SIMILAR PATTERNS OF AMINO ACIDS FOR 6GIQ_A_CUA601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		3 HIS A 233
HIS A 282
HIS A 283
 CU  A 803 (-3.1A)
HAS  A 801 ( 3.3A)
CU  A 803 ( 3.2A)
 0.68A 6giqa-1ehkA:
33.0		 6giqa-1ehkA:
27.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1fft UBIQUINOL OXIDASE

(Escherichia
coli) 		PF00115
(COX1) 		3 HIS A 284
HIS A 333
HIS A 334
 CU  A1003 (-3.3A)
CU  A1003 ( 3.4A)
CU  A1003 ( 3.4A)
 0.71A 6giqa-1fftA:
45.3		 6giqa-1fftA:
33.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 HIS A 224
HIS A 198
HIS A 194
 CU  A 665 (-3.5A)
CU  A 665 (-3.1A)
CU  A 665 (-3.0A)
 0.73A 6giqa-1hcyA:
undetectable		 6giqa-1hcyA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1js8 HEMOCYANIN

(Enteroctopus
dofleini) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A2671
HIS A2702
HIS A2701
 CUO  A 888 (-3.4A)
CUO  A 888 (-3.3A)
None
 0.72A 6giqa-1js8A:
undetectable		 6giqa-1js8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		3 HIS A 149
HIS A 316
HIS A 272
 ZN  A 479 (-3.1A)
None
SO4  A 481 ( 4.8A)
 0.74A 6giqa-1k7hA:
undetectable		 6giqa-1k7hA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrh AUXIN-BINDING
PROTEIN 1

(Zea mays) 		PF02041
(Auxin_BP) 		3 HIS A  59
HIS A 106
HIS A  57
 ZN  A 180 ( 3.5A)
ZN  A 180 (-3.3A)
ZN  A 180 ( 3.4A)
 0.76A 6giqa-1lrhA:
undetectable		 6giqa-1lrhA:
14.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		3 HIS A 276
HIS A 325
HIS A 326
 CU  A 603 (-3.2A)
CU  A 603 ( 3.4A)
CU  A 603 ( 3.3A)
 0.64A 6giqa-1qleA:
46.6		 6giqa-1qleA:
52.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxq YFIT

(Bacillus
subtilis) 		PF12867
(DinB_2) 		3 HIS A  67
HIS A 160
HIS A 164
 NI  A 300 (-3.3A)
NI  A 300 (-3.3A)
NI  A 300 (-3.3A)
 0.58A 6giqa-1rxqA:
2.1		 6giqa-1rxqA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v15 COLICIN E9

(Escherichia
coli) 		no annotation 3 HIS A 102
HIS A 131
HIS A 127
 ZN  A1132 (-3.2A)
ZN  A1132 (-3.3A)
ZN  A1132 (-3.4A)
 0.73A 6giqa-1v15A:
undetectable		 6giqa-1v15A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		3 HIS A 432
HIS A 320
HIS A 360
 ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.3A)
None
 0.73A 6giqa-1zefA:
undetectable		 6giqa-1zefA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5v CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)
(CARBONIC
DEHYDRATASE)

(Mycobacterium
tuberculosis) 		PF00484
(Pro_CA) 		3 HIS A  -3
HIS A  -1
HIS A   0
 ZN  A 405 (-3.1A)
None
ZN  A 405 (-3.2A)
 0.71A 6giqa-2a5vA:
undetectable		 6giqa-2a5vA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 HIS A 392
HIS A  91
HIS A  90
 None
FAD  A1524 (-4.3A)
FAD  A1524 (-4.2A)
 0.59A 6giqa-2c3dA:
undetectable		 6giqa-2c3dA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		3 HIS A 106
HIS A 145
HIS A 104
 FE  A1001 (-3.3A)
FE  A1001 (-3.4A)
FE  A1001 (-3.2A)
 0.71A 6giqa-2d40A:
undetectable		 6giqa-2d40A:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		3 HIS A 240
HIS A 290
HIS A 291
 CU  A 517 (-3.1A)
CU  A 517 ( 3.2A)
CU  A 517 ( 3.1A)
 0.67A 6giqa-2eijA:
49.5		 6giqa-2eijA:
57.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f22 BH3987

