SIMILAR PATTERNS OF AMINO ACIDS FOR 6G2P_B_TRPB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b25 PROTEIN
(FORMALDEHYDE
FERREDOXIN
OXIDOREDUCTASE)

(Pyrococcus
furiosus) 		PF01314
(AFOR_C)
PF02730
(AFOR_N) 		5 ARG A 534
ALA A 471
LEU A 579
LEU A 580
TYR A 584
 None
 1.41A 6g2pB-1b25A:
0.0		 6g2pB-1b25A:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j31 HYPOTHETICAL PROTEIN
PH0642

(Pyrococcus
horikoshii) 		PF00795
(CN_hydrolase) 		5 ALA A  88
LEU A  16
TYR A  20
ASP A  45
VAL A  59
 None
 1.42A 6g2pB-1j31A:
0.0		 6g2pB-1j31A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kqo NICOTINAMIDE
MONONUCLEOTIDE
ADENYLYL TRANSFERASE

(Homo sapiens) 		PF01467
(CTP_transf_like) 		5 ARG A  40
TYR A  34
ALA A  31
HIS A 211
VAL A   9
 None
 1.32A 6g2pB-1kqoA:
0.5		 6g2pB-1kqoA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4i AMINOGLYCOSIDE
2'-N-ACETYLTRANSFERA
SE

(Mycobacterium
tuberculosis) 		PF13527
(Acetyltransf_9) 		5 ALA A  62
LEU A  99
LEU A 100
TYR A 126
VAL A  96
 None
None
None
None
COA  A 600 (-3.8A)
 1.49A 6g2pB-1m4iA:
undetectable		 6g2pB-1m4iA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ

(Glycine max) 		PF00190
(Cupin_1) 		5 TYR A 247
HIS A 203
LEU A 190
TYR A 209
VAL A 168
 None
 1.35A 6g2pB-1uikA:
0.0		 6g2pB-1uikA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wv9 RHODANESE HOMOLOG
TT1651

(Thermus
thermophilus) 		no annotation 5 ALA A  69
LEU A  58
LEU A  56
TYR A  78
VAL A  20
 None
 1.38A 6g2pB-1wv9A:
undetectable		 6g2pB-1wv9A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z72 TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Streptococcus
pneumoniae) 		PF03070
(TENA_THI-4) 		5 TYR A   6
ALA A   7
LEU A 150
ASP A 151
VAL A 181
 None
 1.23A 6g2pB-1z72A:
0.0		 6g2pB-1z72A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckn BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Mus musculus) 		PF00047
(ig) 		5 ALA A  83
LEU A  40
ASP A  84
VAL A  77
TRP A  55
 None
 1.49A 6g2pB-2cknA:
undetectable		 6g2pB-2cknA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dml PROTEIN
DISULFIDE-ISOMERASE
A6

(Mus musculus) 		PF00085
(Thioredoxin) 		5 ALA A 122
LEU A  37
LEU A  39
TYR A 106
VAL A  68
 None
 1.47A 6g2pB-2dmlA:
0.0		 6g2pB-2dmlA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oip CHAIN A, CRYSTAL
STRUCTURE OF DHFR

(Cryptosporidium
hominis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A 436
LEU A 280
LEU A 281
TYR A 240
VAL A 286
 None
 1.42A 6g2pB-2oipA:
undetectable		 6g2pB-2oipA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pn1 CARBAMOYLPHOSPHATE
SYNTHASE LARGE
SUBUNIT

(Exiguobacterium
sibiricum) 		PF02655
(ATP-grasp_3) 		5 ARG A 227
LEU A 262
LEU A 194
ASP A 257
VAL A 234
 None
 1.33A 6g2pB-2pn1A:
undetectable		 6g2pB-2pn1A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2tdd THYMIDYLATE SYNTHASE

