SIMILAR PATTERNS OF AMINO ACIDS FOR 6GBN_D_ADND501_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1b79 | DNAB HELICASE (Escherichiacoli) |
PF00772(DnaB) | 4 | GLN A 95THR A 61HIS A 64LEU A 37 | None | 1.38A | 6gbnD-1b79A:undetectable | 6gbnD-1b79A:16.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ddk | IMP-1 METALLOBETA-LACTAMASE (Pseudomonasaeruginosa) |
PF00753(Lactamase_B) | 4 | GLN A 212THR A 209THR A 140HIS A 77 | NoneNoneNone ZN A 500 (-3.4A) | 1.15A | 6gbnD-1ddkA:2.5 | 6gbnD-1ddkA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e9y | UREASE SUBUNIT BETA (Helicobacterpylori) |
PF00449(Urease_alpha)PF01979(Amidohydro_1) | 4 | GLN B 342THR B 343THR B 251LEU B 318 | None | 1.14A | 6gbnD-1e9yB:undetectable | 6gbnD-1e9yB:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ems | NIT-FRAGILEHISTIDINE TRIADFUSION PROTEIN (Caenorhabditiselegans) |
PF00795(CN_hydrolase)PF01230(HIT) | 4 | GLN A 250THR A 199HIS A 203LEU A 207 | None | 1.41A | 6gbnD-1emsA:undetectable | 6gbnD-1emsA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gnx | BETA-GLUCOSIDASE (Streptomycessp.) |
PF00232(Glyco_hydro_1) | 4 | THR A 382THR A 175HIS A 213LEU A 301 | None | 1.33A | 6gbnD-1gnxA:undetectable | 6gbnD-1gnxA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1iie | PROTEIN (HLA-DRANTIGENS ASSOCIATEDINVARIANT CHAIN) (Homo sapiens) |
PF08831(MHCassoc_trimer) | 4 | GLN A 131THR A 156HIS A 152LEU A 142 | None | 0.95A | 6gbnD-1iieA:undetectable | 6gbnD-1iieA:9.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l4i | SFAE PROTEIN (Escherichiacoli) |
PF00345(PapD_N)PF02753(PapD_C) | 4 | GLN A 170THR A 146THR A 151LEU A 114 | None | 1.38A | 6gbnD-1l4iA:undetectable | 6gbnD-1l4iA:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ml4 | ASPARTATETRANSCARBAMOYLASE (Pyrococcusabyssi) |
PF00185(OTCace)PF02729(OTCace_N) | 4 | GLN A 138THR A 137THR A 49LEU A 60 | PAL A 385 (-4.7A)NoneNoneNone | 1.39A | 6gbnD-1ml4A:4.4 | 6gbnD-1ml4A:22.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nfd | N15 ALPHA-BETAT-CELL RECEPTOR (Mus musculus) |
PF07686(V-set)PF09291(DUF1968) | 4 | GLN A 5THR A 4THR A 30LEU A 66 | None | 1.30A | 6gbnD-1nfdA:undetectable | 6gbnD-1nfdA:18.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1opk | PROTO-ONCOGENETYROSINE-PROTEINKINASE ABL1 (Mus musculus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 4 | GLN A 319THR A 334HIS A 380LEU A 403 | NoneP16 A 2 (-3.7A)NoneNone | 1.28A | 6gbnD-1opkA:undetectable | 6gbnD-1opkA:21.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pem | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2ALPHA CHAIN (Salmonellaenterica) |
PF00317(Ribonuc_red_lgN)PF02867(Ribonuc_red_lgC)PF08343(RNR_N) | 4 | GLN A 158THR A 161THR A 110LEU A 103 | None | 1.41A | 6gbnD-1pemA:undetectable | 6gbnD-1pemA:19.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q40 | MRNA EXPORT FACTORMEX67MRNA TRANSPORTREGULATOR MTR2 (Candidaalbicans) |
PF10429(Mtr2)no annotation | 4 | GLN B 398THR B 495HIS A 91LEU B 385 | None | 1.36A | 6gbnD-1q40B:undetectable | 6gbnD-1q40B:18.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1uun | MSPA (Mycolicibacteriumsmegmatis) |