(Bacillus
halodurans) 		PF05163
(DinB) 		3 HIS A  42
HIS A 114
HIS A 118
 NI  A 144 (-3.3A)
NI  A 144 (-3.2A)
NI  A 144 (-3.2A)
 0.65A 6giqa-2f22A:
2.5		 6giqa-2f22A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f4p HYPOTHETICAL PROTEIN
TM1010

(Thermotoga
maritima) 		PF07883
(Cupin_2) 		3 HIS A  95
HIS A  52
HIS A  93
 UNL  A 136 (-3.9A)
UNL  A 136 (-3.3A)
None
 0.76A 6giqa-2f4pA:
undetectable		 6giqa-2f4pA:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gc1 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Pyrococcus
furiosus) 		PF06560
(GPI) 		3 HIS A  90
HIS A 136
HIS A  88
 ZN  A 401 ( 3.4A)
ZN  A 401 ( 3.3A)
ZN  A 401 ( 3.4A)
 0.75A 6giqa-2gc1A:
undetectable		 6giqa-2gc1A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p3x POLYPHENOL OXIDASE,
CHLOROPLAST

(Vitis vinifera) 		PF00264
(Tyrosinase)
PF12142
(PPO1_DWL) 		3 HIS A 239
HIS A 272
HIS A 271
 C2O  A 340 (-3.2A)
C2O  A 340 (-3.1A)
None
 0.73A 6giqa-2p3xA:
undetectable		 6giqa-2p3xA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p7h HYPOTHETICAL PROTEIN

(Pectobacterium
atrosepticum) 		PF13489
(Methyltransf_23) 		3 HIS A 170
HIS A 114
HIS A 172
 None
None
EDO  A 252 (-3.9A)
 0.66A 6giqa-2p7hA:
undetectable		 6giqa-2p7hA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe9 UNCHARACTERIZED
PROTEIN YIZA

(Bacillus
subtilis) 		PF05163
(DinB) 		3 HIS A  44
HIS A 124
HIS A 128
 NI  A 200 ( 3.3A)
NI  A 200 ( 3.3A)
NI  A 200 ( 3.4A)
 0.67A 6giqa-2qe9A:
2.3		 6giqa-2qe9A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qnl UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF12867
(DinB_2) 		3 HIS A  52
HIS A 148
HIS A 152
 None
 0.70A 6giqa-2qnlA:
undetectable		 6giqa-2qnlA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qt3 N-ISOPROPYLAMMELIDE
ISOPROPYL
AMIDOHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		3 HIS A 217
HIS A 249
HIS A 219
 ZN  A 501 (-3.5A)
None
None
 0.72A 6giqa-2qt3A:
undetectable		 6giqa-2qt3A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd9 BH0186 PROTEIN

(Bacillus
halodurans) 		PF12867
(DinB_2) 		3 HIS A  48
HIS A 142
HIS A 146
 NI  A 300 (-3.3A)
NI  A 300 ( 3.2A)
NI  A 300 ( 3.4A)
 0.58A 6giqa-2rd9A:
2.5		 6giqa-2rd9A:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		3 HIS A 103
HIS A 147
HIS A 101
 MN  A1005 (-3.5A)
MN  A1005 (-3.5A)
MN  A1005 (-3.3A)
 0.73A 6giqa-2vqaA:
undetectable		 6giqa-2vqaA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		3 HIS A 170
HIS A 305
HIS A 255
 PO4  A1474 (-4.5A)
None
None
 0.68A 6giqa-2x98A:
undetectable		 6giqa-2x98A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
POLYPEPTIDE I+III

(Thermus
thermophilus) 		PF00115
(COX1)
PF00510
(COX3) 		3 HIS A 250
HIS A 299
HIS A 300
 CU  A1017 (-3.2A)
CU  A1017 ( 3.3A)
CU  A1017 ( 3.1A)
 0.64A 6giqa-2yevA:
47.3		 6giqa-2yevA:
29.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yqy HYPOTHETICAL PROTEIN
TTHA0303

