SIMILAR PATTERNS OF AMINO ACIDS FOR 6GB9_A_ACTA508

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqb PROTEIN (AUREOLYSIN)

(Staphylococcus
aureus) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		3 VAL A 178
ALA A 143
GLN A  76
 None
 0.69A 6gb9A-1bqbA:
1.4		 6gb9A-1bqbA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1crz TOLB PROTEIN

(Escherichia
coli) 		PF04052
(TolB_N)
PF07676
(PD40) 		3 VAL A 107
ALA A  62
GLN A 110
 None
 0.38A 6gb9A-1crzA:
3.4		 6gb9A-1crzA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2p COLLAGEN ADHESIN

(Staphylococcus
aureus) 		PF05738
(Cna_B) 		3 VAL A 875
ALA A 870
GLN A 842
 None
 0.57A 6gb9A-1d2pA:
undetectable		 6gb9A-1d2pA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL A  67
ALA A  70
GLN A  34
 None
 0.67A 6gb9A-1fujA:
undetectable		 6gb9A-1fujA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fy1 HEPARIN-BINDING
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL A  54
ALA A  57
GLN A  19
 None
 0.63A 6gb9A-1fy1A:
undetectable		 6gb9A-1fy1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3n V-CYCLIN

(Human
gammaherpesvirus
8) 		PF00134
(Cyclin_N)
PF09080
(K-cyclin_vir_C) 		3 VAL C 221
ALA C 203
GLN C 236
 None
 0.46A 6gb9A-1g3nC:
undetectable		 6gb9A-1g3nC:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i1q ANTHRANILATE
SYNTHASE COMPONENT I

(Salmonella
enterica) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 VAL A 404
ALA A 385
GLN A 320
 None
 0.65A 6gb9A-1i1qA:
0.0		 6gb9A-1i1qA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 VAL A 404
ALA A 385
GLN A 320
 None
 0.59A 6gb9A-1i7qA:
undetectable		 6gb9A-1i7qA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN

(Mus musculus) 		PF02816
(Alpha_kinase) 		3 VAL A1703
ALA A1716
GLN A1676
 None
 0.69A 6gb9A-1iahA:
undetectable		 6gb9A-1iahA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o5f SERINE PROTEASE
HEPSIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL H  17
ALA H 221
GLN H 145
 None
 0.44A 6gb9A-1o5fH:
0.0		 6gb9A-1o5fH:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		3 VAL A   6
ALA A   8
GLN A  61
 None
 0.68A 6gb9A-1odiA:
4.2		 6gb9A-1odiA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		3 VAL A  24
ALA A 111
GLN A 296
 VAL  A  24 ( 0.6A)
ALA  A 111 ( 0.0A)
GLN  A 296 ( 0.6A)
 0.62A 6gb9A-1omoA:
undetectable		 6gb9A-1omoA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1osm OMPK36

(Klebsiella
pneumoniae) 		PF00267
(Porin_1) 		3 VAL A 136
ALA A 133
GLN A 156
 None
 0.64A 6gb9A-1osmA:
undetectable		 6gb9A-1osmA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pii N-(5'PHOSPHORIBOSYL)
ANTHRANILATE
ISOMERASE

(Escherichia
coli) 		PF00218
(IGPS)
PF00697
(PRAI) 		3 VAL A 377
ALA A 405
GLN A 332
 None
 0.65A 6gb9A-1piiA:
undetectable		 6gb9A-1piiA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		3 VAL A1420
ALA A1417
GLN A1430
 None
 0.65A 6gb9A-1qhmA:
undetectable		 6gb9A-1qhmA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwy PEPTIDOGLYCAN
HYDROLASE

(Staphylococcus
aureus) 		PF01551
(Peptidase_M23) 		3 VAL A 138
ALA A 122
GLN A 135
 None
 0.69A 6gb9A-1qwyA:
undetectable		 6gb9A-1qwyA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rrv GLYCOSYLTRANSFERASE
GTFD

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		3 VAL A 209
ALA A 211
GLN A 206
 VAL  A 209 ( 0.6A)
ALA  A 211 ( 0.0A)
GLN  A 206 ( 0.6A)
 0.69A 6gb9A-1rrvA:
4.4		 6gb9A-1rrvA:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um2 ENDONUCLEASE PI-SCEI

