SIMILAR PATTERNS OF AMINO ACIDS FOR 6GBF_A_ACTA507

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)

(Homo sapiens) 		PF00079
(Serpin) 		3 LYS A  99
SER A 105
SER A 106
 None
 1.13A 6gbfA-1by7A:
undetectable		 6gbfA-1by7A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		3 LYS A  67
SER A 143
SER A  91
 None
 1.13A 6gbfA-1d9zA:
0.0		 6gbfA-1d9zA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e69 CHROMOSOME
SEGREGATION SMC
PROTEIN

(Thermotoga
maritima) 		PF02463
(SMC_N) 		3 LYS A1096
SER A1098
SER A 132
 None
 1.06A 6gbfA-1e69A:
undetectable		 6gbfA-1e69A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eth TRIACYLGLYCEROL
ACYL-HYDROLASE

(Sus scrofa) 		PF00151
(Lipase)
PF01477
(PLAT) 		3 LYS A  70
SER A 143
SER A 145
 None
 1.12A 6gbfA-1ethA:
3.3		 6gbfA-1ethA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1huj INORGANIC
PYROPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF00719
(Pyrophosphatase) 		3 LYS A 238
SER A 234
SER A 235
 None
 1.10A 6gbfA-1hujA:
0.0		 6gbfA-1hujA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jf0 OBELIN

(Obelia
longissima) 		PF13499
(EF-hand_7)
PF13833
(EF-hand_8) 		3 LYS A 136
SER A 145
SER A 147
 None
 0.95A 6gbfA-1jf0A:
undetectable		 6gbfA-1jf0A:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jru P47 PROTEIN

(Rattus
norvegicus) 		PF00789
(UBX) 		3 LYS A 282
SER A 285
SER A 286
 None
 1.14A 6gbfA-1jruA:
undetectable		 6gbfA-1jruA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll8 PAS KINASE

(Homo sapiens) 		PF13426
(PAS_9) 		3 LYS A  87
SER A  82
SER A  84
 None
 1.00A 6gbfA-1ll8A:
0.0		 6gbfA-1ll8A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lua METHYLENE
TETRAHYDROMETHANOPTE
RIN DEHYDROGENASE

(Methylobacterium
extorquens) 		PF09176
(Mpt_N) 		3 LYS A  56
SER A 271
SER A 270
 None
 1.06A 6gbfA-1luaA:
3.6		 6gbfA-1luaA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olp ALPHA-TOXIN

(Clostridium
sardiniense) 		PF00882
(Zn_dep_PLPC)
PF01477
(PLAT) 		3 LYS A   4
SER A  52
SER A  12
 None
 0.82A 6gbfA-1olpA:
0.0		 6gbfA-1olpA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgu ACTIN INTERACTING
PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		3 LYS A 169
SER A 215
SER A 218
 None
 1.14A 6gbfA-1pguA:
undetectable		 6gbfA-1pguA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qv0 OBELIN

(Obelia
longissima) 		PF00036
(EF-hand_1)
PF13202
(EF-hand_5) 		3 LYS A 136
SER A 145
SER A 147
 None
 1.01A 6gbfA-1qv0A:
undetectable		 6gbfA-1qv0A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1suu DNA GYRASE SUBUNIT A

(Borreliella
burgdorferi) 		PF03989
(DNA_gyraseA_C) 		3 LYS A 696
SER A 667
SER A 671
 None
 1.09A 6gbfA-1suuA:
undetectable		 6gbfA-1suuA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5e FTSZ

(Methanocaldococcus
jannaschii) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		3 LYS A 263
SER A 256
SER A 258
 None
 1.13A 6gbfA-1w5eA:
2.6		 6gbfA-1w5eA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xz9 AFADIN

(Homo sapiens) 		PF00595
(PDZ) 		3 LYS A  47
SER A  26
SER A  44
 None
 0.90A 6gbfA-1xz9A:
undetectable		 6gbfA-1xz9A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z2z PROBABLE TRNA
PSEUDOURIDINE
SYNTHASE D

(Methanosarcina
mazei) 		PF01142
(TruD) 		3 LYS A  77
SER A  96
SER A 124
 None
 1.04A 6gbfA-1z2zA:
undetectable		 6gbfA-1z2zA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aam HYPOTHETICAL PROTEIN
TM1410

