SIMILAR PATTERNS OF AMINO ACIDS FOR 6GNG_A_QPSA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c9w CHO REDUCTASE

(Cricetulus
griseus)
PF00248
(Aldo_ket_red)
5 GLY A 114
VAL A 130
GLY A 157
ASN A 305
GLN A 165
None
1.00A 6gngA-1c9wA:
undetectable
6gngA-1c9wA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89


(Zoogloea
ramigera)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 GLY A 341
VAL A 337
GLY A  16
ASN A 316
ASN A 327
None
1.12A 6gngA-1dm3A:
undetectable
6gngA-1dm3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE


(Escherichia
coli)
PF00343
(Phosphorylase)
5 GLY A 113
LEU A 115
ASP A 307
HIS A 309
ASN A 449
GLC  A 997 (-3.3A)
GLC  A 997 (-3.8A)
GLC  A 997 (-3.6A)
GLC  A 996 (-4.0A)
GLC  A 998 (-3.3A)
0.59A 6gngA-1e4oA:
23.1
6gngA-1e4oA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp2 ISOFLAVONE
O-METHYLTRANSFERASE


(Medicago sativa)
PF00891
(Methyltransf_2)
PF08100
(Dimerisation)
5 LEU A 345
THR A 201
GLY A 200
ASP A 194
ASP A 288
None
None
None
SAH  A1699 ( 4.6A)
None
1.18A 6gngA-1fp2A:
2.2
6gngA-1fp2A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gkr NON-ATP DEPENDENT
L-SELECTIVE
HYDANTOINASE


(Paenarthrobacter
aurescens)
PF01979
(Amidohydro_1)
5 GLY A 444
LEU A 117
THR A 431
GLY A 430
ASP A 388
None
1.16A 6gngA-1gkrA:
2.7
6gngA-1gkrA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i78 PROTEASE VII

(Escherichia
coli)
PF01278
(Omptin)
5 THR A 184
GLY A 185
LEU A 128
GLY A  67
ASN A 122
None
1.19A 6gngA-1i78A:
undetectable
6gngA-1i78A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8a ENDO-1,4-BETA-XYLANA
SE A


(Thermotoga
maritima)
PF06452
(CBM9_1)
5 GLY A  88
THR A 109
GLY A 108
ASP A 169
ASN A 173
None
None
BGC  A 189 ( 4.3A)
None
None
1.04A 6gngA-1i8aA:
undetectable
6gngA-1i8aA:
14.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1


(Mus musculus)
PF01979
(Amidohydro_1)
5 THR A  74
GLY A 332
THR A 101
GLY A 100
ASN A 356
None
1.20A 6gngA-1kcxA:
undetectable
6gngA-1kcxA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kny KANAMYCIN
NUCLEOTIDYLTRANSFERA
SE


(Staphylococcus
aureus)
PF07827
(KNTase_C)
5 GLY A 173
VAL A 191
THR A 238
GLY A 242
HIS A 181
None
1.14A 6gngA-1knyA:
undetectable
6gngA-1knyA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kol FORMALDEHYDE
DEHYDROGENASE


(Pseudomonas
putida)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 133
LEU A  65
VAL A   6
GLY A 120
ASP A  49
None
1.15A 6gngA-1kolA:
3.9
6gngA-1kolA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kxh ALPHA-AMYLASE

(Pseudoalteromonas
haloplanktis)
PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
5 THR A 221
VAL A 197
GLY A 270
ASP A  84
ASN A 174
CL  A 900 ( 4.4A)
None
None
None
ACR  A 598 (-3.2A)
1.16A 6gngA-1kxhA:
undetectable
6gngA-1kxhA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii)
PF01546
(Peptidase_M20)
5 GLY A 116
VAL A  91
GLY A 110
ASP A 107
GLN A 430
None
1.12A 6gngA-1lfwA:
3.2
6gngA-1lfwA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00632
(HECT)
5 GLY A 860
LEU A 858
THR A 851
GLY A 852
GLN A 805
None
0.98A 6gngA-1nd7A:
undetectable
6gngA-1nd7A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9b ADENYLOSUCCINATE
SYNTHETASE


