SIMILAR PATTERNS OF AMINO ACIDS FOR 6GH9_A_MIXA1003_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		4 ASN A  51
GLY A 212
HIS A 242
ASP A 244
 None
 1.27A 6gh9A-1bxcA:
undetectable		 6gh9A-1bxcA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gt9 KUMAMOLYSIN

(Bacillus
subtilis) 		PF00082
(Peptidase_S8) 		4 ASN 1 241
GLY 1 131
HIS 1 177
ASP 1 173
 None
 0.91A 6gh9A-1gt91:
0.0		 6gh9A-1gt91:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h54 MALTOSE
PHOSPHORYLASE

(Lactobacillus
brevis) 		PF03632
(Glyco_hydro_65m)
PF03633
(Glyco_hydro_65C)
PF03636
(Glyco_hydro_65N) 		4 ASN A 663
GLY A 353
HIS A 671
ASP A 658
 None
 1.18A 6gh9A-1h54A:
0.0		 6gh9A-1h54A:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlk BETA-LACTAMASE, TYPE
II

(Bacteroides
fragilis) 		no annotation 4 ASN A  55
GLY A 192
HIS A 223
ASP A 103
 None
113  A2002 ( 3.8A)
113  A2002 ( 3.6A)
ZN  A1002 ( 3.3A)
 0.96A 6gh9A-1hlkA:
undetectable		 6gh9A-1hlkA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ii2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE

(Trypanosoma
cruzi) 		PF01293
(PEPCK_ATP) 		4 TYR A 395
GLY A 396
HIS A 391
ASP A  61
 None
 1.20A 6gh9A-1ii2A:
undetectable		 6gh9A-1ii2A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ASN A  61
GLY A 115
HIS A 123
ASP A 263
 2PG  A 801 (-4.5A)
None
2PG  A 801 (-4.0A)
2PG  A 801 ( 4.4A)
 1.14A 6gh9A-1o99A:
0.2		 6gh9A-1o99A:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pvt SUGAR-PHOSPHATE
ALDOLASE

(Thermotoga
maritima) 		PF00596
(Aldolase_II) 		4 ASN A  94
GLY A  38
HIS A  92
ASP A  74
 None
 1.17A 6gh9A-1pvtA:
0.0		 6gh9A-1pvtA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sde D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptomyces
sp. R61) 		PF00144
(Beta-lactamase) 		4 ASN A 275
TYR A 296
GLY A 297
ASP A 288
 None
 1.30A 6gh9A-1sdeA:
undetectable		 6gh9A-1sdeA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1e KUMAMOLISIN

(Bacillus sp.
MN-32) 		PF00082
(Peptidase_S8)
PF09286
(Pro-kuma_activ) 		4 ASN A 430
GLY A 320
HIS A 366
ASP A 362
 None
 0.93A 6gh9A-1t1eA:
0.0		 6gh9A-1t1eA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		4 ASN A 732
TYR A 325
GLY A 346
HIS A 743
 ASN  A 732 ( 0.6A)
TYR  A 325 ( 1.3A)
GLY  A 346 ( 0.0A)
HIS  A 743 ( 1.0A)
 1.29A 6gh9A-1v0fA:
undetectable		 6gh9A-1v0fA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v8b ADENOSYLHOMOCYSTEINA
SE

(Plasmodium
falciparum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ASN A 342
GLY A 204
HIS A 345
ASP A 348
 None
None
NAD  A 501 (-4.8A)
None
 1.18A 6gh9A-1v8bA:
undetectable		 6gh9A-1v8bA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfk FORMIMIDOYLGLUTAMASE

(Vibrio cholerae) 		PF00491
(Arginase) 		4 ASN A 155
GLY A  55
HIS A 127
ASP A 297
 None
 1.00A 6gh9A-1xfkA:
undetectable		 6gh9A-1xfkA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		4 ASN A 108
GLY A 427
HIS A 434
ASP A 450
 None
 0.45A 6gh9A-2aynA:
26.6		 6gh9A-2aynA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dw6 BLL6730 PROTEIN

