SIMILAR PATTERNS OF AMINO ACIDS FOR 6GNF_C_QPSC602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		5 GLY A 114
LEU A 115
TYR A 256
HIS A 345
VAL A 420
 PLP  A 999 ( 3.6A)
GLC  A 997 (-3.8A)
GLC  A 996 (-3.8A)
GLC  A 998 (-4.3A)
None
 0.66A 6gnfC-1e4oA:
23.9		 6gnfC-1e4oA:
22.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 GLY A  18
LEU A  19
TRP A 139
HIS A 163
PHE A 167
VAL A 213
CYH A 378
 None
 0.95A 6gnfC-1rzvA:
41.3		 6gnfC-1rzvA:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1rzv GLYCOGEN SYNTHASE 1

(Agrobacterium
tumefaciens) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		8 THR A  16
GLY A  18
LEU A  19
TYR A  96
TRP A 139
HIS A 163
PHE A 167
VAL A 213
 None
 0.75A 6gnfC-1rzvA:
41.3		 6gnfC-1rzvA:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		5 GLY A 180
TYR A 256
SER A 250
PHE A  52
VAL A 203
 None
 1.42A 6gnfC-1v72A:
undetectable		 6gnfC-1v72A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wao SERINE/THREONINE
PROTEIN PHOSPHATASE
5

(Homo sapiens) 		PF00149
(Metallophos)
PF00515
(TPR_1)
PF08321
(PPP5) 		5 GLY 1 270
LEU 1 300
SER 1 403
VAL 1 239
CYH 1 240
 None
 1.44A 6gnfC-1wao1:
undetectable		 6gnfC-1wao1:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1woi AGMATINASE

(Deinococcus
radiodurans) 		PF00491
(Arginase) 		5 GLY A 269
LEU A 270
SER A 122
VAL A  31
CYH A 111
 None
 1.47A 6gnfC-1woiA:
2.6		 6gnfC-1woiA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		5 GLY A 135
LEU A 136
TYR A 280
HIS A 377
VAL A 455
 PLP  A 860 ( 3.3A)
None
None
None
None
 0.76A 6gnfC-1ygpA:
20.8		 6gnfC-1ygpA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 GLY A 114
LEU A 115
TYR A 245
HIS A 334
VAL A 408
 PO4  A1794 (-3.4A)
None
None
FMT  A1799 (-3.9A)
None
 0.90A 6gnfC-2c4mA:
22.7		 6gnfC-2c4mA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf8 PROBABLE HYDROGENASE
NICKEL INCORPORATION
PROTEIN HYPB

(Methanocaldococcus
jannaschii) 		PF02492
(cobW) 		5 GLY A  32
LEU A  28
HIS A 136
PHE A 118
VAL A 220
 None
 1.29A 6gnfC-2hf8A:
2.4		 6gnfC-2hf8A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 301
TYR A 267
SER A 259
HIS A 232
VAL A 318
 None
 1.41A 6gnfC-2ipiA:
undetectable		 6gnfC-2ipiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w8s PHOSPHONATE
MONOESTER HYDROLASE

(Paraburkholderia
caryophylli) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 GLY A 336
TYR A 290
TRP A  14
HIS A 325
VAL A  55
 None
None
None
ZN  A1515 ( 3.2A)
None
 1.33A 6gnfC-2w8sA:
undetectable		 6gnfC-2w8sA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wzs PUTATIVE
ALPHA-1,2-MANNOSIDAS
E

(Bacteroides
thetaiotaomicron) 		PF07971
(Glyco_hydro_92) 		5 THR A 344
GLY A 646
LEU A 353
VAL A 653
CYH A 305
 None
 1.41A 6gnfC-2wzsA:
undetectable		 6gnfC-2wzsA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		5 GLY A 257
LEU A 407
HIS A 402
PHE A 364
VAL A 187
 None
 1.39A 6gnfC-3ab4A:
undetectable		 6gnfC-3ab4A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxl N-CHIMERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		5 GLY A 296
LEU A 297
TYR A 303
SER A 306
HIS A 407
 None
 1.23A 6gnfC-3cxlA:
undetectable		 6gnfC-3cxlA:
22.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d1j GLYCOGEN SYNTHASE

