SIMILAR PATTERNS OF AMINO ACIDS FOR 6G9B_A_IXXA609_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bg6 N-(1-D-CARBOXYLETHYL
)-L-NORVALINE
DEHYDROGENASE

(Arthrobacter
sp. 1C) 		PF02317
(Octopine_DH)
PF02558
(ApbA) 		5 ILE A 244
LEU A 308
VAL A 358
LEU A 190
LEU A 250
 None
 1.08A 6g9bA-1bg6A:
0.0
6g9bB-1bg6A:
0.0		 6g9bA-1bg6A:
13.45
6g9bB-1bg6A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jg5 GTP CYCLOHYDROLASE I
FEEDBACK REGULATORY
PROTEIN

(Rattus
norvegicus) 		PF06399
(GFRP) 		4 LEU A  27
VAL A  55
LEU A  59
LEU A  80
 None
 0.75A 6g9bA-1jg5A:
undetectable
6g9bB-1jg5A:
undetectable		 6g9bA-1jg5A:
27.06
6g9bB-1jg5A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 LEU A1312
VAL A1284
LEU A1302
LEU A1299
 None
 0.54A 6g9bA-1jl5A:
0.0
6g9bB-1jl5A:
undetectable		 6g9bA-1jl5A:
10.47
6g9bB-1jl5A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl5 OUTER PROTEIN YOPM

(Yersinia pestis) 		PF12468
(TTSSLRR) 		4 VAL A1118
LEU A1123
LEU A1143
LEU A1109
 None
 0.75A 6g9bA-1jl5A:
0.0
6g9bB-1jl5A:
undetectable		 6g9bA-1jl5A:
10.47
6g9bB-1jl5A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1koa TWITCHIN

(Caenorhabditis
elegans) 		PF00069
(Pkinase)
PF07679
(I-set) 		4 ILE A6174
LEU A6177
VAL A6047
LEU A6064
 None
 0.66A 6g9bA-1koaA:
undetectable
6g9bB-1koaA:
0.0		 6g9bA-1koaA:
10.15
6g9bB-1koaA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1odi PURINE NUCLEOSIDE
PHOSPHORYLASE

(Thermus
thermophilus) 		PF01048
(PNP_UDP_1) 		4 ILE A 199
VAL A  58
LEU A  18
LEU A 233
 None
 0.70A 6g9bA-1odiA:
0.0
6g9bB-1odiA:
0.0		 6g9bA-1odiA:
16.03
6g9bB-1odiA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9n MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		PF03205
(MobB) 		5 ILE A 151
LEU A  18
LEU A 157
LEU A 149
LEU A   5
 None
 1.15A 6g9bA-1p9nA:
0.0
6g9bB-1p9nA:
0.0		 6g9bA-1p9nA:
18.50
6g9bB-1p9nA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5a EP-CADHERIN

(Mus musculus) 		PF00028
(Cadherin) 		4 ILE A 261
LEU A 298
LEU A 282
LEU A 288
 None
 0.00A 6g9bA-1q5aA:
undetectable
6g9bB-1q5aA:
0.0		 6g9bA-1q5aA:
7.12
6g9bB-1q5aA:
6.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tte UBIQUITIN-CONJUGATIN
G ENZYME E2-24 KDA

(Saccharomyces
cerevisiae) 		PF00179
(UQ_con)
PF09288
(UBA_3) 		4 ILE A  91
LEU A  92
VAL A  54
LEU A 102
 None
 0.69A 6g9bA-1tteA:
0.0
6g9bB-1tteA:
0.0		 6g9bA-1tteA:
15.09
6g9bB-1tteA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0n PLATELET
GLYCOPROTEIN IB

(Homo sapiens) 		PF01462
(LRRNT)
PF13855
(LRR_8) 		4 LEU D 167
LEU D 153
LEU D 150
LEU D 115
 None
 0.72A 6g9bA-1u0nD:
0.0
6g9bB-1u0nD:
0.0		 6g9bA-1u0nD:
17.62
6g9bB-1u0nD:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhz ADP COMPOUNDS
HYDROLASE NUDE

(Escherichia
coli) 		PF00293
(NUDIX) 		4 LEU A 158
VAL A  53
LEU A  60
LEU A 152
 None
 0.74A 6g9bA-1vhzA:
undetectable
6g9bB-1vhzA:
0.0		 6g9bA-1vhzA:
16.32
6g9bB-1vhzA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xeu INTERNALIN C