(Lactobacillus
casei) 		PF00303
(Thymidylat_synt) 		5 ALA A 231
LEU A  46
LEU A  47
TYR A   6
VAL A  52
 None
 1.27A 6g2pB-2tddA:
undetectable		 6g2pB-2tddA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 TYR A 765
ALA A 732
LEU A 866
TYR A 844
VAL A 819
 None
 1.41A 6g2pB-2xvgA:
undetectable		 6g2pB-2xvgA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxh MAZG-RELATED PROTEIN

(Thermotoga
maritima) 		PF03819
(MazG) 		5 ALA A  30
LEU A  27
LEU A  63
TYR A  59
ASP A  60
 MG  A 501 ( 4.6A)
None
None
None
MG  A 501 (-2.5A)
 1.44A 6g2pB-2yxhA:
undetectable		 6g2pB-2yxhA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i5b WSPR RESPONSE
REGULATOR

(Pseudomonas
aeruginosa) 		PF00990
(GGDEF) 		5 ARG A 313
TYR A 250
ALA A 248
LEU A 205
VAL A 258
 None
 1.46A 6g2pB-3i5bA:
0.3		 6g2pB-3i5bA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		5 ALA A 426
LEU A 271
LEU A 272
TYR A 231
VAL A 277
 None
 1.41A 6g2pB-3kjrA:
undetectable		 6g2pB-3kjrA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lf2 SHORT CHAIN
OXIDOREDUCTASE
Q9HYA2

(Pseudomonas
aeruginosa) 		PF13561
(adh_short_C2) 		5 ARG A  53
ALA A  11
LEU A  28
LEU A  29
VAL A  25
 None
 1.25A 6g2pB-3lf2A:
5.0		 6g2pB-3lf2A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4x NOL1/NOP2/SUN FAMILY
PROTEIN

(Enterococcus
faecium) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N)
PF17126
(RsmF_methylt_CI) 		5 LEU A 401
LEU A 428
TYR A 411
VAL A 426
TRP A 425
 None
 1.33A 6g2pB-3m4xA:
1.8		 6g2pB-3m4xA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr2 TRYPTOPHAN SYNTHASE
BETA CHAIN

(Salmonella
enterica) 		PF00291
(PALP) 		5 TYR B 186
LEU B  21
LEU B  25
TYR B 197
VAL B  17
 None
 1.48A 6g2pB-3pr2B:
0.0		 6g2pB-3pr2B:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vla EDGP

(Daucus carota) 		PF14541
(TAXi_C)
PF14543
(TAXi_N) 		5 ALA A 179
LEU A 383
LEU A 212
TYR A 214
VAL A 207
 None
 1.29A 6g2pB-3vlaA:
undetectable		 6g2pB-3vlaA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxs VENOM PROTHROMBIN
ACTIVATOR
PSEUTARIN-C
NON-CATALYTIC
SUBUNIT

(Pseudonaja
textilis) 		PF00754
(F5_F8_type_C)
PF07732
(Cu-oxidase_3) 		5 TYR V 941
ALA V 940
LEU V1041
LEU V 855
VAL V 980
 None
 1.25A 6g2pB-4bxsV:
undetectable		 6g2pB-4bxsV:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ew6 D-GALACTOSE-1-DEHYDR
OGENASE PROTEIN

(Rhizobium etli) 		PF01408
(GFO_IDH_MocA) 		5 TYR A  73
ALA A  75
LEU A  65
LEU A  88
VAL A  86
 None
 1.20A 6g2pB-4ew6A:
undetectable		 6g2pB-4ew6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fog THYMIDYLATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00303
(Thymidylat_synt) 		5 ALA A 179
LEU A  44
LEU A  45
TYR A   4
VAL A  50
 None
 1.44A 6g2pB-4fogA:
undetectable		 6g2pB-4fogA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8z DIHYDROFOLATE
REDUCTASE

(Pneumocystis
jirovecii) 		PF00186
(DHFR_1) 		5 ALA X 101
HIS X 135
LEU X  56
LEU X 128
VAL X 122
 None
None
None
NDP  X 302 (-4.0A)
None
 1.18A 6g2pB-4g8zX:
undetectable		 6g2pB-4g8zX:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksa MALONYL-COA
DECARBOXYLASE

