SIMILAR PATTERNS OF AMINO ACIDS FOR 6G31_D_ZOLD401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgp BARLEY GRAIN
PEROXIDASE

(Hordeum vulgare) 		PF00141
(peroxidase) 		4 LEU A  62
ASP A  57
ARG A 298
GLN A  54
 None
NA  A 502 (-3.3A)
None
None
 1.18A 6g31D-1bgpA:
undetectable		 6g31D-1bgpA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 LEU A  92
ASP A  91
ASP A 325
GLN A  87
 None
 1.20A 6g31D-1dnvA:
undetectable		 6g31D-1dnvA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		4 LEU A 114
ASP A 117
ARG A 126
GLN A 185
 None
 0.54A 6g31D-1fpsA:
24.0		 6g31D-1fpsA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g7c ELONGATION FACTOR
1-ALPHA

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 LEU A  63
ASP A  35
ASP A  74
ARG A  67
 None
 1.28A 6g31D-1g7cA:
undetectable		 6g31D-1g7cA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8e FLAGELLAR
TRANSCRIPTIONAL
ACTIVATOR FLHD

(Escherichia
coli) 		PF05247
(FlhD) 		4 ASP A  85
ASP A  81
ARG A  83
GLN A  88
 None
 1.41A 6g31D-1g8eA:
3.7		 6g31D-1g8eA:
25.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
GAMMA SUBUNIT

(Klebsiella
pneumoniae) 		PF02287
(Dehydratase_SU) 		4 LEU G  13
ASP G  10
GLN G   9
GLN G  63
 None
 1.18A 6g31D-1iwpG:
undetectable		 6g31D-1iwpG:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldj CULLIN HOMOLOG 1

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 LEU A 380
ASP A 314
GLN A 347
GLN A 308
 None
 1.41A 6g31D-1ldjA:
2.2		 6g31D-1ldjA:
8.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qu2 ISOLEUCYL-TRNA
SYNTHETASE

(Staphylococcus
aureus) 		PF00133
(tRNA-synt_1)
PF06827
(zf-FPG_IleRS)
PF08264
(Anticodon_1) 		4 LEU A 620
ASP A 644
GLN A 640
GLN A 706
 None
C  T  25 ( 4.3A)
C  T  11 ( 2.6A)
U  T  12 ( 3.5A)
 1.37A 6g31D-1qu2A:
undetectable		 6g31D-1qu2A:
5.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 LEU A 102
ASP A 105
ASP A 111
ARG A 116
GLN A 179
GLN A 241
 None
MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 ( 3.6A)
 0.58A 6g31D-1rqjA:
23.8		 6g31D-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  82
ARG A  93
GLN A 154
 None
 1.26A 6g31D-1rtrA:
22.0		 6g31D-1rtrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  88
ARG A  93
GLN A 154
 None
 0.73A 6g31D-1rtrA:
22.0		 6g31D-1rtrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtr GERANYLTRANSTRANSFER
ASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  88
ARG A  93
GLN A 215
 None
 0.92A 6g31D-1rtrA:
22.0		 6g31D-1rtrA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbl PECTATE LYASE 47

(Bacillus sp.
TS-47) 		PF00544
(Pec_lyase_C) 		4 LEU A 256
ASP A 233
ASP A 190
ARG A 285
 None
CA  A 417 (-3.6A)
CA  A 417 (-2.4A)
None
 1.29A 6g31D-1vblA:
undetectable		 6g31D-1vblA:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8g HYPOTHETICAL UPF0001
PROTEIN YGGS

(Escherichia
coli) 		PF01168
(Ala_racemase_N) 		4 LEU A 120
ASP A  98
ARG A 116
GLN A  70
 None
 1.20A 6g31D-1w8gA:
undetectable		 6g31D-1w8gA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wb0 CHITOTRIOSIDASE 1