(Plasmodium
falciparum)
PF00709
(Adenylsucc_synt)
5 THR A 242
GLY A 241
VAL A 326
ASN A 232
ASN A 330
None
None
None
IMO  A1601 (-3.7A)
None
1.07A 6gngA-1p9bA:
undetectable
6gngA-1p9bA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
7 THR A  16
GLY A  17
LEU A  19
VAL A  22
ASP A 103
ASP A 138
ASN A 246
None
0.76A 6gngA-1rzvA:
40.5
6gngA-1rzvA:
28.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v47 ATP SULFURYLASE

(Thermus
thermophilus)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
5 THR A  23
GLY A  24
LEU A  21
VAL A  29
ASP A  17
None
1.18A 6gngA-1v47A:
3.5
6gngA-1v47A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE


(Saccharomyces
cerevisiae)
PF00343
(Phosphorylase)
6 GLY A 134
LEU A 136
ASP A 283
ASP A 339
HIS A 341
ASN A 484
PO4  A1900 (-3.7A)
None
None
None
None
None
0.99A 6gngA-1ygpA:
20.7
6gngA-1ygpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011


(Haemophilus
influenzae)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 THR A 217
GLY A 218
LEU A 222
THR A 163
GLY A 164
None
1.12A 6gngA-1yzyA:
undetectable
6gngA-1yzyA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avd CATECHOL-O-METHYLTRA
NSFERASE


(Homo sapiens)
PF01596
(Methyltransf_3)
5 LEU A  77
THR A 111
GLY A 110
ASP A 185
ASP A  83
None
None
SAM  A 501 (-3.4A)
SAM  A 501 (-3.4A)
None
1.03A 6gngA-2avdA:
3.5
6gngA-2avdA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azq CATECHOL
1,2-DIOXYGENASE


(Pseudomonas
putida)
PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N)
5 GLY A 195
VAL A 192
GLY A  76
HIS A 222
ASN A 238
None
None
None
FE  A 400 (-3.2A)
None
1.04A 6gngA-2azqA:
undetectable
6gngA-2azqA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE


(Corynebacterium
callunae)
PF00343
(Phosphorylase)
5 GLY A 113
LEU A 115
ASP A 248
ASP A 296
ASN A 437
PO4  A1794 (-3.5A)
None
None
None
FMT  A1799 (-3.5A)
1.01A 6gngA-2c4mA:
22.4
6gngA-2c4mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE


(Corynebacterium
callunae)
PF00343
(Phosphorylase)
5 GLY A 113
LEU A 115
ASP A 296
HIS A 298
ASN A 437
PO4  A1794 (-3.5A)
None
None
None
FMT  A1799 (-3.5A)
0.80A 6gngA-2c4mA:
22.4
6gngA-2c4mA:
23.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cev PROTEIN (ARGINASE)

([Bacillus]
caldovelox)
PF00491
(Arginase)
5 THR A 105
GLY A 104
VAL A  71
GLY A 117
HIS A  99
None
None
None
None
MN  A 301 ( 3.2A)
1.08A 6gngA-2cevA:
2.6
6gngA-2cevA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cx9 ACYL-COA
DEHYDROGENASE


(Thermus
thermophilus)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
5 THR A 160
LEU A  95
VAL A 169
GLY A  83
ASN A  93
None
1.10A 6gngA-2cx9A:
undetectable
6gngA-2cx9A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
5 LEU A 451
VAL A 511
THR A 441
GLY A 369
ASP A 465
None
1.04A 6gngA-2e8yA:
undetectable
6gngA-2e8yA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE


(Bifidobacterium
adolescentis)
PF00128
(Alpha-amylase)
PF09244
(DUF1964)
5 LEU A 341
GLY A 197
ASP A  50
ASN A 347
GLN A 232
SUC  A2064 (-4.7A)
None
SUC  A2064 (-2.6A)
None
SUC  A2064 (-2.7A)
0.97A 6gngA-2gduA:
undetectable
6gngA-2gduA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gj4 GLYCOGEN
PHOSPHORYLASE,
MUSCLE FORM


(Oryctolagus
cuniculus)
PF00343
(Phosphorylase)
5 GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
PLR  A 940 (-3.6A)
None
None
None
None
0.88A 6gngA-2gj4A:
21.8
6gngA-2gj4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2s MICRONEMAL PROTEIN 1