(Bradyrhizobium
japonicum) 		PF13378
(MR_MLE_C) 		4 ASN A 340
GLY A  51
HIS A 325
ASP A 292
 None
 0.99A 6gh9A-2dw6A:
undetectable		 6gh9A-2dw6A:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
HEAVY CHAIN

(Daboia
siamensis) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 ASN A 320
TYR A 311
GLY A 313
ASP A 398
 None
 1.24A 6gh9A-2e3xA:
undetectable		 6gh9A-2e3xA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efi MORTALITY FACTOR
4-LIKE PROTEIN 1

(Homo sapiens) 		PF11717
(Tudor-knot) 		4 ASN A  57
GLY A  21
HIS A  52
ASP A  61
 None
 0.92A 6gh9A-2efiA:
undetectable		 6gh9A-2efiA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8a MICROSOMAL
GLUTATHIONE
S-TRANSFERASE 1

(Rattus
norvegicus) 		PF01124
(MAPEG) 		4 ASN A  77
TYR A 115
GLY A 111
HIS A 116
 None
 1.30A 6gh9A-2h8aA:
undetectable		 6gh9A-2h8aA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hf0 BILE SALT HYDROLASE

(Bifidobacterium
longum) 		PF02275
(CBAH) 		4 TYR A  36
GLY A  35
HIS A  37
ASP A  39
 None
 0.81A 6gh9A-2hf0A:
undetectable		 6gh9A-2hf0A:
12.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odf HYPOTHETICAL PROTEIN
ATU2144

(Agrobacterium
fabrum) 		PF05013
(FGase) 		4 ASN A  90
GLY A 170
HIS A 154
ASP A  59
 None
 1.11A 6gh9A-2odfA:
undetectable		 6gh9A-2odfA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ASN A 256
GLY A 428
HIS A 464
ASP A 462
 None
None
UMP  A 603 ( 4.1A)
None
 1.13A 6gh9A-2oipA:
undetectable		 6gh9A-2oipA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q01 URONATE ISOMERASE

(Caulobacter
vibrioides) 		PF02614
(UxaC) 		4 ASN A 414
GLY A 309
HIS A 307
ASP A 249
 None
 0.98A 6gh9A-2q01A:
undetectable		 6gh9A-2q01A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rd7 COMPLEMENT COMPONENT
C8 ALPHA CHAIN

(Homo sapiens) 		PF01823
(MACPF) 		4 ASN A 181
TYR A 307
GLY A 308
ASP A 281
 None
 1.29A 6gh9A-2rd7A:
undetectable		 6gh9A-2rd7A:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfg CYTOSOLIC
LEUCYL-TRNA
SYNTHETASE

(Candida
albicans) 		PF00133
(tRNA-synt_1) 		4 ASN A 343
TYR A 368
GLY A 367
ASP A 340
 None
 1.26A 6gh9A-2wfgA:
undetectable		 6gh9A-2wfgA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N
LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT B

(Thermosynechococcus
elongatus;
Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro)
PF00148
(Oxidored_nitro) 		4 TYR A  18
GLY A 324
HIS A  19
ASP B  37
 None
 1.24A 6gh9A-2xdqA:
undetectable		 6gh9A-2xdqA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		5 ASN A 306
TYR A 874
GLY A 875
HIS A 881
ASP A 898
 CME  A 311 ( 3.8A)
None
None
CME  A 311 ( 4.1A)
None
 0.36A 6gh9A-2y6eA:
45.8		 6gh9A-2y6eA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z4g HISTIDINOL
PHOSPHATASE

(Thermus
thermophilus) 		PF02811
(PHP)
PF13263
(PHP_C) 		4 TYR A 102
GLY A  78
HIS A   5
ASP A 189
 None
None
FE  A 503 (-3.5A)
None
 1.24A 6gh9A-2z4gA:
undetectable		 6gh9A-2z4gA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce6 ADENOSYLHOMOCYSTEINA
SE

(Mycobacterium
tuberculosis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ASN A  94
GLY A 339
HIS A 363
ASP A 156
 None
NAD  A 550 (-3.3A)
ADN  A 500 ( 3.7A)
ADN  A 500 (-2.9A)
 1.01A 6gh9A-3ce6A:
undetectable		 6gh9A-3ce6A:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmn PUTATIVE HYDROLASE