(Homo sapiens) 		PF00704
(Glyco_hydro_18) 		4 LEU A 228
ASP A 244
GLN A 248
GLN A 351
 None
 1.41A 6g31D-1wb0A:
undetectable		 6g31D-1wb0A:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A  78
ASP A  81
ARG A  90
GLN A 201
 None
 1.00A 6g31D-1wl1A:
21.3		 6g31D-1wl1A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		4 LEU A  76
ASP A  79
GLN A 146
GLN A 209
 None
 1.38A 6g31D-1wmwA:
27.1		 6g31D-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		5 LEU A  76
ASP A  83
ARG A  88
GLN A 146
GLN A 209
 None
 0.82A 6g31D-1wmwA:
27.1		 6g31D-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 LEU A  83
ASP A  90
ARG A  95
GLN A 153
 None
 0.67A 6g31D-1wy0A:
26.7		 6g31D-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 LEU A  83
ASP A  90
ARG A  95
GLN A 215
 None
 0.61A 6g31D-1wy0A:
26.7		 6g31D-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bcc UBIQUINOL CYTOCHROME
C OXIDOREDUCTASE

(Gallus gallus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 LEU A 431
ASP A 433
ARG A 242
GLN A 339
 None
 1.42A 6g31D-2bccA:
undetectable		 6g31D-2bccA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmj CENTAURIN GAMMA 1

(Homo sapiens) 		PF00071
(Ras) 		4 LEU A 172
ASP A 137
ARG A 165
GLN A 237
 None
 1.42A 6g31D-2bmjA:
undetectable		 6g31D-2bmjA:
18.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 LEU A  77
ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
 None
MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
 0.46A 6g31D-2dh4A:
34.2		 6g31D-2dh4A:
39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A  71
ASP A  74
ARG A  85
GLN A 198
 None
UNL  A 273 (-3.0A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 1.01A 6g31D-2ftzA:
23.3		 6g31D-2ftzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftz GERANYLTRANSTRANSFER
ASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		4 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
MLY  A 223 ( 3.6A)
UNL  A 274 (-4.1A)
MLY  A 163 ( 3.8A)
 0.64A 6g31D-2ftzA:
23.3		 6g31D-2ftzA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		6 LEU A 112
ASP A 115
ASP A 119
ARG A 124
GLN A 184
GLN A 251
 None
MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-3.1A)
 0.65A 6g31D-2o1oA:
24.0		 6g31D-2o1oA:
12.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 LEU A  61
ASP A  64
ASP A  68
ARG A  73
GLN A 126
GLN A 185
 None
GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-3.2A)
 0.64A 6g31D-2q80A:
40.5		 6g31D-2q80A:
93.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qsf DNA REPAIR PROTEIN
RAD4

(Saccharomyces
cerevisiae) 		PF03835
(Rad4)
PF10403
(BHD_1)
PF10405
(BHD_3) 		4 LEU A 225
ASP A 263
ASP A 261
GLN A 267
 None
 1.39A 6g31D-2qsfA:
undetectable		 6g31D-2qsfA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xi1 NEF

(Human
immunodeficiency
virus 1) 		PF00469
(F-protein) 		4 LEU A 112
ASP A 111
GLN A 125
GLN A 104
 None
 1.37A 6g31D-2xi1A:
undetectable		 6g31D-2xi1A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A 104
ASP A 107
ASP A 111
ARG A 116
 None
MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
 0.46A 6g31D-3aq0A:
25.0		 6g31D-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		5 LEU B  81
ASP B  84
ASP B  88
ARG B  93
GLN B 208
 None
MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
None
 0.77A 6g31D-3aqcB:
26.2		 6g31D-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 ASP A 185
ARG A 181
GLN A 189
GLN A 121
 None
 1.42A 6g31D-3e3aA:
undetectable		 6g31D-3e3aA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e3a POSSIBLE PEROXIDASE
BPOC

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 LEU A 184
ASP A 185
GLN A 189
GLN A 121
 None
 1.28A 6g31D-3e3aA:
undetectable		 6g31D-3e3aA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8w RIBONUCLEASE H