(Toxoplasma
gondii)
PF11476
(TgMIC1)
5 GLY A  74
LEU A  19
VAL A 125
THR A  51
GLY A  52
None
1.20A 6gngA-2k2sA:
undetectable
6gngA-2k2sA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o96 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT 7


(Homo sapiens)
PF01398
(JAB)
5 GLY A  27
THR A  97
GLY A  98
ASP A 125
GLN A  32
None
1.16A 6gngA-2o96A:
undetectable
6gngA-2o96A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qk4 TRIFUNCTIONAL PURINE
BIOSYNTHETIC PROTEIN
ADENOSINE-3


(Homo sapiens)
PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N)
5 GLY A  73
THR A  39
GLY A  38
ASN A 290
GLN A 299
None
0.99A 6gngA-2qk4A:
4.8
6gngA-2qk4A:
24.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Pseudomonas
aeruginosa)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
5 THR A 112
GLY A 308
VAL A 305
GLY A 185
ASP A 180
None
1.08A 6gngA-2x3eA:
undetectable
6gngA-2x3eA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cem GLYCOGEN
PHOSPHORYLASE, LIVER
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
5 GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
PLP  A 832 (-3.6A)
NBG  A   1 (-4.1A)
None
None
NBG  A   1 (-3.3A)
0.89A 6gngA-3cemA:
22.2
6gngA-3cemA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 THR A  16
ASP A 137
HIS A 139
ASN A 162
ASN A 246
None
1.00A 6gngA-3d1jA:
40.8
6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
7 THR A  16
GLY A  17
LEU A  19
VAL A  22
ASP A 137
HIS A 139
ASN A 246
None
0.77A 6gngA-3d1jA:
40.8
6gngA-3d1jA:
29.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 THR A 433
GLY A 432
VAL A 397
THR A 529
GLY A 527
None
1.18A 6gngA-3eqnA:
undetectable
6gngA-3eqnA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp6 PROTEIN PAGP

(Escherichia
coli)
PF07017
(PagP)
5 GLY A  88
THR A 137
GLY A 132
ASP A  61
ASN A  65
SDS  A 163 ( 4.7A)
None
SDS  A 166 (-3.3A)
None
None
1.16A 6gngA-3gp6A:
undetectable
6gngA-3gp6A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4x PHOSPHATIDYLINOSITOL
-SPECIFIC
PHOSPHOLIPASE C1


(Streptomyces
antibioticus)
PF16670
(PI-PLC-C1)
5 THR A 209
GLY A 133
GLY A 237
ASP A 260
ASP A  62
None
None
None
EOH  A 358 (-4.1A)
None
1.14A 6gngA-3h4xA:
undetectable
6gngA-3h4xA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE


(Agrobacterium
fabrum)
PF00465
(Fe-ADH)
5 GLY A 234
THR A 138
GLY A 129
HIS A 174
ASN A 185
None
1.03A 6gngA-3hl0A:
3.8
6gngA-3hl0A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN


(Desulfovibrio
vulgaris)
PF00857
(Isochorismatase)
5 GLY A  88
VAL A  92
GLY A  64
ASP A  66
ASP A  15
None
0.94A 6gngA-3hu5A:
5.3
6gngA-3hu5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hu5 ISOCHORISMATASE
FAMILY PROTEIN


(Desulfovibrio
vulgaris)
PF00857
(Isochorismatase)
5 THR A  86
GLY A  88
VAL A  92
GLY A  64
ASP A  66
None
1.19A 6gngA-3hu5A:
5.3
6gngA-3hu5A:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3


(Toxoplasma
gondii)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
5 GLY A 276
VAL A 287
GLY A 490
ASP A 280
GLN A 363
None
0.89A 6gngA-3hztA:
undetectable
6gngA-3hztA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00478
(IMPDH)
5 GLY A  67
LEU A  45
VAL A 345
THR A  36
GLY A 208
None
1.17A 6gngA-3khjA:
undetectable
6gngA-3khjA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kl4 SIGNAL RECOGNITION
54 KDA PROTEIN


(Sulfolobus
solfataricus)
PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB)
5 GLY A 293
LEU A 292
VAL A 288
THR A  14
GLY A  15
None
1.17A 6gngA-3kl4A:
2.4
6gngA-3kl4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krn PROTEIN C14A4.5,
CONFIRMED BY
TRANSCRIPT EVIDENCE


