 None
 1.11A 6gngB-5nqdA:
undetectable		 6gngB-5nqdA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5unc PHOSPHOENOLPYRUVATE
PHOSPHOMUTASE

(Streptomyces
platensis) 		PF13714
(PEP_mutase) 		5 VAL A  96
TYR A 103
VAL A 248
GLU A  62
GLY A  38
 None
 1.35A 6gngB-5uncA:
undetectable		 6gngB-5uncA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A  27
HIS A 193
VAL A 247
GLU A 509
GLY A 512
 None
None
None
UDP  A 801 (-3.9A)
UDP  A 801 (-3.5A)
 1.01A 6gngB-5vncA:
10.1		 6gngB-5vncA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnc GLYCOGEN [STARCH]
SYNTHASE ISOFORM 2

(Saccharomyces
cerevisiae) 		no annotation 5 VAL A  27
TRP A 170
HIS A 193
VAL A 247
GLY A 512
 None
None
None
None
UDP  A 801 (-3.5A)
 0.72A 6gngB-5vncA:
10.1		 6gngB-5vncA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 THR A 586
VAL A 556
THR A 281
VAL A 526
GLY A 570
 None
 1.36A 6gngB-5xapA:
undetectable		 6gngB-5xapA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfm ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		no annotation 5 THR A  64
TYR A 131
PRO A  43
VAL A 286
GLY A 218
 None
 1.48A 6gngB-5xfmA:
2.1		 6gngB-5xfmA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq4 SIDE

(Legionella
pneumophila) 		no annotation 5 TYR B 421
HIS B 403
TYR B 285
VAL B 331
GLY B 275
 None
AMP  B 601 (-3.9A)
None
None
None
 1.44A 6gngB-5zq4B:
undetectable		 6gngB-5zq4B:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 9 VAL A  46
TYR A 127
TRP A 162
HIS A 190
TYR A 194
VAL A 244
GLU A 412
CYH A 414
GLY A 415
 ACR  A 602 (-4.9A)
ACR  A 602 ( 4.2A)
ACR  A 602 (-4.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.0A)
ACR  A 602 (-4.3A)
ACR  A 602 (-3.7A)
ACR  A 602 (-4.3A)
ADP  A 601 ( 3.5A)
 0.48A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 6 THR A  17
VAL A  23
TYR A 101
PRO A 216
GLU A 414
GLY A 417
 QPS  A 602 (-3.2A)
None
QPS  A 602 (-3.9A)
None
QPS  A 602 (-3.6A)
QPS  A 602 (-3.7A)
 1.33A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 10 THR A  17
VAL A  23
TYR A 101
TRP A 152
HIS A 181
PRO A 215
VAL A 251
GLU A 414
CYH A 416
GLY A 417
 QPS  A 602 (-3.2A)
None
QPS  A 602 (-3.9A)
SO4  A 606 ( 3.3A)
QPS  A 602 (-4.1A)
SO4  A 606 (-4.7A)
QPS  A 602 ( 4.6A)
QPS  A 602 (-3.6A)
QPS  A 602 (-4.9A)
QPS  A 602 (-3.7A)
 0.35A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
13pk 3-PHOSPHOGLYCERATE
KINASE

(Trypanosoma
brucei) 		PF00162
(PGK) 		5 GLY A 398
GLY A 375
GLY A 412
HIS A  62
PRO A 181
 ADP  A 421 ( 4.3A)
ADP  A 421 (-3.3A)
None
3PG  A 423 (-4.1A)
None
 0.95A 6gngB-13pkA:
3.6		 6gngB-13pkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3d [NIFE] HYDROGENASE
LARGE SUBUNIT

(Desulfovibrio
desulfuricans) 		PF00374
(NiFeSe_Hases) 		5 GLY B 470
GLY B 471
LEU B 472
GLY B  25
PRO B 367
 None
None
FNE  B 543 (-3.4A)
None
None
 1.05A 6gngB-1e3dB:
undetectable		 6gngB-1e3dB:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		6 GLU A  67
GLY A 113
GLY A 114
LEU A 115
HIS A 309
ARG A 534
 GLC  A 997 (-3.3A)
GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
 0.65A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 GLU A  67
GLY A 114
LEU A 115
HIS A 309
ARG A 534
 GLC  A 997 (-3.3A)
PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-4.0A)
GLC  A 996 (-4.1A)
 1.07A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp9 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
thermophilus) 		PF02446
(Glyco_hydro_77) 		5 GLU A 340
GLY A 343
LEU A 342
GLY A 357
PRO A 375
 None
 1.11A 6gngB-1fp9A:
undetectable		 6gngB-1fp9A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		6 GLY A  21
GLY A  22
LEU A  23
GLY A 301
HIS A 132
ARG A 262
 UDP  A 900 (-3.4A)
IMD  A 902 (-3.0A)
G6P  A 901 ( 3.7A)
None
G6P  A 901 (-4.5A)
UDP  A 900 ( 3.8A)
 1.16A 6gngB-1gz5A:
22.1		 6gngB-1gz5A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 GLY A 413
GLY A 415
GLY A 398
ASN A  94
ARG A 412
 IMP  A1331 (-3.5A)
IMP  A1331 ( 3.1A)
None
None
None
 1.07A 6gngB-1jr1A:
undetectable		 6gngB-1jr1A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLU A   9
GLY A  17
GLY A  18
LEU A  19
PRO A 377
 None
 0.68A 6gngB-1rzvA:
40.5		 6gngB-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz5 402AA LONG
HYPOTHETICAL
MOLYBDOPTERIN
BIOSYNTHESIS MOEA
PROTEIN

(Pyrococcus
horikoshii) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		5 GLY A 254
GLY A 302
GLY A 290
ASN A 310
PRO A 283
 None
None
None
None
SO4  A1406 (-4.4A)
 0.94A 6gngB-1uz5A:
undetectable		 6gngB-1uz5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1
GLYCINE
DEHYDROGENASE
SUBUNIT 2
(P-PROTEIN)

(Thermus
thermophilus) 		PF02347
(GDC-P) 		5 GLY A  71
GLY A  70
LEU A  69
GLY B 322
GLN A 256
 None
 1.04A 6gngB-1wytA:
2.2		 6gngB-1wytA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ARG A 569
 None
PO4  A1900 (-3.7A)
PLP  A 860 ( 3.3A)
None
None
PO4  A1900 (-3.7A)
 0.50A 6gngB-1ygpA:
20.8		 6gngB-1ygpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yx2 AMINOMETHYLTRANSFERA
SE

