SIMILAR PATTERNS OF AMINO ACIDS FOR 6GNB_A_ACTA307

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6m DNA TOPOISOMERASE
III

(Escherichia
coli) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG A 167
LYS A  72
TYR A  54
 None
 1.11A 6gnbA-1d6mA:
0.0		 6gnbA-1d6mA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8p MAGNESIUM-CHELATASE
38 KDA SUBUNIT

(Rhodobacter
capsulatus) 		PF01078
(Mg_chelatase) 		3 ARG A 246
LYS A  18
TYR A 234
 None
 1.18A 6gnbA-1g8pA:
undetectable		 6gnbA-1g8pA:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ga8 GALACTOSYL
TRANSFERASE LGTC

(Neisseria
meningitidis) 		PF01501
(Glyco_transf_8) 		3 ARG A 135
LYS A 222
TYR A 230
 None
 1.33A 6gnbA-1ga8A:
undetectable		 6gnbA-1ga8A:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hus RIBOSOMAL PROTEIN S7

(Geobacillus
stearothermophilus) 		PF00177
(Ribosomal_S7) 		3 ARG A 101
LYS A 136
TYR A 106
 None
 0.97A 6gnbA-1husA:
undetectable		 6gnbA-1husA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hx8 SYNAPSE-ENRICHED
CLATHRIN ADAPTOR
PROTEIN LAP

(Drosophila
melanogaster) 		PF07651
(ANTH) 		3 ARG A 260
LYS A 253
TYR A 225
 None
 1.07A 6gnbA-1hx8A:
undetectable		 6gnbA-1hx8A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k6m 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE
2-PHOSPHATASE

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 ARG A  82
LYS A 174
TYR A 180
 None
AGS  A 503 (-2.9A)
None
 1.26A 6gnbA-1k6mA:
0.4		 6gnbA-1k6mA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m1j FIBRINOGEN BETA
CHAIN

(Gallus gallus) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 ARG B 384
LYS B 275
TYR B 342
 None
 1.07A 6gnbA-1m1jB:
undetectable		 6gnbA-1m1jB:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oki BETA CRYSTALLIN B1

(Homo sapiens) 		PF00030
(Crystall) 		3 ARG A 139
LYS A 142
TYR A  58
 None
 1.38A 6gnbA-1okiA:
undetectable		 6gnbA-1okiA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfx CONSERVED
HYPOTHETICAL PROTEIN
AF2008

(Archaeoglobus
fulgidus) 		PF01978
(TrmB) 		3 ARG A  64
LYS A  81
TYR A  25
 None
 1.20A 6gnbA-1sfxA:
undetectable		 6gnbA-1sfxA:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdp CARNOBACTERIOCIN B2
IMMUNITY PROTEIN

(Carnobacterium
maltaromaticum) 		PF08951
(EntA_Immun) 		3 ARG A  56
LYS A 101
TYR A  97
 None
 1.25A 6gnbA-1tdpA:
undetectable		 6gnbA-1tdpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 3 ARG A 270
LYS A 222
TYR A 191
 None
 1.16A 6gnbA-1u5uA:
undetectable		 6gnbA-1u5uA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ufa TT1467 PROTEIN

(Thermus
thermophilus) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		3 ARG A 387
LYS A 175
TYR A 169
 None
 1.31A 6gnbA-1ufaA:
undetectable		 6gnbA-1ufaA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		3 ARG A 161
LYS A 249
TYR A 243
 None
 1.35A 6gnbA-1vqvA:
undetectable		 6gnbA-1vqvA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		3 ARG A  90
LYS A  50
TYR A  52
 None
 1.36A 6gnbA-1x3lA:
2.5		 6gnbA-1x3lA:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvf 3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE

(Saccharomyces
cerevisiae) 		PF06052
(3-HAO) 		3 ARG A 130
LYS A  67
TYR A  48
 None
 1.16A 6gnbA-1zvfA:
undetectable		 6gnbA-1zvfA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a62 CADHERIN-8

(Mus musculus) 		PF00028
(Cadherin) 		3 ARG A 236
LYS A 238
TYR A 252
 None
 1.03A 6gnbA-2a62A:
undetectable		 6gnbA-2a62A:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a6e RNA POLYMERASE SIGMA
FACTOR RPOD

(Thermus
thermophilus) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4) 		3 ARG F 231
LYS F 226
TYR F 238
 None
 1.04A 6gnbA-2a6eF:
undetectable		 6gnbA-2a6eF:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aqx PREDICTED: INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE B