(Listeria
monocytogenes) 		PF08191
(LRR_adjacent)
PF12354
(Internalin_N)
PF12799
(LRR_4) 		4 LEU A 121
VAL A 126
LEU A  90
LEU A 134
 None
 0.72A 6g9bA-1xeuA:
undetectable
6g9bB-1xeuA:
undetectable		 6g9bA-1xeuA:
16.35
6g9bB-1xeuA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		4 LEU A 360
VAL A 319
LEU A 345
LEU A 342
 None
 0.62A 6g9bA-2bexA:
undetectable
6g9bB-2bexA:
undetectable		 6g9bA-2bexA:
12.09
6g9bB-2bexA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bgh VINORINE SYNTHASE

(Rauvolfia
serpentina) 		PF02458
(Transferase) 		4 LEU A  71
VAL A 156
LEU A 140
LEU A 172
 None
 0.74A 6g9bA-2bghA:
undetectable
6g9bB-2bghA:
undetectable		 6g9bA-2bghA:
12.50
6g9bB-2bghA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 172
VAL A 135
LEU A 157
LEU A 154
LEU A 119
 None
 0.70A 6g9bA-2id5A:
undetectable
6g9bB-2id5A:
undetectable		 6g9bA-2id5A:
10.93
6g9bB-2id5A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2idg HYPOTHETICAL PROTEIN
AF0160

(Archaeoglobus
fulgidus) 		PF02613
(Nitrate_red_del) 		5 ILE A  25
LEU A  19
VAL A 148
LEU A 144
LEU A  95
 None
 1.04A 6g9bA-2idgA:
undetectable
6g9bB-2idgA:
undetectable		 6g9bA-2idgA:
18.29
6g9bB-2idgA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iun AVIAN ADENOVIRUS
CELO LONG FIBRE

(Fowl
aviadenovirus A) 		PF16812
(AdHead_fibreRBD) 		4 ILE A 719
VAL A 655
LEU A 755
LEU A 618
 None
 0.73A 6g9bA-2iunA:
undetectable
6g9bB-2iunA:
undetectable		 6g9bA-2iunA:
16.06
6g9bB-2iunA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 255
LEU A 258
VAL A 128
LEU A 145
 None
 0.72A 6g9bA-2jamA:
undetectable
6g9bB-2jamA:
undetectable		 6g9bA-2jamA:
15.49
6g9bB-2jamA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbr URIDINE
DIPHOSPHO-N-ACETYLEN
OLPYRUVYLGLUCOSAMINE
REDUCTASE

(Escherichia
coli) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		4 LEU A 129
VAL A  83
LEU A 178
LEU A 180
 None
 0.75A 6g9bA-2mbrA:
undetectable
6g9bB-2mbrA:
undetectable		 6g9bA-2mbrA:
15.46
6g9bB-2mbrA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qgq PROTEIN TM_1862

(Thermotoga
maritima) 		PF04055
(Radical_SAM) 		4 ILE A 417
LEU A 374
VAL A 290
LEU A 366
 None
 0.67A 6g9bA-2qgqA:
undetectable
6g9bB-2qgqA:
undetectable		 6g9bA-2qgqA:
15.05
6g9bB-2qgqA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		4 VAL A 407
LEU A 339
LEU A 398
LEU A 422
 None
 0.70A 6g9bA-2qqkA:
undetectable
6g9bB-2qqkA:
undetectable		 6g9bA-2qqkA:
10.04
6g9bB-2qqkA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		4 LEU 1 219
VAL 1 319
LEU 1 246
LEU 1 144
 None
 0.46A 6g9bA-2r6r1:
undetectable
6g9bB-2r6r1:
undetectable		 6g9bA-2r6r1:
11.50
6g9bB-2r6r1:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ya2 PUTATIVE ALKALINE
AMYLOPULLULANASE

(Streptococcus
pneumoniae) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		4 ILE A 242
LEU A 241
LEU A 180
LEU A 170
 None
 0.73A 6g9bA-2ya2A:
undetectable
6g9bB-2ya2A:
undetectable		 6g9bA-2ya2A:
7.56
6g9bB-2ya2A:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yru STEROID RECEPTOR RNA
ACTIVATOR 1

(Mus musculus) 		PF07304
(SRA1) 		5 LEU A  57
VAL A 102
LEU A  48
LEU A  19
LEU A  68
 None
 1.05A 6g9bA-2yruA:
undetectable
6g9bB-2yruA:
undetectable		 6g9bA-2yruA:
23.42
6g9bB-2yruA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 194
LEU A 179
LEU A 176
LEU A 139
 None
 0.71A 6g9bA-2z81A:
undetectable
6g9bB-2z81A:
undetectable		 6g9bA-2z81A:
8.93
6g9bB-2z81A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z81 TOLL-LIKE RECEPTOR
2, VARIABLE
LYMPHOCYTE RECEPTOR
B