(Caenorhabditis
elegans)
PF01138
(RNase_PH)
5 GLY A 129
LEU A 156
GLY A  97
ASP A 100
ASN A  71
None
1.15A 6gngA-3krnA:
undetectable
6gngA-3krnA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 GLY A  16
LEU A  18
ASP A 128
HIS A 130
ASN A 217
CL  A5703 ( 3.9A)
GOL  A6500 ( 4.3A)
GOL  A6500 (-3.2A)
GOL  A6502 ( 3.8A)
None
0.99A 6gngA-3l01A:
34.6
6gngA-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE


(Pyrococcus
abyssi)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
5 GLY A  17
LEU A  18
ASP A 128
HIS A 130
ASN A 217
CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6500 (-3.2A)
GOL  A6502 ( 3.8A)
None
0.93A 6gngA-3l01A:
34.6
6gngA-3l01A:
26.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3si9 DIHYDRODIPICOLINATE
SYNTHASE


(Bartonella
henselae)
PF00701
(DHDPS)
5 GLY A 191
LEU A 189
THR A 108
ASN A 200
GLN A 178
None
1.08A 6gngA-3si9A:
undetectable
6gngA-3si9A:
23.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC


(Oryza sativa)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
7 THR A  98
GLY A  99
LEU A 101
VAL A 104
HIS A 236
ASN A 353
GLN A 412
None
SO4  A 704 (-3.2A)
None
None
None
None
SO4  A 704 ( 3.7A)
0.78A 6gngA-3vueA:
47.9
6gngA-3vueA:
46.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC


(Oryza sativa)
PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5)
8 THR A  98
LEU A 101
VAL A 104
ASP A 234
HIS A 236
ASN A 265
ASN A 353
GLN A 412
None
None
None
None
None
SO4  A 704 ( 4.2A)
None
SO4  A 704 ( 3.7A)
0.78A 6gngA-3vueA:
47.9
6gngA-3vueA:
46.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE


(Mycolicibacterium
smegmatis)
PF00155
(Aminotran_1_2)
5 GLY A 214
LEU A 216
VAL A 219
THR A 232
GLY A 104
None
1.07A 6gngA-3wy7A:
2.1
6gngA-3wy7A:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zeu PROBABLE TRNA
THREONYLCARBAMOYLADE
NOSINE BIOSYNTHESIS
PROTEIN GCP


(Salmonella
enterica)
PF00814
(Peptidase_M22)
5 THR B 258
GLY B 259
LEU B 255
THR B 146
GLY B 147
None
1.04A 6gngA-3zeuB:
2.5
6gngA-3zeuB:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyv AOX3

(Mus musculus)
PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C)
5 GLY A 373
LEU A 372
VAL A 416
GLY A 465
HIS A 358
None
None
None
None
FAD  A3005 (-3.8A)
0.81A 6gngA-3zyvA:
undetectable
6gngA-3zyvA:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC


(Arabidopsis
thaliana)
PF00343
(Phosphorylase)
5 GLY A 137
LEU A 139
ASP A 341
HIS A 343
ASN A 487
PLP  A 901 ( 4.2A)
None
None
None
None
0.84A 6gngA-4bqiA:
22.4
6gngA-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC


(Arabidopsis
thaliana)
PF00343
(Phosphorylase)
5 GLY A 137
LEU A 139
GLY A 287
ASP A 341
HIS A 343
PLP  A 901 ( 4.2A)
None
None
None
None
1.08A 6gngA-4bqiA:
22.4
6gngA-4bqiA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis)
PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N)
5 GLY A  98
VAL A 136
GLY A  79
ASP A  81
ASN A 101
None
1.04A 6gngA-4dzaA:
undetectable
6gngA-4dzaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE


(Agrobacterium
sp. H13-3)
PF00701
(DHDPS)
5 GLY A 187
LEU A 185
THR A 104
ASN A 196
GLN A 174
None
1.07A 6gngA-4i7uA:
undetectable
6gngA-4i7uA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igm 2-AMINO-3-CARBOXYMUC
ONATE-6-SEMIALDEHYDE
DECARBOXYLASE