(Mus musculus) 		PF03770
(IPK) 		3 ARG A 791
LYS A 782
TYR A 766
 None
 1.07A 6gnbA-2aqxA:
undetectable		 6gnbA-2aqxA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6x CITRATE SYNTHASE 1

(Bacillus
subtilis) 		PF00285
(Citrate_synt) 		3 ARG A 291
LYS A 238
TYR A 296
 None
 1.18A 6gnbA-2c6xA:
undetectable		 6gnbA-2c6xA:
25.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chg REPLICATION FACTOR C
SMALL SUBUNIT

(Archaeoglobus
fulgidus) 		PF00004
(AAA) 		3 ARG A  86
LYS A  90
TYR A 129
 None
 1.02A 6gnbA-2chgA:
undetectable		 6gnbA-2chgA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cir HEXOSE-6-PHOSPHATE
MUTAROTASE

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim) 		3 ARG A  86
LYS A  54
TYR A  27
 BG6  A 501 (-3.0A)
None
None
 1.15A 6gnbA-2cirA:
undetectable		 6gnbA-2cirA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d13 HYPOTHETICAL PROTEIN
PH1257

(Pyrococcus
horikoshii) 		PF01902
(Diphthami_syn_2) 		3 ARG A  30
LYS A  90
TYR A  33
 None
 1.31A 6gnbA-2d13A:
3.0		 6gnbA-2d13A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ddh ACYL-COA OXIDASE

(Rattus
norvegicus) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 ARG A 493
LYS A 500
TYR A 439
 None
 0.92A 6gnbA-2ddhA:
undetectable		 6gnbA-2ddhA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7v TRANSMEMBRANE
PROTEASE

(Mus musculus) 		PF01390
(SEA) 		3 ARG A 134
LYS A 127
TYR A  50
 None
 1.28A 6gnbA-2e7vA:
undetectable		 6gnbA-2e7vA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e8y AMYX PROTEIN

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ARG A 381
LYS A 385
TYR A 418
 None
 1.28A 6gnbA-2e8yA:
undetectable		 6gnbA-2e8yA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gai DNA TOPOISOMERASE I

(Thermotoga
maritima) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 ARG A 141
LYS A  42
TYR A 149
 None
 1.30A 6gnbA-2gaiA:
undetectable		 6gnbA-2gaiA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gwc GLUTAMATE CYSTEINE
LIGASE

(Brassica juncea) 		PF04107
(GCS2) 		3 ARG A 387
LYS A 381
TYR A 320
 BSC  A   2 (-2.6A)
None
None
 1.24A 6gnbA-2gwcA:
undetectable		 6gnbA-2gwcA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdl SMALL INDUCIBLE
CYTOKINE B14

(Homo sapiens) 		PF00048
(IL8) 		3 ARG A  73
LYS A  19
TYR A  65
 None
 1.15A 6gnbA-2hdlA:
undetectable		 6gnbA-2hdlA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hly HYPOTHETICAL PROTEIN
ATU2299

(Agrobacterium
fabrum) 		PF09641
(DUF2026) 		3 ARG A  14
LYS A   8
TYR A  49
 None
 1.09A 6gnbA-2hlyA:
undetectable		 6gnbA-2hlyA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq9 ENDONUCLEASE 4

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		3 ARG A 227
LYS A 157
TYR A 188
 None
 0.77A 6gnbA-2nq9A:
undetectable		 6gnbA-2nq9A:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o8i HYPOTHETICAL PROTEIN
ATU2327

(Agrobacterium
fabrum) 		PF09349
(OHCU_decarbox) 		3 ARG A  10
LYS A   1
TYR A  26
 None
 1.38A 6gnbA-2o8iA:
undetectable		 6gnbA-2o8iA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ohh TYPE A FLAVOPROTEIN
FPRA

(Methanothermobacter
thermautotrophicus) 		PF00258
(Flavodoxin_1)
PF00753
(Lactamase_B) 		3 ARG A 258
LYS A 303
TYR A 291
 None
 1.36A 6gnbA-2ohhA:
5.1		 6gnbA-2ohhA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p5d UPF0310 PROTEIN
MJECL36

(Methanocaldococcus
jannaschii) 		PF01878
(EVE) 		3 ARG A  62
LYS A  20
TYR A  65
 ARG  A  62 ( 0.6A)
LYS  A  20 ( 0.0A)
TYR  A  65 ( 1.3A)
 1.15A 6gnbA-2p5dA:
undetectable		 6gnbA-2p5dA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgn TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Bacillus
halodurans) 		PF01715
(IPPT) 		3 ARG A 269
LYS A 272
TYR A 205
 None
 1.14A 6gnbA-2qgnA:
1.6		 6gnbA-2qgnA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v14 KINESIN-LIKE MOTOR
PROTEIN C20ORF23