(Escherichia
virus T4) 		PF02739
(5_3_exonuc_N)
PF09293
(RNaseH_C) 		4 LEU A 255
ASP A 259
ASP A 261
GLN A 160
 None
 1.05A 6g31D-3h8wA:
undetectable		 6g31D-3h8wA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l19 CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF13499
(EF-hand_7) 		4 LEU A 419
ASP A 423
ASP A 425
GLN A 385
 None
CA  A   1 (-3.0A)
CA  A   1 (-2.9A)
None
 1.35A 6g31D-3l19A:
undetectable		 6g31D-3l19A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		5 LEU A  91
ASP A 100
ARG A 105
GLN A 168
GLN A 231
 None
 0.94A 6g31D-3lomA:
22.6		 6g31D-3lomA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m0g FARNESYL DIPHOSPHATE
SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  78
ASP A  87
ARG A  92
GLN A 153
 None
 0.60A 6g31D-3m0gA:
20.9		 6g31D-3m0gA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m9u FARNESYL-DIPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		4 LEU A  86
ASP A  89
ARG A 100
GLN A 160
 GOL  A 310 ( 4.3A)
None
None
None
 1.15A 6g31D-3m9uA:
21.7		 6g31D-3m9uA:
11.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3miz PUTATIVE
TRANSCRIPTIONAL
REGULATOR PROTEIN,
LACI FAMILY

(Rhizobium etli) 		PF13377
(Peripla_BP_3) 		4 LEU A 267
ASP A 272
ARG A 243
GLN A 271
 None
 1.36A 6g31D-3mizA:
undetectable		 6g31D-3mizA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  90
ASP A  93
ARG A 102
GLN A 217
 None
 0.83A 6g31D-3mzvA:
24.8		 6g31D-3mzvA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nf2 PUTATIVE POLYPRENYL
SYNTHETASE

(Streptomyces
coelicolor) 		PF00348
(polyprenyl_synt) 		4 LEU A 125
ASP A 132
ARG A 137
GLN A 193
 None
SO4  A   3 (-4.2A)
None
SO4  A   3 ( 4.8A)
 0.82A 6g31D-3nf2A:
24.5		 6g31D-3nf2A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		4 LEU A  75
ASP A  78
ARG A  89
GLN A 149
 None
 1.28A 6g31D-3npkA:
20.8		 6g31D-3npkA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3npk GERANYLTRANSTRANSFER
ASE

(Campylobacter
jejuni) 		PF00348
(polyprenyl_synt) 		4 LEU A  75
ASP A  84
ARG A  89
GLN A 149
 None
 0.53A 6g31D-3npkA:
20.8		 6g31D-3npkA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oh8 NUCLEOSIDE-DIPHOSPHA
TE SUGAR EPIMERASE
(SULA FAMILY)

(Corynebacterium
glutamicum) 		PF01370
(Epimerase)
PF08338
(DUF1731) 		4 LEU A 104
ASP A 107
GLN A 126
GLN A 450
 None
 1.20A 6g31D-3oh8A:
undetectable		 6g31D-3oh8A:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
 0.67A 6g31D-3p41A:
21.1		 6g31D-3p41A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		4 LEU A  79
ASP A  88
ARG A  93
GLN A 153
 None
 0.48A 6g31D-3p8lA:
21.9		 6g31D-3p8lA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		6 LEU A  89
ASP A  92
ASP A  98
ARG A 103
GLN A 163
GLN A 225
 DMA  A 501 ( 4.8A)
MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 ( 3.8A)
 0.63A 6g31D-3q1oA:
22.4		 6g31D-3q1oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 191
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
 0.97A 6g31D-3qqvA:
26.9		 6g31D-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 LEU A 105
ASP A 108
ASP A 112
ARG A 117
GLN A 254
 None
MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
 0.67A 6g31D-3qqvA:
26.9		 6g31D-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ts7 GERANYLTRANSTRANSFER
ASE

(Methylococcus
capsulatus) 		PF00348
(polyprenyl_synt) 		4 LEU A  85
ASP A  94
ARG A  99
GLN A 162
 None
 0.67A 6g31D-3ts7A:
21.7		 6g31D-3ts7A:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txm 26S PROTEASOME
REGULATORY COMPLEX
SUBUNIT P42B

