SIMILAR PATTERNS OF AMINO ACIDS FOR 6G31_J_ZOLJ401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		4 LEU A  62
ASP A  57
ARG A 298
GLN A  54
 None
NA  A 502 (-3.3A)
None
None
 1.08A 6g31J-1bgpA:
undetectable		 6g31J-1bgpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 LEU A  92
ASP A  91
ASP A 325
GLN A  87
 None
 1.21A 6g31J-1dnvA:
undetectable		 6g31J-1dnvA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 LEU A 114
ASP A 117
ARG A 126
GLN A 185
 None
 0.75A 6g31J-1fpsA:
24.8		 6g31J-1fpsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 LEU A 114
ASP A 117
ASP A 121
ARG A 126
 None
 0.91A 6g31J-1fpsA:
24.8		 6g31J-1fpsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gyd ARABINAN
ENDO-1,5-ALPHA-L-ARA
BINOSIDASE A

(Cellvibrio
japonicus) 		PF04616
(Glyco_hydro_43) 		4 LEU B 153
ASP B 211
ARG B 206
GLN B 150
 None
 1.25A 6g31J-1gydB:
undetectable		 6g31J-1gydB:
12.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko0 DIAMINOPIMELATE
DECARBOXYLASE

(Escherichia
coli) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 LEU A 396
ASP A 398
ARG A 403
GLN A  68
 None
 1.31A 6g31J-1ko0A:
undetectable		 6g31J-1ko0A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		4 LEU A 620
ASP A 644
GLN A 640
GLN A 706
 None
C  T  25 ( 4.3A)
C  T  11 ( 2.6A)
U  T  12 ( 3.5A)
 1.36A 6g31J-1qu2A:
undetectable		 6g31J-1qu2A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
 0.86A 6g31J-1rqjA:
24.7		 6g31J-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		5 LEU A 102
ASP A 105
ASP A 111
GLN A 179
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
 0.60A 6g31J-1rqjA:
24.7		 6g31J-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  82
ARG A  93
GLN A 154
 None
 1.33A 6g31J-1rtrA:
22.8		 6g31J-1rtrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  88
ARG A  93
GLN A 154
 None
 0.91A 6g31J-1rtrA:
22.8		 6g31J-1rtrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 228
ASP A 244
GLN A 248
GLN A 351
 None
 1.34A 6g31J-1wb0A:
undetectable		 6g31J-1wb0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A  78
ASP A  81
ARG A  90
GLN A 201
 None
 0.94A 6g31J-1wl1A:
21.7		 6g31J-1wl1A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		6 LEU A  76
ASP A  79
ASP A  83
ARG A  88
GLN A 146
GLN A 209
 None
 1.36A 6g31J-1wmwA:
27.8		 6g31J-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 LEU A  83
ASP A  90
ARG A  95
GLN A 153
 None
 0.81A 6g31J-1wy0A:
26.9		 6g31J-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 LEU A  78
ASP A  81
ARG A  90
GLN A 197
 None
 1.18A 6g31J-2azkA:
21.6		 6g31J-2azkA:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		4 ASP A  84
ASP A  80
ARG A 154
GLN A 211
 MG  A 341 (-3.0A)
MG  A 341 (-2.6A)
None
None
 1.34A 6g31J-2dh4A:
35.0		 6g31J-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
 0.78A 6g31J-2dh4A:
35.0		 6g31J-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  80
ASP A  84
GLN A 147
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
 0.43A 6g31J-2dh4A:
35.0		 6g31J-2dh4A:
39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A  71
ASP A  74
ARG A  85
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 1.17A 6g31J-2ftzA:
24.2		 6g31J-2ftzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 0.92A 6g31J-2ftzA:
24.2		 6g31J-2ftzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		5 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
 0.87A 6g31J-2o1oA:
24.7		 6g31J-2o1oA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		5 LEU A 112
ASP A 115
ASP A 119
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.64A 6g31J-2o1oA:
24.7		 6g31J-2o1oA:
12.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		4 LEU A  61
ASP A  64
ASP A  68
ARG A  73
 None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
 0.74A 6g31J-2q80A:
42.5		 6g31J-2q80A:
93.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A  61
ASP A  64
ASP A  68
GLN A 126
GLN A 185
 None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-3.2A)
 0.62A 6g31J-2q80A:
42.5		 6g31J-2q80A:
93.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi1 NEF