(Bacillus
subtilis) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 GLY A 226
LEU A 225
HIS A  51
ARG A 232
GLN A 242
 None
 1.09A 6gngB-1yx2A:
undetectable		 6gngB-1yx2A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 GLY A 218
GLY A 219
LEU A 222
GLY A 164
PRO A 115
 None
 1.06A 6gngB-1yzyA:
2.3		 6gngB-1yzyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zj9 PROBABLE
FERREDOXIN-DEPENDENT
NITRITE REDUCTASE
NIRA

(Mycobacterium
tuberculosis) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLU A 221
GLY A 502
LEU A 501
GLY A 214
GLU A 180
 None
 1.10A 6gngB-1zj9A:
undetectable		 6gngB-1zj9A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 GLU A  67
GLY A 113
GLY A 114
LEU A 115
HIS A 298
 None
PO4  A1794 (-3.5A)
PO4  A1794 (-3.4A)
None
None
 0.38A 6gngB-2c4mA:
22.2		 6gngB-2c4mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 161
GLY A 160
GLY A  81
HIS A 247
PRO A 202
 None
None
None
HMG  A 500 (-3.3A)
None
 1.06A 6gngB-2fa0A:
undetectable		 6gngB-2fa0A:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gez L-ASPARAGINASE ALPHA
SUBUNIT
L-ASPARAGINASE BETA
SUBUNIT

(Lupinus luteus) 		PF01112
(Asparaginase_2) 		5 GLY B 213
GLY B 212
GLY B 229
HIS A   9
PRO A 105
 CL  B 406 (-3.7A)
None
None
None
None
 1.02A 6gngB-2gezB:
undetectable		 6gngB-2gezB:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 GLU A  88
GLY A 134
GLY A 135
GLY A 612
ASN A 284
 None
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
 1.03A 6gngB-2gj4A:
21.8		 6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ASN A 284
 None
PLR  A 940 (-3.6A)
PLR  A 940 ( 3.8A)
None
None
None
 1.12A 6gngB-2gj4A:
21.8		 6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM

(Oryctolagus
cuniculus) 		PF00343
(Phosphorylase) 		5 GLU A  88
GLY A 134
LEU A 136
HIS A 341
ASN A 284
 None
PLR  A 940 (-3.6A)
None
None
None
 1.07A 6gngB-2gj4A:
21.8		 6gngB-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ics ADENINE DEAMINASE

(Enterococcus
faecalis) 		PF01979
(Amidohydro_1) 		5 GLY A 121
GLY A 247
PRO A 282
ARG A 156
GLN A 125
 None
None
None
ADE  A1114 (-4.3A)
ADE  A1114 (-3.3A)
 1.11A 6gngB-2icsA:
undetectable		 6gngB-2icsA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o5p FERRIPYOVERDINE
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07660
(STN)
PF07715
(Plug) 		5 GLY A 548
LEU A 547
GLY A 463
PRO A  74
PRO A 166
 None
 1.04A 6gngB-2o5pA:
undetectable		 6gngB-2o5pA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p8u HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
CYTOPLASMIC

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 173
GLY A 172
GLY A  93
HIS A 264
PRO A 214
 None
None
None
SCY  A 129 ( 3.7A)
None
 1.06A 6gngB-2p8uA:
undetectable		 6gngB-2p8uA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 GLY A 210
GLY A 209
GLY A 130
HIS A 301
PRO A 251
 None
None
None
HMG  A1509 (-4.1A)
None
 1.11A 6gngB-2wyaA:
undetectable		 6gngB-2wyaA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1i 4-ALPHA-GLUCANOTRANS
FERASE

(Thermus
brockianus) 		PF02446
(Glyco_hydro_77) 		5 GLU A 340
GLY A 343
LEU A 342
GLY A 357
PRO A 375
 None
 1.11A 6gngB-2x1iA:
undetectable		 6gngB-2x1iA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		5 GLY A 245
GLY A 246
GLY A 227
GLU A 228
PRO A 217
 None
 1.08A 6gngB-3b9gA:
4.3		 6gngB-3b9gA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE

(Lactobacillus
plantarum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 GLY A  16
GLY A  19
HIS A  83
GLU A 221
ARG A  17
 NAD  A 400 (-3.3A)
NAD  A 400 ( 4.9A)
NAD  A 400 (-3.8A)
None
NAD  A 400 (-3.2A)
 1.04A 6gngB-3ceaA:
4.1		 6gngB-3ceaA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ARG A 569
 None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
None
 1.47A 6gngB-3cemA:
22.2		 6gngB-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		6 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
ASN A 284
 None
PLP  A 832 (-3.6A)
PLP  A 832 (-3.9A)
NBG  A   1 (-4.1A)
None
NBG  A   1 (-3.5A)
 1.30A 6gngB-3cemA:
22.2		 6gngB-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLU A   9
GLY A  17
GLY A  18
LEU A  19
HIS A 139
 None
 0.78A 6gngB-3d1jA:
40.8		 6gngB-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gri DIHYDROOROTASE

(Staphylococcus
aureus) 		PF01979
(Amidohydro_1) 		5 GLY A 422
GLY A 325
ASN A 408
PRO A 256
ARG A  81
 None
 0.89A 6gngB-3griA:
2.1		 6gngB-3griA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hin PUTATIVE
3-HYDROXYBUTYRYL-COA
DEHYDRATASE

(Rhodopseudomonas
palustris) 		PF00378
(ECH_1) 		5 GLY A 120
GLY A  74
LEU A  75
HIS A  91
ASN A  41
 None
 1.04A 6gngB-3hinA:
2.5		 6gngB-3hinA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ie1 RIBONUCLEASE
TTHA0252

(Thermus
thermophilus) 		PF00753
(Lactamase_B)
PF07521
(RMMBL)
PF10996
(Beta-Casp) 		5 GLY A 164
GLY A 140
GLY A 340
HIS A  61
PRO A 221
 None
None
SO4  A 447 (-3.3A)
ZN  A 453 (-3.4A)
None
 1.09A 6gngB-3ie1A:
2.4		 6gngB-3ie1A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		6 GLU A   9
GLY A  16
GLY A  17
LEU A  18
HIS A 130
PRO A 340
 None
CL  A5703 ( 3.9A)
CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6502 ( 3.8A)
K  A5600 ( 4.8A)
 0.84A 6gngB-3l01A:
34.5		 6gngB-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLU A   9
GLY A  17
LEU A  18
HIS A 130
PRO A 340
 None
CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6502 ( 3.8A)
K  A5600 ( 4.8A)
 0.85A 6gngB-3l01A:
34.5		 6gngB-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		5 GLY A 276
GLY A 262
LEU A 263
GLN A 270
PRO A  32
 None
 1.11A 6gngB-3lm6A:
undetectable		 6gngB-3lm6A:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om8 PROBABLE HYDROLASE

