SIMILAR PATTERNS OF AMINO ACIDS FOR 6G31_I_ZOLI401

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1rqj	GERANYLTRANSTRANSFER ASE (Escherichia coli)	PF00348 (polyprenyl_synt)	4	ASP A 105 ASP A 111 LYS A 202 GLN A 241	MG  A 907 (-2.5A) MG  A 909 (-2.4A) RIS  A 901 (-2.5A) RIS  A 901 ( 3.6A)	0.95A	6g31I-1rqjA: 23.8	6g31I-1rqjA: 13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2a3l	AMP DEAMINASE (Arabidopsis thaliana)	PF00962 (A_deaminase)	4	ASP A 737 ASP A 736 LYS A 466 GLN A 546	CF5  A 841 (-2.5A) CF5  A 841 ( 2.5A) None None	1.34A	6g31I-2a3lA: undetectable	6g31I-2a3lA: 10.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2dh4	YPL069C (Saccharomyces cerevisiae)	PF00348 (polyprenyl_synt)	4	ASP A  80 ASP A  84 LYS A 174 GLN A 211	MG  A 341 (-2.6A) MG  A 341 (-3.0A) None None	0.74A	6g31I-2dh4A: 33.2	6g31I-2dh4A: 39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2o1o	PUTATIVE FARNESYL PYROPHOSPHATE SYNTHASE (Cryptosporidium parvum)	PF00348 (polyprenyl_synt)	4	ASP A 115 ASP A 119 LYS A 210 GLN A 251	MG  A 503 (-2.5A) MG  A 502 (-2.4A) RIS  A 400 (-2.8A) RIS  A 400 (-3.1A)	0.86A	6g31I-2o1oA: 23.6	6g31I-2o1oA: 12.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2q80	GERANYLGERANYL PYROPHOSPHATE SYNTHETASE (Homo sapiens)	PF00348 (polyprenyl_synt)	4	ASP A  64 ASP A  68 LYS A 151 GLN A 185	GRG  A 500 (-2.4A) MG  A 400 (-2.6A) GRG  A 500 (-2.8A) GRG  A 500 (-3.2A)	0.62A	6g31I-2q80A: 38.9	6g31I-2q80A: 93.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3q1o	GERANYLTRANSTRANSFER ASE (ISPA) (Helicobacter pylori)	PF00348 (polyprenyl_synt)	4	ASP A  92 ASP A  98 LYS A 186 GLN A 225	MG  A 400 ( 2.8A) MG  A 400 ( 3.2A) DMA  A 501 (-3.1A) DMA  A 501 ( 3.8A)	0.83A	6g31I-3q1oA: 22.9	6g31I-3q1oA: 14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4e1e	FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma cruzi)	PF00348 (polyprenyl_synt)	4	ASP A  98 ASP A 102 LYS A 207 GLN A 247	MG  A 403 (-2.5A) MG  A 403 (-2.4A) 0MW  A 404 (-2.8A) 0MW  A 404 ( 3.8A)	0.88A	6g31I-4e1eA: 24.5	6g31I-4e1eA: 11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4jzx	FARNESYL PYROPHOSPHATE SYNTHASE (Leishmania major)	PF00348 (polyprenyl_synt)	4	ASP A  98 ASP A 102 LYS A 207 GLN A 247	CA  A 403 (-2.5A) CA  A 403 (-2.5A) 476  A 402 (-2.7A) IPE  A 401 (-3.7A)	0.96A	6g31I-4jzxA: 24.2	6g31I-4jzxA: 14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4p0v	FARNESYL PYROPHOSPHATE SYNTHASE (Homo sapiens)	PF00348 (polyprenyl_synt)	4	ASP A 103 ASP A 107 LYS A 200 GLN A 240	MG  A 405 (-2.5A) MG  A 405 (-2.4A) ZOL  A 401 (-2.7A) ZOL  A 401 (-3.5A)	1.00A	6g31I-4p0vA: 25.3	6g31I-4p0vA: 15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4rxe	FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma brucei)	PF00348 (polyprenyl_synt)	4	ASP A 103 ASP A 107 LYS A 212 GLN A 252	MG  A3004 (-2.5A) MG  A3004 (-2.3A) 3YQ  A3001 (-2.9A) 3YQ  A3001 ( 4.2A)	0.91A	6g31I-4rxeA: 24.8	6g31I-4rxeA: 11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5ahu	FARNESYL PYROPHOSPHATE SYNTHASE (Trypanosoma brucei)	PF00348 (polyprenyl_synt)	4	ASP B 103 ASP B 107 LYS B 212 GLN B 252	MG  B1370 (-2.5A) MG  B1369 (-2.2A) G76  B1368 (-2.8A) G76  B1368 ( 4.0A)	0.88A	6g31I-5ahuB: 21.9	6g31I-5ahuB: 13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5hn7	FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE (Plasmodium vivax)	PF00348 (polyprenyl_synt)	4	ASP A 126 ASP A 130 LYS A 243 GLN A 284	04M  A 401 ( 4.0A) None 04M  A 401 (-4.5A) None	0.73A	6g31I-5hn7A: 25.1	6g31I-5hn7A: 13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6b07	FARNESYL DIPHOSPHATE SYNTHASE (Choristoneura fumiferana)	no annotation	4	ASP A 147 ASP A 151 LYS A 244 GLN A 284	MG  A 402 (-2.6A) MG  A 402 (-2.5A) C6M  A 401 (-2.6A) C6M  A 401 (-3.7A)	0.90A	6g31I-6b07A: 25.7	6g31I-6b07A: 24.14