PF09203(MspA) | 4 | THR A 176THR A 130HIS A 42LEU A 25 | None | 1.30A | 6gbnD-1uunA:undetectable | 6gbnD-1uunA:18.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vsl | PROTEIN (INTEGRASE) (Rous sarcomavirus) |
PF00665(rve) | 4 | GLN A 59THR A 120HIS A 142LEU A 135 | None | 1.24A | 6gbnD-1vslA:undetectable | 6gbnD-1vslA:15.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wd3 | ALPHA-L-ARABINOFURANOSIDASE B (Aspergilluskawachii) |
PF05270(AbfB)PF09206(ArabFuran-catal) | 4 | GLN A 103THR A 144THR A 37LEU A 52 | None | 1.20A | 6gbnD-1wd3A:undetectable | 6gbnD-1wd3A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wdn | GLUTAMINE BINDINGPROTEIN (Escherichiacoli) |
PF00497(SBP_bac_3) | 4 | GLN A 184THR A 118HIS A 156LEU A 90 | NoneGLN A 227 (-4.2A)GLN A 227 (-4.0A)None | 1.40A | 6gbnD-1wdnA:undetectable | 6gbnD-1wdnA:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a81 | CARB (Pectobacteriumcarotovorum) |
PF00378(ECH_1) | 4 | GLN A 220THR A 221THR A 148LEU A 91 | None | 1.13A | 6gbnD-2a81A:undetectable | 6gbnD-2a81A:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b39 | C3 (Bos taurus) |
PF00207(A2M)PF01759(NTR)PF01821(ANATO)PF01835(A2M_N)PF07677(A2M_recep)PF07678(A2M_comp)PF07703(A2M_N_2)PF10569(Thiol-ester_cl) | 4 | GLN A1126THR A1398THR A1268LEU A1483 | None | 1.39A | 6gbnD-2b39A:undetectable | 6gbnD-2b39A:14.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpw | GREEN FLUORESCENTPROTEIN (Clytia gregaria) |
PF01353(GFP) | 4 | GLN A 89THR A 88HIS A 200LEU A 202 | None | 1.18A | 6gbnD-2hpwA:undetectable | 6gbnD-2hpwA:19.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hro | PHOSPHOENOLPYRUVATE-PROTEINPHOSPHOTRANSFERASE (Staphylococcuscarnosus) |
PF00391(PEP-utilizers)PF02896(PEP-utilizers_C)PF05524(PEP-utilisers_N) | 4 | GLN A 510THR A 511THR A 454LEU A 521 | None | 1.12A | 6gbnD-2hroA:undetectable | 6gbnD-2hroA:23.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ice | COMPLEMENT C3 BETACHAIN (Homo sapiens) |
PF01835(A2M_N)PF07703(A2M_N_2) | 4 | GLN A 631THR A 632THR A 514HIS A 25 | None | 0.92A | 6gbnD-2iceA:undetectable | 6gbnD-2iceA:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nvv | ACETYL-COAHYDROLASE/TRANSFERASE FAMILY PROTEIN (Porphyromonasgingivalis) |
PF02550(AcetylCoA_hydro)PF13336(AcetylCoA_hyd_C) | 4 | GLN A 333THR A 107THR A 383HIS A 414 | GLN A 333 ( 0.6A)THR A 107 ( 0.8A)THR A 383 ( 0.8A)HIS A 414 ( 1.0A) | 1.03A | 6gbnD-2nvvA:undetectable | 6gbnD-2nvvA:23.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2puq | TISSUE FACTOR (Homo sapiens) |
PF01108(Tissue_fac)PF09294(Interfer-bind) | 4 | GLN T 190THR T 203THR T 106LEU T 143 | None | 1.31A | 6gbnD-2puqT:undetectable | 6gbnD-2puqT:17.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qzu | PUTATIVE SULFATASEYIDJ (Bacteroidesfragilis) |
PF00884(Sulfatase) | 4 | GLN A 380THR A 378HIS A 164LEU A 109 | None | 1.01A | 6gbnD-2qzuA:undetectable | 6gbnD-2qzuA:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rk5 | PUTATIVE HEMOLYSIN (Streptococcusmutans) |