(Eptatretus
burgeri;
Mus musculus) 		PF11921
(DUF3439)
PF13306
(LRR_5)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 497
VAL A 451
LEU A 489
LEU A 462
 None
 0.73A 6g9bA-2z81A:
undetectable
6g9bB-2z81A:
undetectable		 6g9bA-2z81A:
8.93
6g9bB-2z81A:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zrr MUNDTICIN KS
IMMUNITY PROTEIN

(Enterococcus
mundtii) 		PF08951
(EntA_Immun) 		4 LEU A  77
LEU A  37
LEU A  88
MET A  89
 None
 0.74A 6g9bA-2zrrA:
undetectable
6g9bB-2zrrA:
undetectable		 6g9bA-2zrrA:
23.14
6g9bB-2zrrA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bz5 INTERNALIN-J

(Listeria
monocytogenes) 		PF12799
(LRR_4) 		4 LEU A 257
LEU A 247
LEU A 244
LEU A 215
 None
 0.72A 6g9bA-3bz5A:
undetectable
6g9bB-3bz5A:
undetectable		 6g9bA-3bz5A:
11.85
6g9bB-3bz5A:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvr INVASION PLASMID
ANTIGEN

(Shigella
flexneri) 		PF12468
(TTSSLRR)
PF14496
(NEL) 		4 LEU A 115
LEU A 105
LEU A 102
LEU A  74
 None
 0.61A 6g9bA-3cvrA:
undetectable
6g9bB-3cvrA:
undetectable		 6g9bA-3cvrA:
8.95
6g9bB-3cvrA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daw TWINFILIN-1

(Mus musculus) 		PF00241
(Cofilin_ADF) 		5 ILE B 282
LEU B 279
VAL B 201
LEU B 190
LEU B 287
 None
 1.50A 6g9bA-3dawB:
undetectable
6g9bB-3dawB:
undetectable		 6g9bA-3dawB:
18.40
6g9bB-3dawB:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e4e CYTOCHROME P450 2E1

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 455
LEU A 312
LEU A 487
LEU A 154
 None
 0.72A 6g9bA-3e4eA:
0.0
6g9bB-3e4eA:
0.1		 6g9bA-3e4eA:
11.42
6g9bB-3e4eA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		4 LEU A 257
LEU A 247
LEU A 244
LEU A 216
 None
 0.60A 6g9bA-3g06A:
undetectable
6g9bB-3g06A:
undetectable		 6g9bA-3g06A:
9.43
6g9bB-3g06A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g06 SSPH2 (LEUCINE-RICH
REPEAT PROTEIN)

(Salmonella
enterica) 		PF14496
(NEL) 		4 LEU A 277
LEU A 267
LEU A 264
LEU A 237
 None
 0.73A 6g9bA-3g06A:
undetectable
6g9bB-3g06A:
undetectable		 6g9bA-3g06A:
9.43
6g9bB-3g06A:
8.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9v NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT 3

(Thermus
thermophilus) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
PF10588
(NADH-G_4Fe-4S_3)
PF13510
(Fer2_4) 		4 LEU 3 477
VAL 3 532
LEU 3 507
LEU 3 512
 None
 0.74A 6g9bA-3i9v3:
undetectable
6g9bB-3i9v3:
undetectable		 6g9bA-3i9v3:
6.74
6g9bB-3i9v3:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 4 VAL B  77
LEU B  64
LEU B  67
LEU B  49
 None
 0.69A 6g9bA-3jruB:
undetectable
6g9bB-3jruB:
undetectable		 6g9bA-3jruB:
10.84
6g9bB-3jruB:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o4z TELOMERE LENGTH
REGULATION PROTEIN
TEL2

(Saccharomyces
cerevisiae) 		PF10193
(Telomere_reg-2) 		4 ILE A 250
VAL A 237
LEU A 241
LEU A 270
 None
 0.75A 6g9bA-3o4zA:
undetectable
6g9bB-3o4zA:
undetectable		 6g9bA-3o4zA:
10.02
6g9bB-3o4zA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o5d PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP5

(Homo sapiens) 		PF00254
(FKBP_C) 		4 LEU A 142
VAL A 245
LEU A 217
LEU A 219
 None
 0.69A 6g9bA-3o5dA:
undetectable
6g9bB-3o5dA:
undetectable		 6g9bA-3o5dA:
15.21
6g9bB-3o5dA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q6v BETA-LACTAMASE