(Saccharomyces
cerevisiae) 		PF05203
(Hom_end_hint)
PF05204
(Hom_end) 		3 VAL A 734
ALA A 463
GLN A 726
 None
 0.70A 6gb9A-1um2A:
undetectable		 6gb9A-1um2A:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyx CRK-ASSOCIATED
SUBSTRATE

(Homo sapiens) 		PF00018
(SH3_1) 		3 VAL A  30
ALA A   6
GLN A  33
 None
 0.64A 6gb9A-1wyxA:
undetectable		 6gb9A-1wyxA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xd6 GASTRODIANIN-4

(Gastrodia elata) 		PF01453
(B_lectin) 		3 VAL A  63
ALA A  70
GLN A  57
 None
None
SO4  A1001 ( 4.7A)
 0.70A 6gb9A-1xd6A:
undetectable		 6gb9A-1xd6A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xd6 GASTRODIANIN-4

(Gastrodia elata) 		PF01453
(B_lectin) 		3 VAL A  94
ALA A 102
GLN A  88
 None
 0.70A 6gb9A-1xd6A:
undetectable		 6gb9A-1xd6A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		3 VAL A 622
ALA A 617
GLN A 584
 None
 0.68A 6gb9A-1xjeA:
1.5		 6gb9A-1xjeA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrg PUTATIVE TRANSLATION
INITIATION
INHIBITOR, YJGF
FAMILY

(Ruminiclostridium
thermocellum) 		PF01042
(Ribonuc_L-PSP) 		3 VAL A  62
ALA A  21
GLN A  33
 None
 0.70A 6gb9A-1xrgA:
undetectable		 6gb9A-1xrgA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y60 FORMALDEHYDE-ACTIVAT
ING ENZYME FAE

(Methylobacterium
extorquens) 		PF08714
(Fae) 		3 VAL A  99
ALA A 109
GLN A  96
 None
 0.61A 6gb9A-1y60A:
undetectable		 6gb9A-1y60A:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2atf CYSTEINE DIOXYGENASE
TYPE I

(Mus musculus) 		PF05995
(CDO_I) 		3 VAL A 152
ALA A  51
GLN A  99
 None
 0.67A 6gb9A-2atfA:
undetectable		 6gb9A-2atfA:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxe RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Pyrococcus
horikoshii) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		3 VAL A 368
ALA A 156
GLN A 309
 None
 0.67A 6gb9A-2cxeA:
undetectable		 6gb9A-2cxeA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4y FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 1

(Salmonella
enterica) 		no annotation 3 VAL A 467
ALA A 476
GLN A 299
 None
 0.66A 6gb9A-2d4yA:
undetectable		 6gb9A-2d4yA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4u THIOESTERASE
SUPERFAMILY MEMBER 2

(Homo sapiens) 		PF03061
(4HBT) 		3 VAL A 106
ALA A  71
GLN A 109
 None
 0.71A 6gb9A-2h4uA:
undetectable		 6gb9A-2h4uA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hg4 6-DEOXYERYTHRONOLIDE
B SYNTHASE

(Saccharopolyspora
erythraea) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08990
(Docking)
PF16197
(KAsynt_C_assoc) 		3 VAL A  44
ALA A 131
GLN A 272
 None
 0.68A 6gb9A-2hg4A:
3.9		 6gb9A-2hg4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imh HYPOTHETICAL PROTEIN
UNP Q5LQD5_SILPO

(Ruegeria
pomeroyi) 		PF06267
(DUF1028) 		3 VAL A  30
ALA A  19
GLN A  43
 None
 0.69A 6gb9A-2imhA:
undetectable		 6gb9A-2imhA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2imr HYPOTHETICAL PROTEIN
DR_0824

(Deinococcus
radiodurans) 		PF01979
(Amidohydro_1) 		3 VAL A 392
ALA A 348
GLN A 236
 None
 0.68A 6gb9A-2imrA:
undetectable		 6gb9A-2imrA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j59 RHO-GTPASE
ACTIVATING PROTEIN
10

(Homo sapiens) 		PF15410
(PH_9) 		3 VAL M 963
ALA M 931
GLN M 978
 None
 0.58A 6gb9A-2j59M:
undetectable		 6gb9A-2j59M:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsp TRANSCRIPTIONAL
REGULATORY PROTEIN
ROS

(Agrobacterium
tumefaciens) 		PF05443
(ROS_MUCR) 		3 VAL A  23
ALA A  10
GLN A  18
 None
 0.67A 6gb9A-2jspA:
undetectable		 6gb9A-2jspA:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3e NEUROLYSIN