(Escherichia
coli) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 THR A  16
GLY A  18
LEU A  19
TYR A  95
TRP A 138
HIS A 161
VAL A 211
 None
 0.73A 6gnfC-3d1jA:
41.6		 6gnfC-3d1jA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 GLY A 145
LEU A 148
TYR A 107
SER A 101
VAL A 226
 None
None
EDO  A  14 (-3.7A)
EDO  A   8 ( 4.8A)
None
 1.21A 6gnfC-3kezA:
undetectable		 6gnfC-3kezA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 GLY A  17
LEU A  18
TYR A  89
TRP A 129
HIS A 151
 CL  A5703 (-4.7A)
GOL  A6500 ( 4.3A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
 0.85A 6gnfC-3l01A:
34.5		 6gnfC-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l01 GLGA GLYCOGEN
SYNTHASE

(Pyrococcus
abyssi) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		5 LEU A  18
TYR A  89
TRP A 129
HIS A 151
VAL A 193
 GOL  A6500 ( 4.3A)
GOL  A6500 ( 3.9A)
GOL  A6502 (-4.3A)
None
None
 0.56A 6gnfC-3l01A:
34.5		 6gnfC-3l01A:
28.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3w 3-ISOPROPYLMALATE
DEHYDRATASE SMALL
SUBUNIT

(Campylobacter
jejuni) 		PF00694
(Aconitase_C) 		5 GLY A 115
LEU A 114
SER A  71
HIS A 167
PHE A   4
 None
 1.49A 6gnfC-3q3wA:
undetectable		 6gnfC-3q3wA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu4 KMHSV2

(Kluyveromyces
marxianus) 		no annotation 5 LEU A  62
SER A 111
HIS A  63
PHE A 102
CYH A  28
 None
None
SO4  A 408 ( 3.7A)
None
None
 1.43A 6gnfC-3vu4A:
undetectable		 6gnfC-3vu4A:
20.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vue GRANULE-BOUND STARCH
SYNTHASE 1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Oryza sativa) 		PF00534
(Glycos_transf_1)
PF08323
(Glyco_transf_5) 		7 THR A  98
GLY A 100
LEU A 101
TRP A 235
HIS A 264
VAL A 321
CYH A 487
 None
SO4  A 704 (-4.1A)
None
SO4  A 701 ( 4.8A)
None
None
None
 0.62A 6gnfC-3vueA:
49.0		 6gnfC-3vueA:
43.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE

(Thermotoga
maritima) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 THR A 335
GLY A 337
LEU A 213
PHE A 217
VAL A 241
 None
AGS  A1393 (-3.4A)
None
AGS  A1393 ( 4.3A)
None
 1.41A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE

(Thermotoga
maritima) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 THR A 335
GLY A 338
LEU A 213
PHE A 217
VAL A 241
 None
AGS  A1393 ( 4.5A)
None
AGS  A1393 ( 4.3A)
None
 1.25A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2b CELL DIVISION
PROTEIN FTSA,
PUTATIVE

(Thermotoga
maritima) 		PF02491
(SHS2_FTSA)
PF14450
(FtsA) 		5 THR A 335
GLY A 338
LEU A 213
SER A 189
VAL A 241
 None
AGS  A1393 ( 4.5A)
None
None
None
 1.47A 6gnfC-4a2bA:
undetectable		 6gnfC-4a2bA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bqi ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC

(Arabidopsis
thaliana) 		PF00343
(Phosphorylase) 		5 GLY A 138
LEU A 139
TYR A 285
HIS A 379
VAL A 458
 PLP  A 901 (-3.3A)
None
None
None
None
 0.79A 6gnfC-4bqiA:
23.0		 6gnfC-4bqiA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci8 ECHINODERM
MICROTUBULE-ASSOCIAT
ED PROTEIN-LIKE 1

(Homo sapiens) 		PF00400
(WD40)
PF03451
(HELP) 		5 THR A 788
GLY A 548
LEU A 549
SER A 784
TRP A 812
 None
 1.44A 6gnfC-4ci8A:
undetectable		 6gnfC-4ci8A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cog KYNURENINE
FORMAMIDASE

(Burkholderia
cenocepacia) 		PF04199
(Cyclase) 		5 THR A 146
GLY A 143
LEU A 108
SER A 154
VAL A 139
 None
 1.31A 6gnfC-4cogA:
undetectable		 6gnfC-4cogA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 5 GLY A 219
LEU A 220
TYR A 226
SER A  28
PHE A 223
 None
None
COA  A 401 ( 4.8A)
None
CL  A 402 (-4.9A)
 1.35A 6gnfC-4hzpA:
undetectable		 6gnfC-4hzpA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il1 CALMODULIN,
CALCINEURIN SUBUNIT
B TYPE 1,
SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2B
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Rattus
norvegicus) 		PF00149
(Metallophos)
PF13499
(EF-hand_7) 		5 GLY A 450
LEU A 480
SER A 590
VAL A 420
CYH A 421
 None
 1.41A 6gnfC-4il1A:
undetectable		 6gnfC-4il1A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l22 PHOSPHORYLASE