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		4 LEU A 112
ASP A 111
GLN A 125
GLN A 104
 None
 1.33A 6g31J-2xi1A:
undetectable		 6g31J-2xi1A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 104
ASP A 107
ASP A 111
ARG A 116
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
 0.69A 6g31J-3aq0A:
25.8		 6g31J-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csv AMINOGLYCOSIDE
PHOSPHOTRANSFERASE

(Ruegeria sp.
TM1040) 		PF01636
(APH) 		4 LEU A 216
ASP A 181
ARG A 133
GLN A 127
 None
 1.31A 6g31J-3csvA:
undetectable		 6g31J-3csvA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A 184
ARG A 181
GLN A 189
GLN A 121
 None
 1.16A 6g31J-3e3aA:
undetectable		 6g31J-3e3aA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A 184
ASP A 185
GLN A 189
GLN A 121
 None
 1.28A 6g31J-3e3aA:
undetectable		 6g31J-3e3aA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8w RIBONUCLEASE H

(Escherichia
virus T4) 		PF02739
(5_3_exonuc_N)
PF09293
(RNaseH_C) 		4 LEU A 255
ASP A 259
ASP A 261
GLN A 160
 None
 1.08A 6g31J-3h8wA:
undetectable		 6g31J-3h8wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		4 LEU A  80
ASP A  83
ARG A  94
GLN A 156
 None
 1.34A 6g31J-3krcA:
21.7		 6g31J-3krcA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krc GERANYL DIPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Mentha x
piperita) 		PF00348
(polyprenyl_synt) 		4 LEU A  80
ASP A  83
ASP A  89
ARG A  94
 None
 1.15A 6g31J-3krcA:
21.7		 6g31J-3krcA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF13499
(EF-hand_7) 		4 LEU A 419
ASP A 423
ASP A 425
GLN A 385
 None
CA  A   1 (-3.0A)
CA  A   1 (-2.9A)
None
 1.25A 6g31J-3l19A:
undetectable		 6g31J-3l19A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ASP A 100
ARG A 105
GLN A 168
GLN A 231
 None
 0.95A 6g31J-3lomA:
23.6		 6g31J-3lomA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lul 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Legionella
pneumophila) 		PF01063
(Aminotran_4) 		4 LEU A 262
ASP A 269
GLN A 268
GLN A 211
 None
 1.26A 6g31J-3lulA:
undetectable		 6g31J-3lulA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  78
ASP A  87
ARG A  92
GLN A 153
 None
 0.74A 6g31J-3m0gA:
21.6		 6g31J-3m0gA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 LEU A  86
ASP A  89
ARG A 100
GLN A 160
 GOL  A 310 ( 4.3A)
None
None
None
 1.18A 6g31J-3m9uA:
22.8		 6g31J-3m9uA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		4 LEU A 267
ASP A 272
ARG A 243
GLN A 271
 None
 1.34A 6g31J-3mizA:
undetectable		 6g31J-3mizA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  90
ASP A  93
ARG A 102
GLN A 217
 None
 1.01A 6g31J-3mzvA:
25.5		 6g31J-3mzvA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		4 LEU A 125
ASP A 132
ARG A 137
GLN A 193
 None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
 1.12A 6g31J-3nf2A:
24.8		 6g31J-3nf2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		4 LEU A  75
ASP A  84
ARG A  89
GLN A 149
 None
 0.84A 6g31J-3npkA:
21.3		 6g31J-3npkA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 LEU A 104
ASP A 107
GLN A 126
GLN A 450
 None
 1.08A 6g31J-3oh8A:
undetectable		 6g31J-3oh8A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
 0.94A 6g31J-3p41A:
21.8		 6g31J-3p41A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  82
ARG A  93
GLN A 153
 None
 1.27A 6g31J-3p8lA:
22.7		 6g31J-3p8lA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  88
ARG A  93
GLN A 153
 None
 0.67A 6g31J-3p8lA:
22.7		 6g31J-3p8lA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfo PUTATIVE
ACETYLORNITHINE
DEACETYLASE

(Rhodopseudomonas
palustris) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ASP A 378
ARG A 380
GLN A 108
GLN A  91
 None
 1.25A 6g31J-3pfoA:
undetectable		 6g31J-3pfoA:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
 DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
 0.96A 6g31J-3q1oA:
23.4		 6g31J-3q1oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		5 LEU A  89
ASP A  92
ASP A  98
GLN A 163
GLN A 225
 DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.6A)
DMA  A 501 ( 3.8A)
 0.65A 6g31J-3q1oA:
23.4		 6g31J-3q1oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
 1.24A 6g31J-3qqvA:
13.3		 6g31J-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 254
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
 1.01A 6g31J-3qqvA:
13.3		 6g31J-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  85
ASP A  88
ARG A  99
GLN A 162
 None
 1.36A 6g31J-3ts7A:
22.5		 6g31J-3ts7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  85
ASP A  94
ARG A  99
GLN A 162
 None
 0.73A 6g31J-3ts7A:
22.5		 6g31J-3ts7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B