(Drosophila
melanogaster) 		PF01399
(PCI) 		4 LEU A 270
ASP A 266
ASP A 265
GLN A 263
 None
GD3  A   1 (-2.1A)
GD3  A   1 (-3.9A)
GD3  A   1 ( 4.8A)
 1.37A 6g31D-3txmA:
2.1		 6g31D-3txmA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uca GERANYLTRANSTRANSFER
ASE

(Clostridium
perfringens) 		PF00348
(polyprenyl_synt) 		4 LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 0.73A 6g31D-3ucaA:
21.9		 6g31D-3ucaA:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v71 PUF (PUMILIO/FBF)
DOMAIN-CONTAINING
PROTEIN 7, CONFIRMED
BY TRANSCRIPT
EVIDENCE

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 LEU A 382
ASP A 379
ASP A 376
GLN A 427
 None
 1.25A 6g31D-3v71A:
2.2		 6g31D-3v71A:
13.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 LEU A  81
ASP A  84
ARG A  93
GLN A 208
 None
IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 402 (-3.6A)
 0.69A 6g31D-3wjoA:
24.3		 6g31D-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 LEU A  81
ASP A  84
ASP A  88
ARG A  93
 None
IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
 0.42A 6g31D-3wjoA:
24.3		 6g31D-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 LEU A  80
ASP A  83
ASP A  89
ARG A  94
GLN A 157
 None
MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
 0.41A 6g31D-3zouA:
20.8		 6g31D-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zsc PECTATE
TRISACCHARIDE-LYASE

(Thermotoga
maritima) 		PF00544
(Pec_lyase_C) 		4 LEU A 166
ASP A 143
ASP A 117
ARG A 197
 AQA  A1338 ( 4.8A)
None
None
AQA  A1338 (-3.2A)
 1.42A 6g31D-3zscA:
undetectable		 6g31D-3zscA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b52 BACILLOLYSIN

(Paenibacillus
polymyxa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 LEU A   9
ASP A 179
ASP A 178
GLN A 170
 None
CA  A 402 (-3.7A)
CA  A 402 (-2.9A)
CA  A 402 (-2.9A)
 1.22A 6g31D-4b52A:
undetectable		 6g31D-4b52A:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A  59
ASP A 139
GLN A 175
GLN A 182
 None
 1.28A 6g31D-4bc5A:
undetectable		 6g31D-4bc5A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c1o BETA-XYLOSIDASE

(Parageobacillus
thermoglucosidasius) 		PF03512
(Glyco_hydro_52) 		4 LEU A 368
ASP A 367
ARG A 715
GLN A 450
 GOL  A1737 ( 4.9A)
GOL  A1737 (-2.8A)
GOL  A1737 (-3.3A)
None
 1.01A 6g31D-4c1oA:
2.7		 6g31D-4c1oA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 LEU A 122
ASP A 119
ASP A 117
ARG A 145
 None
MG  A1664 ( 3.9A)
None
None
 1.13A 6g31D-4c30A:
undetectable		 6g31D-4c30A:
8.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 ( 3.8A)
 0.58A 6g31D-4e1eA:
24.9		 6g31D-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 0.96A 6g31D-4fp4A:
15.0		 6g31D-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 LEU A  82
ASP A  85
ASP A  89
ARG A  94
 None
 0.57A 6g31D-4gp1A:
25.5		 6g31D-4gp1A:
12.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hwv PECTATE LYASE/AMB
ALLERGEN

(Acidovorax
citrulli) 		PF00544
(Pec_lyase_C) 		4 LEU A 319
ASP A 296
ASP A 241
ARG A 351
 None
CA  A 601 (-3.2A)
CA  A 601 (-2.0A)
None
 1.32A 6g31D-4hwvA:
undetectable		 6g31D-4hwvA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		6 LEU A  95
ASP A  98
ASP A 102
ARG A 107
GLN A 167
GLN A 247
 None
CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
IPE  A 401 (-3.7A)
 0.67A 6g31D-4jzxA:
24.9		 6g31D-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kk2 MONOTERPENE SYNTHASE
FDS-5, CHLOROPLASTIC
- FARNESYL
DIPHOSPHATE SYNTHASE
1 CHIMERA