(Rattus
norvegicus) 		PF01432
(Peptidase_M3) 		3 VAL A 292
ALA A 286
GLN A 563
 None
 0.67A 6gb9A-2o3eA:
undetectable		 6gb9A-2o3eA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2olt HYPOTHETICAL PROTEIN

(Shewanella
oneidensis) 		PF01865
(PhoU_div) 		3 VAL A 215
ALA A 135
GLN A  92
 None
 0.66A 6gb9A-2oltA:
undetectable		 6gb9A-2oltA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2os3 PEPTIDE DEFORMYLASE

(Streptococcus
pyogenes) 		PF01327
(Pep_deformylase) 		3 VAL A  80
ALA A  75
GLN A   4
 None
 0.70A 6gb9A-2os3A:
undetectable		 6gb9A-2os3A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3z TRANSGLUTAMINASE 2

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		3 VAL A  54
ALA A   2
GLN A  51
 None
 0.70A 6gb9A-2q3zA:
undetectable		 6gb9A-2q3zA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r76 RARE LIPOPROTEIN B

(Shewanella
oneidensis) 		PF04390
(LptE) 		3 VAL A  65
ALA A  68
GLN A  37
 None
 0.66A 6gb9A-2r76A:
undetectable		 6gb9A-2r76A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		3 VAL B 228
ALA B 207
GLN B 276
 None
 0.68A 6gb9A-2rhqB:
undetectable		 6gb9A-2rhqB:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wex APOLIPOPROTEIN M

(Homo sapiens) 		PF11032
(ApoM) 		3 VAL A  70
ALA A 182
GLN A  46
 None
 0.69A 6gb9A-2wexA:
undetectable		 6gb9A-2wexA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztg ALANYL-TRNA
SYNTHETASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 VAL A 729
ALA A 621
GLN A 726
 None
 0.62A 6gb9A-2ztgA:
undetectable		 6gb9A-2ztgA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zzg ALANYL-TRNA
SYNTHETASE

(Pyrococcus
horikoshii) 		PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD) 		3 VAL A 743
ALA A 634
GLN A 740
 None
 0.59A 6gb9A-2zzgA:
undetectable		 6gb9A-2zzgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dez OROTATE
PHOSPHORIBOSYLTRANSF
ERASE

(Streptococcus
mutans) 		PF00156
(Pribosyltran) 		3 VAL A  69
ALA A  93
GLN A 116
 None
 0.66A 6gb9A-3dezA:
undetectable		 6gb9A-3dezA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eua PUTATIVE
FRUCTOSE-AMINOACID-6
-PHOSPHATE DEGLYCASE

(Bacillus
subtilis) 		PF01380
(SIS) 		3 VAL A  12
ALA A 122
GLN A 142
 None
 0.58A 6gb9A-3euaA:
4.7		 6gb9A-3euaA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ezq PROTEIN FADD

(Homo sapiens) 		PF00531
(Death) 		3 VAL B 158
ALA B 100
GLN B 181
 None
 0.64A 6gb9A-3ezqB:
undetectable		 6gb9A-3ezqB:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		3 VAL A 280
ALA A 201
GLN A 289
 None
 0.68A 6gb9A-3f85A:
undetectable		 6gb9A-3f85A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f85 HOMO TRIMERIC FUSION
OF CFA/I FIMBRIAL
SUBUNITS B

(Escherichia
coli) 		PF04449
(Fimbrial_CS1) 		3 VAL A 431
ALA A 352
GLN A 440
 None
 0.55A 6gb9A-3f85A:
undetectable		 6gb9A-3f85A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f9k INTEGRASE

(Human
immunodeficiency
virus 2) 		PF00665
(rve)
PF02022
(Integrase_Zn) 		3 VAL A  79
ALA A  56
GLN A  62
 None
 0.64A 6gb9A-3f9kA:
undetectable		 6gb9A-3f9kA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh0 TRANSCRIPTIONAL
REGULATOR, MERR
FAMILY

(Bacillus cereus) 		PF13411
(MerR_1) 		3 VAL A  14
ALA A  18
GLN A  53
 None
 0.49A 6gb9A-3hh0A:
undetectable		 6gb9A-3hh0A:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if8 PROTEIN ZWILCH
HOMOLOG
PROTEIN ZWILCH
HOMOLOG