(Pseudomonas
aeruginosa) 		PF00561
(Abhydrolase_1) 		5 GLY A 102
GLY A  97
LEU A  98
GLY A 188
ASN A  32
 None
 1.09A 6gngB-3om8A:
5.6		 6gngB-3om8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox5 CALCIUM-BINDING
PROTEIN 1

(Homo sapiens) 		PF13499
(EF-hand_7) 		5 GLY A  76
GLY A  75
LEU A  74
GLY A  48
GLN A  68
 None
 1.01A 6gngB-3ox5A:
undetectable		 6gngB-3ox5A:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 GLY A 728
GLY A 729
LEU A 730
GLY A 616
PRO A 720
 None
None
None
AMP  A 747 ( 4.0A)
None
 0.91A 6gngB-3ttfA:
undetectable		 6gngB-3ttfA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgl GLUCOKINASE

(Streptomyces
griseus) 		PF00480
(ROK) 		5 GLY A 112
GLY A 133
ASN A 107
PRO A  79
GLU A 176
 None
BGC  A 324 ( 3.9A)
NA  A 323 (-3.2A)
BGC  A 324 (-3.9A)
BGC  A 324 (-2.8A)
 1.08A 6gngB-3vglA:
undetectable		 6gngB-3vglA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vre HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA/DELTA HYBRID

(Mammuthus
primigenius) 		PF00042
(Globin) 		5 GLY B  24
GLY B  25
LEU B  28
GLU B 131
PRO A 119
 None
 1.06A 6gngB-3vreB:
undetectable		 6gngB-3vreB:
14.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
GLY A 100
HIS A 236
ARG A 408
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
SO4  A 704 (-4.1A)
None
SO4  A 704 (-3.7A)
SO4  A 704 ( 3.7A)
None
 0.83A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
GLY A 100
LEU A 101
HIS A 236
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
SO4  A 704 (-4.1A)
None
None
SO4  A 704 ( 3.7A)
None
 0.78A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
HIS A 236
ASN A 265
ARG A 408
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
None
SO4  A 704 ( 4.2A)
SO4  A 704 (-3.7A)
SO4  A 704 ( 3.7A)
None
 1.16A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A  99
LEU A 101
HIS A 236
ASN A 265
GLN A 412
PRO A 486
 None
SO4  A 704 (-3.2A)
None
None
SO4  A 704 ( 4.2A)
SO4  A 704 ( 3.7A)
None
 1.23A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A 100
HIS A 236
ASN A 265
ARG A 408
GLN A 412
PRO A 486
 None
SO4  A 704 (-4.1A)
None
SO4  A 704 ( 4.2A)
SO4  A 704 (-3.7A)
SO4  A 704 ( 3.7A)
None
 0.83A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLU A  91
GLY A 100
LEU A 101
HIS A 236
ASN A 265
GLN A 412
PRO A 486
 None
SO4  A 704 (-4.1A)
None
None
SO4  A 704 ( 4.2A)
SO4  A 704 ( 3.7A)
None
 0.78A 6gngB-3vueA:
47.6		 6gngB-3vueA:
46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bbw SIALIDASE
(NEURAMINIDASE)

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2)
PF14873
(BNR_assoc_N) 		5 GLY A 420
GLY A 419
GLY A 509
PRO A 206
GLU A 526
 None
 1.05A 6gngB-4bbwA:
undetectable		 6gngB-4bbwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		6 GLU A  91
GLY A 137
GLY A 138
LEU A 139
GLY A 287
HIS A 343
 None
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
 1.04A 6gngB-4bqiA:
22.3		 6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		6 GLU A  91
GLY A 137
GLY A 138
LEU A 139
HIS A 343
ARG A 573
 None
PLP  A 901 ( 4.2A)
PLP  A 901 (-3.3A)
None
None
None
 0.60A 6gngB-4bqiA:
22.3		 6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		5 GLU A  91
GLY A 137
LEU A 139
GLY A 287
HIS A 343
 None
PLP  A 901 ( 4.2A)
None
None
None
 1.09A 6gngB-4bqiA:
22.3		 6gngB-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 GLY A 332
GLY A 333
LEU A 334
GLY A  98
ASN A 114
 None
 0.98A 6gngB-4fl0A:
undetectable		 6gngB-4fl0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fl0 AMINOTRANSFERASE
ALD1

(Arabidopsis
thaliana) 		PF00155
(Aminotran_1_2) 		5 GLY A 332
GLY A 333
LEU A 334
GLY A 104
ASN A 114
 None
 0.93A 6gngB-4fl0A:
undetectable		 6gngB-4fl0A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		5 GLY A 354
GLY A 355
GLY A 430
ASN A 450
GLN A 367
 None
None
None
None
TRH  A 502 (-4.1A)
 0.97A 6gngB-4j7hA:
undetectable		 6gngB-4j7hA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		6 GLU A  58
GLY A 104
GLY A 105
LEU A 106
HIS A 281
ARG A 498
 None
 0.67A 6gngB-4l22A:
23.1		 6gngB-4l22A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lhe THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Bacillus sp.
H-257) 		PF12146
(Hydrolase_4) 		5 GLY A  99
GLY A  95
LEU A  96
GLY A  57
GLU A   3
 None
None
SO4  A 302 ( 4.9A)
None
None
 0.94A 6gngB-4lheA:
5.8		 6gngB-4lheA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lz6 BH2163 PROTEIN

(Bacillus
halodurans) 		PF01554
(MatE) 		5 GLY A 380
GLY A 379
GLY A 308
GLU A  87
PRO A 247
 None
 1.10A 6gngB-4lz6A:
undetectable		 6gngB-4lz6A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A 186
GLY A 185
LEU A 227
GLY A 222
PRO A 251
 SEP  A 184 ( 3.2A)
SEP  A 184 ( 2.4A)
None
None
None
 1.05A 6gngB-4m69A:
undetectable		 6gngB-4m69A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Campylobacter
jejuni) 		PF00478
(IMPDH) 		5 GLY A 383
GLY A 385
GLY A 368
ASN A  72
ARG A 382
 IMP  A 500 (-3.3A)
IMP  A 500 ( 3.3A)
None
None
None
 1.00A 6gngB-4mz1A:
undetectable		 6gngB-4mz1A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovq TRAP DICARBOXYLATE
ABC TRANSPORTER,
SUBSTRATE-BINDING
PROTEIN

(Roseobacter
denitrificans) 		PF03480
(DctP) 		5 GLY A 184
GLY A 183
LEU A 182
HIS A 230
PRO A  92
 None
 1.04A 6gngB-4ovqA:
undetectable		 6gngB-4ovqA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 GLY A 181
LEU A 184
GLY A 312
GLN A 496
PRO A 497
 None
None
AER  A 601 ( 3.7A)
None
None
 1.05A 6gngB-4r1zA:
undetectable		 6gngB-4r1zA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvh D-MYCAROSE
3-C-METHYLTRANSFERAS
E

