SIMILAR PATTERNS OF AMINO ACIDS FOR 6G31_A_ZOLA401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ASP A 122
GLN A 175
LYS A 167
GLN A  62
 None
 0.91A 6g31A-1fcpA:
undetectable		 6g31A-1fcpA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nar NARBONIN

(Vicia
narbonensis) 		PF00704
(Glyco_hydro_18) 		4 ASP A 156
ASP A 154
GLN A 114
LYS A 106
 None
 1.37A 6g31A-1narA:
undetectable		 6g31A-1narA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rqj GERANYLTRANSTRANSFER
ASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		6 ASP A 105
ASP A 111
ARG A 116
GLN A 179
LYS A 202
GLN A 241
 MG  A 907 (-2.5A)
MG  A 909 (-2.4A)
RIS  A 901 (-2.7A)
RIS  A 901 (-3.2A)
RIS  A 901 (-2.5A)
RIS  A 901 ( 3.6A)
 1.06A 6g31A-1rqjA:
24.3		 6g31A-1rqjA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 41 KDA
SUBUNIT
ACTIVATOR 1 40 KDA
SUBUNIT

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C)
PF13177
(DNA_pol3_delta2) 		4 ASP E  35
ARG E 166
GLN E  32
LYS D 240
 None
 1.48A 6g31A-1sxjE:
undetectable		 6g31A-1sxjE:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		4 ASP A  79
ARG A  88
GLN A 146
GLN A 209
 None
 1.43A 6g31A-1wmwA:
27.8		 6g31A-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wmw GERANYLGERANYL
DIPHOSPHATE
SYNTHETASE

(Thermus
thermophilus) 		PF00348
(polyprenyl_synt) 		4 ASP A  83
ARG A  88
GLN A 146
GLN A 209
 None
 0.87A 6g31A-1wmwA:
27.8		 6g31A-1wmwA:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 ASP A  90
ARG A  95
GLN A 153
LYS A 242
 None
 0.84A 6g31A-1wy0A:
26.8		 6g31A-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		4 ASP A  90
ARG A  95
GLN A 215
LYS A 242
 None
 0.84A 6g31A-1wy0A:
26.8		 6g31A-1wy0A:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		4 ASP A 737
ASP A 736
LYS A 466
GLN A 546
 CF5  A 841 (-2.5A)
CF5  A 841 ( 2.5A)
None
None
 1.31A 6g31A-2a3lA:
undetectable		 6g31A-2a3lA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2azk GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Sulfolobus
solfataricus) 		PF00348
(polyprenyl_synt) 		4 ASP A  85
ARG A  90
LYS A 160
GLN A 197
 None
 1.13A 6g31A-2azkA:
21.3		 6g31A-2azkA:
14.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 ASP A  80
ASP A  84
ARG A  89
GLN A 147
GLN A 211
LYS A 238
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
MG  A 341 ( 4.6A)
 0.77A 6g31A-2dh4A:
34.8		 6g31A-2dh4A:
39.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dh4 YPL069C

(Saccharomyces
cerevisiae) 		PF00348
(polyprenyl_synt) 		6 ASP A  80
ASP A  84
ARG A  89
GLN A 147
LYS A 174
GLN A 211
 MG  A 341 (-2.6A)
MG  A 341 (-3.0A)
MG  A 341 ( 4.6A)
None
None
None
 0.82A 6g31A-2dh4A:
34.8		 6g31A-2dh4A:
39.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f66 SUPPRESSOR PROTEIN
STP22 OF
TEMPERATURE-SENSITIV
E ALPHA-FACTOR
RECEPTOR AND
ARGININE PERMEASE
PROTEIN SRN2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF09454
(Vps23_core)
PF07200
(Mod_r) 		4 ASP C 182
GLN A 362
GLN A 369
LYS C 186
 None
 1.20A 6g31A-2f66C:
5.6		 6g31A-2f66C:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 ASP A 360
GLN A 374
GLN A 405
LYS A 363
 None
 1.20A 6g31A-2jiiA:
undetectable		 6g31A-2jiiA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1o PUTATIVE FARNESYL
PYROPHOSPHATE
SYNTHASE