(Homo sapiens;
Homo sapiens) 		PF09817
(Zwilch)
PF09817
(Zwilch) 		3 VAL B 461
ALA A 276
GLN B 465
 None
 0.68A 6gb9A-3if8B:
undetectable		 6gb9A-3if8B:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kq5 HYPOTHETICAL
CYTOSOLIC PROTEIN

(Coxiella
burnetii) 		PF07515
(TraI_2_C) 		3 VAL A 127
ALA A 123
GLN A 170
 None
 0.67A 6gb9A-3kq5A:
undetectable		 6gb9A-3kq5A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksx NITRATE TRANSPORT
PROTEIN

(Xanthomonas
citri) 		PF09084
(NMT1) 		3 VAL A 304
ALA A 291
GLN A  94
 None
 0.57A 6gb9A-3ksxA:
undetectable		 6gb9A-3ksxA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens) 		PF03483
(B3_4)
PF03484
(B5) 		3 VAL B 449
ALA B 436
GLN B 420
 None
 0.63A 6gb9A-3l4gB:
undetectable		 6gb9A-3l4gB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3loy COPPER AMINE OXIDASE

(Ogataea angusta) 		PF01179
(Cu_amine_oxid) 		3 VAL A 630
ALA A 370
GLN A 396
 None
 0.45A 6gb9A-3loyA:
undetectable		 6gb9A-3loyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lu2 LMO2462 PROTEIN

(Listeria
monocytogenes) 		PF01244
(Peptidase_M19) 		3 VAL A  31
ALA A 275
GLN A  44
 None
 0.63A 6gb9A-3lu2A:
undetectable		 6gb9A-3lu2A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q3c PROBABLE
3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		3 VAL A  37
ALA A  47
GLN A  34
 None
 0.65A 6gb9A-3q3cA:
undetectable		 6gb9A-3q3cA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r0s ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Campylobacter
jejuni) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		3 VAL A 240
ALA A 214
GLN A 235
 None
 0.66A 6gb9A-3r0sA:
undetectable		 6gb9A-3r0sA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rag UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF00092
(VWA) 		3 VAL A 171
ALA A 159
GLN A 188
 None
 0.66A 6gb9A-3ragA:
3.4		 6gb9A-3ragA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shs HOC HEAD OUTER
CAPSID PROTEIN

(Escherichia
virus RB49) 		no annotation 3 VAL A 290
ALA A 182
GLN A 281
 None
 0.31A 6gb9A-3shsA:
undetectable		 6gb9A-3shsA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		3 VAL A 729
ALA A 621
GLN A 726
 None
 0.68A 6gb9A-3wqyA:
undetectable		 6gb9A-3wqyA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zs6 PERIPLASMIC
OLIGOPEPTIDE-BINDING
PROTEIN

(Burkholderia
pseudomallei) 		PF00496
(SBP_bac_5) 		3 VAL A 446
ALA A 449
GLN A 440
 None
 0.51A 6gb9A-3zs6A:
undetectable		 6gb9A-3zs6A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu4 PUTATIVE REDUCTASE
YPO4104/Y4119/YP_401
1

(Yersinia pestis) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		3 VAL A  44
ALA A  67
GLN A 134
 None
 0.63A 6gb9A-3zu4A:
2.3		 6gb9A-3zu4A:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare) 		PF02922
(CBM_48)
PF11852
(DUF3372) 		3 VAL A 203
ALA A  37
GLN A 149
 None
 0.70A 6gb9A-4aioA:
undetectable		 6gb9A-4aioA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aip FE-REGULATED PROTEIN
B

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 VAL A 579
ALA A 581
GLN A 567
 None
 0.66A 6gb9A-4aipA:
undetectable		 6gb9A-4aipA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4al8 ENVELOPE PROTEIN

(Dengue virus) 		PF02832
(Flavi_glycop_C) 		3 VAL C 379
ALA C 386
GLN C 340
 None
 0.65A 6gb9A-4al8C:
undetectable		 6gb9A-4al8C:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxb MALTOSE-BINDING
PERIPLASMIC PROTEIN,
BETA-LACTAMASE TEM
CHIMERA

(Escherichia
coli) 		PF01547
(SBP_bac_1)
PF13354
(Beta-lactamase2) 		3 VAL A 464
ALA A 481
GLN A 253
 None
None
ZN  A 701 ( 4.0A)
 0.65A 6gb9A-4dxbA:
undetectable		 6gb9A-4dxbA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7a PUTATIVE
UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF12741
(SusD-like) 		3 VAL A 390
ALA A 402
GLN A 452
 None
 0.67A 6gb9A-4f7aA:
undetectable		 6gb9A-4f7aA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3n DNA GYRASE SUBUNIT A