(Serratia
fonticola) 		PF00753
(Lactamase_B) 		4 ILE A 222
LEU A 223
LEU A 249
LEU A 192
 None
 0.70A 6g9bA-3q6vA:
undetectable
6g9bB-3q6vA:
undetectable		 6g9bA-3q6vA:
16.45
6g9bB-3q6vA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qsv MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4

(Mus musculus) 		PF03165
(MH1) 		5 ILE A  19
LEU A  23
VAL A 128
LEU A  57
LEU A  47
 None
 1.24A 6g9bA-3qsvA:
undetectable
6g9bB-3qsvA:
undetectable		 6g9bA-3qsvA:
21.54
6g9bB-3qsvA:
16.55
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s88 ENVELOPE
GLYCOPROTEIN

(Sudan
ebolavirus) 		PF01611
(Filo_glycop)
no annotation 		4 LEU I  43
VAL I  66
LEU I 184
LEU J 515
 None
 0.68A 6g9bA-3s88I:
28.3
6g9bB-3s88I:
undetectable		 6g9bA-3s88I:
74.39
6g9bB-3s88I:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A 301
VAL A 329
LEU A 316
LEU A 318
 None
 0.66A 6g9bA-3stjA:
undetectable
6g9bB-3stjA:
undetectable		 6g9bA-3stjA:
16.23
6g9bB-3stjA:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t51 CATION EFFLUX SYSTEM
PROTEIN CUSB

(Escherichia
coli) 		PF00529
(HlyD)
PF16576
(HlyD_D23) 		4 VAL B 355
LEU B 371
LEU B 325
LEU B 332
 None
 0.75A 6g9bA-3t51B:
undetectable
6g9bB-3t51B:
undetectable		 6g9bA-3t51B:
19.92
6g9bB-3t51B:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txa CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		4 ILE A 643
VAL A 595
LEU A 663
LEU A 205
 None
 0.68A 6g9bA-3txaA:
0.4
6g9bB-3txaA:
undetectable		 6g9bA-3txaA:
7.40
6g9bB-3txaA:
8.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ucq AMYLOSUCRASE

(Deinococcus
geothermalis) 		PF00128
(Alpha-amylase) 		4 ILE A 170
LEU A 112
LEU A 161
LEU A 172
 None
 0.69A 6g9bA-3ucqA:
undetectable
6g9bB-3ucqA:
0.5		 6g9bA-3ucqA:
7.50
6g9bB-3ucqA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		4 ILE A 243
LEU A 241
VAL A 184
LEU A 237
 EDO  A1004 (-4.4A)
None
FAD  A1001 (-3.9A)
FAD  A1001 ( 4.3A)
 0.71A 6g9bA-3vqrA:
undetectable
6g9bB-3vqrA:
undetectable		 6g9bA-3vqrA:
11.87
6g9bB-3vqrA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w5i FERROUS IRON
TRANSPORT PROTEIN B

(Gallionella
capsiferriformans) 		PF02421
(FeoB_N) 		4 LEU A  98
LEU A  55
LEU A 105
MET A 107
 None
 0.73A 6g9bA-3w5iA:
undetectable
6g9bB-3w5iA:
undetectable		 6g9bA-3w5iA:
18.52
6g9bB-3w5iA:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00155
(Aminotran_1_2) 		4 LEU A 361
VAL A 336
LEU A  40
LEU A 355
 None
 0.73A 6g9bA-3wy7A:
undetectable
6g9bB-3wy7A:
undetectable		 6g9bA-3wy7A:
11.76
6g9bB-3wy7A:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ays AMYLOSUCRASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase) 		4 ILE A 166
LEU A 108
LEU A 157
LEU A 168
 None
 0.72A 6g9bA-4aysA:
undetectable
6g9bB-4aysA:
undetectable		 6g9bA-4aysA:
8.97
6g9bB-4aysA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckm SAS-6

(Leishmania
major) 		PF16531
(SAS-6_N) 		4 ILE A 263
VAL A 139
LEU A 249
LEU A 135
 None
 0.74A 6g9bA-4ckmA:
undetectable
6g9bB-4ckmA:
undetectable		 6g9bA-4ckmA:
19.88
6g9bB-4ckmA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckn SAS-6

(Leishmania
major) 		PF16531
(SAS-6_N) 		5 ILE A 263
VAL A 139
LEU A 232
LEU A 249
LEU A 135
 None
 0.96A 6g9bA-4cknA:
undetectable
6g9bB-4cknA:
undetectable		 6g9bA-4cknA:
14.75
6g9bB-4cknA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cp6 CHOLINE BINDING
PROTEIN PCPA

