SIMILAR PATTERNS OF AMINO ACIDS FOR 6G31_I_ZOLI401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE


(Escherichia
coli)
PF00348
(polyprenyl_synt)
4 ASP A 105
ASP A 111
LYS A 202
GLN A 241
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
0.95A 6g31I-1rqjA:
23.8
6g31I-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana)
PF00962
(A_deaminase)
4 ASP A 737
ASP A 736
LYS A 466
GLN A 546
CF5  A 841 (-2.5A)
CF5  A 841 ( 2.5A)
None
None
1.34A 6g31I-2a3lA:
undetectable
6g31I-2a3lA:
10.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae)
PF00348
(polyprenyl_synt)
4 ASP A  80
ASP A  84
LYS A 174
GLN A 211
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
None
None
0.74A 6g31I-2dh4A:
33.2
6g31I-2dh4A:
39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE


(Cryptosporidium
parvum)
PF00348
(polyprenyl_synt)
4 ASP A 115
ASP A 119
LYS A 210
GLN A 251
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
0.86A 6g31I-2o1oA:
23.6
6g31I-2o1oA:
12.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
4 ASP A  64
ASP A  68
LYS A 151
GLN A 185
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
0.62A 6g31I-2q80A:
38.9
6g31I-2q80A:
93.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)


(Helicobacter
pylori)
PF00348
(polyprenyl_synt)
4 ASP A  92
ASP A  98
LYS A 186
GLN A 225
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.1A)
DMA  A 501 ( 3.8A)
0.83A 6g31I-3q1oA:
22.9
6g31I-3q1oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
cruzi)
PF00348
(polyprenyl_synt)
4 ASP A  98
ASP A 102
LYS A 207
GLN A 247
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
0.88A 6g31I-4e1eA:
24.5
6g31I-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE


(Leishmania
major)
PF00348
(polyprenyl_synt)
4 ASP A  98
ASP A 102
LYS A 207
GLN A 247
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
0.96A 6g31I-4jzxA:
24.2
6g31I-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE


(Homo sapiens)
PF00348
(polyprenyl_synt)
4 ASP A 103
ASP A 107
LYS A 200
GLN A 240
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
1.00A 6g31I-4p0vA:
25.3
6g31I-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
4 ASP A 103
ASP A 107
LYS A 212
GLN A 252
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
0.91A 6g31I-4rxeA:
24.8
6g31I-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE


(Trypanosoma
brucei)
PF00348
(polyprenyl_synt)
4 ASP B 103
ASP B 107
LYS B 212
GLN B 252
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
0.88A 6g31I-5ahuB:
21.9
6g31I-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE


(Plasmodium
vivax)
PF00348
(polyprenyl_synt)
4 ASP A 126
ASP A 130
LYS A 243
GLN A 284
04M  A 401 ( 4.0A)
None
04M  A 401 (-4.5A)
None
0.73A 6g31I-5hn7A:
25.1
6g31I-5hn7A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE


(Choristoneura
fumiferana)
no annotation 4 ASP A 147
ASP A 151
LYS A 244
GLN A 284
MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
0.90A 6g31I-6b07A:
25.7
6g31I-6b07A:
24.14