(Thermotoga
maritima) 		PF03537
(Glyco_hydro_114) 		3 LYS A  63
SER A  66
SER A  68
 None
 0.70A 6gbfA-2aamA:
undetectable		 6gbfA-2aamA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axw DRAD INVASIN

(Escherichia
coli) 		PF05775
(AfaD) 		3 LYS A  75
SER A  83
SER A  72
 None
 1.11A 6gbfA-2axwA:
undetectable		 6gbfA-2axwA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bib TEICHOIC ACID
PHOSPHORYLCHOLINE
ESTERASE/ CHOLINE
BINDING PROTEIN

(Streptococcus
pneumoniae) 		PF00753
(Lactamase_B)
PF01473
(CW_binding_1) 		3 LYS A 178
SER A 112
SER A 114
 None
 1.14A 6gbfA-2bibA:
undetectable		 6gbfA-2bibA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 LYS A 215
SER A 211
SER A 212
 None
 1.06A 6gbfA-2cf5A:
undetectable		 6gbfA-2cf5A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d40 PUTATIVE GENTISATE
1,2-DIOXYGENASE

(Escherichia
coli) 		PF07883
(Cupin_2) 		3 LYS A 265
SER A 320
SER A 286
 None
 1.13A 6gbfA-2d40A:
undetectable		 6gbfA-2d40A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dyp LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY B
MEMBER 2

(Homo sapiens) 		PF13895
(Ig_2) 		3 LYS D   3
SER D  29
SER D  79
 None
 1.11A 6gbfA-2dypD:
undetectable		 6gbfA-2dypD:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eix NADH-CYTOCHROME B5
REDUCTASE

(Physarum
polycephalum) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		3 LYS A 155
SER A 244
SER A 248
 None
 1.13A 6gbfA-2eixA:
undetectable		 6gbfA-2eixA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fhd DNA REPAIR PROTEIN
RHP9/CRB2

(Schizosaccharomyces
pombe) 		no annotation 3 LYS A 363
SER A 492
SER A 494
 None
 1.09A 6gbfA-2fhdA:
undetectable		 6gbfA-2fhdA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1s RENIN

(Homo sapiens) 		PF00026
(Asp) 		3 LYS A  68
SER A  64
SER A  66
 None
 1.16A 6gbfA-2g1sA:
undetectable		 6gbfA-2g1sA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h3g BIOSYNTHETIC PROTEIN

(Bacillus
anthracis) 		PF03309
(Pan_kinase) 		3 LYS X 182
SER X 186
SER X 177
 None
 1.12A 6gbfA-2h3gX:
undetectable		 6gbfA-2h3gX:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j5b TYROSYL-TRNA
SYNTHETASE

(Acanthamoeba
polyphaga
mimivirus) 		PF00579
(tRNA-synt_1b) 		3 LYS A 220
SER A 215
SER A 217
 LYS  A 220 ( 0.0A)
SER  A 215 ( 0.0A)
SER  A 217 ( 0.0A)
 1.00A 6gbfA-2j5bA:
3.2		 6gbfA-2j5bA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jwp MALECTIN

(Xenopus laevis) 		PF11721
(Malectin) 		3 LYS A 136
SER A 141
SER A 134
 None
 1.12A 6gbfA-2jwpA:
undetectable		 6gbfA-2jwpA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mq9 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
SUBUNIT 1

(Homo sapiens) 		PF03463
(eRF1_1) 		3 LYS A 109
SER A  33
SER A  70
 None
 0.82A 6gbfA-2mq9A:
undetectable		 6gbfA-2mq9A:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2nqn MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
MOEA

(Escherichia
coli) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 LYS A 279
SER A 303
SER A 371
 None
 0.58A 6gbfA-2nqnA:
36.0		 6gbfA-2nqnA:
33.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q5c NTRC FAMILY
TRANSCRIPTIONAL
REGULATOR

(Clostridium
acetobutylicum) 		PF06506
(PrpR_N) 		3 LYS A  64
SER A  55
SER A  73
 None
 1.15A 6gbfA-2q5cA:
6.8		 6gbfA-2q5cA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7c ORPHAN NUCLEAR
RECEPTOR NR1D2