(Chloroflexus
aurantiacus) 		PF10103
(Zincin_2) 		4 ASN A 298
TYR A 168
GLY A 166
HIS A 214
 None
 1.26A 6gh9A-3cmnA:
undetectable		 6gh9A-3cmnA:
11.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ASN A 269
TYR A 291
GLY A 299
ASP A 276
 None
 1.16A 6gh9A-3cmvA:
undetectable		 6gh9A-3cmvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ASN A1269
TYR A1291
GLY A1299
ASP A1276
 None
 1.11A 6gh9A-3cmvA:
undetectable		 6gh9A-3cmvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ASN A2269
TYR A2291
GLY A2299
ASP A2276
 None
 1.21A 6gh9A-3cmvA:
undetectable		 6gh9A-3cmvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmv PROTEIN RECA

(Escherichia
coli) 		PF00154
(RecA) 		4 ASN A3269
TYR A3291
GLY A3299
ASP A3276
 None
 1.14A 6gh9A-3cmvA:
undetectable		 6gh9A-3cmvA:
4.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxi PUTATIVE ALDOLASE

(Bacteroides
vulgatus) 		PF00682
(HMGL-like) 		4 ASN A 131
GLY A 198
HIS A 190
ASP A  10
 None
 0.92A 6gh9A-3dxiA:
undetectable		 6gh9A-3dxiA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN
HEMAGGLUTININ HA2
CHAIN

(Influenza A
virus;
Influenza A
virus) 		PF00509
(Hemagglutinin)
PF00509
(Hemagglutinin) 		4 ASN B  12
TYR B  22
GLY B  20
HIS A  17
 None
 1.24A 6gh9A-3eykB:
undetectable		 6gh9A-3eykB:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila) 		PF00753
(Lactamase_B) 		4 ASN A  70
GLY A 232
HIS A 263
ASP A 120
 None
GOL  A 320 (-3.5A)
ZN  A   1 ( 3.2A)
ZN  A   1 ( 2.5A)
 1.02A 6gh9A-3faiA:
undetectable		 6gh9A-3faiA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ASN A  87
GLY A 320
HIS A 344
ASP A 139
 None
NAD  A 601 (-3.5A)
RAB  A 602 ( 3.5A)
RAB  A 602 (-3.0A)
 1.06A 6gh9A-3glqA:
undetectable		 6gh9A-3glqA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxw ALANYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01411
(tRNA-synt_2c) 		4 ASN A  75
TYR A 307
GLY A 306
ASP A 406
 None
 1.11A 6gh9A-3hxwA:
undetectable		 6gh9A-3hxwA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 ASN A 247
GLY A 418
HIS A 454
ASP A 452
 None
 1.16A 6gh9A-3kjrA:
undetectable		 6gh9A-3kjrA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3k UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 8

(Homo sapiens) 		PF00443
(UCH) 		5 ASN A 781
TYR A1060
GLY A1061
HIS A1067
ASP A1084
 None
 0.38A 6gh9A-3n3kA:
43.1		 6gh9A-3n3kA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovg AMIDOHYDROLASE

(Mycoplasma
synoviae) 		PF02126
(PTE) 		4 ASN A 216
GLY A 155
HIS A 214
ASP A 272
 None
None
ZN  A 363 (-3.5A)
ZN  A 362 (-2.7A)
 1.28A 6gh9A-3ovgA:
undetectable		 6gh9A-3ovgA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q08 CHLORITE DISMUTASE

(Dechloromonas
aromatica) 		PF06778
(Chlor_dismutase) 		4 ASN A 117
TYR A 186
GLY A 111
HIS A 187
 HEM  A1000 (-4.9A)
None
None
None
 1.07A 6gh9A-3q08A:
undetectable		 6gh9A-3q08A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rfr PMOA

(Methylocystis
sp. M) 		no annotation 4 ASN J 108
TYR J  42
GLY J  41
HIS J  43
 None
 1.19A 6gh9A-3rfrJ:
undetectable		 6gh9A-3rfrJ:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u07 UNCHARACTERIZED
PROTEIN VPA0106