(Streptococcus
pneumoniae) 		PF13306
(LRR_5) 		4 ILE A 346
LEU A 324
VAL A 358
LEU A 368
 None
 0.72A 6g9bA-4cp6A:
undetectable
6g9bB-4cp6A:
undetectable		 6g9bA-4cp6A:
13.51
6g9bB-4cp6A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es6 UROPORPHYRINOGEN-III
SYNTHASE

(Pseudomonas
aeruginosa) 		PF02602
(HEM4) 		4 VAL A  27
LEU A   6
LEU A   8
LEU A 244
 None
None
CL  A 301 ( 4.6A)
None
 0.69A 6g9bA-4es6A:
undetectable
6g9bB-4es6A:
undetectable		 6g9bA-4es6A:
15.51
6g9bB-4es6A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glp MONOCYTE
DIFFERENTIATION
ANTIGEN CD14

(Homo sapiens) 		PF13516
(LRR_6) 		4 ILE A 128
LEU A 106
LEU A 123
LEU A 168
 None
 0.68A 6g9bA-4glpA:
undetectable
6g9bB-4glpA:
undetectable		 6g9bA-4glpA:
13.09
6g9bB-4glpA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hh5 PUTATIVE TYPE VI
SECRETION PROTEIN

(Escherichia
coli) 		PF02861
(Clp_N) 		5 LEU A  55
VAL A 129
LEU A  44
LEU A  73
LEU A 138
 BR  A 201 ( 4.4A)
None
None
None
None
 1.04A 6g9bA-4hh5A:
undetectable
6g9bB-4hh5A:
undetectable		 6g9bA-4hh5A:
17.90
6g9bB-4hh5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 VAL A 129
LEU A 124
LEU A 117
LEU A 107
 None
 0.74A 6g9bA-4j7mA:
undetectable
6g9bB-4j7mA:
undetectable		 6g9bA-4j7mA:
13.50
6g9bB-4j7mA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keg MALTOSE-BINDING
PERIPLASMIC/PALATE
LUNG AND NASAL
EPITHELIUM CLONE
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF13416
(SBP_bac_8) 		4 LEU A1234
VAL A1131
LEU A1055
LEU A1059
 None
 0.72A 6g9bA-4kegA:
undetectable
6g9bB-4kegA:
undetectable		 6g9bA-4kegA:
9.67
6g9bB-4kegA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kny KDP OPERON
TRANSCRIPTIONAL
REGULATORY PROTEIN
KDPE

(Escherichia
coli) 		PF00072
(Response_reg)
PF00486
(Trans_reg_C) 		5 ILE A 105
LEU A 108
VAL A   4
LEU A  21
LEU A 116
 None
 1.29A 6g9bA-4knyA:
0.8
6g9bB-4knyA:
undetectable		 6g9bA-4knyA:
18.13
6g9bB-4knyA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 4 LEU A 252
LEU A 241
LEU A 238
LEU A 210
 None
 0.62A 6g9bA-4nkhA:
undetectable
6g9bB-4nkhA:
undetectable		 6g9bA-4nkhA:
15.19
6g9bB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkh E3 UBIQUITIN-PROTEIN
LIGASE SSPH1

(Salmonella
enterica) 		no annotation 4 LEU A 272
LEU A 262
LEU A 259
LEU A 231
 None
 0.71A 6g9bA-4nkhA:
undetectable
6g9bB-4nkhA:
undetectable		 6g9bA-4nkhA:
15.19
6g9bB-4nkhA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ILE A 488
LEU A 498
LEU A 483
LEU A 574
 None
 0.64A 6g9bA-4o1oA:
undetectable
6g9bB-4o1oA:
undetectable		 6g9bA-4o1oA:
9.60
6g9bB-4o1oA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oav PROTEIN (RNASE L)

(Homo sapiens) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		4 ILE B 491
LEU B 501
LEU B 486
LEU B 577
 None
 0.66A 6g9bA-4oavB:
undetectable
6g9bB-4oavB:
undetectable		 6g9bA-4oavB:
7.78
6g9bB-4oavB:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ofx CYSTATHIONINE
BETA-SYNTHASE

(Coxiella
burnetii) 		PF00291
(PALP) 		5 VAL A 291
LEU A  29
LEU A  25
LEU A 257
MET A 253
 None
 1.49A 6g9bA-4ofxA:
undetectable
6g9bB-4ofxA:
undetectable		 6g9bA-4ofxA:
12.50
6g9bB-4ofxA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4peq RIBONUCLEASE/ANGIOGE
NIN INHIBITOR 1