(Homo sapiens) 		PF00104
(Hormone_recep) 		3 LYS A 403
SER A 465
SER A 408
 None
 1.13A 6gbfA-2v7cA:
undetectable		 6gbfA-2v7cA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vl8 CYTOTOXIN L

(Paeniclostridium
sordellii) 		PF12918
(TcdB_N)
PF12919
(TcdA_TcdB) 		3 LYS A 278
SER A 389
SER A 393
 None
 1.13A 6gbfA-2vl8A:
undetectable		 6gbfA-2vl8A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w40 GLYCEROL KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 LYS A  15
SER A   6
SER A 443
 EDO  A1504 ( 4.6A)
None
None
 0.97A 6gbfA-2w40A:
2.7		 6gbfA-2w40A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a57 THERMOSTABLE DIRECT
HEMOLYSIN 2

(Vibrio
parahaemolyticus) 		PF03347
(TDH) 		3 LYS A  12
SER A  85
SER A  92
 None
 0.97A 6gbfA-3a57A:
undetectable		 6gbfA-3a57A:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		3 LYS A 191
SER A 169
SER A 175
 None
 1.08A 6gbfA-3b5iA:
undetectable		 6gbfA-3b5iA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chx PMOB

(Methylosinus
trichosporium) 		PF04744
(Monooxygenase_B) 		3 LYS A 277
SER A 120
SER A  93
 None
 1.14A 6gbfA-3chxA:
undetectable		 6gbfA-3chxA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmi PEROXIREDOXIN HYR1

(Saccharomyces
cerevisiae) 		PF00255
(GSHPx) 		3 LYS A 124
SER A 144
SER A 143
 None
 1.06A 6gbfA-3cmiA:
undetectable		 6gbfA-3cmiA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3co8 ALANINE RACEMASE

(Oenococcus oeni) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LYS A 243
SER A  14
SER A  16
 None
 0.92A 6gbfA-3co8A:
undetectable		 6gbfA-3co8A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3u 4-HYDROXYBUTYRATE
COA-TRANSFERASE

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		3 LYS A 346
SER A 309
SER A 353
 None
 1.14A 6gbfA-3d3uA:
undetectable		 6gbfA-3d3uA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9x ADHESIN A

(Bartonella
henselae) 		PF05662
(YadA_stalk) 		3 LYS A 415
SER A 409
SER A 411
 None
 1.06A 6gbfA-3d9xA:
undetectable		 6gbfA-3d9xA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnh UNCHARACTERIZED
PROTEIN ATU2129

(Agrobacterium
fabrum) 		PF13883
(Pyrid_oxidase_2) 		3 LYS A 208
SER A 226
SER A 228
 None
 1.10A 6gbfA-3dnhA:
undetectable		 6gbfA-3dnhA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc8 TRANSTHYRETIN

(Homo sapiens) 		PF00576
(Transthyretin) 		3 LYS A  15
SER A  50
SER A  52
 IFA  A3000 (-3.0A)
None
None
 0.85A 6gbfA-3fc8A:
undetectable		 6gbfA-3fc8A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fzu IMMUNOGLOBULIN IGG1
FAB, HEAVY CHAIN

(Homo sapiens) 		no annotation 3 LYS H   1
SER H 100
SER H 105
 None
 0.98A 6gbfA-3fzuH:
undetectable		 6gbfA-3fzuH:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gtt SUPEROXIDE DISMUTASE
[CU-ZN]

(Mus musculus) 		PF00080
(Sod_Cu) 		3 LYS A   1
SER A 107
SER A  25
 None
 1.06A 6gbfA-3gttA:
undetectable		 6gbfA-3gttA:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 LYS A 242
SER A 275
SER A 271
 None
 0.94A 6gbfA-3hrdA:
undetectable		 6gbfA-3hrdA:
25.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrp UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01833
(TIG) 		3 LYS A 150
SER A 135
SER A 137
 None
 0.90A 6gbfA-3hrpA:
undetectable		 6gbfA-3hrpA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2n WD REPEAT-CONTAINING
PROTEIN 92

(Homo sapiens) 		PF00400
(WD40) 		3 LYS A  25
SER A 340
SER A 326
 None
 1.15A 6gbfA-3i2nA:
undetectable		 6gbfA-3i2nA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kt4 PKHD-TYPE
HYDROXYLASE TPA1