(Streptomyces
argillaceus) 		PF08421
(Methyltransf_13)
PF08484
(Methyltransf_14)
PF13489
(Methyltransf_23) 		5 GLY A 257
GLY A 256
GLY A 176
HIS A 226
GLU A 112
 None
None
None
3YN  A 503 (-4.5A)
None
 0.99A 6gngB-4rvhA:
2.8		 6gngB-4rvhA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1k POLYHEDRIN

(Uranotaenia
sapphirina
cypovirus) 		PF17515
(CPV_Polyhedrin) 		5 GLU A 131
GLY A 121
GLY A 124
LEU A 125
GLN A  76
 None
 1.00A 6gngB-4s1kA:
undetectable		 6gngB-4s1kA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9i PERIPLASMIC [NIFE]
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
vulgaris) 		PF00374
(NiFeSe_Hases) 		5 GLY L 480
GLY L 481
LEU L 482
GLY L  35
PRO L 376
 None
None
NWN  L 601 (-3.4A)
None
None
 1.05A 6gngB-4u9iL:
undetectable		 6gngB-4u9iL:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk4 INTEGRIN ALPHA-5

(Homo sapiens) 		PF01839
(FG-GAP) 		5 GLY A 393
LEU A 394
GLY A 238
ASN A 367
GLU A 246
 None
 0.93A 6gngB-4wk4A:
undetectable		 6gngB-4wk4A:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xij SHIKIMATE
5-DEHYDROGENASE

(Mycolicibacterium
fortuitum) 		PF08501
(Shikimate_dh_N) 		5 GLY A 175
GLY A 176
LEU A 179
GLY A 127
PRO A 131
 None
None
None
EDO  A 303 ( 3.7A)
None
 1.10A 6gngB-4xijA:
5.2		 6gngB-4xijA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zow MULTIDRUG
TRANSPORTER MDFA

(Escherichia
coli) 		PF07690
(MFS_1) 		5 GLY A  64
GLY A 116
LEU A 119
GLY A 364
ASN A  33
 None
None
CLM  A 500 ( 4.7A)
None
CLM  A 500 (-3.5A)
 0.99A 6gngB-4zowA:
undetectable		 6gngB-4zowA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahm INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00478
(IMPDH) 		5 GLY A 386
GLY A 388
GLY A 371
ASN A  73
ARG A 385
 IMP  A 501 (-3.1A)
IMP  A 501 (-3.1A)
None
None
None
 0.99A 6gngB-5ahmA:
undetectable		 6gngB-5ahmA:
25.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3v BILIVERDIN REDUCTASE

(Synechocystis
sp. PCC 6803) 		no annotation 5 GLU B 262
GLY B 135
GLY B 278
GLU B 101
GLN B 286
 None
 0.87A 6gngB-5b3vB:
3.9		 6gngB-5b3vB:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5epg ALDEHYDE OXIDASE

(Homo sapiens) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		5 GLY A 342
LEU A 341
GLY A 465
HIS A 358
ARG A 429
 None
None
None
FAD  A3004 (-4.0A)
FAD  A3004 (-4.1A)
 1.06A 6gngB-5epgA:
undetectable		 6gngB-5epgA:
17.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		5 GLY A 269
GLY A 268
LEU A 267
GLY A 364
PRO A 168
 None
 0.94A 6gngB-5htpA:
undetectable		 6gngB-5htpA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 GLU A  88
GLY A 134
GLY A 135
LEU A 136
HIS A 341
 None
PLP  A 901 ( 4.1A)
PLP  A 901 ( 3.8A)
None
None
 0.59A 6gngB-5ikpA:
21.6		 6gngB-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		6 GLU A 135
GLY A 181
GLY A 182
LEU A 183
GLY A 331
HIS A 385
 None
PLP  A1002 ( 4.3A)
GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
None
 1.18A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 GLU A 135
GLY A 181
LEU A 183
GLY A 331
HIS A 385
 None
PLP  A1002 ( 4.3A)
GLC  A1001 (-4.3A)
None
None
 1.10A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 GLU A 135
GLY A 182
LEU A 183
HIS A 385
ARG A 699
 None
GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
GLC  A1001 ( 4.9A)
 0.75A 6gngB-5lrbA:
22.4		 6gngB-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		5 GLY A 211
GLY A 212
LEU A 213
PRO A 260
PRO A 170
 None
 1.10A 6gngB-5m49A:
undetectable		 6gngB-5m49A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 GLY A 485
GLY A 516
GLY A 560
ASN A 511
GLU A 559
 None
 1.08A 6gngB-5o3wA:
2.5		 6gngB-5o3wA:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ou3 INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Mycolicibacterium
thermoresistibile) 		no annotation 5 GLY A 283
GLY A 285
GLY A 268
ASN A  94
ARG A 282
 IMP  A 400 (-3.3A)
AUN  A 401 ( 3.2A)
None
None
None
 1.11A 6gngB-5ou3A:
undetectable		 6gngB-5ou3A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v0t ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Paraburkholderia
xenovorans) 		PF00982
(Glyco_transf_20) 		5 GLY A  30
GLY A  31
LEU A  32
HIS A 142
ARG A 277
 UDP  A 501 (-3.4A)
UDP  A 501 ( 3.1A)
G6P  A 502 (-3.9A)
G6P  A 502 (-4.7A)
UDP  A 501 ( 3.9A)
 0.88A 6gngB-5v0tA:
21.9		 6gngB-5v0tA:
25.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn5 2,2',3-TRIHYDROXY-3'
-METHOXY-5,5'-DICARB
OXYBIPHENYL
META-CLEAVAGE
COMPOUND HYDROLASE

(Sphingobium sp.
SYK-6) 		PF04909
(Amidohydro_2) 		5 GLY A 226
GLY A 225
GLY A 182
HIS A   6
GLU A 148
 None
None
None
ZN  A 400 (-3.3A)
None
 1.00A 6gngB-5vn5A:
undetectable		 6gngB-5vn5A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 5 GLY A  99
GLY A  95
LEU A  96
GLY A  57
GLU A   3
 None
 0.97A 6gngB-5xksA:
6.0		 6gngB-5xksA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avw CARBOXYLESTERASE
SOBER1

(Arabidopsis
thaliana) 		no annotation 5 GLY A 109
GLY A 108
LEU A 111
GLY A 124
PRO A  39
 None
 0.94A 6gngB-6avwA:
5.6		 6gngB-6avwA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co9 PROBABLE
COA-TRANSFERASE
ALPHA SUBUNIT