(Homo sapiens)
PF04909
(Amidohydro_2)
5 THR A 116
GLY A 115
LEU A 100
THR A  89
ASN A  98
None
1.15A 6gngA-4igmA:
undetectable
6gngA-4igmA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 GLY A 134
LEU A  66
VAL A   7
GLY A 121
ASP A  50
None
1.15A 6gngA-4jlwA:
2.8
6gngA-4jlwA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 ACETALDEHYDE
DEHYDROGENASE


(Mycobacterium
tuberculosis)
PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer)
5 GLY B 129
THR B 163
GLY B 162
ASN B 123
ASN B 112
None
0.91A 6gngA-4jn6B:
3.2
6gngA-4jn6B:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans)
PF00343
(Phosphorylase)
5 GLY A 104
LEU A 106
ASP A 279
HIS A 281
ASN A 413
None
0.73A 6gngA-4l22A:
23.1
6gngA-4l22A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8j L-CARNITINE/GAMMA-BU
TYROBETAINE
ANTIPORTER


(Proteus
mirabilis)
PF02028
(BCCT)
5 THR A 206
GLY A 205
LEU A 202
VAL A  22
GLN A 330
None
1.12A 6gngA-4m8jA:
undetectable
6gngA-4m8jA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mju NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
5 GLY A 193
VAL A 214
THR A 135
GLY A 137
ASN A 216
None
1.16A 6gngA-4mjuA:
undetectable
6gngA-4mjuA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n03 ABC-TYPE
BRANCHED-CHAIN AMINO
ACID TRANSPORT
SYSTEMS PERIPLASMIC
COMPONENT-LIKE
PROTEIN


(Thermomonospora
curvata)
PF13458
(Peripla_BP_6)
5 THR A 353
GLY A 356
LEU A 357
THR A  36
GLY A  37
None
1.16A 6gngA-4n03A:
2.2
6gngA-4n03A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE


(Bacillus
anthracis)
PF00185
(OTCace)
PF02729
(OTCace_N)
5 LEU A 171
VAL A 167
THR A 207
GLY A 208
ASN A 165
None
None
None
None
NVA  A 402 (-3.8A)
1.18A 6gngA-4nf2A:
2.1
6gngA-4nf2A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7


(Colwellia
psychrerythraea)
PF03480
(DctP)
5 GLY A 185
LEU A 188
THR A 244
GLY A 243
ASN A 316
None
None
PYR  A 402 ( 4.1A)
None
None
1.12A 6gngA-4petA:
undetectable
6gngA-4petA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rsm PERIPLASMIC BINDING
PROTEIN/LACI
TRANSCRIPTIONAL
REGULATOR


(Mycolicibacterium
smegmatis)
PF13407
(Peripla_BP_4)
5 THR A 335
GLY A 336
LEU A 333
VAL A 291
GLY A 342
None
1.20A 6gngA-4rsmA:
3.5
6gngA-4rsmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uph SULFATASE (SULFURIC
ESTER HYDROLASE)
PROTEIN


(Agrobacterium
tumefaciens)
PF00884
(Sulfatase)
PF16347
(DUF4976)
5 GLY A  51
LEU A  53
VAL A 368
GLY A 306
ASP A 302
None
1.16A 6gngA-4uphA:
undetectable
6gngA-4uphA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwv AMINOPEPTIDASE FROM
FAMILY M42


(Desulfurococcus
amylolyticus)
PF05343
(Peptidase_M42)
5 THR A 320
GLY A 319
VAL A 316
THR A 239
ASP A 184
None
1.16A 6gngA-4wwvA:
undetectable
6gngA-4wwvA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE


(Homo sapiens)
PF02350
(Epimerase_2)
5 GLY A 299
LEU A 218
VAL A 216
GLY A 140
ASP A 143
None
UDP  A 501 (-4.3A)
None
None
None
1.12A 6gngA-4zhtA:
14.1
6gngA-4zhtA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT


(Pseudomonas
protegens)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 GLY A 448
VAL A 470
THR A  83
GLY A  84
GLN A 454
TPP  A 700 (-3.7A)
None
None
None
None
1.19A 6gngA-5ahkA:
2.2
6gngA-5ahkA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7i CRISPR-ASSOCIATED
NUCLEASE/HELICASE
CAS3 SUBTYPE
I-F/YPEST