(Cryptosporidium
parvum) 		PF00348
(polyprenyl_synt) 		6 ASP A 115
ASP A 119
ARG A 124
GLN A 184
LYS A 210
GLN A 251
 MG  A 503 (-2.5A)
MG  A 502 (-2.4A)
RIS  A 400 (-2.9A)
RIS  A 400 ( 3.5A)
RIS  A 400 (-2.8A)
RIS  A 400 (-3.1A)
 0.99A 6g31A-2o1oA:
24.6		 6g31A-2o1oA:
12.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A  64
ASP A  68
ARG A  73
GLN A 126
GLN A 185
LYS A 212
 GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-3.2A)
GRG  A 500 (-2.8A)
 0.84A 6g31A-2q80A:
41.9		 6g31A-2q80A:
93.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2q80 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A  64
ASP A  68
ARG A  73
GLN A 126
LYS A 151
GLN A 185
 GRG  A 500 (-2.4A)
MG  A 400 (-2.6A)
GRG  A 500 (-2.9A)
GRG  A 500 ( 3.5A)
GRG  A 500 (-2.8A)
GRG  A 500 (-3.2A)
 0.89A 6g31A-2q80A:
41.9		 6g31A-2q80A:
93.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yeq ALKALINE PHOSPHATASE
D

(Bacillus
subtilis) 		PF09423
(PhoD)
PF16655
(PhoD_N) 		4 ASP A 380
ASP A 209
ARG A 506
GLN A 285
 CA  A1525 ( 3.4A)
CA  A1525 (-3.4A)
PO4  A1527 (-3.9A)
NA  A 577 (-3.3A)
 1.48A 6g31A-2yeqA:
undetectable		 6g31A-2yeqA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zg6 PUTATIVE
UNCHARACTERIZED
PROTEIN ST2620

(Sulfurisphaera
tokodaii) 		PF13419
(HAD_2) 		4 ASP A  31
ARG A  79
GLN A  27
LYS A  24
 None
 1.49A 6g31A-2zg6A:
undetectable		 6g31A-2zg6A:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 ASP A 107
ASP A 111
ARG A 116
LYS A 193
 MG  A1000 (-2.9A)
MG  A1001 (-2.8A)
FPP  A1002 (-2.9A)
FPP  A1002 (-2.5A)
 0.79A 6g31A-3aq0A:
25.6		 6g31A-3aq0A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 ASP B  84
ARG B  93
LYS B 170
GLN B 208
 MG  B 326 (-2.6A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
None
 1.28A 6g31A-3aqcB:
26.6		 6g31A-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqc COMPONENT B OF
HEXAPRENYL
DIPHOSPHATE SYNTHASE

(Micrococcus
luteus) 		PF00348
(polyprenyl_synt) 		4 ASP B  84
ASP B  88
ARG B  93
LYS B 170
 MG  B 326 (-2.6A)
MG  B 327 (-2.4A)
2DE  B 329 (-3.8A)
2DE  B 329 (-2.5A)
 0.94A 6g31A-3aqcB:
26.6		 6g31A-3aqcB:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gux PUTATIVE
ZN-DEPENDENT
EXOPEPTIDASE

(Bacteroides
vulgatus) 		PF04389
(Peptidase_M28) 		4 ASP A  45
ARG A 162
LYS A 320
GLN A 324
 None
 1.40A 6g31A-3guxA:
undetectable		 6g31A-3guxA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1d 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 591
ARG A 588
GLN A 594
GLN A 576
 None
 1.50A 6g31A-3k1dA:
undetectable		 6g31A-3k1dA:
7.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lom GERANYLTRANSTRANSFER
ASE