PF03471(CorC_HlyC) | 4 | GLN A 3THR A 19THR A 29LEU A 70 | None | 1.40A | 6gbnD-2rk5A:undetectable | 6gbnD-2rk5A:12.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2v9u | MSPA (Mycolicibacteriumsmegmatis) |
PF09203(MspA) | 4 | THR A 176THR A 130HIS A 42LEU A 25 | THR A 176 ( 0.8A)THR A 130 ( 0.8A)HIS A 42 ( 1.0A)LEU A 25 ( 0.5A) | 1.27A | 6gbnD-2v9uA:undetectable | 6gbnD-2v9uA:16.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wok | CLAVULANIC ACIDBIOSYNTHESISOLIGOPEPTIDE BINDINGPROTEIN 2 (Streptomycesclavuligerus) |
PF00496(SBP_bac_5) | 4 | THR A 355THR A 531HIS A 533LEU A 550 | None | 1.37A | 6gbnD-2wokA:undetectable | 6gbnD-2wokA:21.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ww2 | ALPHA-1,2-MANNOSIDASE (Bacteroidesthetaiotaomicron) |
PF07971(Glyco_hydro_92) | 4 | GLN A 304THR A 652HIS A 603LEU A 635 | GOL A 801 (-2.8A)NoneNoneNone | 1.33A | 6gbnD-2ww2A:undetectable | 6gbnD-2ww2A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x6k | PHOSPHOTIDYLINOSITOL3 KINASE 59F (Drosophilamelanogaster) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka) | 4 | GLN A 863THR A 798HIS A 821LEU A 819 | None | 1.37A | 6gbnD-2x6kA:undetectable | 6gbnD-2x6kA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xt0 | HALOALKANEDEHALOGENASE (Plesiocystispacifica) |
PF00561(Abhydrolase_1) | 4 | GLN A 236THR A 235THR A 241LEU A 130 | None | 1.39A | 6gbnD-2xt0A:undetectable | 6gbnD-2xt0A:23.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y9y | ISWI ONE COMPLEXPROTEIN 3 (Saccharomycescerevisiae) |
PF15612(WHIM1) | 4 | GLN B 428THR B 426THR B 608HIS B 606 | None | 1.18A | 6gbnD-2y9yB:undetectable | 6gbnD-2y9yB:19.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aeu | LIGHT-INDEPENDENTPROTOCHLOROPHYLLIDEREDUCTASE SUBUNIT N (Rhodobactercapsulatus) |
PF00148(Oxidored_nitro) | 4 | THR A 348THR A 368HIS A 360LEU A 357 | None | 1.32A | 6gbnD-3aeuA:undetectable | 6gbnD-3aeuA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3any | ETHANOLAMINEAMMONIA-LYASE HEAVYCHAIN (Escherichiacoli) |
PF06751(EutB) | 4 | GLN A 405THR A 366THR A 325LEU A 379 | None | 1.20A | 6gbnD-3anyA:undetectable | 6gbnD-3anyA:22.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ce6 | ADENOSYLHOMOCYSTEINASE (Mycobacteriumtuberculosis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 73THR A 74THR A 219HIS A 363LEU A 407 | ADN A 500 (-3.6A)ADN A 500 (-4.5A)NAD A 550 ( 2.8A)ADN A 500 ( 3.7A)NAD A 550 (-4.2A) | 0.61A | 6gbnD-3ce6A:55.0 | 6gbnD-3ce6A:54.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e0m | PEPTIDE METHIONINESULFOXIDE REDUCTASEMSRA/MSRB 1 (Streptococcuspneumoniae) |
PF01625(PMSR)PF01641(SelR) | 4 | GLN A 35THR A 47THR A 52LEU A 128 | None | 1.29A | 6gbnD-3e0mA:undetectable | 6gbnD-3e0mA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eeg | 2-ISOPROPYLMALATESYNTHASE (Cytophagahutchinsonii) |
PF00682(HMGL-like) | 4 | THR A 211THR A 259HIS A 263LEU A 266 | None | 1.12A | 6gbnD-3eegA:undetectable | 6gbnD-3eegA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eo7 | PUTATIVENITROREDUCTASE (Trichormusvariabilis) |