(Drosophila
melanogaster) 		PF01399
(PCI) 		4 LEU A 270
ASP A 266
ASP A 265
GLN A 263
 None
GD3  A   1 (-2.1A)
GD3  A   1 (-3.9A)
GD3  A   1 ( 4.8A)
 1.28A 6g31J-3txmA:
3.4		 6g31J-3txmA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		4 LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 0.81A 6g31J-3ucaA:
22.6		 6g31J-3ucaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v71 PUF (PUMILIO/FBF)
DOMAIN-CONTAINING
PROTEIN 7, CONFIRMED
BY TRANSCRIPT
EVIDENCE

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 LEU A 382
ASP A 379
ASP A 376
GLN A 427
 None
 1.29A 6g31J-3v71A:
undetectable		 6g31J-3v71A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 LEU A  81
ASP A  84
ARG A  93
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 (-3.6A)
 0.92A 6g31J-3wjoA:
24.7		 6g31J-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 LEU A  81
ASP A  84
ASP A  88
ARG A  93
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
 0.76A 6g31J-3wjoA:
24.7		 6g31J-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.66A 6g31J-3zouA:
21.5		 6g31J-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 LEU A   9
ASP A 179
ASP A 178
GLN A 170
 None
CA  A 402 (-3.7A)
CA  A 402 (-2.9A)
CA  A 402 (-2.9A)
 1.24A 6g31J-4b52A:
undetectable		 6g31J-4b52A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 LEU A 368
ASP A 367
ARG A 715
GLN A 450
 GOL  A1737 ( 4.9A)
GOL  A1737 (-2.8A)
GOL  A1737 (-3.3A)
None
 0.92A 6g31J-4c1oA:
undetectable		 6g31J-4c1oA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
 0.90A 6g31J-4e1eA:
25.8		 6g31J-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.96A 6g31J-4fp4A:
18.5		 6g31J-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  86
ASP A  90
ARG A  95
GLN A 199
 UNL  A 303 ( 4.7A)
UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
None
 0.95A 6g31J-4fp4A:
18.5		 6g31J-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.77A 6g31J-4gp1A:
26.2		 6g31J-4gp1A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 1.01A 6g31J-4jzxA:
25.7		 6g31J-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kcd GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 3A

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 LEU A 240
ASP A 235
ASP A 237
GLN A 209
 None
 1.36A 6g31J-4kcdA:
undetectable		 6g31J-4kcdA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		4 LEU A  94
ASP A  97
ARG A 106
GLN A 165
 None
 0.74A 6g31J-4kk2A:
24.3		 6g31J-4kk2A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
 None
 1.00A 6g31J-4kkmA:
22.6		 6g31J-4kkmA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 LEU A  75
ASP A  78
ARG A  89
GLN A 149
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 1.02A 6g31J-4lfeA:
23.5		 6g31J-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 1.01A 6g31J-4lfeA:
23.5		 6g31J-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.68A 6g31J-4llsA:
23.8		 6g31J-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 1.01A 6g31J-4llsA:
23.8		 6g31J-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myc IRON-SULFUR CLUSTERS
TRANSPORTER ATM1,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 LEU A 381
ASP A 374
GLN A 253
GLN A 134
 None
 1.36A 6g31J-4mycA:
undetectable		 6g31J-4mycA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nre ARACHIDONATE
15-LIPOXYGENASE B

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 LEU A 289
ASP A 291
ARG A 252
GLN A 335
 None
None
SO4  A 707 (-3.5A)
None
 1.31A 6g31J-4nreA:
undetectable		 6g31J-4nreA:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		4 LEU A 387
ASP A 390
ASP A 394
GLN A 318
 None
 1.32A 6g31J-4oyeA:
undetectable		 6g31J-4oyeA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
 0.86A 6g31J-4p0vA:
26.4		 6g31J-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		5 LEU A 100
ASP A 103
ASP A 107
GLN A 171
GLN A 240
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.50A 6g31J-4p0vA:
26.4		 6g31J-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmn TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 ASP A 227
ASP A  43
GLN A 213
GLN A 101
 MES  A 301 (-3.6A)
MES  A 301 ( 4.2A)
MES  A 301 (-2.9A)
MES  A 301 (-3.3A)
 1.28A 6g31J-4pmnA:
undetectable		 6g31J-4pmnA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 LEU A 346
ASP A 345
ARG A 693
GLN A 428
 None
TRS  A 803 (-2.7A)
TRS  A 803 (-3.4A)
None
 0.93A 6g31J-4rhhA:
undetectable		 6g31J-4rhhA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
GLN A 252
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 1.01A 6g31J-4rxeA:
26.1		 6g31J-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wia PUTATIVE
FLAGELLA-RELATED
PROTEIN H