(Legionella
pneumophila) 		PF00348
(polyprenyl_synt) 		4 ASP A 100
ARG A 105
GLN A 168
GLN A 231
 None
 0.90A 6g31A-3lomA:
23.2		 6g31A-3lomA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mzv DECAPRENYL
DIPHOSPHATE SYNTHASE

(Rhodobacter
capsulatus) 		PF00348
(polyprenyl_synt) 		4 ASP A  93
ARG A 102
LYS A 179
GLN A 217
 None
 1.47A 6g31A-3mzvA:
25.5		 6g31A-3mzvA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3or2 SULFITE REDCUTASE
SUBUNIT ALPHA

(Desulfovibrio
gigas) 		PF01077
(NIR_SIR) 		4 ASP A 138
GLN A 104
LYS A 108
LYS A 217
 SRM  A 582 (-3.8A)
None
None
SRM  A 582 (-2.7A)
 1.50A 6g31A-3or2A:
2.4		 6g31A-3or2A:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p41 GERANYLTRANSTRANSFER
ASE

(Pseudomonas
protegens) 		PF00348
(polyprenyl_synt) 		5 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A 297 (-2.5A)
MG  A 297 (-2.5A)
DMA  A 300 (-2.9A)
DMA  A 300 (-3.6A)
POP  A 301 ( 2.4A)
 0.93A 6g31A-3p41A:
21.7		 6g31A-3p41A:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1o GERANYLTRANSTRANSFER
ASE (ISPA)

(Helicobacter
pylori) 		PF00348
(polyprenyl_synt) 		6 ASP A  92
ASP A  98
ARG A 103
GLN A 163
LYS A 186
GLN A 225
 MG  A 400 ( 2.8A)
MG  A 400 ( 3.2A)
DMA  A 501 (-3.0A)
DMA  A 501 (-3.6A)
DMA  A 501 (-3.1A)
DMA  A 501 ( 3.8A)
 1.00A 6g31A-3q1oA:
23.2		 6g31A-3q1oA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q35 VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN 75

(Saccharomyces
cerevisiae) 		PF00956
(NAP) 		4 ASP B  99
ASP B 102
ARG B  30
LYS B 129
 None
 1.27A 6g31A-3q35B:
undetectable		 6g31A-3q35B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 ASP A 108
ARG A 117
GLN A 191
LYS A 215
 MG  A 381 (-2.4A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-3.0A)
 1.02A 6g31A-3qqvA:
27.4		 6g31A-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		4 ASP A 108
ARG A 117
GLN A 191
LYS A 281
 MG  A 381 (-2.4A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.9A)
DMA  A 384 (-2.4A)
 1.20A 6g31A-3qqvA:
27.4		 6g31A-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 ASP A 108
ASP A 112
ARG A 117
GLN A 254
LYS A 281
 MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
DMA  A 384 (-2.4A)
 1.07A 6g31A-3qqvA:
27.4		 6g31A-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qqv GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Corynebacterium
glutamicum) 		PF00348
(polyprenyl_synt) 		5 ASP A 108
ASP A 112
ARG A 117
LYS A 215
GLN A 254
 MG  A 381 (-2.4A)
MG  A 381 (-2.8A)
DMA  A 384 (-3.0A)
DMA  A 384 (-3.0A)
DMA  A 383 (-3.2A)
 0.96A 6g31A-3qqvA:
27.4		 6g31A-3qqvA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ASP A  84
ARG A  93
LYS A 170
GLN A 208
 IPE  A 401 (-2.6A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
IPE  A 402 (-3.6A)
 0.88A 6g31A-3wjoA:
24.8		 6g31A-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		4 ASP A  84
ASP A  88
ARG A  93
LYS A 170
 IPE  A 401 (-2.6A)
IPE  A 401 (-3.3A)
IPE  A 401 ( 4.2A)
IPE  A 401 ( 2.9A)
 0.62A 6g31A-3wjoA:
24.8		 6g31A-3wjoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxy PUTATIVE
UNCHARACTERIZED
PROTEIN CSYB