(Rhodococcus
jostii) 		no annotation 5 GLY A  56
GLY A  57
LEU A  60
GLY A 111
PRO A  35
 None
 1.06A 6gngB-6co9A:
undetectable		 6gngB-6co9A:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6con COA-TRANSFERASE
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 5 GLY A  53
GLY A  54
LEU A  57
GLY A 108
PRO A  32
 None
 1.09A 6gngB-6conA:
2.1		 6gngB-6conA:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 5 GLY A 545
GLY A 544
LEU A 328
GLY A 439
PRO A 512
 None
 1.00A 6gngB-6etzA:
undetectable		 6gngB-6etzA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 GLY A 193
GLY A 147
LEU A 146
GLY A 442
ASN A 456
 None
None
FAD  A 600 (-4.9A)
None
None
 0.91A 6gngB-6fydA:
undetectable		 6gngB-6fydA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g1i -

(-) 		no annotation 5 GLY A 198
GLY A 318
LEU A 317
GLY A 293
PRO A 345
 None
 1.03A 6gngB-6g1iA:
undetectable		 6gngB-6g1iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 8 GLU A  33
GLY A  41
GLY A  42
LEU A  43
ASN A 191
ARG A 332
GLN A 336
PRO A 413
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.5A)
 0.51A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 6 GLU A  33
GLY A  42
LEU A  43
ASN A 191
GLN A 336
PRO A 413
 ACR  A 602 ( 4.6A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.1A)
ACR  A 602 (-3.5A)
 0.98A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 6 GLY A  41
GLY A  42
GLY A 128
ASN A 191
ARG A 332
PRO A 413
 ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.9A)
ACR  A 602 (-4.9A)
ACR  A 602 ( 3.7A)
ACR  A 602 (-3.5A)
 1.34A 6gngB-6gneA:
42.2		 6gngB-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 10 GLU A  10
GLY A  18
GLY A  19
LEU A  20
HIS A 153
ASN A 182
PRO A 216
ARG A 338
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.3A)
QPS  A 602 (-3.9A)
QPS  A 602 (-4.4A)
None
ADP  A 601 ( 4.1A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.39A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 8 GLU A  10
GLY A  18
GLY A  19
LEU A  20
PRO A 215
ARG A 338
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.3A)
SO4  A 606 (-4.7A)
ADP  A 601 ( 4.1A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.92A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 6 GLU A  10
GLY A  19
GLY A 368
ASN A 182
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.3A)
None
QPS  A 602 (-4.4A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 1.36A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 7 GLU A  10
GLY A  19
LEU A  20
HIS A 153
ASN A 182
GLN A 342
PRO A 415
 QPS  A 602 ( 4.5A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.3A)
QPS  A 602 (-3.9A)
QPS  A 602 (-4.4A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.97A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 7 GLY A  18
GLY A  19
ASN A 182
PRO A 225
ARG A 338
GLN A 342
PRO A 415
 ADP  A 601 ( 3.8A)
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.4A)
None
ADP  A 601 ( 4.1A)
QPS  A 602 (-3.2A)
QPS  A 602 (-3.6A)
 0.74A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00215
(OMPdecase) 		3 ASP A  67
ASP A  63
ASN A 120
 None
 0.80A 6gngB-1dqwA:
undetectable		 6gngB-1dqwA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		3 ASP A 259
ASP A 307
ASN A 449
 GLC  A 995 ( 4.4A)
GLC  A 997 (-3.6A)
GLC  A 998 (-3.3A)
 0.64A 6gngB-1e4oA:
23.2		 6gngB-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2d 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
DEAMINASE

(Cyberlindnera
saturnus) 		PF00291
(PALP) 		3 ASP A 257
ASP A 261
ASN A 273
 None
 0.78A 6gngB-1f2dA:
undetectable		 6gngB-1f2dA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fep FERRIC ENTEROBACTIN
RECEPTOR

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ASP A 263
ASP A 201
ASN A 162
 None
 0.84A 6gngB-1fepA:
undetectable		 6gngB-1fepA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiu TYPE II RESTRICTION
ENZYME NGOMI

(Neisseria
gonorrhoeae) 		PF09015
(NgoMIV_restric) 		3 ASP A 193
ASP A  34
ASN A  25
 None
 0.77A 6gngB-1fiuA:
undetectable		 6gngB-1fiuA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gzg DELTA-AMINOLEVULINIC
ACID DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF00490
(ALAD) 		3 ASP A 240
ASP A 274
ASN A  31
 None
 0.82A 6gngB-1gzgA:
3.5		 6gngB-1gzgA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		3 ASP A 189
ASP A 275
ASN A 296
 None
 0.77A 6gngB-1h09A:
undetectable		 6gngB-1h09A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ASP A  14
ASP A 340
ASN A 390
 None
 0.84A 6gngB-1kyiA:
undetectable		 6gngB-1kyiA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		3 ASP A 389
ASP A 281
ASN A 319
 None
 0.86A 6gngB-1mvhA:
undetectable		 6gngB-1mvhA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogk DEOXYURIDINE
TRIPHOSPHATASE

(Trypanosoma
cruzi) 		PF08761
(dUTPase_2) 		3 ASP A  70
ASP A  80
ASN A 201
 None
 0.81A 6gngB-1ogkA:
undetectable		 6gngB-1ogkA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvl LEUCOCIDIN

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		3 ASP A 291
ASP A  89
ASN A 158
 None
 0.80A 6gngB-1pvlA:
undetectable		 6gngB-1pvlA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		3 ASP A 655
ASP A 660
ASN A 560
 None
 0.85A 6gngB-1qxpA:
undetectable		 6gngB-1qxpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		3 ASP A 103
ASP A 138
ASN A 246
 None
 0.64A 6gngB-1rzvA:
40.4		 6gngB-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sus CAFFEOYL-COA
O-METHYLTRANSFERASE

(Medicago sativa) 		PF01596
(Methyltransf_3) 		3 ASP A  27
ASP A 238
ASN A 220
 None
SPF  A 401 ( 4.1A)
None
 0.53A 6gngB-1susA:
2.4		 6gngB-1susA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		3 ASP C 316
ASP C 276
ASN C 202
 None
 0.76A 6gngB-1sxjC:
undetectable		 6gngB-1sxjC:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w99 PESTICIDIAL CRYSTAL
PROTEIN CRY4BA

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 ASP A 478
ASP A 470
ASN A 377
 None
 0.58A 6gngB-1w99A:
undetectable		 6gngB-1w99A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8a HYPOTHETICAL PROTEIN
AF1437