(Saccharomyces
cerevisiae) 		PF10637
(Ofd1_CTDD)
PF13661
(2OG-FeII_Oxy_4) 		3 LYS A 384
SER A 621
SER A 543
 None
 1.14A 6gbfA-3kt4A:
undetectable		 6gbfA-3kt4A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llk SULFHYDRYL OXIDASE 1

(Homo sapiens) 		PF04777
(Evr1_Alr) 		3 LYS A 298
SER A 536
SER A 538
 None
 1.02A 6gbfA-3llkA:
undetectable		 6gbfA-3llkA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc3 DSRE/DSRF-LIKE
FAMILY PROTEIN

(Sulfolobus
solfataricus) 		PF02635
(DrsE) 		3 LYS A  85
SER A  43
SER A  39
 MLY  A  84 ( 2.9A)
None
None
 0.79A 6gbfA-3mc3A:
undetectable		 6gbfA-3mc3A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mse CALCIUM-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
falciparum) 		PF10591
(SPARC_Ca_bdg)
PF13202
(EF-hand_5) 		3 LYS B 118
SER B 125
SER B 127
 None
CA  B 180 ( 4.3A)
None
 0.73A 6gbfA-3mseB:
undetectable		 6gbfA-3mseB:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mz2 GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE

(Parabacteroides
distasonis) 		PF03009
(GDPD) 		3 LYS A 311
SER A 307
SER A 308
 None
 1.04A 6gbfA-3mz2A:
undetectable		 6gbfA-3mz2A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		3 LYS A  10
SER A 130
SER A   6
 None
 1.10A 6gbfA-3q9cA:
undetectable		 6gbfA-3q9cA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rr5 DNA LIGASE

(Thermococcus
sp. 1519) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		3 LYS A 383
SER A 299
SER A 379
 None
 0.96A 6gbfA-3rr5A:
undetectable		 6gbfA-3rr5A:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4w FANCONI ANEMIA GROUP
D2 PROTEIN HOMOLOG

(Mus musculus) 		PF14631
(FancD2) 		3 LYS B 723
SER B 729
SER B 627
 None
 0.75A 6gbfA-3s4wB:
undetectable		 6gbfA-3s4wB:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s97 CONTACTIN-1

(Homo sapiens) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 LYS C 133
SER C 215
SER C 217
 None
 0.84A 6gbfA-3s97C:
undetectable		 6gbfA-3s97C:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t36 ENDO-TYPE
MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF01464
(SLT) 		3 LYS A  84
SER A  73
SER A  75
 None
 1.15A 6gbfA-3t36A:
undetectable		 6gbfA-3t36A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		3 LYS A 361
SER A 929
SER A 926
 None
 0.84A 6gbfA-3u6nA:
undetectable		 6gbfA-3u6nA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		3 LYS A  14
SER A 183
SER A 185
 None
 1.04A 6gbfA-3vlaA:
undetectable		 6gbfA-3vlaA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zyy IRON-SULFUR CLUSTER
BINDING PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF00111
(Fer2)
PF14574
(DUF4445) 		3 LYS X 198
SER X 180
SER X 201
 None
 1.15A 6gbfA-3zyyX:
undetectable		 6gbfA-3zyyX:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		3 LYS A 780
SER A 434
SER A 431
 None
 0.99A 6gbfA-4a2wA:
undetectable		 6gbfA-4a2wA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae0 DIPHTHERIA TOXIN

(Corynebacterium
diphtheriae) 		PF01324
(Diphtheria_R)
PF02763
(Diphtheria_C)
PF02764
(Diphtheria_T) 		3 LYS A   5
SER A  11
SER A   8
 None
 1.09A 6gbfA-4ae0A:
undetectable		 6gbfA-4ae0A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ate BETA-PORPHYRANASE A

(Zobellia
galactanivorans) 		no annotation 3 LYS A 120
SER A 128
SER A 122
 None
 1.16A 6gbfA-4ateA:
undetectable		 6gbfA-4ateA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN

(Homo sapiens) 		PF00450
(Peptidase_S10) 		3 LYS A  27
SER A 124
SER A  29
 None
 1.05A 6gbfA-4az3A:
undetectable		 6gbfA-4az3A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0j MITOCHONDRIAL RHO
GTPASE