(Homo sapiens) 		PF00787
(PX) 		3 ARG A1190
LYS A1207
TYR A1311
 None
 1.24A 6gnbA-2v14A:
undetectable		 6gnbA-2v14A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vk4 PYRUVATE
DECARBOXYLASE

(Kluyveromyces
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 ARG A 532
LYS A 463
TYR A 465
 None
 1.31A 6gnbA-2vk4A:
undetectable		 6gnbA-2vk4A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxg CG6181-PA, ISOFORM A

(Drosophila
melanogaster) 		no annotation 3 ARG A1340
LYS A1344
TYR A1320
 None
 0.91A 6gnbA-2vxgA:
undetectable		 6gnbA-2vxgA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5s PROCESSED GLYCEROL
PHOSPHATE
LIPOTEICHOIC ACID
SYNTHASE

(Staphylococcus
aureus) 		PF00884
(Sulfatase) 		3 ARG A 619
LYS A 323
TYR A 328
 None
 0.94A 6gnbA-2w5sA:
undetectable		 6gnbA-2w5sA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wno TUMOR NECROSIS
FACTOR-INDUCIBLE
GENE 6 PROTEIN

(Homo sapiens) 		PF00431
(CUB) 		3 ARG A 208
LYS A 228
TYR A 196
 None
 1.20A 6gnbA-2wnoA:
undetectable		 6gnbA-2wnoA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy9 ANGIOTENSIN-CONVERTI
NG ENZYME

(Homo sapiens) 		PF01401
(Peptidase_M2) 		3 ARG A 186
LYS A 511
TYR A 146
 CL  A1626 (-3.8A)
3ES  A1635 (-2.6A)
None
 1.36A 6gnbA-2xy9A:
undetectable		 6gnbA-2xy9A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b54 NUCLEOSIDE
DIPHOSPHATE KINASE

(Saccharomyces
cerevisiae) 		PF00334
(NDK) 		3 ARG A  86
LYS A  82
TYR A  34
 None
 0.83A 6gnbA-3b54A:
undetectable		 6gnbA-3b54A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqo FBP32

(Morone
saxatilis) 		PF00754
(F5_F8_type_C) 		3 ARG A 147
LYS A   4
TYR A   1
 None
 1.25A 6gnbA-3cqoA:
undetectable		 6gnbA-3cqoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3els PRE-MRNA LEAKAGE
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00498
(FHA) 		3 ARG A 181
LYS A 153
TYR A 155
 None
 1.28A 6gnbA-3elsA:
undetectable		 6gnbA-3elsA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fv5 DNA TOPOISOMERASE 4
SUBUNIT B

(Escherichia
coli) 		PF02518
(HATPase_c) 		3 ARG A  21
LYS A  15
TYR A  26
 None
 1.17A 6gnbA-3fv5A:
undetectable		 6gnbA-3fv5A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE

(Pseudomonas
putida) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		3 ARG A 246
LYS A 224
TYR A 235
 None
 1.34A 6gnbA-3h8fA:
undetectable		 6gnbA-3h8fA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		3 ARG A 100
LYS A 180
TYR A  46
 DST  A 460 (-3.0A)
None
None
 1.37A 6gnbA-3i4xA:
undetectable		 6gnbA-3i4xA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyn QUINONE
OXIDOREDUCTASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 ARG A 316
LYS A 307
TYR A 300
 None
 1.28A 6gnbA-3jynA:
4.1		 6gnbA-3jynA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kk7 PUTATIVE CELL
INVASION PROTEIN
WITH MAC/PERFORIN
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF01823
(MACPF) 		3 ARG A 105
LYS A 199
TYR A 109
 EDO  A 605 ( 3.7A)
EDO  A 605 (-2.9A)
None
 0.97A 6gnbA-3kk7A:
undetectable		 6gnbA-3kk7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kwv LETHAL FACTOR