(Streptococcus
mutans) 		PF00343
(Phosphorylase) 		5 GLY A 105
LEU A 106
TYR A 228
HIS A 317
VAL A 384
 None
 0.81A 6gnfC-4l22A:
24.1		 6gnfC-4l22A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pet EXTRACELLULAR
SOLUTE-BINDING
PROTEIN, FAMILY 7

(Colwellia
psychrerythraea) 		PF03480
(DctP) 		5 THR A 244
GLY A 153
LEU A 246
TYR A 101
HIS A  97
 PYR  A 402 ( 4.1A)
None
PYR  A 402 ( 4.6A)
None
None
 1.23A 6gnfC-4petA:
undetectable		 6gnfC-4petA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po5 ALLOPHYCOCYANIN
SUBUNIT ALPHA-B

(Synechocystis
sp. PCC 6803) 		PF00502
(Phycobilisome) 		5 THR A 106
GLY A 108
LEU A 109
SER A   2
VAL A 130
 None
CYC  A 201 ( 4.4A)
None
None
None
 1.25A 6gnfC-4po5A:
undetectable		 6gnfC-4po5A:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Pseudoalteromonas
atlantica) 		PF03480
(DctP) 		5 THR A 238
GLY A 147
LEU A 240
TYR A  95
HIS A  91
 PYR  A 401 (-3.8A)
None
PYR  A 401 (-4.6A)
PYR  A 401 (-4.6A)
None
 1.26A 6gnfC-5cm6A:
undetectable		 6gnfC-5cm6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fok IRON TRANSPORT OUTER
MEMBRANE RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 LEU A  66
SER A 149
HIS A 193
PHE A 120
VAL A 205
 None
 1.44A 6gnfC-5fokA:
undetectable		 6gnfC-5fokA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1u TRANSCRIPTION
INTERMEDIARY FACTOR
1-ALPHA

(Homo sapiens) 		no annotation 5 THR B 947
LEU B 945
SER B 957
VAL B 831
CYH B 852
 None
None
None
None
ZN  B1103 (-2.3A)
 1.45A 6gnfC-5h1uB:
undetectable		 6gnfC-5h1uB:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 GLY A 135
LEU A 136
TYR A 280
HIS A 377
VAL A 455
 PLP  A 901 ( 3.8A)
None
None
None
None
 0.68A 6gnfC-5ikpA:
21.7		 6gnfC-5ikpA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 GLY A 182
LEU A 183
TYR A 329
HIS A 421
VAL A 584
 GLC  A1001 ( 3.7A)
GLC  A1001 (-4.3A)
None
GLC  A1001 (-3.7A)
None
 0.78A 6gnfC-5lrbA:
23.1		 6gnfC-5lrbA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 THR A 242
GLY A 113
LEU A 239
HIS A 230
VAL A 125
 None
 1.42A 6gnfC-6f5dA:
undetectable		 6gnfC-6f5dA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 5 GLY A  42
LEU A  43
SER A 362
HIS A 190
VAL A 244
 ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
None
ACR  A 602 (-3.8A)
ACR  A 602 (-4.3A)
 1.20A 6gnfC-6gneA:
42.4		 6gnfC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gne -

(-) 		no annotation 7 GLY A  42
LEU A  43
TYR A 127
TRP A 162
HIS A 190
VAL A 244
CYH A 414
 ADP  A 601 ( 3.2A)
ACR  A 602 ( 4.7A)
ACR  A 602 ( 4.2A)
ACR  A 602 (-4.2A)
ACR  A 602 (-3.8A)
ACR  A 602 (-4.3A)
ACR  A 602 (-4.3A)
 0.46A 6gnfC-6gneA:
42.4		 6gnfC-6gneA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gng -

(-) 		no annotation 8 THR A  35
GLY A  37
LEU A  38
TYR A 120
TRP A 170
HIS A 199
VAL A 269
CYH A 436
 QPS  A 601 ( 3.0A)
ADP  A 602 ( 3.4A)
QPS  A 601 (-4.1A)
QPS  A 601 (-4.4A)
QPS  A 601 (-4.2A)
QPS  A 601 (-4.4A)
QPS  A 601 ( 4.7A)
QPS  A 601 (-4.8A)
 0.33A 6gnfC-6gngA:
52.3		 6gnfC-6gngA:
undetectable