PF00881(Nitroreductase) | 4 | GLN A 403THR A 312HIS A 436LEU A 462 | None | 1.29A | 6gbnD-3eo7A:undetectable | 6gbnD-3eo7A:22.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eqn | GLUCAN1,3-BETA-GLUCOSIDASE (Phanerochaetechrysosporium) |
PF12708(Pectate_lyase_3) | 4 | GLN A 292THR A 291THR A 337LEU A 332 | None | 0.87A | 6gbnD-3eqnA:undetectable | 6gbnD-3eqnA:19.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3g1u | ADENOSYLHOMOCYSTEINASE (Leishmaniamajor) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 56THR A 57THR A 156HIS A 300LEU A 343 | ADN A 438 (-3.8A)ADN A 438 (-4.6A)NAD A 439 ( 3.0A)ADN A 438 ( 4.0A)NAD A 439 ( 4.0A) | 0.59A | 6gbnD-3g1uA:59.2 | 6gbnD-3g1uA:63.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3glq | ADENOSYLHOMOCYSTEINASE (Burkholderiapseudomallei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 66THR A 67THR A 200HIS A 344LEU A 385 | RAB A 602 (-3.9A)RAB A 602 (-4.5A)NAD A 601 ( 2.9A)RAB A 602 ( 3.5A)NAD A 601 ( 4.1A) | 0.51A | 6gbnD-3glqA:57.8 | 6gbnD-3glqA:59.21 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3h9u | ADENOSYLHOMOCYSTEINASE (Trypanosomabrucei) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 56THR A 57THR A 156HIS A 300LEU A 343 | ADN A 439 (-3.6A)ADN A 439 (-4.7A)NAD A 438 (-3.8A)NoneNAD A 438 (-4.0A) | 0.44A | 6gbnD-3h9uA:61.4 | 6gbnD-3h9uA:65.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4x | TRYPTOPHANDIMETHYLALLYLTRANSFERASE (Aspergillusfumigatus) |
PF11991(Trp_DMAT) | 4 | GLN A 343THR A 348HIS A 396LEU A 360 | DST A 460 (-3.1A)NoneNoneNone | 1.36A | 6gbnD-3i4xA:undetectable | 6gbnD-3i4xA:22.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ibj | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I)PF01590(GAF)PF13185(GAF_2) | 4 | GLN A 875THR A 805HIS A 773LEU A 780 | None | 1.24A | 6gbnD-3ibjA:undetectable | 6gbnD-3ibjA:21.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ip1 | ALCOHOLDEHYDROGENASE,ZINC-CONTAINING (Thermotogamaritima) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 4 | GLN A 74THR A 75THR A 87LEU A 93 | None | 1.40A | 6gbnD-3ip1A:8.1 | 6gbnD-3ip1A:22.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3isl | PURINE CATABOLISMPROTEIN PUCG (Bacillussubtilis) |
PF00266(Aminotran_5) | 4 | THR A 212THR A 178HIS A 146LEU A 157 | None | 1.38A | 6gbnD-3islA:4.8 | 6gbnD-3islA:23.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3jts | MHC CLASS IMAMU-A*02 (Macaca mulatta) |
PF00129(MHC_I)PF07654(C1-set) | 4 | GLN A 218THR A 216THR A 187LEU A 266 | None | 1.37A | 6gbnD-3jtsA:undetectable | 6gbnD-3jtsA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm6 | STAGE V SPORULATIONPROTEIN AD (Bacillussubtilis) |
PF07451(SpoVAD) | 4 | GLN A 7THR A 186THR A 232LEU A 247 | None | 1.35A | 6gbnD-3lm6A:undetectable | 6gbnD-3lm6A:19.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lma | STAGE V SPORULATIONPROTEIN AD (SPOVAD) (Bacilluslicheniformis) |
PF07451(SpoVAD) | 4 | GLN A 7THR A 186THR A 232LEU A 247 | None | 1.32A | 6gbnD-3lmaA:undetectable | 6gbnD-3lmaA:23.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mr1 | METHIONINEAMINOPEPTIDASE (Rickettsiaprowazekii) |