(Archaeoglobus
fulgidus) 		no annotation 3 ASP A 163
ASP A  37
ASN A 231
 None
 0.79A 6gngB-1y8aA:
2.1		 6gngB-1y8aA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 ASP A 283
ASP A 339
ASN A 484
 None
 0.85A 6gngB-1ygpA:
20.8		 6gngB-1ygpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 ASP A 378
ASP A 501
ASN A  88
 None
None
NAG  A2008 (-1.7A)
 0.83A 6gngB-1zpuA:
undetectable		 6gngB-1zpuA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bwm PSATHYRELLA VELUTINA
LECTIN PVL

(Lacrymaria
velutina) 		PF13517
(VCBS) 		3 ASP A 181
ASP A 237
ASN A 310
 CA  A1402 (-3.0A)
None
None
 0.84A 6gngB-2bwmA:
undetectable		 6gngB-2bwmA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		3 ASP A 248
ASP A 296
ASN A 437
 None
None
FMT  A1799 (-3.5A)
 0.81A 6gngB-2c4mA:
22.4		 6gngB-2c4mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfi PHYTASE

(Debaryomyces
castellii) 		PF00328
(His_Phos_2) 		3 ASP A 212
ASP A 336
ASN A 267
 None
 0.58A 6gngB-2gfiA:
undetectable		 6gngB-2gfiA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hi4 CYTOCHROME P450 1A2

(Homo sapiens) 		PF00067
(p450) 		3 ASP A 103
ASP A 128
ASN A 309
 None
 0.65A 6gngB-2hi4A:
undetectable		 6gngB-2hi4A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jc4 EXODEOXYRIBONUCLEASE
III

(Neisseria
meningitidis) 		PF03372
(Exo_endo_phos) 		3 ASP A 186
ASP A 231
ASN A  25
 None
 0.79A 6gngB-2jc4A:
undetectable		 6gngB-2jc4A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lav VACCINIA-RELATED
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 ASP A 222
ASP A 197
ASN A 346
 None
 0.74A 6gngB-2lavA:
undetectable		 6gngB-2lavA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1f URIDINE
5'-MONOPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ASP A 100
ASP A  96
ASN A 152
 None
 0.85A 6gngB-2p1fA:
2.2		 6gngB-2p1fA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p22 HYPOTHETICAL 12.0
KDA PROTEIN IN
ADE3-SER2 INTERGENIC
REGION
PROTEIN SRN2
SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE

(Saccharomyces
cerevisiae) 		PF07200
(Mod_r)
PF09452
(Mvb12)
PF09454
(Vps23_core) 		3 ASP C 190
ASP A 313
ASN D  16
 None
 0.70A 6gngB-2p22C:
undetectable		 6gngB-2p22C:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q7s N-FORMYLGLUTAMATE
AMIDOHYDROLASE

(Cupriavidus
pinatubonensis) 		PF05013
(FGase) 		3 ASP A 225
ASP A 191
ASN A 264
 None
 0.79A 6gngB-2q7sA:
undetectable		 6gngB-2q7sA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qcm URIDINE
5'-MONOPHOSPHATE
SYNTHASE (UMP
SYNTHASE)

(Homo sapiens) 		PF00215
(OMPdecase) 		3 ASP A 289
ASP A 285
ASN A 341
 None
None
JW5  A 482 (-4.3A)
 0.83A 6gngB-2qcmA:
undetectable		 6gngB-2qcmA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qfv ISOCITRATE
DEHYDROGENASE [NADP]

(Saccharomyces
cerevisiae) 		PF00180
(Iso_dh) 		3 ASP A 301
ASP A 204
ASN A 359
 None
 0.77A 6gngB-2qfvA:
undetectable		 6gngB-2qfvA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		3 ASP A 183
ASP A 124
ASN A 299
 None
 0.86A 6gngB-2qvlA:
4.5		 6gngB-2qvlA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		3 ASP A 350
ASP A 404
ASN A 366
 None
 0.85A 6gngB-2vpjA:
undetectable		 6gngB-2vpjA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7w SUPEROXIDE DISMUTASE
[FE]

(Aliivibrio
salmonicida) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ASP A 131
ASP A 148
ASN A  73
 None
 0.86A 6gngB-2w7wA:
undetectable		 6gngB-2w7wA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wau ERYTHROCYTE MEMBRANE
PROTEIN 1 (PFEMP1)

(Plasmodium
falciparum) 		PF05424
(Duffy_binding) 		3 ASP A2380
ASP A2447
ASN A2358
 None
 0.86A 6gngB-2wauA:
undetectable		 6gngB-2wauA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnw ACTIVATED BY
TRANSCRIPTION FACTOR
SSRB

(Salmonella
enterica) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 ASP A 104
ASP A 204
ASN A 332
 None
 0.81A 6gngB-2wnwA:
undetectable		 6gngB-2wnwA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wp8 EXOSOME COMPLEX
EXONUCLEASE DIS3

(Saccharomyces
cerevisiae) 		PF00773
(RNB)
PF13638
(PIN_4)
PF17215
(Rrp44_S1)
PF17216
(Rrp44_CSD1) 		3 ASP J 947
ASP J 367
ASN J 197
 None
 0.72A 6gngB-2wp8J:
undetectable		 6gngB-2wp8J:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		3 ASP A  15
ASP A 505
ASN A 466
 None
 0.64A 6gngB-2x2iA:
undetectable		 6gngB-2x2iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		3 ASP A  15
ASP A 505
ASN A 476
 None
 0.79A 6gngB-2x2iA:
undetectable		 6gngB-2x2iA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 ASP A1319
ASP A1313
ASN A 739
 None
 0.78A 6gngB-2zxqA:
undetectable		 6gngB-2zxqA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Rhodobacter
capsulatus) 		PF00148
(Oxidored_nitro) 		3 ASP B 171
ASP B 381
ASN B 361
 None
 0.83A 6gngB-3aeqB:
2.9		 6gngB-3aeqB:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfm BIOTIN PROTEIN
LIGASE-LIKE PROTEIN
OF UNKNOWN FUNCTION

(Ruegeria sp.
TM1040) 		PF14563
(DUF4444)
PF16917
(BPL_LplA_LipB_2) 		3 ASP A 135
ASP A 141
ASN A  93
 None
 0.67A 6gngB-3bfmA:
undetectable		 6gngB-3bfmA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ckb SUSD

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB) 		3 ASP A 373
ASP A 381
ASN A 277
 None
 0.86A 6gngB-3ckbA:
undetectable		 6gngB-3ckbA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezy DEHYDROGENASE

(Thermotoga
maritima) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 ASP A 207
ASP A 152
ASN A 252
 None
 0.84A 6gngB-3ezyA:
5.3		 6gngB-3ezyA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4b ENOYL-ACYL CARRIER
PROTEIN REDUCTASE