(Thermus
thermophilus) 		PF12867
(DinB_2) 		3 HIS A  53
HIS A 155
HIS A 159
 None
 0.65A 6giqa-2yqyA:
2.5		 6giqa-2yqyA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		3 HIS A 508
HIS A 559
HIS A 560
 ZN  A 803 (-3.1A)
ZN  A 803 ( 3.3A)
ZN  A 803 (-3.2A)
 0.51A 6giqa-3ayfA:
21.9		 6giqa-3ayfA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8z PROTEIN ADAMTS-5

(Homo sapiens) 		PF01421
(Reprolysin) 		3 HIS A 420
HIS A 414
HIS A 410
 ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.3A)
ZN  A 901 ( 3.2A)
 0.75A 6giqa-3b8zA:
undetectable		 6giqa-3b8zA:
15.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bcz PROTEIN MEMO1

(Homo sapiens) 		PF01875
(Memo) 		3 HIS A  49
HIS A  81
HIS A 131
 GOL  A 302 (-4.0A)
GOL  A 302 (-3.9A)
GOL  A 302 (-4.0A)
 0.60A 6giqa-3bczA:
undetectable		 6giqa-3bczA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfj 1,3-PROPANEDIOL
OXIDOREDUCTASE

(Klebsiella
pneumoniae) 		PF00465
(Fe-ADH) 		3 HIS A 267
HIS A 281
HIS A 271
 FE2  A1388 (-3.2A)
FE2  A1388 (-3.6A)
None
 0.71A 6giqa-3bfjA:
undetectable		 6giqa-3bfjA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		3 HIS A 121
HIS A 160
HIS A 119
 FE2  A 400 (-3.4A)
FE2  A 400 (-3.4A)
FE2  A 400 (-3.6A)
 0.73A 6giqa-3bu7A:
undetectable		 6giqa-3bu7A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bu7 GENTISATE
1,2-DIOXYGENASE

(Ruegeria
pomeroyi) 		PF07883
(Cupin_2) 		3 HIS A 292
HIS A 330
HIS A 290
 FE2  A 500 (-3.5A)
FE2  A 500 (-3.4A)
FE2  A 500 (-3.5A)
 0.67A 6giqa-3bu7A:
undetectable		 6giqa-3bu7A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5m OLIGOGALACTURONATE
LYASE

(Vibrio
parahaemolyticus) 		PF14583
(Pectate_lyase22) 		3 HIS A 353
HIS A 287
HIS A 355
 MN  A 401 (-3.3A)
MN  A 401 (-3.1A)
MN  A 401 (-3.3A)
 0.57A 6giqa-3c5mA:
undetectable		 6giqa-3c5mA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3di5 DINB-LIKE PROTEIN

(Bacillus cereus) 		PF05163
(DinB) 		3 HIS A  48
HIS A 127
HIS A 131
 NI  A 168 (-3.5A)
NI  A 168 (-3.5A)
NI  A 168 (-3.5A)
 0.70A 6giqa-3di5A:
undetectable		 6giqa-3di5A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dka DINB-LIKE PROTEIN

(Bacillus
subtilis) 		PF05163
(DinB) 		3 HIS A  47
HIS A 127
HIS A 131
 None
 0.53A 6giqa-3dkaA:
2.1		 6giqa-3dkaA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 HIS A1098
HIS A1092
HIS A1163
 MD1  A1245 ( 3.5A)
MGD  A1246 ( 3.7A)
MD1  A1245 (-3.4A)
 0.62A 6giqa-3egwA:
undetectable		 6giqa-3egwA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7t ENVELOPE PROTEIN

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		3 HIS A 317
HIS A  27
HIS A 282
 None
 0.76A 6giqa-3g7tA:
undetectable		 6giqa-3g7tA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gor PUTATIVE
METAL-DEPENDENT
HYDROLASE