PF00557(Peptidase_M24) | 4 | THR A 28THR A 106HIS A 234LEU A 248 | None | 1.31A | 6gbnD-3mr1A:undetectable | 6gbnD-3mr1A:22.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3n58 | ADENOSYLHOMOCYSTEINASE (Brucellaabortus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 59THR A 60THR A 193HIS A 337LEU A 378 | K A 2 ( 3.3A)ADN A 500 (-4.6A)NAD A 550 ( 3.0A)ADN A 500 ( 3.6A)NAD A 550 (-4.3A) | 0.52A | 6gbnD-3n58A:58.4 | 6gbnD-3n58A:60.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3one | ADENOSYLHOMOCYSTEINASE (Lupinus luteus) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 66THR A 67THR A 206HIS A 350LEU A 395 | ADE A 506 (-3.8A)ADE A 506 (-4.5A)NAD A 501 (-2.8A)NoneNAD A 501 (-4.2A) | 0.37A | 6gbnD-3oneA:54.7 | 6gbnD-3oneA:58.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl1 | PYRAZINAMIDASE/NICOTINAMIDASE PNCA(PZASE) (Mycobacteriumtuberculosis) |
PF00857(Isochorismatase) | 4 | GLN A 141THR A 142THR A 160LEU A 172 | None | 1.36A | 6gbnD-3pl1A:undetectable | 6gbnD-3pl1A:17.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qlt | GLUTAMATE RECEPTOR,IONOTROPIC KAINATE 2 (Rattusnorvegicus) |
PF01094(ANF_receptor) | 4 | THR A 253THR A 227HIS A 201LEU A 233 | None | 1.25A | 6gbnD-3qltA:5.5 | 6gbnD-3qltA:20.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rha | PUTRESCINE OXIDASE (Paenarthrobacteraurescens) |
PF01593(Amino_oxidase) | 4 | GLN A 217THR A 46THR A 21LEU A 77 | NoneFDA A 483 ( 4.2A)NoneNone | 1.20A | 6gbnD-3rhaA:2.3 | 6gbnD-3rhaA:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rw9 | SPERMIDINE SYNTHASE (Homo sapiens) |
PF01564(Spermine_synth)PF17284(Spermine_synt_N) | 4 | GLN A 245THR A 237THR A 72LEU A 33 | None | 1.42A | 6gbnD-3rw9A:5.0 | 6gbnD-3rw9A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vbo | GENOME POLYPROTEIN,CAPSID PROTEIN VP2 (Enterovirus A) |
PF00073(Rhv) | 4 | THR B 137THR B 298HIS B 187LEU B 291 | None | 1.38A | 6gbnD-3vboB:undetectable | 6gbnD-3vboB:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3x27 | CUCUMOPINE SYNTHASE (Marinactinosporathermotolerans) |
no annotation | 4 | GLN A 168THR A 171THR A 263LEU A 219 | None | 1.33A | 6gbnD-3x27A:undetectable | 6gbnD-3x27A:20.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aij | TRANSCRIPTIONALREGULATOR SLYA (Yersiniapseudotuberculosis) |
PF01047(MarR) | 4 | GLN A 60THR A 32HIS A 33LEU A 70 | None | 1.27A | 6gbnD-4aijA:undetectable | 6gbnD-4aijA:17.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c3h | DNA-DIRECTED RNAPOLYMERASE I SUBUNITRPA190 (Saccharomycescerevisiae) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4) | 4 | THR A 594THR A 653HIS A 603LEU A 616 | None | 1.22A | 6gbnD-4c3hA:undetectable | 6gbnD-4c3hA:14.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnk | L-AMINO ACID OXIDASE (Streptococcuscristatus) |
PF03486(HI0933_like) | 4 | GLN A 156THR A 6THR A 348HIS A 389 | None | 1.15A | 6gbnD-4cnkA:undetectable | 6gbnD-4cnkA:23.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4htz | CGMP-DEPENDENT3',5'-CYCLICPHOSPHODIESTERASE (Homo sapiens) |
PF00233(PDEase_I) | 4 | GLN A 875THR A 805HIS A 773LEU A 780 | None | 1.29A | 6gbnD-4htzA:undetectable | 6gbnD-4htzA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lry | PTS-DEPENDENTDIHYDROXYACETONEKINASE,DIHYDROXYACETONE-BINDING SUBUNIT DHAK (Escherichiacoli) |