(Vibrio
parahaemolyticus) 		PF06742
(DUF1214)
PF06863
(DUF1254) 		4 ASN A 366
TYR A 353
GLY A 354
HIS A 368
 None
 1.09A 6gh9A-3u07A:
undetectable		 6gh9A-3u07A:
12.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		4 ASN A 253
GLY A 189
HIS A 184
ASP A 229
 None
 0.90A 6gh9A-3ucaA:
undetectable		 6gh9A-3ucaA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsz RICIN B LECTIN

(Ruminiclostridium
thermocellum) 		PF04616
(Glyco_hydro_43)
PF14200
(RicinB_lectin_2) 		4 ASN A 200
TYR A 176
GLY A 175
ASP A 202
 None
 1.22A 6gh9A-3vszA:
undetectable		 6gh9A-3vszA:
7.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ASN A  64
GLY A 183
HIS A  66
ASP A  13
 None
 1.28A 6gh9A-3wjoA:
undetectable		 6gh9A-3wjoA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aov ISOCITRATE
DEHYDROGENASE [NADP]

(Desulfotalea
psychrophila) 		PF00180
(Iso_dh) 		4 ASN A 181
GLY A 130
HIS A 132
ASP A 103
 None
 1.26A 6gh9A-4aovA:
undetectable		 6gh9A-4aovA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ASN A 364
GLY A 195
HIS A 297
ASP A 360
 None
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
 0.91A 6gh9A-4az7A:
undetectable		 6gh9A-4az7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az7 BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ASN A 364
GLY A 227
HIS A 297
ASP A 360
 None
None
LOG  A1614 (-4.1A)
LOG  A1614 (-3.9A)
 0.89A 6gh9A-4az7A:
undetectable		 6gh9A-4az7A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ASN A 808
GLY A 640
HIS A 742
ASP A 804
 None
None
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
 0.89A 6gh9A-4azcA:
undetectable		 6gh9A-4azcA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azc BETA-N-ACETYLHEXOSAM
INIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 ASN A 808
GLY A 672
HIS A 742
ASP A 804
 None
None
NGW  A2042 (-4.0A)
NGW  A2042 (-3.6A)
 0.85A 6gh9A-4azcA:
undetectable		 6gh9A-4azcA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 TYR A1446
GLY A1443
HIS A1410
ASP A1429
 None
 1.26A 6gh9A-4bpcA:
undetectable		 6gh9A-4bpcA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cvu BETA-MANNOSIDASE

(Trichoderma
harzianum) 		PF00703
(Glyco_hydro_2) 		4 ASN A 415
GLY A 830
HIS A 739
ASP A 760
 None
 1.27A 6gh9A-4cvuA:
undetectable		 6gh9A-4cvuA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dim PHOSPHORIBOSYLGLYCIN
AMIDE SYNTHETASE

(Anaerococcus
prevotii) 		PF01071
(GARS_A) 		4 TYR A 226
GLY A 321
HIS A 225
ASP A 212
 None
 0.80A 6gh9A-4dimA:
undetectable		 6gh9A-4dimA:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzi PUTATIVE TIM-BARREL
METAL-DEPENDENT
HYDROLASE

(Mycobacterium
avium) 		PF04909
(Amidohydro_2) 		4 ASN A 293
GLY A 124
HIS A 229
ASP A  12
 None
None
CD  A 502 (-3.6A)
CD  A 502 (-2.1A)
 1.09A 6gh9A-4dziA:
undetectable		 6gh9A-4dziA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gzv HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14869
(DUF4488) 		4 ASN A  57
TYR A  42
GLY A  51
HIS A  41
 None
 1.27A 6gh9A-4gzvA:
undetectable		 6gh9A-4gzvA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kem MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azospirillum
lipoferum) 		PF13378
(MR_MLE_C) 		4 ASN A 339
GLY A  49
HIS A 324
ASP A 291
 None
 0.96A 6gh9A-4kemA:
undetectable		 6gh9A-4kemA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8k PUTATIVE PEPTIDASE