(Artemisia
spiciformis) 		PF00348
(polyprenyl_synt) 		4 LEU A  94
ASP A  97
ARG A 106
GLN A 165
 None
 0.48A 6g31D-4kk2A:
23.7		 6g31D-4kk2A:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 159
 None
 0.87A 6g31D-4kkmA:
21.8		 6g31D-4kkmA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 LEU A  75
ASP A  78
ARG A  89
GLN A 149
GLN A 210
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
None
 0.82A 6g31D-4lfeA:
22.6		 6g31D-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 LEU A  75
ASP A  78
ASP A  84
ARG A  89
GLN A 149
 IPE  A 301 (-4.7A)
MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
 0.71A 6g31D-4lfeA:
22.6		 6g31D-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 153
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
 0.52A 6g31D-4llsA:
23.1		 6g31D-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 LEU A  77
ASP A  80
ASP A  86
ARG A  91
GLN A 213
 None
CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
IPE  A 301 ( 4.1A)
 0.76A 6g31D-4llsA:
23.1		 6g31D-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkq CYTOKINE RECEPTOR
COMMON SUBUNIT BETA

(Homo sapiens) 		PF00041
(fn3)
PF09240
(IL6Ra-bind) 		4 LEU A 222
ASP A 168
ARG A 221
GLN A 160
 None
 1.29A 6g31D-4nkqA:
undetectable		 6g31D-4nkqA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		4 LEU A 387
ASP A 390
ASP A 394
GLN A 318
 None
 1.36A 6g31D-4oyeA:
undetectable		 6g31D-4oyeA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 171
GLN A 240
 None
MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-3.5A)
 0.54A 6g31D-4p0vA:
25.4		 6g31D-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 LEU A 122
ASP A 125
ARG A 276
GLN A 169
 None
 1.37A 6g31D-4pfzA:
undetectable		 6g31D-4pfzA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmn TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 ASP A 227
ASP A  43
GLN A 213
GLN A 101
 MES  A 301 (-3.6A)
MES  A 301 ( 4.2A)
MES  A 301 (-2.9A)
MES  A 301 (-3.3A)
 1.35A 6g31D-4pmnA:
undetectable		 6g31D-4pmnA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 ASP A 292
ASP A 209
ARG A 294
GLN A 392
 MG  A 506 (-3.2A)
None
None
MG  A 506 (-3.7A)
 1.36A 6g31D-4r7fA:
undetectable		 6g31D-4r7fA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rhh BETA-XYLOSIDASE

(Geobacillus
stearothermophilus) 		PF03512
(Glyco_hydro_52) 		4 LEU A 346
ASP A 345
ARG A 693
GLN A 428
 None
TRS  A 803 (-2.7A)
TRS  A 803 (-3.4A)
None
 1.05A 6g31D-4rhhA:
3.0		 6g31D-4rhhA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN

(Pseudomonas
putida) 		PF13557
(Phenol_MetA_deg) 		4 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.29A 6g31D-4rl8A:
undetectable		 6g31D-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 LEU A 100
ASP A 103
ASP A 107
ARG A 112
GLN A 172
GLN A 252
 3YQ  A3001 ( 4.6A)
MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 ( 4.2A)
 0.74A 6g31D-4rxeA:
25.3		 6g31D-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upk PHOSPHONATE
MONOESTER HYDROLASE

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase) 		4 LEU A 476
ASP A 472
ARG A 475
GLN A 455
 None
 1.18A 6g31D-4upkA:
undetectable		 6g31D-4upkA:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wk5 GERANYLTRANSTRANSFER
ASE

(Thermotoga
neapolitana) 		PF00348
(polyprenyl_synt) 		4 LEU A  71
ASP A  80
ARG A  85
GLN A 198
 None
 0.51A 6g31D-4wk5A:
23.6		 6g31D-4wk5A:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x86 UBIQUITIN-LIKE
PROTEIN 4A
LARGE PROLINE-RICH
PROTEIN BAG6