PF02733(Dak1) | 4 | THR A 129THR A 153HIS A 60LEU A 69 | None | 1.26A | 6gbnD-4lryA:undetectable | 6gbnD-4lryA:22.87 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4lvc | S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE(SAHASE) (Bradyrhizobiumelkanii) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 62THR A 63THR A 198HIS A 342LEU A 383 | NH4 A 502 ( 3.1A)ADN A 501 (-4.5A)NAD A 503 ( 2.9A)ADN A 501 ( 3.7A)NAD A 503 ( 3.9A) | 0.13A | 6gbnD-4lvcA:57.8 | 6gbnD-4lvcA:60.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lwo | ARGININEN-METHYLTRANSFERASE,PUTATIVE (Trypanosomabrucei) |
no annotation | 4 | GLN B 321THR B 323HIS B 280LEU B 238 | None | 1.33A | 6gbnD-4lwoB:3.2 | 6gbnD-4lwoB:21.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n0r | PUTATIVE GLYCOSIDEHYDROLASE (Bacteroidesvulgatus) |
PF13204(DUF4038)PF16586(DUF5060) | 4 | GLN A 404THR A 136HIS A 389LEU A 408 | None | 1.27A | 6gbnD-4n0rA:2.3 | 6gbnD-4n0rA:22.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6k | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriosalexigens) |
PF03480(DctP) | 4 | GLN A 159THR A 229THR A 235HIS A 237 | None | 1.39A | 6gbnD-4n6kA:undetectable | 6gbnD-4n6kA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6k | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriosalexigens) |
PF03480(DctP) | 4 | GLN A 159THR A 229THR A 235LEU A 168 | None | 1.37A | 6gbnD-4n6kA:undetectable | 6gbnD-4n6kA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4n6k | TRAP DICARBOXYLATETRANSPORTER-DCTPSUBUNIT (Desulfovibriosalexigens) |
PF03480(DctP) | 4 | THR A 229THR A 235HIS A 237LEU A 185 | None | 0.96A | 6gbnD-4n6kA:undetectable | 6gbnD-4n6kA:21.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nq1 | 4-HYDROXY-TETRAHYDRODIPICOLINATESYNTHASE (Legionellapneumophila) |
PF00701(DHDPS) | 4 | GLN A 111THR A 110THR A 81HIS A 120 | NoneNoneMRD A 301 ( 4.2A)MRD A 301 ( 4.8A) | 1.28A | 6gbnD-4nq1A:undetectable | 6gbnD-4nq1A:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pcb | TRWC (Escherichiacoli) |
PF08751(TrwC) | 4 | GLN A 126THR A 189HIS A 4LEU A 84 | None | 1.30A | 6gbnD-4pcbA:undetectable | 6gbnD-4pcbA:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qn3 | NEURAMINIDASE (Influenza Avirus) |
PF00064(Neur) | 4 | THR A 303THR A 207HIS A 202LEU A 9 | None | 1.18A | 6gbnD-4qn3A:undetectable | 6gbnD-4qn3A:22.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rk2 | PUTATIVE SUGAR ABCTRANSPORTER,SUBSTRATE-BINDINGPROTEIN (Rhizobium etli) |
PF01547(SBP_bac_1) | 4 | GLN A 274THR A 273HIS A 197LEU A 195 | None | 1.30A | 6gbnD-4rk2A:undetectable | 6gbnD-4rk2A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rsl | FRUCTOSYL PEPTIDEOXIDASE (Penicilliumterrenum) |
PF01266(DAO) | 4 | THR A 199THR A 8HIS A 3LEU A 393 | None | 1.39A | 6gbnD-4rslA:3.2 | 6gbnD-4rslA:21.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tvm | CITRATE SYNTHASE (Mycobacteriumtuberculosis) |