(Parabacteroides
merdae) 		PF03572
(Peptidase_S41)
PF14684
(Tricorn_C1) 		4 ASN A 108
TYR A 240
GLY A 265
ASP A 174
 None
MPD  A 402 (-4.0A)
None
None
 1.15A 6gh9A-4l8kA:
undetectable		 6gh9A-4l8kA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lvc S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE)

(Bradyrhizobium
elkanii) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ASN A  83
GLY A 318
HIS A 342
ASP A 135
 None
NAD  A 503 ( 3.4A)
ADN  A 501 ( 3.7A)
ADN  A 501 (-3.0A)
 1.01A 6gh9A-4lvcA:
undetectable		 6gh9A-4lvcA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myn FORMIMINOGLUTAMASE

(Trypanosoma
cruzi) 		PF00491
(Arginase) 		4 ASN A 136
GLY A  34
HIS A 114
ASP A 270
 MN  A 400 ( 4.9A)
None
MN  A 400 (-3.3A)
None
 0.90A 6gh9A-4mynA:
undetectable		 6gh9A-4mynA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oua LATENT FORM OF PPO4
TYROSINASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase) 		4 TYR B 378
GLY B 379
HIS B 373
ASP B 354
 None
None
TRS  B 606 (-3.6A)
None
 1.26A 6gh9A-4ouaB:
undetectable		 6gh9A-4ouaB:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		4 ASN A  71
GLY A  27
HIS A   4
ASP A  98
 None
 1.17A 6gh9A-4pzkA:
undetectable		 6gh9A-4pzkA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qla JUVENILE HORMONE
EPOXIDE HYDROLASE

(Bombyx mori) 		PF06441
(EHN) 		4 ASN A 250
GLY A 246
HIS A 248
ASP A 443
 None
 0.92A 6gh9A-4qlaA:
undetectable		 6gh9A-4qlaA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a12 CHLORITE DISMUTASE

(Magnetospirillum
sp.) 		PF06778
(Chlor_dismutase) 		4 ASN A 117
TYR A 186
GLY A 111
HIS A 187
 HEM  A 250 (-4.6A)
None
None
None
 1.01A 6gh9A-5a12A:
undetectable		 6gh9A-5a12A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 46

(Homo sapiens) 		PF00443
(UCH) 		4 ASN B  39
GLY B 306
HIS B 313
ASP B 328
 None
 0.42A 6gh9A-5cvoB:
29.4		 6gh9A-5cvoB:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8w ENDOGLUCANASE

(Ganoderma
lucidum) 		PF00150
(Cellulase) 		4 ASN A 163
GLY A 278
HIS A 235
ASP A 233
 None
 1.27A 6gh9A-5d8wA:
undetectable		 6gh9A-5d8wA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfa BETA-GALACTOSIDASE

(Geobacillus
stearothermophilus) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 TYR A 145
GLY A 146
HIS A 148
ASP A  76
 None
 1.03A 6gh9A-5dfaA:
undetectable		 6gh9A-5dfaA:
9.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		4 ASN A   9
GLY A 209
HIS A 239
ASP A 144
 None
 1.19A 6gh9A-5ewtA:
undetectable		 6gh9A-5ewtA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewt EXODEOXYRIBONUCLEASE
III XTH

(Sulfolobus
islandicus) 		PF03372
(Exo_endo_phos) 		4 ASN A 146
GLY A  10
HIS A 239
ASP A 213
 None
 1.05A 6gh9A-5ewtA:
undetectable		 6gh9A-5ewtA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4z EPOXIDE HYDROLASE

(Streptomyces
carzinostaticus) 		PF06441
(EHN) 		4 ASN A 198
GLY A 194
HIS A 196
ASP A 376
 None
 0.94A 6gh9A-5f4zA:
undetectable		 6gh9A-5f4zA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fft PULMONARY
SURFACTANT-ASSOCIATE
D PROTEIN A

(Rattus
norvegicus) 		PF00059
(Lectin_C) 		4 ASN A 151
TYR A 192
GLY A 194
ASP A 210
 None
 1.28A 6gh9A-5fftA:
undetectable		 6gh9A-5fftA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gjq UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 ASN x 108
GLY x 427
HIS x 434
ASP x 450
 None
 0.64A 6gh9A-5gjqx:
undetectable		 6gh9A-5gjqx:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdf HYDROLASE