(Geobacillus
stearothermophilus) 		PF05163
(DinB) 		3 HIS A  47
HIS A 127
HIS A 131
 NI  A 200 (-3.5A)
NI  A 200 (-3.3A)
NI  A 200 (-3.4A)
 0.63A 6giqa-3gorA:
undetectable		 6giqa-3gorA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		3 HIS A 859
HIS A 879
HIS A 861
 None
 0.73A 6giqa-3h09A:
undetectable		 6giqa-3h09A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		3 HIS A  52
HIS A  91
HIS A  50
 CO  A 244 (-3.3A)
CO  A 244 (-3.3A)
CO  A 244 (-3.3A)
 0.71A 6giqa-3h7jA:
undetectable		 6giqa-3h7jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7j BACILYSIN
BIOSYNTHESIS PROTEIN
BACB

(Bacillus
subtilis) 		PF07883
(Cupin_2) 		3 HIS A 164
HIS A 202
HIS A 162
 CO  A 245 ( 3.4A)
CO  A 245 ( 3.2A)
CO  A 245 ( 3.4A)
 0.70A 6giqa-3h7jA:
undetectable		 6giqa-3h7jA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht1 REMF PROTEIN

(Streptomyces
resistomycificus) 		PF07883
(Cupin_2) 		3 HIS A  55
HIS A  95
HIS A  53
 NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
NI  A 151 (-3.3A)
 0.72A 6giqa-3ht1A:
undetectable		 6giqa-3ht1A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7n K-LIKE

(Naja atra) 		PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		3 HIS A 351
HIS A 345
HIS A 341
 ZN  A 704 (-3.2A)
ZN  A 704 (-3.3A)
ZN  A 704 (-3.1A)
 0.77A 6giqa-3k7nA:
undetectable		 6giqa-3k7nA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkc TETR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptococcus
agalactiae) 		PF00440
(TetR_N)
PF14278
(TetR_C_8) 		3 HIS A  67
HIS A  83
HIS A  87
 NI  A 201 (-3.4A)
NI  A 201 (-3.4A)
NI  A 201 ( 3.3A)
 0.66A 6giqa-3kkcA:
undetectable		 6giqa-3kkcA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 156
HIS A 104
HIS A 154
 None
 0.74A 6giqa-3kw8A:
undetectable		 6giqa-3kw8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		3 HIS A 102
HIS A  96
HIS A  92
 ZN  A 999 (-3.3A)
ZN  A 999 (-3.3A)
ZN  A 999 (-3.3A)
 0.76A 6giqa-3lq0A:
undetectable		 6giqa-3lq0A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o0r NITRIC OXIDE
REDUCTASE SUBUNIT B

(Pseudomonas
aeruginosa) 		PF00115
(COX1) 		3 HIS B 207
HIS B 258
HIS B 259
 FE  B 803 (-3.3A)
FE  B 803 (-3.3A)
FE  B 803 (-3.3A)
 0.68A 6giqa-3o0rB:
29.4		 6giqa-3o0rB:
23.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		3 HIS A 284
HIS A 333
HIS A 334
 CU1  A   5 ( 3.2A)
HEA  A   2 ( 3.3A)
CU1  A   5 (-3.1A)
 0.62A 6giqa-3omnA:
48.7		 6giqa-3omnA:
52.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ox4 ALCOHOL
DEHYDROGENASE 2

(Zymomonas
mobilis) 		PF00465
(Fe-ADH) 		3 HIS A 263
HIS A 277
HIS A 267
 FE2  A 501 (-3.3A)
NAD  A1385 ( 3.6A)
None
 0.73A 6giqa-3ox4A:
undetectable		 6giqa-3ox4A:
23.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p77 MHC RFP-Y CLASS I
ALPHA CHAIN

(Gallus gallus) 		PF00129
(MHC_I)
PF07654
(C1-set) 		3 HIS A 200
HIS A 238
HIS A 202
 None
 0.64A 6giqa-3p77A:
undetectable		 6giqa-3p77A:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe7 OLIGOGALACTURONATE
LYASE