PF00285(Citrate_synt) | 4 | GLN A 111THR A 195THR A 204LEU A 389 | None | 1.21A | 6gbnD-4tvmA:undetectable | 6gbnD-4tvmA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4txd | CSC2 (Thermofilumpendens) |
no annotation | 4 | GLN A 88THR A 85THR A 156LEU A 331 | None | 1.36A | 6gbnD-4txdA:undetectable | 6gbnD-4txdA:21.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ubq | BETA-LACTAMASE (Acinetobacterbaumannii) |
no annotation | 4 | GLN A 213THR A 210THR A 141HIS A 78 | NoneNoneNone ZN A 301 (-3.4A) | 1.18A | 6gbnD-4ubqA:undetectable | 6gbnD-4ubqA:20.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4upk | PHOSPHONATEMONOESTER HYDROLASE (Ruegeriapomeroyi) |
PF00884(Sulfatase) | 4 | THR A 341THR A 209HIS A 207LEU A 61 | None | 1.15A | 6gbnD-4upkA:undetectable | 6gbnD-4upkA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wss | HEMAGGLUTININ (Influenza Avirus) |
PF00509(Hemagglutinin) | 4 | GLN A 15THR A 14HIS A 439LEU A 436 | None | 1.29A | 6gbnD-4wssA:undetectable | 6gbnD-4wssA:22.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yff | SERINE/THREONINE-PROTEIN KINASE TNNI3K (Homo sapiens) |
PF07714(Pkinase_Tyr) | 4 | GLN A 523THR A 539HIS A 586LEU A 577 | None4CV A 801 (-2.8A)NoneNone | 1.35A | 6gbnD-4yffA:undetectable | 6gbnD-4yffA:18.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yvs | CAPSID PROTEIN VP0 (Enterovirus A) |
PF00073(Rhv) | 4 | THR C 68THR C 229HIS C 118LEU C 222 | None | 1.35A | 6gbnD-4yvsC:undetectable | 6gbnD-4yvsC:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a8r | METHYL-COENZYME MREDUCTASE II,SUBUNIT BETA (Methanothermobactermarburgensis) |
PF02240(MCR_gamma) | 4 | THR C 119THR C 218HIS C 21LEU C 145 | None | 1.40A | 6gbnD-5a8rC:undetectable | 6gbnD-5a8rC:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aca | VP3 (Foot-and-mouthdisease virus) |
PF00073(Rhv) | 4 | GLN 3 156THR 3 88HIS 3 85LEU 3 104 | None | 1.37A | 6gbnD-5aca3:undetectable | 6gbnD-5aca3:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3r | IMP-18 (Pseudomonasaeruginosa) |
no annotation | 4 | GLN A 230THR A 227THR A 158HIS A 95 | NoneNoneNone ZN A2001 ( 3.4A) | 1.19A | 6gbnD-5b3rA:2.5 | 6gbnD-5b3rA:20.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d01 | N-ACETYL-ALPHA-D-GLUCOSAMINYL L-MALATESYNTHASE (Bacillussubtilis) |
PF00534(Glycos_transf_1)PF13439(Glyco_transf_4) | 4 | GLN A 368THR A 119HIS A 94LEU A 24 | None | 1.40A | 6gbnD-5d01A:5.9 | 6gbnD-5d01A:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kyu | PROTEIN TRANSPORTPROTEIN SEC24D (Homo sapiens) |
PF00626(Gelsolin)PF04810(zf-Sec23_Sec24)PF04811(Sec23_trunk)PF04815(Sec23_helical)PF08033(Sec23_BS) | 4 | GLN B 563THR B 556HIS B 582LEU B 648 | None | 1.40A | 6gbnD-5kyuB:undetectable | 6gbnD-5kyuB:20.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lmc | ANAEROBIC NITRICOXIDE REDUCTASEFLAVORUBREDOXIN (Escherichiacoli) |
PF00258(Flavodoxin_1)PF00301(Rubredoxin)PF00753(Lactamase_B) | 4 | GLN A 190THR A 29HIS A 147LEU A 199 | NoneNoneFEO A 501 ( 3.4A)None | 1.02A | 6gbnD-5lmcA:5.0 | 6gbnD-5lmcA:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lqd | ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (Streptomycesvenezuelae) |