(Streptomyces
flocculus) 		no annotation 4 ASN B 213
TYR B 184
GLY B 187
ASP B 308
 None
 1.26A 6gh9A-5hdfB:
undetectable		 6gh9A-5hdfB:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hxb EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		no annotation 4 ASN X 523
GLY X 528
HIS X 526
ASP X 608
 None
 1.30A 6gh9A-5hxbX:
undetectable		 6gh9A-5hxbX:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibo OPLOPHORUS-LUCIFERIN
2-MONOOXYGENASE
CATALYTIC SUBUNIT

(Oplophorus
gracilirostris) 		no annotation 4 TYR A  62
GLY A  64
HIS A  87
ASP A  84
 None
 1.14A 6gh9A-5iboA:
undetectable		 6gh9A-5iboA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jtv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF14533
(USP7_C2) 		4 ASN A 218
GLY A 458
HIS A 464
ASP A 481
 None
 0.66A 6gh9A-5jtvA:
26.3		 6gh9A-5jtvA:
8.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		4 ASN A 210
GLY A  66
HIS A  83
ASP A 219
 ARG  A 801 (-2.9A)
None
ARG  A 801 (-3.6A)
None
 1.26A 6gh9A-5jxfA:
undetectable		 6gh9A-5jxfA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxl FLAGELLAR HOOK
PROTEIN FLGE

(Campylobacter
jejuni) 		PF00460
(Flg_bb_rod)
PF06429
(Flg_bbr_C)
PF07196
(Flagellin_IN)
PF07559
(FlaE) 		4 ASN A 364
TYR A 568
GLY A 253
ASP A 360
 None
 1.24A 6gh9A-5jxlA:
undetectable		 6gh9A-5jxlA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 12

(Homo sapiens) 		PF00443
(UCH) 		4 ASN A  43
GLY A 310
HIS A 317
ASP A 332
 None
 0.57A 6gh9A-5k1cA:
28.0		 6gh9A-5k1cA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5knn ALANINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF01411
(tRNA-synt_2c) 		4 ASN A  83
TYR A 322
GLY A 321
ASP A 423
 None
 1.26A 6gh9A-5knnA:
undetectable		 6gh9A-5knnA:
10.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqc PEPTIDASE M23

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		4 TYR A  67
GLY A  74
HIS A  76
ASP A  80
 None
None
ZN  A 201 (-3.7A)
ZN  A 201 (-1.5A)
 1.19A 6gh9A-5kqcA:
undetectable		 6gh9A-5kqcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6u PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		4 ASN A 640
TYR A 254
GLY A 252
ASP A 606
 None
 1.28A 6gh9A-5m6uA:
undetectable		 6gh9A-5m6uA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mio KINESIN-LIKE PROTEIN
KIF2C,KIF2C FUSED TO
A DARPIN,KIF2C FUSED
TO A DARPIN

(Homo sapiens) 		PF00023
(Ank)
PF00225
(Kinesin)
PF12796
(Ank_2) 		4 ASN C 321
GLY C 351
HIS C 356
ASP C 361
 None
ANP  C 802 (-3.5A)
ANP  C 802 (-3.7A)
ANP  C 802 (-3.6A)
 1.18A 6gh9A-5mioC:
undetectable		 6gh9A-5mioC:
9.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmd METALLO-BETA-LACTAMA
SE 1

(Acinetobacter
baumannii) 		PF00753
(Lactamase_B) 		4 ASN E  70
GLY E 232
HIS E 263
ASP E 120
 None
CL  E 404 ( 4.8A)
ZN  E 401 (-3.3A)
ZN  E 401 (-2.5A)
 1.03A 6gh9A-5mmdE:
undetectable		 6gh9A-5mmdE:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqs BETA-L-ARABINOBIOSID
ASE