(Bos taurus) 		PF13516
(LRR_6) 		4 LEU B 356
VAL B 315
LEU B 341
LEU B 338
 None
 0.70A 6g9bA-4peqB:
undetectable
6g9bB-4peqB:
undetectable		 6g9bA-4peqB:
11.90
6g9bB-4peqB:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4per RIBONUCLEASE
INHIBITOR

(Gallus gallus) 		PF13516
(LRR_6) 		4 LEU A 356
VAL A 315
LEU A 341
LEU A 338
 None
 0.65A 6g9bA-4perA:
undetectable
6g9bB-4perA:
undetectable		 6g9bA-4perA:
13.88
6g9bB-4perA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4psj OR464

(synthetic
construct) 		PF12354
(Internalin_N)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 LEU A 262
LEU A 241
LEU A 238
LEU A 203
 None
 0.71A 6g9bA-4psjA:
undetectable
6g9bB-4psjA:
undetectable		 6g9bA-4psjA:
14.13
6g9bB-4psjA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qds NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		4 VAL A 407
LEU A 339
LEU A 398
LEU A 422
 None
 0.71A 6g9bA-4qdsA:
undetectable
6g9bB-4qdsA:
undetectable		 6g9bA-4qdsA:
18.42
6g9bB-4qdsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 LEU A 171
LEU A 161
LEU A 158
LEU A 125
 None
 0.70A 6g9bA-4u09A:
undetectable
6g9bB-4u09A:
undetectable		 6g9bA-4u09A:
14.13
6g9bB-4u09A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u09 LIC12759

(Leptospira
interrogans) 		PF13855
(LRR_8) 		4 VAL A 198
LEU A 204
LEU A 227
LEU A 186
 None
 0.73A 6g9bA-4u09A:
undetectable
6g9bB-4u09A:
undetectable		 6g9bA-4u09A:
14.13
6g9bB-4u09A:
10.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 ILE A 534
LEU A 535
VAL A 449
LEU A 492
 None
1PE  A1611 ( 4.7A)
None
None
 0.74A 6g9bA-4uopA:
undetectable
6g9bB-4uopA:
undetectable		 6g9bA-4uopA:
12.54
6g9bB-4uopA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b0n E3 UBIQUITIN-PROTEIN
LIGASE IPAH9.8

(Shigella
flexneri) 		PF12468
(TTSSLRR) 		4 LEU A 112
VAL A  84
LEU A 102
LEU A  99
 None
 0.73A 6g9bA-5b0nA:
undetectable
6g9bB-5b0nA:
undetectable		 6g9bA-5b0nA:
19.78
6g9bB-5b0nA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5o I-SMAMI LAGLIDADG
ENDONUCLEASE

(Sordaria
macrospora) 		PF00961
(LAGLIDADG_1) 		4 ILE A 185
LEU A 186
LEU A 200
MET A 297
 None
 0.70A 6g9bA-5e5oA:
undetectable
6g9bB-5e5oA:
undetectable		 6g9bA-5e5oA:
12.75
6g9bB-5e5oA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 VAL A 673
LEU A 678
LEU A 616
LEU A 612
 None
 0.63A 6g9bA-5es9A:
undetectable
6g9bB-5es9A:
undetectable		 6g9bA-5es9A:
7.51
6g9bB-5es9A:
9.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f1b GP1

(Zaire
ebolavirus) 		PF01611
(Filo_glycop) 		4 LEU A  43
VAL A  66
LEU A 184
LEU A 186
 None
 0.27A 6g9bA-5f1bA:
23.1
6g9bB-5f1bA:
undetectable		 6g9bA-5f1bA:
98.70
6g9bB-5f1bA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg3 PROBABLE TRANSLATION
INITIATION FACTOR
IF-2

(Aeropyrum
pernix) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2)
PF14578
(GTP_EFTU_D4) 		4 VAL A 262
LEU A  97
LEU A  93
LEU A  84
 None
 0.64A 6g9bA-5fg3A:
undetectable
6g9bB-5fg3A:
undetectable		 6g9bA-5fg3A:
8.75
6g9bB-5fg3A:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fms INTRAFLAGELLAR
TRANSPORT PROTEIN 52
HOMOLOG

(Mus musculus) 		PF09822
(ABC_transp_aux) 		5 VAL A 237
LEU A 241
LEU A  55
LEU A 214
MET A  86
 None
 1.13A 6g9bA-5fmsA:
undetectable
6g9bB-5fmsA:
undetectable		 6g9bA-5fmsA:
17.12
6g9bB-5fmsA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gnd PUTATIVE SERINE
PROTEASE HHOA