(Mycobacterium
tuberculosis) 		PF03989
(DNA_gyraseA_C) 		3 VAL A 777
ALA A 814
GLN A 551
 None
 0.57A 6gb9A-4g3nA:
undetectable		 6gb9A-4g3nA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ga2 E3 SUMO-PROTEIN
LIGASE RANBP2

(Pan troglodytes) 		PF00515
(TPR_1) 		3 VAL A 109
ALA A 114
GLN A 137
 None
 0.57A 6gb9A-4ga2A:
undetectable		 6gb9A-4ga2A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0u THYMIDYLATE SYNTHASE

(Corynebacterium
glutamicum) 		PF00303
(Thymidylat_synt) 		3 VAL A  72
ALA A  87
GLN A  76
 None
 0.38A 6gb9A-4h0uA:
undetectable		 6gb9A-4h0uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hfk PUTATIVE CYTOPLASMIC
PROTEIN

(Enterobacter
cloacae) 		PF14113
(Tae4) 		3 VAL A 100
ALA A 157
GLN A 107
 None
 0.68A 6gb9A-4hfkA:
undetectable		 6gb9A-4hfkA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjt MONALYSIN

(Pseudomonas
entomophila) 		no annotation 3 VAL A 179
ALA A 216
GLN A  95
 None
 0.42A 6gb9A-4mjtA:
undetectable		 6gb9A-4mjtA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mkq MONALYSIN

(Pseudomonas
entomophila) 		no annotation 3 VAL A 179
ALA A 216
GLN A  95
 None
 0.47A 6gb9A-4mkqA:
undetectable		 6gb9A-4mkqA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8m NUCLEOPHOSMIN

(Mus musculus) 		PF03066
(Nucleoplasmin) 		3 VAL A  87
ALA A  77
GLN A  84
 None
 0.71A 6gb9A-4n8mA:
undetectable		 6gb9A-4n8mA:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oit LYSM DOMAIN PROTEIN

(Mycolicibacterium
smegmatis) 		PF01453
(B_lectin) 		3 VAL A  35
ALA A  42
GLN A  29
 MAN  A 201 ( 4.7A)
MAN  A 201 ( 3.7A)
MAN  A 201 (-3.2A)
 0.70A 6gb9A-4oitA:
undetectable		 6gb9A-4oitA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omb PHOSPHATE BINDING
PROTEIN

(Pseudomonas
aeruginosa) 		PF12849
(PBP_like_2) 		3 VAL A  46
ALA A  84
GLN A  74
 None
 0.67A 6gb9A-4ombA:
undetectable		 6gb9A-4ombA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p08 COCAINE ESTERASE

(Rhodococcus sp.
MB1) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		3 VAL A 465
ALA A 473
GLN A 523
 None
 0.69A 6gb9A-4p08A:
3.6		 6gb9A-4p08A:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p8e 3,4-DIHYDROXY-2-BUTA
NONE 4-PHOSPHATE
SYNTHASE

(Vibrio cholerae) 		PF00926
(DHBP_synthase) 		3 VAL A 159
ALA A 143
GLN A 163
 None
 0.70A 6gb9A-4p8eA:
undetectable		 6gb9A-4p8eA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcl O-METHYLTRANSFERASE
FAMILY PROTEIN

(Anaplasma
phagocytophilum) 		PF01596
(Methyltransf_3) 		3 VAL A  19
ALA A  24
GLN A  49
 None
 0.67A 6gb9A-4pclA:
undetectable		 6gb9A-4pclA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0i SUPPRESSOR OF
TUMORIGENICITY 14
PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL A  17
ALA A 221
GLN A 145
 None
 0.36A 6gb9A-4r0iA:
undetectable		 6gb9A-4r0iA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs3 ABC TRANSPORTER,
CARBOHYDRATE UPTAKE
TRANSPORTER-2 (CUT2)
FAMILY, PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Mycolicibacterium
smegmatis) 		PF13407
(Peripla_BP_4) 		3 VAL A 326
ALA A  61
GLN A 330
 None
 0.69A 6gb9A-4rs3A:
3.3		 6gb9A-4rs3A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfe TRAP DICARBOXYLATE
TRANSPORTER SUBUNIT
DCTP