(Bacteroides
thetaiotaomicron) 		PF13088
(BNR_2) 		4 ASN A 215
TYR A 170
GLY A 171
ASP A 217
 None
 0.90A 6gh9A-5mqsA:
undetectable		 6gh9A-5mqsA:
5.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		4 ASN A 380
TYR A 354
GLY A 351
HIS A 382
 None
 1.18A 6gh9A-5suoA:
undetectable		 6gh9A-5suoA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 ASN A 644
TYR A 657
GLY A 658
ASP A 642
 None
 1.22A 6gh9A-5svcA:
undetectable		 6gh9A-5svcA:
6.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u24 PUTATIVE
AMINOTRANSFERASE

(Campylobacter
jejuni) 		PF01041
(DegT_DnrJ_EryC1) 		4 ASN A  94
TYR A 222
GLY A 213
ASP A  70
 None
 0.77A 6gh9A-5u24A:
undetectable		 6gh9A-5u24A:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7g CREB-BINDING PROTEIN

(Mus musculus) 		PF00439
(Bromodomain)
PF00569
(ZZ)
PF06001
(DUF902)
PF08214
(HAT_KAT11) 		4 TYR A1706
GLY A1747
HIS A1720
ASP A1726
 None
 1.25A 6gh9A-5u7gA:
undetectable		 6gh9A-5u7gA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 ASN E  35
GLY E 244
HIS E 126
ASP E 124
 None
 1.04A 6gh9A-5u8sE:
undetectable		 6gh9A-5u8sE:
9.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5utu ADENOSYLHOMOCYSTEINA
SE

(Cryptosporidium
parvum) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ASN A 353
GLY A 215
HIS A 356
ASP A 359
 None
None
NAD  A 501 ( 4.4A)
None
 0.97A 6gh9A-5utuA:
undetectable		 6gh9A-5utuA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpu 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Acinetobacter
baumannii) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ASN A  66
GLY A 120
HIS A 128
ASP A 264
 3PG  A 603 (-4.8A)
None
3PG  A 603 (-3.9A)
3PG  A 603 ( 4.9A)
 1.15A 6gh9A-5vpuA:
undetectable		 6gh9A-5vpuA:
9.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wch PROBABLE UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE FAF-X

(Homo sapiens) 		no annotation 4 ASN A1561
GLY A1873
HIS A1879
ASP A1901
 None
 0.35A 6gh9A-5wchA:
27.5		 6gh9A-5wchA:
32.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 4 TYR A 414
GLY A 415
HIS A 409
ASP A 407
 None
 1.23A 6gh9A-5wp4A:
undetectable		 6gh9A-5wp4A:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 4 TYR A 414
GLY A 415
HIS A 409
ASP A 407
 None
 1.25A 6gh9A-5wp5A:
undetectable		 6gh9A-5wp5A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		4 ASN A1213
GLY A1158
HIS A1181
ASP A1183
 MES  A1707 (-3.4A)
None
None
TB  A1608 (-2.4A)
 1.17A 6gh9A-5x7sA:
undetectable		 6gh9A-5x7sA:
6.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE ALPHA
SUBUNIT
3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2;
Diaphorobacter
sp. DS2) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
PF00866
(Ring_hydroxyl_B) 		4 ASN C 109
GLY A 218
HIS C 100
ASP A 359
 None
 1.28A 6gh9A-5xbpC:
undetectable		 6gh9A-5xbpC:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3m -

(-) 		no annotation 4 ASN B  86
GLY B 299
HIS B 323
ASP B 139
 None
NAD  B 501 (-3.4A)
ZN  B 505 (-3.2A)
ZN  B 505 ( 2.5A)
 0.96A 6gh9A-6f3mB:
undetectable		 6gh9A-6f3mB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 4 ASN A  84
GLY A 249
HIS A  86
ASP A  49
 None
 1.29A 6gh9A-6f9mA:
undetectable		 6gh9A-6f9mA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 4 ASN A  81
GLY A 280
HIS A 304
ASP A 134
 None
NAD  A 502 (-3.5A)
ADN  A 501 ( 3.6A)
ADN  A 501 (-2.9A)
 1.02A 6gh9A-6gbnA:
undetectable		 6gh9A-6gbnA:
undetectable