(Methanocaldococcus
jannaschii) 		PF06745
(ATPase) 		4 LEU A  16
ASP A  17
ASP A  10
ARG A  46
 None
GOL  A 306 (-3.3A)
GOL  A 306 (-3.9A)
None
 1.29A 6g31J-4wiaA:
undetectable		 6g31J-4wiaA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		4 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
 0.80A 6g31J-4wk5A:
24.2		 6g31J-4wk5A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
GLN B 252
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
 0.95A 6g31J-5ahuB:
23.3		 6g31J-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 160
 None
 1.04A 6g31J-5aypA:
20.1		 6g31J-5aypA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A  89
ASP A  92
ARG A 103
GLN A 166
 None
 1.37A 6g31J-5e8hA:
20.9		 6g31J-5e8hA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
 None
 1.16A 6g31J-5e8lA:
21.1		 6g31J-5e8lA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ASP D 390
ASP D 392
GLN A 458
GLN A 241
 None
None
ATP  A 600 (-3.7A)
None
 1.28A 6g31J-5fl7D:
undetectable		 6g31J-5fl7D:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjp OXYSTEROLS RECEPTOR
LXR-BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU B 475
ASP B 477
ARG B 297
GLN B 288
 None
 1.24A 6g31J-5hjpB:
undetectable		 6g31J-5hjpB:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		5 ASP A 126
ASP A 130
ARG A 135
GLN A 195
GLN A 284
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
None
 0.96A 6g31J-5hn7A:
26.4		 6g31J-5hn7A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A1211
ASP A1178
ARG A1260
GLN A1190
 None
 1.16A 6g31J-5iy9A:
2.9		 6g31J-5iy9A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		4 ASP A  56
ASP A  60
GLN A 113
GLN A 166
 MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
 0.56A 6g31J-5iysA:
9.2		 6g31J-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 LEU B  41
ASP B  55
ARG B  43
GLN B 184
 C2E  B 304 ( 3.5A)
C2E  B 304 (-3.8A)
C2E  B 304 (-2.6A)
C2E  B 304 (-3.1A)
 1.22A 6g31J-5mkgB:
undetectable		 6g31J-5mkgB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Sulfolobus
solfataricus) 		no annotation 4 LEU A  64
ASP A  67
ASP A  71
GLN A  16
 None
 1.24A 6g31J-5n2pA:
undetectable		 6g31J-5n2pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5neu INTEGRIN ALPHA-V

(Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 LEU A 350
ASP A 351
ASP A 353
GLN A 580
 None
 1.38A 6g31J-5neuA:
undetectable		 6g31J-5neuA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t7k AOAA13

(Aspergillus
oryzae) 		PF03067
(LPMO_10) 		4 LEU A  37
ASP A  38
ASP A 129
ARG A 157
 None
 1.02A 6g31J-5t7kA:
undetectable		 6g31J-5t7kA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v10 UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF03061
(4HBT) 		4 LEU A  59
ASP A  57
ARG A 127
GLN A  53
 None
 1.11A 6g31J-5v10A:
undetectable		 6g31J-5v10A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vtm TYPE II SECRETION
SYSTEM PROTEIN K

(Pseudomonas
aeruginosa) 		no annotation 4 LEU X 205
ASP X 187
GLN X 315
GLN X 280
 None
 1.37A 6g31J-5vtmX:
undetectable		 6g31J-5vtmX:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ASP A 147
ASP A 151
ARG A 156
GLN A 215
GLN A 284
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-3.7A)
 0.81A 6g31J-6b07A:
26.8		 6g31J-6b07A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k ACTF

(Rhodothermus
marinus) 		no annotation 4 LEU F 410
ASP F 407
GLN F 183
GLN F  87
 None
 1.38A 6g31J-6f0kF:
4.4		 6g31J-6f0kF:
24.71