(Yersinia
enterocolitica) 		PF14583
(Pectate_lyase22) 		3 HIS A 353
HIS A 287
HIS A 355
 MN  A 389 ( 3.2A)
MN  A 389 ( 3.3A)
MN  A 389 ( 3.3A)
 0.53A 6giqa-3pe7A:
undetectable		 6giqa-3pe7A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl0 UNCHARACTERIZED
PROTEIN

(Methylibium
petroleiphilum) 		PF10014
(2OG-Fe_Oxy_2) 		3 HIS A  89
HIS A 146
HIS A  69
 None
 0.55A 6giqa-3pl0A:
undetectable		 6giqa-3pl0A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pl1 PYRAZINAMIDASE/NICOT
INAMIDASE PNCA
(PZASE)

(Mycobacterium
tuberculosis) 		PF00857
(Isochorismatase) 		3 HIS A  57
HIS A  71
HIS A  51
 FE2  A 188 (-3.5A)
FE2  A 188 (-3.4A)
FE2  A 188 (-3.5A)
 0.74A 6giqa-3pl1A:
undetectable		 6giqa-3pl1A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plw RECOMBINATION
ENHANCEMENT FUNCTION
PROTEIN

(Escherichia
virus P1) 		PF16786
(RecA_dep_nuc) 		3 HIS A 112
HIS A 153
HIS A 134
 ZN  A 187 ( 3.1A)
ZN  A 187 ( 3.2A)
ZN  A 187 ( 3.2A)
 0.72A 6giqa-3plwA:
undetectable		 6giqa-3plwA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		3 HIS A 223
HIS A  87
HIS A 192
 ZN  A 319 (-3.2A)
ZN  A 319 (-3.3A)
ZN  A 319 (-3.3A)
 0.63A 6giqa-3pm6A:
undetectable		 6giqa-3pm6A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s0m OXALATE
DECARBOXYLASE OXDC

(Bacillus
subtilis) 		PF00190
(Cupin_1) 		3 HIS A  97
HIS A 140
HIS A  95
 MN  A 500 ( 3.6A)
MN  A 500 (-3.5A)
MN  A 500 ( 3.3A)
 0.73A 6giqa-3s0mA:
undetectable		 6giqa-3s0mA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s1s RESTRICTION
ENDONUCLEASE BPUSI

(Bacillus
pumilus) 		PF02384
(N6_Mtase)
PF15516
(BpuSI_N) 		3 HIS A  26
HIS A  51
HIS A  50
 None
None
EDO  A 915 (-3.8A)
 0.69A 6giqa-3s1sA:
undetectable		 6giqa-3s1sA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9w SMALL LACCASE,
MULTI-COPPER OXIDASE

(Amycolatopsis
sp. ATCC 39116) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 144
HIS A  92
HIS A 142
 None
 0.70A 6giqa-3t9wA:
undetectable		 6giqa-3t9wA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujz METALLOPROTEASE STCE

(Escherichia
coli) 		PF10462
(Peptidase_M66) 		3 HIS A 456
HIS A 450
HIS A 446
 ZN  A   1 (-3.3A)
ZN  A   1 (-3.2A)
ZN  A   1 (-3.2A)
 0.76A 6giqa-3ujzA:
undetectable		 6giqa-3ujzA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS A 633
HIS A 606
HIS A 602
 CUO  A9002 (-3.3A)
CUO  A9002 (-3.3A)
CUO  A9002 (-3.4A)
 0.73A 6giqa-4bedA:
undetectable		 6giqa-4bedA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B1878
HIS B1851
HIS B1847
 CUO  B9005 (-3.3A)
CUO  B9005 (-3.2A)
CUO  B9005 (-3.2A)
 0.66A 6giqa-4bedB:
undetectable		 6giqa-4bedB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B2701
HIS B2674
HIS B2670
 CUO  B9007 (-3.1A)
CUO  B9007 (-3.4A)
CUO  B9007 (-3.4A)
 0.62A 6giqa-4bedB:
undetectable		 6giqa-4bedB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 HIS B3106
HIS B3079
HIS B3075
 CUO  B9008 (-3.3A)
CUO  B9008 (-3.5A)
CUO  B9008 (-2.8A)
 0.70A 6giqa-4bedB:
undetectable		 6giqa-4bedB:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bif CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Granulicella
tundricola) 		PF07883
(Cupin_2) 		3 HIS A  96
HIS A  53
HIS A  94
 MN  A1132 (-3.4A)
MN  A1132 (-3.3A)
MN  A1132 (-3.6A)
 0.76A 6giqa-4bifA:
undetectable		 6giqa-4bifA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fah GENTISATE
1,2-DIOXYGENASE