(Pseudomonas
putida) 		PF03480
(DctP) 		3 VAL A  83
ALA A  30
GLN A  77
 None
 0.47A 6gb9A-4xfeA:
undetectable		 6gb9A-4xfeA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfq L,D-TRANSPEPTIDASE 5

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		3 VAL A 170
ALA A 174
GLN A 168
 None
 0.69A 6gb9A-4zfqA:
undetectable		 6gb9A-4zfqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a8z NEUTROPHIL ELASTASE

(Homo sapiens) 		PF00089
(Trypsin) 		3 VAL A  67
ALA A  70
GLN A  34
 None
 0.63A 6gb9A-5a8zA:
undetectable		 6gb9A-5a8zA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aeo R. EQUI VAPG PROTEIN

(Rhodococcus
hoagii) 		PF05526
(R_equi_Vir) 		3 VAL A 135
ALA A 107
GLN A  56
 None
 0.70A 6gb9A-5aeoA:
undetectable		 6gb9A-5aeoA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm9 RAL GUANINE
NUCLEOTIDE
DISSOCIATION
STIMULATOR-LIKE 2

(Mus musculus) 		PF00617
(RasGEF)
PF00618
(RasGEF_N) 		3 VAL A 318
ALA A 308
GLN A 502
 None
 0.69A 6gb9A-5cm9A:
undetectable		 6gb9A-5cm9A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g2h -

(Salmonella
enterica) 		PF00977
(His_biosynth) 		3 VAL A 100
ALA A 127
GLN A  77
 None
 0.63A 6gb9A-5g2hA:
undetectable		 6gb9A-5g2hA:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai PEPTIDOGLYCAN
HYDROLASE GP4

(Salmonella
virus P22) 		PF11650
(P22_Tail-4) 		3 VAL K  46
ALA K  21
GLN K  43
 None
 0.60A 6gb9A-5gaiK:
undetectable		 6gb9A-5gaiK:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hax NUCLEOPORIN NUP170

(Chaetomium
thermophilum) 		PF08801
(Nucleoporin_N) 		3 VAL A 576
ALA A 616
GLN A 551
 None
 0.56A 6gb9A-5haxA:
undetectable		 6gb9A-5haxA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzh BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		3 VAL A  55
ALA A  72
GLN A  62
 None
 0.53A 6gb9A-5kzhA:
undetectable		 6gb9A-5kzhA:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		3 VAL A 357
ALA A  96
GLN A 360
 None
 0.70A 6gb9A-5l25A:
undetectable		 6gb9A-5l25A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9c OSMOPORIN OMP36

(Klebsiella
aerogenes) 		no annotation 3 VAL C 129
ALA C 126
GLN C 149
 None
 0.62A 6gb9A-5o9cC:
undetectable		 6gb9A-5o9cC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		3 VAL A 217
ALA A  16
GLN A  45
 None
 0.48A 6gb9A-5tqiA:
3.0		 6gb9A-5tqiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb5 PUTATIVE EUKARYOTIC
TRANSLATION
INITIATION FACTOR
EIF-4E

(Leishmania
major) 		no annotation 3 VAL A  79
ALA A  87
GLN A  76
 None
 0.66A 6gb9A-5wb5A:
undetectable		 6gb9A-5wb5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wol 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE

(Coxiella
burnetii) 		PF01113
(DapB_N)
PF05173
(DapB_C) 		3 VAL A 193
ALA A 118
GLN A 191
 None
 0.69A 6gb9A-5wolA:
undetectable		 6gb9A-5wolA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		3 VAL A 934
ALA A 926
GLN A 800
 None
 0.69A 6gb9A-5x59A:
undetectable		 6gb9A-5x59A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zu5 ALGINATE LYASE

(Vibrio
splendidus) 		no annotation 3 VAL A 271
ALA A 265
GLN A 479
 None
 0.69A 6gb9A-5zu5A:
undetectable		 6gb9A-5zu5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 3 VAL A1431
ALA A1458
GLN A 714
 ATP  A1601 ( 4.7A)
None
None
 0.43A 6gb9A-6bhuA:
undetectable		 6gb9A-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fay ODZ3 PROTEIN

(Mus musculus) 		no annotation 3 VAL A1992
ALA A1990
GLN A2011
 None
 0.59A 6gb9A-6fayA:
undetectable		 6gb9A-6fayA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbc MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1

(Arabidopsis
thaliana) 		no annotation 3 VAL A 203
ALA A 207
GLN A 214
 None
 0.06A 6gb9A-6gbcA:
52.8		 6gb9A-6gbcA:
undetectable