(Bacillus
anthracis) 		PF07737
(ATLF) 		3 ARG C 230
LYS C  65
TYR C 148
 None
 1.31A 6gnbA-3kwvC:
undetectable		 6gnbA-3kwvC:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
virus Qbeta) 		no annotation 3 ARG G  67
LYS G 399
TYR G 401
 None
 1.31A 6gnbA-3mmpG:
undetectable		 6gnbA-3mmpG:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwe ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF16114
(Citrate_bind) 		3 ARG A 359
LYS A 321
TYR A 364
 None
 1.18A 6gnbA-3mweA:
undetectable		 6gnbA-3mweA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdw UNCHARACTERIZED
HYDROLASE YUTF

(Bacillus
subtilis) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 ARG A  32
LYS A  35
TYR A  41
 None
 1.20A 6gnbA-3pdwA:
undetectable		 6gnbA-3pdwA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		3 ARG A 260
LYS A 264
TYR A 300
 None
 1.26A 6gnbA-3pzlA:
1.8		 6gnbA-3pzlA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rju BETA-LACTAMASE/D-ALA
NINE
CARBOXYPEPTIDASE

(Yersinia pestis) 		PF00144
(Beta-lactamase) 		3 ARG A 104
LYS A  79
TYR A  87
 None
 1.31A 6gnbA-3rjuA:
undetectable		 6gnbA-3rjuA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		3 ARG B 443
LYS B 291
TYR B 293
 None
 1.31A 6gnbA-3thwB:
undetectable		 6gnbA-3thwB:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tr2 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Coxiella
burnetii) 		PF00215
(OMPdecase) 		3 ARG A  58
LYS A   5
TYR A 209
 None
 1.10A 6gnbA-3tr2A:
undetectable		 6gnbA-3tr2A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um1 BRO1
DOMAIN-CONTAINING
PROTEIN BROX

(Homo sapiens) 		PF03097
(BRO1) 		3 ARG A 145
LYS A  58
TYR A 122
 None
 1.14A 6gnbA-3um1A:
undetectable		 6gnbA-3um1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		3 ARG A 130
LYS A 154
TYR A 123
 None
 1.20A 6gnbA-3vexA:
undetectable		 6gnbA-3vexA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a39 METALLO-CARBOXYPEPTI
DASE

(Pseudomonas
aeruginosa) 		PF00246
(Peptidase_M14) 		3 ARG A 151
LYS A 159
TYR A 202
 None
 1.19A 6gnbA-4a39A:
1.7		 6gnbA-4a39A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4l 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		3 ARG A  75
LYS A 168
TYR A 174
 None
PO4  A1447 (-2.9A)
None
 1.37A 6gnbA-4d4lA:
undetectable		 6gnbA-4d4lA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f5x RNA-DIRECTED RNA
POLYMERASE

(Rotavirus A) 		PF02123
(RdRP_4)
PF12289
(Rotavirus_VP1) 		3 ARG W 879
LYS W 882
TYR W1036
 None
 1.32A 6gnbA-4f5xW:
undetectable		 6gnbA-4f5xW:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flx DNA POLYMERASE 1

(Pyrococcus
abyssi) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 ARG A 504
LYS A 502
TYR A 497
 ARG  A 504 (-0.6A)
LYS  A 502 ( 0.0A)
TYR  A 497 ( 1.3A)
 1.33A 6gnbA-4flxA:
1.3		 6gnbA-4flxA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyp IMMUNOGLOBULIN-BINDI
NG PROTEIN 1

(Homo sapiens) 		PF04177
(TAP42) 		3 ARG A 199
LYS A 176
TYR A 192
 None
 1.21A 6gnbA-4iypA:
undetectable		 6gnbA-4iypA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jng NUCLEOCAPSID PROTEIN

(Sathuperi
orthobunyavirus) 		PF00952
(Bunya_nucleocap) 		3 ARG A 102
LYS A 109
TYR A 138
 None
 0.93A 6gnbA-4jngA:
undetectable		 6gnbA-4jngA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxo FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		3 ARG A1508
LYS A1478
TYR A1483
 None
 1.20A 6gnbA-4lxoA:
undetectable		 6gnbA-4lxoA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mit RHO FAMILY GTPASE

(Entamoeba
histolytica) 		PF00071
(Ras) 		3 ARG A  33
LYS A 173
TYR A  30
 None
 1.29A 6gnbA-4mitA:
undetectable		 6gnbA-4mitA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		3 ARG D 131
LYS D 179
TYR D 190
 None
 0.44A 6gnbA-4mwaD:
undetectable		 6gnbA-4mwaD:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qam X-LINKED RETINITIS
PIGMENTOSA GTPASE
REGULATOR-INTERACTIN
G PROTEIN 1