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		4 LEU A 127
ASP B1106
ARG B1110
GLN B1102
 None
 1.35A 6g31D-4x86A:
undetectable		 6g31D-4x86A:
26.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 LEU B 100
ASP B 103
ASP B 107
ARG B 112
GLN B 172
GLN B 252
 None
MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 ( 4.0A)
 0.65A 6g31D-5ahuB:
23.4		 6g31D-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aog CATIONIC PEROXIDASE
SPC4

(Sorghum bicolor) 		PF00141
(peroxidase) 		4 LEU A  94
ASP A  89
ARG A 330
GLN A  86
 None
NA  A1343 (-3.1A)
None
None
 1.17A 6g31D-5aogA:
undetectable		 6g31D-5aogA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		5 LEU A  83
ASP A  86
ASP A  92
ARG A  97
GLN A 160
 None
 0.77A 6g31D-5aypA:
19.4		 6g31D-5aypA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8h GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 3,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A  89
ASP A  92
ARG A 103
GLN A 166
 None
 1.31A 6g31D-5e8hA:
20.4		 6g31D-5e8hA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 LEU A  88
ASP A  97
ARG A 102
GLN A 163
 None
 1.26A 6g31D-5e8kA:
20.2		 6g31D-5e8kA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8l HETERODIMERIC
GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE LARGE
SUBUNIT 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A  88
ASP A  91
ASP A  97
ARG A 102
GLN A 166
 None
 1.10A 6g31D-5e8lA:
20.5		 6g31D-5e8lA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fl7 ATP SYNTHASE SUBUNIT
ALPHA
ATP SYNTHASE SUBUNIT
BETA

(Yarrowia
lipolytica;
Yarrowia
lipolytica) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 ASP D 390
ASP D 392
GLN A 458
GLN A 241
 None
None
ATP  A 600 (-3.7A)
None
 1.25A 6g31D-5fl7D:
undetectable		 6g31D-5fl7D:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		5 ASP A 126
ASP A 130
ARG A 135
GLN A 195
GLN A 284
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
None
 0.69A 6g31D-5hn7A:
25.5		 6g31D-5hn7A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 LEU A1211
ASP A1178
ARG A1260
GLN A1190
 None
 1.20A 6g31D-5iy9A:
5.1		 6g31D-5iy9A:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		4 ASP A  56
ASP A  60
GLN A 113
GLN A 166
 MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
 0.55A 6g31D-5iysA:
11.2		 6g31D-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		4 LEU A 414
ASP A 411
ARG A 478
GLN A 408
 None
 1.31A 6g31D-5jboA:
undetectable		 6g31D-5jboA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkg DIGUANYLATE
PHOSPHODIESTERASE

(Pseudomonas
aeruginosa) 		PF00563
(EAL) 		4 LEU B  41
ASP B  55
ARG B  43
GLN B 184
 C2E  B 304 ( 3.5A)
C2E  B 304 (-3.8A)
C2E  B 304 (-2.6A)
C2E  B 304 (-3.1A)
 1.14A 6g31D-5mkgB:
undetectable		 6g31D-5mkgB:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2p TRYPTOPHAN SYNTHASE
ALPHA CHAIN

(Sulfolobus
solfataricus) 		no annotation 4 LEU A  64
ASP A  67
ASP A  71
GLN A  16
 None
 1.22A 6g31D-5n2pA:
undetectable		 6g31D-5n2pA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA

(Homo sapiens) 		no annotation 4 LEU A 584
ASP A 583
ASP A2629
GLN A 607
 None
 1.36A 6g31D-5wg6A:
undetectable		 6g31D-5wg6A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 5 ASP A 147
ASP A 151
ARG A 156
GLN A 215
GLN A 284
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-3.7A)
 0.48A 6g31D-6b07A:
25.8		 6g31D-6b07A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 4 LEU D 407
ASP D 455
ARG D 411
GLN D 456
 None
 1.20A 6g31D-6f5dD:
undetectable		 6g31D-6f5dD:
17.28