(Pseudaminobacter
salicylatoxidans) 		PF07883
(Cupin_2) 		3 HIS A 121
HIS A 160
HIS A 119
 FE  A 401 (-3.4A)
FE  A 401 (-3.3A)
FE  A 401 (-3.2A)
 0.70A 6giqa-4fahA:
undetectable		 6giqa-4fahA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fr2 1,3-PROPANEDIOL
DEHYDROGENASE

(Oenococcus oeni) 		PF00465
(Fe-ADH) 		3 HIS A 267
HIS A 281
HIS A 271
 NI  A 501 (-3.4A)
NI  A 501 (-3.6A)
None
 0.68A 6giqa-4fr2A:
undetectable		 6giqa-4fr2A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 156
HIS A 104
HIS A 154
 None
 0.73A 6giqa-4gybA:
undetectable		 6giqa-4gybA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiw PUTATIVE
UNCHARACTERIZED
PROTEIN

(Escherichia
coli) 		PF05488
(PAAR_motif) 		3 HIS D  14
HIS D  54
HIS D  46
 ZN  D 101 (-3.2A)
ZN  D 101 (-2.9A)
ZN  D 101 (-3.1A)
 0.69A 6giqa-4jiwD:
undetectable		 6giqa-4jiwD:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ku0 UNCHARACTERIZED 10.2
KDA PROTEIN IN
SEGC-GP6 INTERGENIC
REGION

(Escherichia
virus T4) 		PF05488
(PAAR_motif) 		3 HIS D  14
HIS D  56
HIS D  46
 FE  D 101 (-3.2A)
FE  D 101 (-3.2A)
FE  D 101 (-3.2A)
 0.72A 6giqa-4ku0D:
undetectable		 6giqa-4ku0D:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua PROTEOLYTICALLY
ACTIVATED FORM OF
PPO4 TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		3 HIS A 251
HIS A 283
HIS A 282
 CU1  A 402 (-3.0A)
CU1  A 402 (-2.9A)
CU1  A 402 (-3.0A)
 0.76A 6giqa-4ouaA:
undetectable		 6giqa-4ouaA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psp ALPHA-FUCOSIDASE
GH29

(Fusarium
graminearum) 		PF01120
(Alpha_L_fucos)
PF16757
(Fucosidase_C) 		3 HIS A  34
HIS A 171
HIS A 126
 GOL  A 622 (-3.6A)
GOL  A 622 (-4.2A)
GOL  A 622 (-3.3A)
 0.74A 6giqa-4pspA:
undetectable		 6giqa-4pspA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		3 HIS A 153
HIS A 101
HIS A 151
 CU  A 404 (-3.0A)
CU  A 404 (-3.1A)
None
 0.68A 6giqa-4w1tA:
undetectable		 6giqa-4w1tA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x8d SULFOXIDE SYNTHASE
EGTB

(Mycolicibacterium
thermoresistibile) 		PF03781
(FGE-sulfatase)
PF12867
(DinB_2) 		3 HIS A  51
HIS A 134
HIS A 138
 MN  A 503 ( 3.5A)
MN  A 503 ( 3.3A)
MN  A 503 (-3.4A)
 0.62A 6giqa-4x8dA:
2.5		 6giqa-4x8dA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyd NITRIC-OXIDE
REDUCTASE SUBUNIT B