(Aspergillus
oryzae) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ASP A 107
ARG A 103
GLN A 233
LYS A 361
 None
 1.06A 6g31A-3wxyA:
undetectable		 6g31A-3wxyA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zou FARNESYL
PYROPHOSPHATE
SYNTHASE

(Pseudomonas
aeruginosa) 		PF00348
(polyprenyl_synt) 		5 ASP A  83
ASP A  89
ARG A  94
GLN A 157
LYS A 180
 MG  A1295 (-2.5A)
MG  A1295 (-2.4A)
GPP  A1297 (-3.0A)
GPP  A1297 (-3.7A)
GPP  A1297 (-3.0A)
 0.74A 6g31A-3zouA:
21.4		 6g31A-3zouA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a0l CULLIN-4B

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ASP E 512
ARG E 555
LYS E 565
GLN E 835
 None
 1.26A 6g31A-4a0lE:
undetectable		 6g31A-4a0lE:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e1e FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
cruzi) 		PF00348
(polyprenyl_synt) 		6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 MG  A 403 (-2.5A)
MG  A 403 (-2.4A)
0MW  A 404 (-2.7A)
0MW  A 404 (-3.7A)
0MW  A 404 (-2.8A)
0MW  A 404 ( 3.8A)
 0.97A 6g31A-4e1eA:
25.5		 6g31A-4e1eA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 ASP A  86
ASP A  90
ARG A  95
GLN A 147
GLN A 199
 UNX  A 302 ( 2.6A)
UNX  A 302 ( 3.2A)
UNX  A 302 ( 4.6A)
GER  A 301 ( 4.7A)
None
 1.00A 6g31A-4fp4A:
19.1		 6g31A-4fp4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		4 ASP A  84
LYS A 170
GLN A 208
LYS A 235
 None
 1.39A 6g31A-4jxyA:
25.6		 6g31A-4jxyA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzx FARNESYL
PYROPHOSPHATE
SYNTHASE

(Leishmania
major) 		PF00348
(polyprenyl_synt) 		6 ASP A  98
ASP A 102
ARG A 107
GLN A 167
LYS A 207
GLN A 247
 CA  A 403 (-2.5A)
CA  A 403 (-2.5A)
476  A 402 (-2.9A)
476  A 402 (-3.5A)
476  A 402 (-2.7A)
IPE  A 401 (-3.7A)
 1.04A 6g31A-4jzxA:
25.3		 6g31A-4jzxA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kkm POLYPRENYL
SYNTHETASE

(Zymomonas
mobilis) 		PF00348
(polyprenyl_synt) 		4 ASP A  86
ASP A  92
ARG A  97
GLN A 159
 None
 0.83A 6g31A-4kkmA:
22.5		 6g31A-4kkmA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 ASP A  78
ARG A  89
GLN A 149
LYS A 172
GLN A 210
 MG  A 302 (-2.5A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
None
 1.20A 6g31A-4lfeA:
23.3		 6g31A-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lfe GERANYLGERANYL
DIPHOSPHATE SYNTHASE

(Streptococcus
uberis) 		PF00348
(polyprenyl_synt) 		5 ASP A  78
ASP A  84
ARG A  89
GLN A 149
LYS A 172
 MG  A 302 (-2.5A)
MG  A 302 (-2.4A)
IPE  A 301 (-2.8A)
IPE  A 301 ( 3.7A)
IPE  A 301 (-3.0A)
 0.88A 6g31A-4lfeA:
23.3		 6g31A-4lfeA:
13.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		4 ASP A  80
ARG A  91
GLN A 153
LYS A 178
 CA  A 304 ( 2.9A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
GST  A 302 (-3.4A)
 0.95A 6g31A-4llsA:
23.7		 6g31A-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lls GERANYLTRANSTRANSFER
ASE