PF00982(Glyco_transf_20) | 4 | GLN A 151THR A 165HIS A 94LEU A 90 | None | 1.38A | 6gbnD-5lqdA:3.4 | 6gbnD-5lqdA:20.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nci | LEUCINE HYDROXYLASE (Streptomycesmuensis) |
PF05721(PhyH) | 4 | GLN A 111THR A 227HIS A 92LEU A 122 | None | 1.04A | 6gbnD-5nciA:undetectable | 6gbnD-5nciA:20.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swk | DE NOVO PROTEINBASED ON THEINHIBITORAMOEBIASIN-1E3 UBIQUITIN-PROTEINLIGASE MDM2 (Entamoebahistolytica;Homo sapiens) |
no annotation | 4 | GLN A 72THR C 85HIS A 96LEU C 94 | None | 0.98A | 6gbnD-5swkA:undetectable | 6gbnD-5swkA:16.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u47 | PENICILLIN BINDINGPROTEIN 2X (Streptococcusthermophilus) |
PF00905(Transpeptidase)PF03717(PBP_dimer)PF03793(PASTA) | 4 | GLN A 484THR A 303THR A 297LEU A 270 | None | 1.35A | 6gbnD-5u47A:undetectable | 6gbnD-5u47A:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w63 | APOPTOSIS REGULATORBAX (Ictaluruspunctatus) |
no annotation | 4 | GLN A 154THR A 54HIS A 55LEU A 21 | None | 1.36A | 6gbnD-5w63A:undetectable | 6gbnD-5w63A:9.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Komagataellaphaffii) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 4 | GLN B1065THR B1090HIS B1025LEU B1026 | None | 1.36A | 6gbnD-5xogB:undetectable | 6gbnD-5xogB:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xs5 | GENOME POLYPROTEIN (Enterovirus A) |
PF00073(Rhv) | 4 | THR B 68THR B 231HIS B 118LEU B 224 | None | 1.40A | 6gbnD-5xs5B:undetectable | 6gbnD-5xs5B:18.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5y0e | - (-) |
no annotation | 4 | GLN A 57THR A 53THR A 169LEU A 153 | None | 1.40A | 6gbnD-5y0eA:undetectable | 6gbnD-5y0eA:undetectable | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 6aph | ADENOSYLHOMOCYSTEINASE (Elizabethkingiaanophelis) |
PF00670(AdoHcyase_NAD)PF05221(AdoHcyase) | 5 | GLN A 62THR A 63THR A 162HIS A 306LEU A 349 | ADN A 501 (-3.8A)ADN A 501 (-4.5A)NAD A 500 ( 2.9A)ADN A 501 ( 3.7A)NAD A 500 ( 4.3A) | 0.59A | 6gbnD-6aphA:65.9 | 6gbnD-6aphA:77.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bog | RNAPOLYMERASE-ASSOCIATED PROTEIN RAPA (Escherichiacoli) |
no annotation | 4 | THR A 421THR A 313HIS A 324LEU A 417 | None | 1.33A | 6gbnD-6bogA:undetectable | 6gbnD-6bogA:11.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c01 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 3 (Homo sapiens) |
no annotation | 4 | GLN A 466THR A 378THR A 203HIS A 373 | NoneNoneNone ZN A 902 (-3.3A) | 1.17A | 6gbnD-6c01A:undetectable | 6gbnD-6c01A:11.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6f3m | - (-) |
no annotation | 5 | GLN B 65THR B 66THR B 165HIS B 323LEU B 373 | K B 504 ( 3.0A)ADN B 502 (-4.6A)NAD B 501 ( 2.8A) ZN B 505 (-3.2A)NAD B 501 ( 3.9A) | 0.16A | 6gbnD-6f3mB:56.8 | 6gbnD-6f3mB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 7mdh | PROTEIN (MALATEDEHYDROGENASE) (Sorghum bicolor) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 4 | GLN A 208THR A 198HIS A 229LEU A 385 | NoneNone ZN A 501 (-2.9A) ZN A 503 (-4.0A) | 1.21A | 6gbnD-7mdhA:5.5 | 6gbnD-7mdhA:22.96 |