(Homo sapiens) 		no annotation 3 ARG B1189
LYS B1177
TYR B1146
 None
 1.21A 6gnbA-4qamB:
undetectable		 6gnbA-4qamB:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhb UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF09112
(N-glycanase_N)
PF09113
(N-glycanase_C) 		3 ARG A  69
LYS A 101
TYR A 218
 None
 1.26A 6gnbA-4qhbA:
undetectable		 6gnbA-4qhbA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qni UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF14274
(DUF4361)
PF16343
(DUF4973) 		3 ARG A 251
LYS A 155
TYR A 229
 None
 1.25A 6gnbA-4qniA:
undetectable		 6gnbA-4qniA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvs TORSIN-1A-INTERACTIN
G PROTEIN 1
VHH DOMAIN BS-1

(Homo sapiens;
Vicugna pacos) 		PF05609
(LAP1C)
PF05609
(LAP1C) 		3 ARG a  54
LYS A 556
TYR A 493
 None
 1.12A 6gnbA-4tvsa:
undetectable		 6gnbA-4tvsa:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u36 SEED LECTIN

(Vatairea
macrocarpa) 		PF00139
(Lectin_legB) 		3 ARG A 136
LYS A 152
TYR A 187
 CIT  A 308 (-4.0A)
None
None
 1.28A 6gnbA-4u36A:
undetectable		 6gnbA-4u36A:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uoo LIPOTEICHOIC ACID
SYNTHASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		3 ARG A 625
LYS A 330
TYR A 335
 None
 0.84A 6gnbA-4uooA:
0.2		 6gnbA-4uooA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yit MEGANUCLEASE I-AABMI

(Gremmeniella
abietina) 		PF00961
(LAGLIDADG_1) 		3 ARG A  44
LYS A  51
TYR A  69
 None
 1.31A 6gnbA-4yitA:
undetectable		 6gnbA-4yitA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		3 ARG A 443
LYS A 322
TYR A 466
 None
 1.10A 6gnbA-4yj5A:
undetectable		 6gnbA-4yj5A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zcf RESTRICTION
ENDONUCLEASE
ECOP15I, RESTRICTION
SUBUNIT

(Escherichia
coli) 		PF04851
(ResIII) 		3 ARG C 505
LYS C 527
TYR C 556
 None
 1.33A 6gnbA-4zcfC:
undetectable		 6gnbA-4zcfC:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zhj MG-CHELATASE SUBUNIT
CHLH

(Synechocystis
sp. PCC 6803) 		PF02514
(CobN-Mg_chel)
PF11965
(DUF3479) 		3 ARG A 667
LYS A 641
TYR A 669
 None
 1.37A 6gnbA-4zhjA:
2.3		 6gnbA-4zhjA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2a APO FORM OF
ANOXYBACILLUS
ALPHA-AMYLASES

(Anoxybacillus
ayderensis) 		PF00128
(Alpha-amylase) 		3 ARG A 442
LYS A 439
TYR A 457
 None
 1.17A 6gnbA-5a2aA:
undetectable		 6gnbA-5a2aA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a2r ANGIOTENSIN-CONVERTI
NG ENZYME

(Drosophila
melanogaster) 		PF01401
(Peptidase_M2) 		3 ARG A 473
LYS A 495
TYR A 170
 None
MLT  A1615 (-2.7A)
None
 1.17A 6gnbA-5a2rA:
undetectable		 6gnbA-5a2rA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8j VWA2

(Sulfolobus
acidocaldarius) 		PF00092
(VWA) 		3 ARG A 147
LYS A 143
TYR A 149
 None
 1.36A 6gnbA-5a8jA:
1.8		 6gnbA-5a8jA:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 ARG A 373
LYS A 287
TYR A 731
 None
 1.35A 6gnbA-5chcA:
2.0		 6gnbA-5chcA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exc GREEN FLUORESCENT
PROTEIN

(Dendronephthya
sp. SSAL-2002) 		PF01353
(GFP) 		3 ARG I 216
LYS I 145
TYR I 188
 None
 1.36A 6gnbA-5excI:
undetectable		 6gnbA-5excI:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fb3 GLYCEROL-1-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Pyrobaculum
calidifontis) 		PF13685
(Fe-ADH_2) 		3 ARG A  32
LYS A  69
TYR A  90
 None
SO4  A2004 (-3.8A)
None
 1.03A 6gnbA-5fb3A:
2.7		 6gnbA-5fb3A:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpy GENERAL
TRANSCRIPTION FACTOR
IIE SUBUNIT 1
TRANSCRIPTION
INITIATION FACTOR
IIE SUBUNIT BETA