(Rhodopseudomonas
palustris) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 TYR A 370
ALA A 367
LEU A 399
LEU A 396
VAL A 418
 None
 1.25A 6g2pB-4ksaA:
undetectable		 6g2pB-4ksaA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksf MALONYL-COA
DECARBOXYLASE

(Agrobacterium
vitis) 		PF05292
(MCD)
PF17408
(MCD_N) 		5 TYR A 362
ALA A 359
LEU A 391
LEU A 388
VAL A 410
 None
 1.29A 6g2pB-4ksfA:
undetectable		 6g2pB-4ksfA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qb9 ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN

(Mycolicibacterium
smegmatis) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		5 TYR A 360
ALA A 134
LEU A 292
LEU A  69
VAL A 117
 None
 1.44A 6g2pB-4qb9A:
undetectable		 6g2pB-4qb9A:
25.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfu GLYCOSIDE HYDROLASE
FAMILY 5

(Bacteroides
vulgatus) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 TYR A 322
ALA A 309
LEU A 363
LEU A  56
TYR A  84
 None
 1.37A 6g2pB-4qfuA:
undetectable		 6g2pB-4qfuA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r85 CYTOSINE DEAMINASE

(Klebsiella
pneumoniae) 		PF07969
(Amidohydro_3) 		5 ARG A  98
LEU A 128
LEU A 131
VAL A 118
TRP A  83
 None
 1.38A 6g2pB-4r85A:
undetectable		 6g2pB-4r85A:
23.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd0 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Paenarthrobacter
aurescens) 		PF00977
(His_biosynth) 		5 LEU A 113
LEU A 160
TYR A 168
VAL A 156
TRP A 154
 None
 1.29A 6g2pB-4wd0A:
undetectable		 6g2pB-4wd0A:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aee ALPHA-GLUCOSIDASE
YIHQ

(Escherichia
coli) 		PF01055
(Glyco_hydro_31) 		5 ALA A 616
HIS A 637
LEU A 628
LEU A 630
VAL A 649
 None
 1.37A 6g2pB-5aeeA:
undetectable		 6g2pB-5aeeA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 TYR A 734
ALA A 701
LEU A 835
TYR A 813
VAL A 788
 None
 1.46A 6g2pB-5jouA:
undetectable		 6g2pB-5jouA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5msy GLYCOSIDE HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF12904
(Collagen_bind_2)
PF13204
(DUF4038) 		5 TYR A 324
ALA A 311
LEU A 362
LEU A  58
TYR A  86
 None
 1.38A 6g2pB-5msyA:
undetectable		 6g2pB-5msyA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 TYR A 239
ALA A 242
LEU A 379
TYR A 400
VAL A 378
 None
 1.41A 6g2pB-5u4hA:
undetectable		 6g2pB-5u4hA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xeq MAM
DOMAIN-CONTAINING
GLYCOSYLPHOSPHATIDYL
INOSITOL ANCHOR
PROTEIN 1

(Homo sapiens) 		PF13927
(Ig_3) 		5 LEU B 201
LEU B 204
TYR B 209
ASP B 208
VAL B 153
 None
 1.42A 6g2pB-5xeqB:
undetectable		 6g2pB-5xeqB:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esd FLAVIN-DEPENDENT
L-TRYPTOPHAN OXIDASE
VIOA

(Chromobacterium
violaceum) 		no annotation 9 ARG B  64
TYR B 143
ALA B 145
HIS B 163
LEU B 267
TYR B 309
ASP B 311
VAL B 363
TRP B 397
 CL  B 502 ( 3.6A)
None
None
CL  B 502 ( 4.9A)
FAD  B 501 (-3.8A)
None
None
None
FAD  B 501 (-4.9A)
 0.27A 6g2pB-6esdB:
61.3		 6g2pB-6esdB:
undetectable