(Roseobacter
denitrificans) 		PF00115
(COX1) 		3 HIS A 194
HIS A 245
HIS A 246
 FE  A 505 (-2.9A)
FE  A 505 ( 3.1A)
FE  A 505 ( 3.0A)
 0.67A 6giqa-4xydA:
30.5		 6giqa-4xydA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 272
HIS A 249
HIS A 268
 ZN  A 402 (-3.4A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.5A)
 0.70A 6giqa-4zr0A:
2.4		 6giqa-4zr0A:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 272
HIS A 249
HIS A 268
 ZN  A 402 (-3.5A)
ZN  A 402 (-3.2A)
ZN  A 402 (-3.3A)
 0.74A 6giqa-4zr1A:
2.4		 6giqa-4zr1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		3 HIS A 348
HIS A 272
HIS A 349
 ZN  A 402 (-3.3A)
ZN  A 402 (-3.5A)
ZN  A 401 (-3.2A)
 0.75A 6giqa-4zr1A:
2.4		 6giqa-4zr1A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		3 HIS A 770
HIS A 764
HIS A 835
 MD1  A1004 ( 3.5A)
MGD  A1003 ( 3.5A)
MD1  A1004 ( 4.4A)
 0.77A 6giqa-5chcA:
undetectable		 6giqa-5chcA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		3 HIS A 207
HIS A 257
HIS A 258
 CU  A 503 ( 3.0A)
CU  A 503 ( 3.1A)
CU  A 503 (-3.1A)
 0.54A 6giqa-5djqA:
31.6		 6giqa-5djqA:
23.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ebb ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Homo sapiens) 		PF00149
(Metallophos) 		3 HIS A 152
HIS A 114
HIS A  47
 MLI  A 706 (-3.9A)
MLI  A 706 (-3.9A)
ZN  A 702 ( 3.4A)
 0.75A 6giqa-5ebbA:
undetectable		 6giqa-5ebbA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fca ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3A

(Mus musculus) 		PF00149
(Metallophos) 		3 HIS A 149
HIS A 111
HIS A  44
 ZN  A 503 (-3.8A)
GOL  A 518 (-2.7A)
ZN  A 501 (-3.3A)
 0.71A 6giqa-5fcaA:
undetectable		 6giqa-5fcaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		3 HIS A  73
HIS A  85
HIS A  89
 NI  A 202 (-3.3A)
NI  A 202 (-3.3A)
NI  A 202 (-3.2A)
 0.75A 6giqa-5i14A:
undetectable		 6giqa-5i14A:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3a TYROSINASE

(Bacillus
megaterium) 		PF00264
(Tyrosinase) 		3 HIS A 204
HIS A 231
HIS A 230
 ZN  A 302 ( 3.4A)
ZN  A 302 (-3.1A)
None
 0.76A 6giqa-5i3aA:
undetectable		 6giqa-5i3aA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i85 SPHINGOMYELIN
PHOSPHODIESTERASE

(Homo sapiens) 		PF00149
(Metallophos) 		3 HIS A 319
HIS A 282
HIS A 208
 PC  A 727 (-3.7A)
PC  A 727 (-3.8A)
ZN  A 715 ( 3.4A)
 0.75A 6giqa-5i85A:
undetectable		 6giqa-5i85A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j55 CAROTENOID OXYGENASE

(Novosphingobium
aromaticivorans) 		PF03055
(RPE65) 		3 HIS A 284
HIS A 218
HIS A 167
 FE  A 501 ( 3.3A)
FE  A 501 (-3.2A)
FE  A 501 (-3.3A)
 0.72A 6giqa-5j55A:
undetectable		 6giqa-5j55A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jir OOP FAMILY OMPA-OMPF
PORIN

(Treponema
pallidum) 		no annotation 3 HIS B 166
HIS B 149
HIS B 150
 None
 0.55A 6giqa-5jirB:
undetectable		 6giqa-5jirB:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		3 HIS A 135
HIS A  97
HIS A  30
 None
None
ZN  A 502 (-3.3A)
 0.74A 6giqa-5karA:
undetectable		 6giqa-5karA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxg ADIPONECTIN RECEPTOR
PROTEIN 1