(Roseobacter
denitrificans) 		PF00348
(polyprenyl_synt) 		5 ASP A  80
ASP A  86
ARG A  91
GLN A 153
GLN A 213
 CA  A 304 ( 2.9A)
CA  A 305 (-2.3A)
GST  A 302 (-2.9A)
GST  A 302 (-3.7A)
IPE  A 301 ( 4.1A)
 0.83A 6g31A-4llsA:
23.7		 6g31A-4llsA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n7t PHOSPHOPENTOMUTASE

(Streptococcus
mutans) 		PF01676
(Metalloenzyme) 		4 ASP A  13
ASP A 339
LYS A 249
LYS A  93
 MN  A 501 (-2.0A)
MN  A 501 (-2.2A)
TPO  A  92 ( 3.6A)
TPO  A  92 ( 2.9A)
 1.19A 6g31A-4n7tA:
undetectable		 6g31A-4n7tA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p0v FARNESYL
PYROPHOSPHATE
SYNTHASE

(Homo sapiens) 		PF00348
(polyprenyl_synt) 		6 ASP A 103
ASP A 107
ARG A 112
GLN A 171
LYS A 200
GLN A 240
 MG  A 405 (-2.5A)
MG  A 405 (-2.4A)
ZOL  A 401 ( 2.7A)
ZOL  A 401 ( 3.8A)
ZOL  A 401 (-2.7A)
ZOL  A 401 (-3.5A)
 1.07A 6g31A-4p0vA:
26.2		 6g31A-4p0vA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmn TAT-SECRETED PROTEIN
RV2525C

(Mycobacterium
tuberculosis) 		PF08924
(DUF1906) 		4 ASP A 227
ASP A  43
GLN A 213
GLN A 101
 MES  A 301 (-3.6A)
MES  A 301 ( 4.2A)
MES  A 301 (-2.9A)
MES  A 301 (-3.3A)
 1.29A 6g31A-4pmnA:
undetectable		 6g31A-4pmnA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 ASP A  98
GLN A 119
GLN A 345
LYS A 332
 None
 1.34A 6g31A-4r6hA:
undetectable		 6g31A-4r6hA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r6h SOLUTE BINDING
PROTEIN MSME

(Bacillus
subtilis) 		PF01547
(SBP_bac_1) 		4 ASP A  98
GLN A 119
LYS A 121
LYS A 332
 None
 1.08A 6g31A-4r6hA:
undetectable		 6g31A-4r6hA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7f UNCHARACTERIZED
PROTEIN

(Parabacteroides
merdae) 		PF17116
(DUF5103) 		4 ASP A 292
ASP A 209
ARG A 294
GLN A 392
 MG  A 506 (-3.2A)
None
None
MG  A 506 (-3.7A)
 1.41A 6g31A-4r7fA:
undetectable		 6g31A-4r7fA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rl8 PROTEIN INVOLVED IN
META-PATHWAY OF
PHENOL
DEGRADATION-LIKE
PROTEIN

(Pseudomonas
putida) 		PF13557
(Phenol_MetA_deg) 		4 ASP A   4
ASP A   7
GLN A 241
GLN A  23
 None
C8E  A 303 (-3.8A)
None
None
 1.44A 6g31A-4rl8A:
undetectable		 6g31A-4rl8A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 ASP A 103
ASP A 107
ARG A 112
GLN A 172
LYS A 212
GLN A 252
 MG  A3004 (-2.5A)
MG  A3004 (-2.3A)
3YQ  A3001 (-2.8A)
MG  A3004 ( 3.8A)
3YQ  A3001 (-2.9A)
3YQ  A3001 ( 4.2A)
 0.97A 6g31A-4rxeA:
25.7		 6g31A-4rxeA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x81 MYCINAMICIN III
3''-O-METHYLTRANSFER
ASE