(Homo sapiens;
Homo sapiens) 		PF02002
(TFIIE_alpha)
PF08271
(TF_Zn_Ribbon)
no annotation 		3 ARG B 239
LYS B 232
TYR A 105
 None
 1.24A 6gnbA-5gpyB:
undetectable		 6gnbA-5gpyB:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		3 ARG A 239
LYS A 248
TYR A 250
 None
 1.27A 6gnbA-5h5jA:
3.1		 6gnbA-5h5jA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		3 ARG A 279
LYS A   5
TYR A  10
 None
 1.32A 6gnbA-5i0pA:
undetectable		 6gnbA-5i0pA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j44 SERINE PROTEASE SEPA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF02395
(Peptidase_S6) 		3 ARG A 139
LYS A 223
TYR A 218
 None
 1.31A 6gnbA-5j44A:
undetectable		 6gnbA-5j44A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k66 NTA1P

(Saccharomyces
cerevisiae) 		PF00795
(CN_hydrolase) 		3 ARG A 135
LYS A  84
TYR A 108
 None
 1.35A 6gnbA-5k66A:
undetectable		 6gnbA-5k66A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m62 C-TYPE LECTIN DOMAIN
FAMILY 4 MEMBER K

(Mus musculus) 		PF00059
(Lectin_C) 		3 ARG A 324
LYS A 192
TYR A 326
 GOL  A 407 (-3.3A)
None
None
 1.37A 6gnbA-5m62A:
undetectable		 6gnbA-5m62A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7x RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN11

(Saccharomyces
cerevisiae) 		PF04090
(RNA_pol_I_TF) 		3 ARG C  17
LYS C  20
TYR C 187
 None
 1.37A 6gnbA-5o7xC:
undetectable		 6gnbA-5o7xC:
18.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 ARG A 348
LYS A 351
TYR A 374
 None
 1.26A 6gnbA-5opjA:
undetectable		 6gnbA-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ori ALBUMIN

(Capra hircus) 		no annotation 3 ARG A 144
LYS A 136
TYR A 160
 None
 1.24A 6gnbA-5oriA:
undetectable		 6gnbA-5oriA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9j FLAP ENDONUCLEASE
GEN HOMOLOG 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 ARG A 401
LYS A 404
TYR A 456
 None
 1.20A 6gnbA-5t9jA:
undetectable		 6gnbA-5t9jA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5te1 ATP-CITRATE SYNTHASE

(Homo sapiens) 		PF00549
(Ligase_CoA)
PF02629
(CoA_binding)
PF16114
(Citrate_bind) 		3 ARG A 359
LYS A 321
TYR A 364
 None
 1.07A 6gnbA-5te1A:
2.3		 6gnbA-5te1A:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5up2 N-METHYL-D-ASPARTATE
RECEPTOR SUBUNIT
NR2A

(Xenopus laevis) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		3 ARG B 283
LYS B 352
TYR B 347
 None
 0.97A 6gnbA-5up2B:
undetectable		 6gnbA-5up2B:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v57 SMOOTHENED
HOMOLOG,FLAVODOXIN,S
MOOTHENED HOMOLOG

(Desulfovibrio
vulgaris;
Homo sapiens) 		PF00258
(Flavodoxin_1)
PF01392
(Fz)
PF01534
(Frizzled) 		3 ARG A 161
LYS A 105
TYR A 130
 None
 1.04A 6gnbA-5v57A:
undetectable		 6gnbA-5v57A:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w2h INOSITOL
POLYPHOSPHATE
MULTIKINASE,INOSITOL
POLYPHOSPHATE
MULTIKINASE

(Homo sapiens) 		PF03770
(IPK) 		3 ARG A 272
LYS A 112
TYR A  94
 None
 1.34A 6gnbA-5w2hA:
undetectable		 6gnbA-5w2hA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yg7 RIBOSE
1,5-BISPHOSPHATE
ISOMERASE

(Pyrococcus
horikoshii) 		no annotation 3 ARG A 162
LYS A 168
TYR A 183
 None
 1.38A 6gnbA-5yg7A:
undetectable		 6gnbA-5yg7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 3 ARG A 197
LYS A 179
TYR A 220
 None
 1.38A 6gnbA-5znnA:
undetectable		 6gnbA-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 3 ARG A 227
LYS A  96
TYR A 114
 None
None
NAG  A1099 ( 3.6A)
 1.17A 6gnbA-6bfuA:
undetectable		 6gnbA-6bfuA:
14.83