(Synechocystis
sp. PCC 6803) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 LEU A 356
VAL A 384
LEU A 371
LEU A 373
 None
 0.69A 6g9bA-5gndA:
undetectable
6g9bB-5gndA:
undetectable		 6g9bA-5gndA:
14.51
6g9bB-5gndA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9x BETA-1,3-GLUCANASE

(Paenibacillus
barengoltzii) 		PF16483
(Glyco_hydro_64) 		4 ILE A 182
VAL A 235
LEU A 200
LEU A 415
 None
 0.65A 6g9bA-5h9xA:
undetectable
6g9bB-5h9xA:
undetectable		 6g9bA-5h9xA:
11.90
6g9bB-5h9xA:
9.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hj3 ENVELOPE
GLYCOPROTEIN

(Ebola virus sp.) 		PF01611
(Filo_glycop) 		4 LEU C  43
VAL C  66
LEU C 184
LEU C 186
 None
 0.35A 6g9bA-5hj3C:
23.4
6g9bB-5hj3C:
undetectable		 6g9bA-5hj3C:
95.12
6g9bB-5hj3C:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5htp PROBABLE SUGAR
KINASE

(Synechococcus
elongatus) 		PF02782
(FGGY_C) 		4 ILE A 138
LEU A  77
LEU A 132
LEU A 182
 None
 0.74A 6g9bA-5htpA:
undetectable
6g9bB-5htpA:
undetectable		 6g9bA-5htpA:
10.67
6g9bB-5htpA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7k BPI FOLD-CONTAINING
FAMILY A MEMBER 1

(Homo sapiens) 		PF01273
(LBP_BPI_CETP) 		4 LEU A 234
VAL A 131
LEU A  55
LEU A  59
 None
 0.69A 6g9bA-5i7kA:
undetectable
6g9bB-5i7kA:
undetectable		 6g9bA-5i7kA:
14.29
6g9bB-5i7kA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iaa UBIQUITIN-LIKE
MODIFIER-ACTIVATING
ENZYME 5

(Homo sapiens) 		PF00899
(ThiF) 		4 ILE A 216
VAL A  76
LEU A 179
LEU A 273
 None
 0.63A 6g9bA-5iaaA:
undetectable
6g9bB-5iaaA:
undetectable		 6g9bA-5iaaA:
14.34
6g9bB-5iaaA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5irm UNCHARACTERIZED
PROTEIN

(Oryctolagus
cuniculus) 		PF05729
(NACHT)
PF13516
(LRR_6) 		4 LEU A 452
LEU A 453
LEU A 496
MET A 493
 None
 0.65A 6g9bA-5irmA:
undetectable
6g9bB-5irmA:
undetectable		 6g9bA-5irmA:
7.21
6g9bB-5irmA:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 LEU A 494
VAL A 483
LEU A 513
LEU A 515
 None
 0.66A 6g9bA-5jvkA:
undetectable
6g9bB-5jvkA:
undetectable		 6g9bA-5jvkA:
8.11
6g9bB-5jvkA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ke1 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin)
PF12951
(PATR) 		4 LEU A 527
LEU A 535
LEU A 498
LEU A 483
 None
 0.68A 6g9bA-5ke1A:
undetectable
6g9bB-5ke1A:
undetectable		 6g9bA-5ke1A:
14.20
6g9bB-5ke1A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ke1 OUTER MEMBRANE
PROTEIN ICSA
AUTOTRANSPORTER

(Shigella
flexneri) 		PF03212
(Pertactin)
PF12951
(PATR) 		4 VAL A 506
LEU A 535
LEU A 498
LEU A 483
 None
 0.71A 6g9bA-5ke1A:
undetectable
6g9bB-5ke1A:
undetectable		 6g9bA-5ke1A:
14.20
6g9bB-5ke1A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l75 FIG000988: PREDICTED
PERMEASE

(Klebsiella
pneumoniae) 		PF03739
(YjgP_YjgQ) 		4 ILE F  21
LEU F  22
LEU F  73
MET F  74
 None
 0.71A 6g9bA-5l75F:
undetectable
6g9bB-5l75F:
undetectable		 6g9bA-5l75F:
13.80
6g9bB-5l75F:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 LEU T1596
VAL T1607
LEU T1620
LEU T1636
 None
 0.74A 6g9bA-5ojsT:
undetectable
6g9bB-5ojsT:
undetectable		 6g9bA-5ojsT:
2.21
6g9bB-5ojsT:
1.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9t PROTOCADHERIN GAMMA
B2-ALPHA C