(Micromonospora
griseorubida) 		PF05711
(TylF) 		4 ASP A 216
ASP A 217
ARG A 187
GLN A 246
 MG  A 304 ( 2.9A)
MG  A 304 ( 2.6A)
None
MVI  A 305 (-3.3A)
 1.49A 6g31A-4x81A:
undetectable		 6g31A-4x81A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 ASP A 308
ARG A 158
GLN A 306
GLN A 290
 FAD  A 701 (-2.9A)
FAD  A 701 (-3.9A)
None
FAD  A 701 (-3.8A)
 1.49A 6g31A-5ahkA:
undetectable		 6g31A-5ahkA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahu FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		6 ASP B 103
ASP B 107
ARG B 112
GLN B 172
LYS B 212
GLN B 252
 MG  B1370 (-2.5A)
MG  B1369 (-2.2A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.1A)
G76  B1368 (-2.8A)
G76  B1368 ( 4.0A)
 1.03A 6g31A-5ahuB:
22.8		 6g31A-5ahuB:
13.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ayp FARNESYL DIPHOSPHATE
SYNTHASE

(Geobacillus
stearothermophilus) 		PF00348
(polyprenyl_synt) 		4 ASP A  86
ASP A  92
ARG A  97
GLN A 160
 None
 0.79A 6g31A-5aypA:
20.0		 6g31A-5aypA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bw0 TYPE II SECRETION
SYSTEM PROTEIN J

(Pseudomonas
aeruginosa) 		PF11612
(T2SSJ) 		4 ASP A  60
ARG A  59
GLN A 109
GLN A 139
 None
 1.20A 6g31A-5bw0A:
undetectable		 6g31A-5bw0A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9d FARNESYL
PYROPHOSPHATE
SYNTHETASE

(Staphylococcus
aureus) 		PF00348
(polyprenyl_synt) 		4 ASP A  82
ARG A  91
LYS A 168
GLN A 206
 None
PO4  A 501 ( 4.9A)
None
None
 1.42A 6g31A-5h9dA:
26.6		 6g31A-5h9dA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn7 FARNESYL
PYROPHOSPHATE
SYNTHASE, PUTATIVE

(Plasmodium
vivax) 		PF00348
(polyprenyl_synt) 		6 ASP A 126
ASP A 130
ARG A 135
GLN A 195
LYS A 243
GLN A 284
 04M  A 401 ( 4.0A)
None
04M  A 401 (-3.5A)
04M  A 401 (-3.3A)
04M  A 401 (-4.5A)
None
 0.76A 6g31A-5hn7A:
26.1		 6g31A-5hn7A:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iys PHYTOENE SYNTHASE

(Enterococcus
hirae) 		PF00494
(SQS_PSY) 		4 ASP A  56
ASP A  60
GLN A 113
GLN A 166
 MG  A 505 (-2.5A)
MG  A 504 (-2.5A)
MG  A 504 (-3.9A)
FPS  A 507 (-3.9A)
 0.50A 6g31A-5iysA:
11.6		 6g31A-5iysA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j2s KILLER CELL
LECTIN-LIKE RECEPTOR
SUBFAMILY B MEMBER
1B ALLELE A

(Rattus
norvegicus) 		no annotation 4 ASP A 134
GLN A 102
LYS A 104
GLN A 211
 None
 1.41A 6g31A-5j2sA:
undetectable		 6g31A-5j2sA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b07 FARNESYL DIPHOSPHATE
SYNTHASE

(Choristoneura
fumiferana) 		no annotation 6 ASP A 147
ASP A 151
ARG A 156
GLN A 215
LYS A 244
GLN A 284
 MG  A 402 (-2.6A)
MG  A 402 (-2.5A)
C6M  A 401 (-2.7A)
C6M  A 401 (-3.3A)
C6M  A 401 (-2.6A)
C6M  A 401 (-3.7A)
 0.95A 6g31A-6b07A:
26.3		 6g31A-6b07A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ffl MALTOSE/MALTODEXTRIN
TRANSPORT PERMEASE
HOMOLOGUE

(Bdellovibrio
bacteriovorus) 		no annotation 4 ASP A 240
ARG A  16
GLN A 243
LYS A 224
 None
SO4  A 406 (-2.8A)
None
None
 1.42A 6g31A-6fflA:
undetectable		 6g31A-6fflA:
16.28