(Drosophila
melanogaster) 		PF00071
(Ras)
PF08355
(EF_assoc_1)
PF08356
(EF_assoc_2) 		3 LYS A 375
SER A 368
SER A 370
 SO4  A1612 (-2.9A)
None
None
 1.09A 6gbfA-4c0jA:
undetectable		 6gbfA-4c0jA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmo N-HYDROXYARYLAMINE
O-ACETYLTRANSFERASE

(Bacillus cereus) 		PF00797
(Acetyltransf_2) 		3 LYS A 158
SER A  91
SER A 106
 None
 0.85A 6gbfA-4dmoA:
undetectable		 6gbfA-4dmoA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		3 LYS A 276
SER A  48
SER A  50
 None
 0.96A 6gbfA-4dzaA:
undetectable		 6gbfA-4dzaA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fhn NUCLEOPORIN NUP120

(Schizosaccharomyces
pombe) 		PF11715
(Nup160) 		3 LYS B  66
SER B  76
SER B  64
 None
 1.04A 6gbfA-4fhnB:
undetectable		 6gbfA-4fhnB:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g1g MATRIX PROTEIN

(Avian
avulavirus 1) 		PF00661
(Matrix) 		3 LYS A 281
SER A 295
SER A 297
 None
 0.60A 6gbfA-4g1gA:
undetectable		 6gbfA-4g1gA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaf EBI-005

(Homo sapiens) 		PF00340
(IL1) 		3 LYS A   1
SER A  44
SER A   5
 None
 1.10A 6gbfA-4gafA:
undetectable		 6gbfA-4gafA:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnr ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN-BRANCHED
CHAIN AMINO ACID
TRANSPORT

(Streptococcus
pneumoniae) 		PF13458
(Peripla_BP_6) 		3 LYS A 202
SER A 167
SER A 200
 None
 1.01A 6gbfA-4gnrA:
4.2		 6gbfA-4gnrA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		3 LYS A 805
SER A 799
SER A 801
 None
SO4  A1008 (-2.7A)
SO4  A1008 (-4.4A)
 0.85A 6gbfA-4k6mA:
undetectable		 6gbfA-4k6mA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgn CELLULOSE-BINDING,
FAMILY II

(Acidothermus
cellulolyticus) 		no annotation 3 LYS A 581
SER A 534
SER A 538
 None
 1.06A 6gbfA-4lgnA:
undetectable		 6gbfA-4lgnA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nky STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE

(Homo sapiens) 		PF00067
(p450) 		3 LYS A 374
SER A  94
SER A 117
 None
 0.90A 6gbfA-4nkyA:
undetectable		 6gbfA-4nkyA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsx U3 SMALL NUCLEOLAR
RNA-ASSOCIATED
PROTEIN 21

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		3 LYS A  56
SER A 682
SER A 680
 None
 1.07A 6gbfA-4nsxA:
undetectable		 6gbfA-4nsxA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		3 LYS A 167
SER A  85
SER A  83
 UNX  A 405 ( 3.6A)
None
None
 1.04A 6gbfA-4rfqA:
2.0		 6gbfA-4rfqA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z0b ANTIBODY HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS H 124
SER H 121
SER H 122
 None
 1.02A 6gbfA-4z0bH:
undetectable		 6gbfA-4z0bH:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a1n BIFUNCTIONAL
GLUTAMATE/PROLINE--T
RNA LIGASE

(Homo sapiens) 		PF00043
(GST_C) 		3 LYS A  88
SER A  94
SER A  97
 None
 1.16A 6gbfA-5a1nA:
undetectable		 6gbfA-5a1nA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c8c VP1
VP0

(Enterovirus A;
Enterovirus A) 		PF00073
(Rhv)
PF00073
(Rhv)
PF02226
(Pico_P1A) 		3 LYS A 256
SER B  20
SER B  18
 None
 0.93A 6gbfA-5c8cA:
undetectable		 6gbfA-5c8cA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cd3 DRVIA7 HEAVY CHAIN

