SIMILAR PATTERNS OF AMINO ACIDS FOR 6GMD_B_ACTB403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm7 HYPOTHETICAL PROTEIN
AQ_1665

(Aquifex
aeolicus) 		PF12850
(Metallophos_2) 		4 ARG A 125
TYR A 122
HIS A 145
HIS A 111
 None
 1.49A 6gmdB-1xm7A:
0.0		 6gmdB-1xm7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nym SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		4 ARG C  89
TYR C 127
HIS C 118
HIS C  59
 None
None
None
MN  C 502 (-3.5A)
 1.49A 6gmdB-2nymC:
0.0		 6gmdB-2nymC:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4y SERINE/THREONINE-PRO
TEIN PHOSPHATASE
PP1-ALPHA CATALYTIC
SUBUNIT

(Homo sapiens) 		PF00149
(Metallophos)
PF16891
(STPPase_N) 		4 ARG A  96
TYR A 134
HIS A 125
HIS A  66
 None
None
MN  A 402 ( 4.8A)
MN  A 402 (-3.3A)
 1.46A 6gmdB-3v4yA:
0.0		 6gmdB-3v4yA:
21.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4md8 CASEIN KINASE II
SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		4 ARG E 195
TYR E 196
HIS E 234
HIS E 236
 None
 0.46A 6gmdB-4md8E:
43.4		 6gmdB-4md8E:
93.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6etz BETA-GALACTOSIDASE

(Arthrobacter
sp. 32cB) 		no annotation 4 ARG A 342
TYR A 369
HIS A 334
HIS A 553
 None
 1.16A 6gmdB-6etzA:
0.0		 6gmdB-6etzA:
undetectable