(Plasmodium
berghei) 		PF13561
(adh_short_C2) 		3 ASP A 217
ASP A 163
ASN A 173
 None
 0.85A 6gngB-3f4bA:
2.7		 6gngB-3f4bA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fnr ARGINYL-TRNA
SYNTHETASE

(Campylobacter
jejuni) 		PF00750
(tRNA-synt_1d)
PF05746
(DALR_1) 		3 ASP A 278
ASP A 297
ASN A 114
 None
GOL  A 539 (-3.4A)
None
 0.75A 6gngB-3fnrA:
3.0		 6gngB-3fnrA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8y SUSD/RAGB-ASSOCIATED
ESTERASE-LIKE
PROTEIN

(Bacteroides
vulgatus) 		PF12715
(Abhydrolase_7) 		3 ASP A 341
ASP A 279
ASN A 190
 None
EDO  A   2 (-3.6A)
None
 0.86A 6gngB-3g8yA:
5.5		 6gngB-3g8yA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbr ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sulfolobus
solfataricus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		3 ASP A 209
ASP A  70
ASN A 141
 None
 0.84A 6gngB-3gbrA:
3.8		 6gngB-3gbrA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h3l PUTATIVE SUGAR
HYDROLASE

(Parabacteroides
distasonis) 		PF06439
(DUF1080) 		3 ASP A  71
ASP A  98
ASN A 121
 None
 0.85A 6gngB-3h3lA:
undetectable		 6gngB-3h3lA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hur ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 ASP A 141
ASP A 129
ASN A 352
 None
 0.71A 6gngB-3hurA:
undetectable		 6gngB-3hurA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibj CGMP-DEPENDENT
3',5'-CYCLIC
PHOSPHODIESTERASE

(Homo sapiens) 		PF00233
(PDEase_I)
PF01590
(GAF)
PF13185
(GAF_2) 		3 ASP A 683
ASP A 625
ASN A 599
 None
 0.86A 6gngB-3ibjA:
undetectable		 6gngB-3ibjA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ljf IRON SUPEROXIDE
DISMUTASE

(Pseudoalteromonas
haloplanktis) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		3 ASP A 130
ASP A 147
ASN A  72
 None
 0.85A 6gngB-3ljfA:
undetectable		 6gngB-3ljfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 3 ASP G 274
ASP G 280
ASN G 207
 None
 0.87A 6gngB-3mmpG:
undetectable		 6gngB-3mmpG:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
EPSILON

(Saccharomyces
cerevisiae) 		PF04733
(Coatomer_E) 		3 ASP B  51
ASP B  30
ASN B 160
 None
 0.83A 6gngB-3mv3B:
undetectable		 6gngB-3mv3B:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		3 ASP A 601
ASP A 591
ASN A 584
 None
 0.83A 6gngB-3n2oA:
undetectable		 6gngB-3n2oA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nog DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		3 ASP D  77
ASP D  89
ASN D 156
 None
 0.73A 6gngB-3nogD:
undetectable		 6gngB-3nogD:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT
6-PHOSPHOFRUCTO-1-KI
NASE BETA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 ASP A 421
ASP A 657
ASN B 197
 None
SO4  A1001 (-4.4A)
None
 0.81A 6gngB-3opyA:
4.1		 6gngB-3opyA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz9 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE. GLYCOSYL
HYDROLASE FAMILY 5

(Thermotoga
petrophila) 		PF00150
(Cellulase) 		3 ASP A 362
ASP A 371
ASN A 197
 None
 0.85A 6gngB-3pz9A:
undetectable		 6gngB-3pz9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpk BACKBONE PILUS
SUBUNIT

(Streptococcus
pneumoniae) 		PF16555
(GramPos_pilinD1)
PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		3 ASP A 209
ASP A 319
ASN A 323
 None
 0.62A 6gngB-3rpkA:
undetectable		 6gngB-3rpkA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrp PROBABLE FUMARATE
HYDRATASE FUM

(Mycobacteroides
abscessus) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		3 ASP A 262
ASP A 140
ASN A  62
 None
 0.84A 6gngB-3rrpA:
undetectable		 6gngB-3rrpA:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 ASP A 714
ASP A 411
ASN A 564
 None
CA  A 897 (-2.4A)
TTP  A 896 (-3.2A)
 0.79A 6gngB-3sunA:
undetectable		 6gngB-3sunA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uau SURFACE-EXPOSED
LIPOPROTEIN

(Campylobacter
jejuni) 		PF16668
(JLPA) 		3 ASP A 118
ASP A 215
ASN A 234
 None
 0.77A 6gngB-3uauA:
undetectable		 6gngB-3uauA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		3 ASP A4092
ASP A4051
ASN A4650
 SPM  A9016 ( 4.4A)
None
None
 0.86A 6gngB-3vkgA:
undetectable		 6gngB-3vkgA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wic GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 ASP A 241
ASP A 211
ASN A 179
 None
 0.81A 6gngB-3wicA:
4.0		 6gngB-3wicA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		3 ASP A 602
ASP A 660
ASN A 733
 None
 0.86A 6gngB-3wpeA:
undetectable		 6gngB-3wpeA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zmr CELLULASE (GLYCOSYL
HYDROLASE FAMILY 5)

(Bacteroides
ovatus) 		PF00150
(Cellulase)
PF13004
(BACON) 		3 ASP A 288
ASP A 204
ASN A 502
 None
 0.67A 6gngB-3zmrA:
undetectable		 6gngB-3zmrA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 ASP A 834
ASP A 730
ASN A 519
 None
 0.71A 6gngB-3zuqA:
undetectable		 6gngB-3zuqA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 ASP A 687
ASP A 642
ASN A 403
 None
None
GOL  A1888 ( 4.0A)
 0.70A 6gngB-4aioA:
undetectable		 6gngB-4aioA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bih UNCHARACTERIZED
LIPOPROTEIN
SAOUHSC_00053

(Staphylococcus
aureus) 		PF04507
(DUF576) 		3 ASP A 112
ASP A 108
ASN A  73
 None
 0.85A 6gngB-4bihA:
undetectable		 6gngB-4bihA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c5n PHOSPHOMETHYLPYRIMID
INE KINASE

(Staphylococcus
aureus) 		PF08543
(Phos_pyr_kin) 		3 ASP A 105
ASP A  13
ASN A 252
 None
PXL  A 300 (-4.3A)
None
 0.86A 6gngB-4c5nA:
undetectable		 6gngB-4c5nA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cdb LISTERIOLYSIN O