(Homo sapiens) 		PF03006
(HlyIII) 		3 HIS A 191
HIS A 337
HIS A 341
 ZN  A 401 (-3.5A)
ZN  A 401 (-3.5A)
ZN  A 401 (-3.2A)
 0.73A 6giqa-5lxgA:
3.2		 6giqa-5lxgA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 3 HIS A 157
HIS A 105
HIS A 155
 CU  A 402 ( 3.2A)
CU  A 402 (-3.2A)
None
 0.77A 6giqa-5mkmA:
undetectable		 6giqa-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tfz DIMETHYLSULFONIOPROP
IONATE LYASE DDDK

(Candidatus
Pelagibacter
ubique) 		PF07883
(Cupin_2) 		3 HIS A  58
HIS A  96
HIS A  56
 NI  A 201 ( 3.3A)
NI  A 201 ( 3.5A)
NI  A 201 ( 3.8A)
 0.72A 6giqa-5tfzA:
undetectable		 6giqa-5tfzA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v2d DIOXYGENASE

(Pseudomonas
brassicacearum) 		no annotation 3 HIS A 284
HIS A 219
HIS A 168
 FE  A 500 (-3.3A)
FE  A 500 (-3.2A)
FE  A 500 (-3.3A)
 0.76A 6giqa-5v2dA:
undetectable		 6giqa-5v2dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wk0 DAMAGE-INDUCIBLE
PROTEIN DINB

(Staphylococcus
sp. HMSC055H04) 		no annotation 3 HIS A  47
HIS A 135
HIS A 139
 NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
NI  A 201 (-3.3A)
 0.66A 6giqa-5wk0A:
undetectable		 6giqa-5wk0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yim SDEA

(Legionella
pneumophila) 		no annotation 3 HIS A 407
HIS A 277
HIS A 281
 None
 0.70A 6giqa-5yimA:
2.9		 6giqa-5yimA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq4 SIDE

(Legionella
pneumophila) 		no annotation 3 HIS B 403
HIS B 274
HIS B 278
 AMP  B 601 (-3.9A)
AMP  B 601 ( 4.9A)
None
 0.72A 6giqa-5zq4B:
undetectable		 6giqa-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq6 SIDE

(Legionella
pneumophila) 		no annotation 3 HIS A 403
HIS A 274
HIS A 278
 ADP  A1101 (-4.0A)
ADP  A1101 (-4.5A)
None
 0.75A 6giqa-5zq6A:
undetectable		 6giqa-5zq6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bbp CYTOHESIN-3,ADP-RIBO
SYLATION FACTOR 6

(Homo sapiens;
Mus musculus) 		no annotation 3 HIS A  55
HIS A  58
HIS A  60
 None
 0.55A 6giqa-6bbpA:
undetectable		 6giqa-6bbpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c5c 3-DEHYDROQUINATE
SYNTHASE

(Candida
albicans) 		no annotation 3 HIS A 264
HIS A 280
HIS A 268
 EDO  A 409 ( 4.8A)
None
None
 0.72A 6giqa-6c5cA:
undetectable		 6giqa-6c5cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fwf NITRIC-OXIDE
REDUCTASE

(Neisseria
meningitidis) 		no annotation 3 HIS A 490
HIS A 541
HIS A 542
 FE  A1004 ( 2.4A)
FE  A1004 (-3.0A)
FE  A1004 ( 3.0A)
 0.49A 6giqa-6fwfA:
17.3		 6giqa-6fwfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7cei PROTEIN (COLICIN E7
IMMUNITY PROTEIN)

(Escherichia
coli) 		no annotation 3 HIS B 544
HIS B 573
HIS B 569
 ZN  B 600 ( 2.8A)
ZN  B 600 ( 3.6A)
ZN  B 600 ( 3.1A)
 0.60A 6giqa-7ceiB:
undetectable		 6giqa-7ceiB:
15.04