(Homo sapiens) 		no annotation 3 LYS G  98
SER G  32
SER G  31
 None
 1.06A 6gbfA-5cd3G:
undetectable		 6gbfA-5cd3G:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		3 LYS A1173
SER A1257
SER A1219
 None
 1.09A 6gbfA-5cs4A:
undetectable		 6gbfA-5cs4A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5deu METHYLCYTOSINE
DIOXYGENASE TET2,
CHIMERIC CONSTRUCT

(Homo sapiens) 		PF12851
(Tet_JBP) 		3 LYS A1208
SER A1203
SER A1204
 None
 0.97A 6gbfA-5deuA:
undetectable		 6gbfA-5deuA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dyo FAB 43.1 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 LYS A   2
SER A  98
SER A 100
 None
 0.85A 6gbfA-5dyoA:
undetectable		 6gbfA-5dyoA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edj FRPC OPERON PROTEIN

(Neisseria
meningitidis) 		PF06901
(FrpC) 		3 LYS A  87
SER A  90
SER A  47
 None
 1.11A 6gbfA-5edjA:
undetectable		 6gbfA-5edjA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejy MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00784
(MyTH4) 		3 LYS A 232
SER A 202
SER A 198
 None
 0.97A 6gbfA-5ejyA:
undetectable		 6gbfA-5ejyA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kg9 ANTIBODY RE505-22
FAB LIGHT CHAIN

(Homo sapiens;
Mus musculus) 		no annotation 3 LYS L  19
SER L  63
SER L  65
 None
 1.01A 6gbfA-5kg9L:
undetectable		 6gbfA-5kg9L:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 3 LYS A  73
SER A 343
SER A 342
 None
 1.07A 6gbfA-5m6gA:
undetectable		 6gbfA-5m6gA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nlw NANOBODY NB36

(Lama glama) 		PF07686
(V-set) 		3 LYS A  77
SER A  31
SER A  28
 None
 1.07A 6gbfA-5nlwA:
undetectable		 6gbfA-5nlwA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP3

(Streptococcus
gordonii) 		no annotation 3 LYS B 132
SER B  60
SER B  61
 None
 1.09A 6gbfA-5vaeB:
undetectable		 6gbfA-5vaeB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x5s AMYLASE

(uncultured
bacterium) 		no annotation 3 LYS A  41
SER A  87
SER A  91
 None
 0.91A 6gbfA-5x5sA:
undetectable		 6gbfA-5x5sA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzu BETA-XYLANASE

(Bispora sp.
MEY-1) 		no annotation 3 LYS A 193
SER A 145
SER A 139
 None
 1.14A 6gbfA-5xzuA:
undetectable		 6gbfA-5xzuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 LYS C1671
SER C1677
SER C1658
 None
 0.94A 6gbfA-5y3rC:
undetectable		 6gbfA-5y3rC:
7.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yqj MEMBRANE-ANCHORED
LIPID-BINDING
PROTEIN LAM4

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 900
SER A 863
SER A 866
 None
 0.98A 6gbfA-5yqjA:
undetectable		 6gbfA-5yqjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf6 INSULIN-DEGRADING
ENZYME

(Homo sapiens) 		no annotation 3 LYS A 303
SER A 482
SER A 484
 None
 1.03A 6gbfA-6bf6A:
undetectable		 6gbfA-6bf6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwo RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 3 LYS A 178
SER A 173
SER A 251
 None
 1.04A 6gbfA-6cwoA:
undetectable		 6gbfA-6cwoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cwp RIBONUCLEOTIDE
REDUCTASE

(Flavobacterium
johnsoniae) 		no annotation 3 LYS A 178
SER A 173
SER A 251
 None
 1.01A 6gbfA-6cwpA:
undetectable		 6gbfA-6cwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 835
SER A1529
SER A 830
 None
 1.14A 6gbfA-6emkA:
undetectable		 6gbfA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ezn DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT WBP1

(Saccharomyces
cerevisiae) 		no annotation 3 LYS G 136
SER G 178
SER G 113
 None
 1.12A 6gbfA-6eznG:
2.8		 6gbfA-6eznG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1

(Arabidopsis
thaliana) 		no annotation 3 LYS A 294
SER A 328
SER A 400
 None
MOO  A 507 (-2.7A)
MOO  A 507 (-2.6A)
 0.49A 6gbfA-6gbcA:
53.4		 6gbfA-6gbcA:
undetectable