(Listeria
monocytogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 ASP A 320
ASP A 207
ASN A 402
 NA  A1542 (-3.8A)
NA  A1531 (-3.5A)
NA  A1533 (-3.1A)
 0.85A 6gngB-4cdbA:
undetectable		 6gngB-4cdbA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6u ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 ASP A 165
ASP A 130
ASN A  59
 None
 0.84A 6gngB-4e6uA:
undetectable		 6gngB-4e6uA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f21 CARBOXYLESTERASE/PHO
SPHOLIPASE FAMILY
PROTEIN

(Francisella
tularensis) 		PF02230
(Abhydrolase_2) 		3 ASP A  51
ASP A  28
ASN A  34
 None
 0.74A 6gngB-4f21A:
5.4		 6gngB-4f21A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fdd RNA-BINDING PROTEIN
FUS
TRANSPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ)
no annotation 		3 ASP B 520
ASP B 512
ASN A 770
 None
 0.86A 6gngB-4fddB:
undetectable		 6gngB-4fddB:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		3 ASP A 968
ASP A 974
ASN A 901
 CA  A2502 (-2.7A)
None
None
 0.72A 6gngB-4fwtA:
4.1		 6gngB-4fwtA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4haq GH7 FAMILY PROTEIN

(Limnoria
quadripunctata) 		PF00840
(Glyco_hydro_7) 		3 ASP A 367
ASP A 266
ASN A 209
 None
 0.77A 6gngB-4haqA:
undetectable		 6gngB-4haqA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		3 ASP A 101
ASP A 126
ASN A 309
 None
 0.60A 6gngB-4i8vA:
undetectable		 6gngB-4i8vA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 ASP A 284
ASP A  27
ASN A  36
 None
 0.84A 6gngB-4iuwA:
undetectable		 6gngB-4iuwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iuw NEUTRAL
ENDOPEPTIDASE

(Lactobacillus
rhamnosus) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		3 ASP A 484
ASP A 440
ASN A 131
 None
 0.82A 6gngB-4iuwA:
undetectable		 6gngB-4iuwA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		3 ASP A 196
ASP A  12
ASN A 555
 None
 0.77A 6gngB-4om9A:
undetectable		 6gngB-4om9A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		3 ASP A 168
ASP A 507
ASN A 324
 None
 0.70A 6gngB-4txgA:
undetectable		 6gngB-4txgA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 2

(Drosophila
melanogaster) 		PF04084
(ORC2) 		3 ASP B 400
ASP B 392
ASN B 444
 None
 0.66A 6gngB-4xgcB:
undetectable		 6gngB-4xgcB:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ASP A  91
ASP A 393
ASN A 473
 FAD  A 701 ( 4.8A)
None
MG  A 702 ( 2.6A)
 0.86A 6gngB-5ahkA:
undetectable		 6gngB-5ahkA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d1z IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B
Y10 HEAVY CHAIN

(Homo sapiens;
Staphylococcus
aureus) 		PF05031
(NEAT)
PF07654
(C1-set)
PF07686
(V-set) 		3 ASP B  63
ASP B  51
ASN I 135
 None
 0.79A 6gngB-5d1zB:
undetectable		 6gngB-5d1zB:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		3 ASP A 481
ASP A 462
ASN A 266
 None
 0.69A 6gngB-5fqeA:
undetectable		 6gngB-5fqeA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fws KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		3 ASP A 306
ASP A 260
ASN A  36
 CA  A1327 (-2.8A)
None
None
 0.55A 6gngB-5fwsA:
undetectable		 6gngB-5fwsA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fww KREMEN PROTEIN 1

(Homo sapiens) 		PF00051
(Kringle)
PF00431
(CUB)
PF01822
(WSC) 		3 ASP B 306
ASP B 260
ASN B  36
 CA  B1323 (-3.5A)
None
None
 0.75A 6gngB-5fwwB:
undetectable		 6gngB-5fwwB:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PORTAL PROTEIN

(Salmonella
virus P22) 		PF16510
(P22_portal) 		3 ASP A 473
ASP A 460
ASN A 452
 None
 0.81A 6gngB-5gaiA:
undetectable		 6gngB-5gaiA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5m ALPHA-CATENIN-LIKE
PROTEIN HMP-1

(Caenorhabditis
elegans) 		PF01044
(Vinculin) 		3 ASP A 371
ASP A 503
ASN A 641
 None
 0.84A 6gngB-5h5mA:
undetectable		 6gngB-5h5mA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		3 ASP A 225
ASP A 252
ASN A 247
 None
 0.77A 6gngB-5h9xA:
undetectable		 6gngB-5h9xA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		3 ASP A 352
ASP A 585
ASN A 540
 None
 0.78A 6gngB-5hp5A:
undetectable		 6gngB-5hp5A:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5u RAGB/SUSD DOMAIN
PROTEIN

(Flavobacterium
johnsoniae) 		PF12771
(SusD-like_2) 		3 ASP A 174
ASP A 162
ASN A 479
 None
 0.59A 6gngB-5j5uA:
undetectable		 6gngB-5j5uA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kva CAFFEOYL-COA
O-METHYLTRANSFERASE

(Sorghum bicolor) 		PF01596
(Methyltransf_3) 		3 ASP A  41
ASP A 252
ASN A 234
 None
 0.65A 6gngB-5kvaA:
2.7		 6gngB-5kvaA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		3 ASP A  65
ASP A 155
ASN A  32
 None
CA  A 501 (-3.3A)
None
 0.84A 6gngB-5ldtA:
undetectable		 6gngB-5ldtA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		3 ASP A 297
ASP A 212
ASN A 449
 None
 0.86A 6gngB-5m8tA:
undetectable		 6gngB-5m8tA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mch CELLOBIOHYDROLASE
CHBI

(Daphnia pulex) 		PF00840
(Glyco_hydro_7) 		3 ASP A 376
ASP A 269
ASN A 212
 None
 0.80A 6gngB-5mchA:
undetectable		 6gngB-5mchA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 3 ASP A 569
ASP A 561
ASN A 320
 None
 0.85A 6gngB-5n4lA:
undetectable		 6gngB-5n4lA:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01493
(GXGXG) 		3 ASP B 185
ASP B 204
ASN C 160
 MGD  B 504 (-3.1A)
None
None
 0.64A 6gngB-5t5iB:
undetectable		 6gngB-5t5iB:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 3 ASP A 257
ASP A 231
ASN A 440
 None
 0.83A 6gngB-6eoeA:
undetectable		 6gngB-6eoeA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 3 ASP A 108
ASP A 151
ASN A 283
 QPS  A 602 ( 2.5A)
QPS  A 602 (-3.3A)
QPS  A 602 (-3.4A)
 0.33A 6gngB-6gnfA:
54.2		 6gngB-6gnfA:
undetectable