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 LEU A 471
VAL A 520
LEU A 500
LEU A 502
 None
 0.71A 6g9bA-5t9tA:
undetectable
6g9bB-5t9tA:
undetectable		 6g9bA-5t9tA:
11.75
6g9bB-5t9tA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9p GLUCONATE
5-DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF13561
(adh_short_C2) 		4 LEU A  28
VAL A 249
LEU A 189
LEU A 234
 None
 0.69A 6g9bA-5u9pA:
undetectable
6g9bB-5u9pA:
undetectable		 6g9bA-5u9pA:
16.33
6g9bB-5u9pA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN L

(Human
betaherpesvirus
5) 		PF01801
(Cytomega_gL) 		4 ILE B  86
LEU B  82
VAL B 151
LEU B 126
 None
 0.71A 6g9bA-5vocB:
undetectable
6g9bB-5vocB:
undetectable		 6g9bA-5vocB:
17.49
6g9bB-5vocB:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wyr TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A  25
VAL A   7
LEU A  35
LEU A 161
 None
 0.57A 6g9bA-5wyrA:
undetectable
6g9bB-5wyrA:
undetectable		 6g9bA-5wyrA:
25.68
6g9bB-5wyrA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT

(Komagataella
phaffii) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 VAL A  17
LEU A1412
LEU A1433
MET A1432
 None
 0.72A 6g9bA-5xogA:
undetectable
6g9bB-5xogA:
undetectable		 6g9bA-5xogA:
4.27
6g9bB-5xogA:
3.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxi CYTOCHROME P450 2C9

(Homo sapiens) 		no annotation 4 LEU A 453
LEU A 310
LEU A 485
LEU A 152
 None
 0.71A 6g9bA-5xxiA:
undetectable
6g9bB-5xxiA:
0.0		 6g9bA-5xxiA:
9.72
6g9bB-5xxiA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zln TOLL-LIKE RECEPTOR 9

(Mus musculus) 		no annotation 5 ILE A 114
LEU A  78
LEU A  94
LEU A  89
MET A 122
 None
 1.44A 6g9bA-5zlnA:
undetectable
6g9bB-5zlnA:
undetectable		 6g9bA-5zlnA:
16.87
6g9bB-5zlnA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6all FE(3+)-CITRATE-BINDI
NG PROTEIN YFMC

(Bacillus
anthracis) 		PF01497
(Peripla_BP_2) 		4 LEU A 132
VAL A  99
LEU A  58
LEU A 113
 None
 0.72A 6g9bA-6allA:
undetectable
6g9bB-6allA:
undetectable		 6g9bA-6allA:
16.07
6g9bB-6allA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ap4 DNA POLYMERASE III
SUBUNIT BETA

(Acinetobacter
baumannii) 		no annotation 4 LEU A 208
LEU A 228
LEU A 252
LEU A 171
 None
 0.74A 6g9bA-6ap4A:
undetectable
6g9bB-6ap4A:
undetectable		 6g9bA-6ap4A:
27.17
6g9bB-6ap4A:
15.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f5u ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 5 ILE A  38
LEU A  43
VAL A  66
LEU A 184
LEU A 186
 None
CQN  A 610 ( 4.7A)
CQN  A 610 (-4.0A)
CQN  A 610 ( 4.6A)
None
 0.50A 6g9bA-6f5uA:
36.6
6g9bB-6f5uA:
undetectable		 6g9bA-6f5uA:
100.00
6g9bB-6f5uA:
10.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f6s ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1

(Zaire
ebolavirus) 		no annotation 5 ILE A  38
LEU A  43
VAL A  66
LEU A 184
LEU A 186
 None
 0.36A 6g9bA-6f6sA:
36.6
6g9bB-6f6sA:
undetectable		 6g9bA-6f6sA:
100.00
6g9bB-6f6sA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg8 SOMATIC
EMBRYOGENESIS
RECEPTOR KINASE 1

(Arabidopsis
thaliana) 		no annotation 5 LEU A  85
VAL A  74
LEU A  98
LEU A 116
LEU A  33
 None
 1.08A 6g9bA-6fg8A:
undetectable
6g9bB-6fg8A:
undetectable		 6g9bA-6fg8A:
24.14
6g9bB-6fg8A:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fnw VOLUME-REGULATED
ANION CHANNEL
SUBUNIT LRRC8A

(Mus musculus) 		no annotation 4 VAL A 562
LEU A 569
LEU A 593
LEU A 551
 None
 0.75A 6g9bA-6fnwA:
undetectable
6g9bB-6fnwA:
undetectable		 6g9bA-6fnwA:
20.83
6g9bB-6fnwA:
20.88