(Pseudomonas
aeruginosa)
no annotation 5 GLY A 451
VAL A 574
GLY A 886
ASN A 430
GLN A 847
None
None
None
None
ADP  A1103 (-3.7A)
1.11A 6gngA-5b7iA:
undetectable
6gngA-5b7iA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bsz N-METHYLTRANSFERASE

(Streptoalloteichus
sp. ATCC 53650)
PF13649
(Methyltransf_25)
5 GLY A 140
LEU A 142
VAL A 240
GLY A 103
ASP A 101
None
1.13A 6gngA-5bszA:
undetectable
6gngA-5bszA:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cer BD0816
BD3460


(Bdellovibrio
bacteriovorus)
PF02113
(Peptidase_S13)
PF12796
(Ank_2)
5 THR A 346
GLY A 347
GLY A 335
ASN B 106
ASN A 350
None
1.16A 6gngA-5cerA:
undetectable
6gngA-5cerA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gin FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE


(Sulfolobus
solfataricus)
PF01269
(Fibrillarin)
5 THR E  89
GLY E  88
VAL E 114
GLY E  63
ASP E 220
A  I   6 ( 3.5A)
None
None
None
G  I   5 ( 3.8A)
0.99A 6gngA-5ginE:
2.5
6gngA-5ginE:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM


(Homo sapiens)
PF00343
(Phosphorylase)
5 GLY A 134
LEU A 136
ASP A 339
HIS A 341
ASN A 484
PLP  A 901 ( 4.1A)
None
None
None
None
0.73A 6gngA-5ikpA:
21.5
6gngA-5ikpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT


(Aromatoleum
aromaticum)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
5 GLY B  19
THR B 312
GLY B 310
ASP B 308
ASP B  23
None
1.12A 6gngA-5l9wB:
2.7
6gngA-5l9wB:
24.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE


(Hordeum vulgare)
PF00343
(Phosphorylase)
5 GLY A 181
LEU A 183
ASP A 383
HIS A 385
ASN A 613
PLP  A1002 ( 4.3A)
GLC  A1001 (-4.3A)
None
None
GLC  A1001 (-3.8A)
0.79A 6gngA-5lrbA:
22.4
6gngA-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE


(Hordeum vulgare)
PF00343
(Phosphorylase)
5 GLY A 181
LEU A 183
GLY A 331
ASP A 383
HIS A 385
PLP  A1002 ( 4.3A)
GLC  A1001 (-4.3A)
None
None
None
1.10A 6gngA-5lrbA:
22.4
6gngA-5lrbA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lta PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43


(Chaetomium
thermophilum)
PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind)
5 LEU A  90
THR A  78
GLY A  79
ASP A  71
ASN A  99
None
1.17A 6gngA-5ltaA:
undetectable
6gngA-5ltaA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN
2,4-DIACETYLPHLOROGL
UCINOL BIOSYNTHESIS
PROTEIN PHLC


(Pseudomonas
protegens)
no annotation 5 GLY C 249
VAL B  94
THR C 256
GLY B  49
ASP B  98
None
0.96A 6gngA-5mg5C:
undetectable
6gngA-5mg5C:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL


(Rhodopseudomonas
palustris)
no annotation 5 GLY A 103
VAL A  45
THR A 174
GLY A 175
ASP A 215
None
None
OOG  A 401 (-3.1A)
None
OOG  A 401 ( 4.7A)
1.05A 6gngA-5oeiA:
2.1
6gngA-5oeiA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ACYL-COA
DEHYDROGENASE


(Clostridioides
difficile)
no annotation 5 THR C 157
LEU C  92
VAL C 166
THR C  81
GLY C  80
FAD  C 401 (-3.7A)
None
None
None
None
1.15A 6gngA-5ol2C:
undetectable
6gngA-5ol2C:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT II


(Synechocystis
sp. PCC 6803)
no annotation 5 GLY 4  46
VAL 1 422
GLY 1 569
ASP 1 417
GLN 4  71
None
1.13A 6gngA-5oy04:
undetectable
6gngA-5oy04:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5th5 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE


(Bacillus
subtilis)
PF04055
(Radical_SAM)
PF13394
(Fer4_14)
5 THR A 234
GLY A 238
LEU A 236
GLY A 208
GLN A 200
None
1.13A 6gngA-5th5A:
2.8
6gngA-5th5A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tlc DIBENZOTHIOPHENE
DESULFURIZATION
ENZYME A


(Bacillus
subtilis)
PF00296
(Bac_luciferase)
5 GLY A  60
VAL A 137
GLY A  78
HIS A 316
ASN A 135
None
1.18A 6gngA-5tlcA:
undetectable
6gngA-5tlcA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A


(Xenopus laevis)
PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd)
5 GLY B 498
LEU B 399
VAL B 397
THR B 519
GLY B 520
None
1.06A 6gngA-5up2B:
undetectable
6gngA-5up2B:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfr 26S PROTEASOME
NON-ATPASE
REGULATORY SUBUNIT
11
26S PROTEASOME
REGULATORY SUBUNIT
6B


(Homo sapiens)
no annotation 5 GLY X 273
LEU X 275
GLY D 169
ASP D 171
ASP X 240
None
0.98A 6gngA-5vfrX:
undetectable
6gngA-5vfrX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vld HISTIDINOL
DEHYDROGENASE,
CHLOROPLASTIC


(Medicago
truncatula)
PF00815
(Histidinol_dh)
5 GLY A 248
VAL A 254
GLY A 217
ASN A 197
ASN A 251
None
NAD  A 502 ( 4.9A)
None
None
NAD  A 502 (-3.2A)
1.14A 6gngA-5vldA:
undetectable
6gngA-5vldA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
6 GLY A 662
LEU A 659
THR A 540
GLY A 575
ASN A 655
ASN B 834
None
1.41A 6gngA-5xogA:
undetectable
6gngA-5xogA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-)
no annotation 5 LEU B 373
GLY B  58
ASP B 138
HIS B 323
ASN B 378
NAD  B 501 ( 3.9A)
None
None
ZN  B 505 (-3.2A)
None
1.18A 6gngA-6f3mB:
6.3
6gngA-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE


(Neisseria
meningitidis)
no annotation 5 THR A 301
GLY A 298
LEU A 297
VAL A 293
GLY A  70
HEM  A1002 (-4.4A)
HEM  A1002 (-3.4A)
None
None
None
1.17A 6gngA-6fwfA:
undetectable
6gngA-6fwfA:
9.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-)
no annotation 5 GLY A  41
LEU A  43
VAL A  46
ASP A 132
ASN A 277
ADP  A 601 ( 3.8A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
None
ACR  A 602 (-3.3A)
0.84A 6gngA-6gneA:
42.2
6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-)
no annotation 7 GLY A  41
LEU A  43
VAL A  46
ASP A 161
ASN A 191
ASN A 277
GLN A 336
ADP  A 601 ( 3.8A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.4A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.3A)
ACR  A 602 (-3.1A)
0.53A 6gngA-6gneA:
42.2
6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-)
no annotation 5 GLY A  42
LEU A  43
ASP A 161
ASN A 191
GLN A 336
ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 (-3.4A)
ACR  A 602 (-4.9A)
ACR  A 602 (-3.1A)
0.91A 6gngA-6gneA:
42.2
6gngA-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-)
no annotation 6 GLY A  19
LEU A  20
ASP A 151
HIS A 153
ASN A 182
GLN A 342
ADP  A 601 ( 3.3A)
QPS  A 602 (-4.3A)
QPS  A 602 (-3.3A)
QPS  A 602 (-3.9A)
QPS  A 602 (-4.4A)
QPS  A 602 (-3.2A)
0.88A 6gngA-6gnfA:
54.4
6gngA-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-)
no annotation 10 THR A  17
GLY A  18
LEU A  20
VAL A  23
ASP A 108
ASP A 151
HIS A 153
ASN A 182
ASN A 283
GLN A 342
QPS  A 602 (-3.2A)
ADP  A 601 ( 3.8A)
QPS  A 602 (-4.3A)
None
QPS  A 602 ( 2.5A)
QPS  A 602 (-3.3A)
QPS  A 602 (-3.9A)
QPS  A 602 (-4.4A)
QPS  A 602 (-3.4A)
QPS  A 602 (-3.2A)
0.41A 6gngA-6gnfA:
54.4
6gngA-6gnfA:
undetectable