SIMILAR PATTERNS OF AMINO ACIDS FOR 6G1P_B_ACTB403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8v MATURE CAPSID
PROTEIN BETA


(Pariacoto virus)
PF01829
(Peptidase_A6)
3 PHE A  81
ARG A 160
GLN A 320
None
1.10A 6g1pB-1f8vA:
0.0
6g1pB-1f8vA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iah TRANSIENT RECEPTOR
POTENTIAL-RELATED
PROTEIN


(Mus musculus)
PF02816
(Alpha_kinase)
3 PHE A1791
ARG A1671
GLN A1675
None
1.17A 6g1pB-1iahA:
undetectable
6g1pB-1iahA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmc PROTEIN (REPLICATION
PROTEIN A (RPA))


(Homo sapiens)
PF01336
(tRNA_anti-codon)
PF16900
(REPA_OB_2)
3 PHE A 415
ARG A 412
GLN A 420
None
1.02A 6g1pB-1jmcA:
undetectable
6g1pB-1jmcA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8f ENDOGLUCANASE

(Melanocarpus
albomyces)
PF02015
(Glyco_hydro_45)
3 PHE A  41
ARG A  19
GLN A  26
None
1.10A 6g1pB-1l8fA:
undetectable
6g1pB-1l8fA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mpo MALTOPORIN

(Escherichia
coli)
PF02264
(LamB)
3 PHE A  23
ARG A 405
GLN A  21
None
0.79A 6g1pB-1mpoA:
undetectable
6g1pB-1mpoA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n76 LACTOFERRIN

(Homo sapiens)
PF00405
(Transferrin)
3 PHE A  20
ARG A  24
GLN A  23
None
0.93A 6g1pB-1n76A:
0.0
6g1pB-1n76A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd7 WW DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00632
(HECT)
3 PHE A 891
ARG A 893
GLN A 871
None
1.03A 6g1pB-1nd7A:
0.0
6g1pB-1nd7A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohf NUDAURELIA CAPENSIS
OMEGA VIRUS CAPSID
PROTEIN


(Nudaurelia
capensis omega
virus)
PF03566
(Peptidase_A21)
3 PHE A 491
ARG A 495
GLN A 324
None
1.17A 6g1pB-1ohfA:
0.0
6g1pB-1ohfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6m RIBONUCLEASE PH

(Pseudomonas
aeruginosa)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
3 PHE A 230
ARG A 234
GLN A 233
None
1.08A 6g1pB-1r6mA:
undetectable
6g1pB-1r6mA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlv TRANSCRIPTION
ANTITERMINATOR LICT


(Bacillus
subtilis)
PF00874
(PRD)
3 PHE A 210
ARG A 214
GLN A 213
None
1.15A 6g1pB-1tlvA:
0.0
6g1pB-1tlvA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w4t ARYLAMINE
N-ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00797
(Acetyltransf_2)
3 PHE A 228
ARG A 240
GLN A 230
None
1.10A 6g1pB-1w4tA:
0.0
6g1pB-1w4tA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls ORPHAN NUCLEAR
RECEPTOR NR1I3


(Mus musculus)
PF00104
(Hormone_recep)
3 PHE E 145
ARG E 146
GLN E 144
None
1.18A 6g1pB-1xlsE:
0.3
6g1pB-1xlsE:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xv9 ORPHAN NUCLEAR
RECEPTOR NR1I3


(Homo sapiens)
PF00104
(Hormone_recep)
3 PHE B 135
ARG B 136
GLN B 134
None
1.03A 6g1pB-1xv9B:
0.0
6g1pB-1xv9B:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z14 VP2

(Rodent
protoparvovirus
1)
PF00740
(Parvo_coat)
3 PHE A 338
ARG A 407
GLN A 340
None
1.00A 6g1pB-1z14A:
undetectable
6g1pB-1z14A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1n SIXTEEN HEME
CYTOCHROME


(Desulfovibrio
gigas)
PF02085
(Cytochrom_CIII)
PF14522
(Cytochrome_C7)
3 PHE X 487
ARG X 490
GLN X 488
None
1.14A 6g1pB-1z1nX:
0.0
6g1pB-1z1nX:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5u COLICIN E3

(Escherichia
coli)
PF03515
(Cloacin)
PF09000
(Cytotoxic)
PF11570
(E2R135)
3 PHE A 375
ARG A 377
GLN A 374
None
1.16A 6g1pB-2b5uA:
undetectable
6g1pB-2b5uA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cly ATP SYNTHASE B
CHAIN, MITOCHONDRIAL


(Bos taurus)
PF05405
(Mt_ATP-synt_B)
3 PHE A 125
ARG A 129
GLN A 128
None
0.74A 6g1pB-2clyA:
undetectable
6g1pB-2clyA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7c RAB11
FAMILY-INTERACTING
PROTEIN 3


(Homo sapiens)
PF09457
(RBD-FIP)
3 PHE C 732
ARG C 733
GLN C 735
None
0.99A 6g1pB-2d7cC:
undetectable
6g1pB-2d7cC:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dn0 ZINC FINGERS AND
HOMEOBOXES PROTEIN 3


(Homo sapiens)
PF00046
(Homeobox)
3 PHE A  32
ARG A  60
GLN A  31
None
1.14A 6g1pB-2dn0A:
undetectable
6g1pB-2dn0A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1z UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7


(Homo sapiens)
PF00443
(UCH)
PF00917
(MATH)
3 PHE A 234
ARG A 239
GLN A 230
None
1.16A 6g1pB-2f1zA:
undetectable
6g1pB-2f1zA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3t TRAFFICKING PROTEIN
PARTICLE COMPLEX
SUBUNIT 6A


(Homo sapiens)
PF04051
(TRAPP)
3 PHE B  42
ARG B  43
GLN B  46
None
0.92A 6g1pB-2j3tB:
undetectable
6g1pB-2j3tB:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgl MESODERM DEVELOPMENT
CANDIDATE 2


(Mus musculus)
PF10185
(Mesd)
3 PHE A 112
ARG A 111
GLN A 110
None
1.11A 6g1pB-2kglA:
undetectable
6g1pB-2kglA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2moq IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B


(Staphylococcus
aureus)
PF05031
(NEAT)
3 PHE A 194
ARG A 130
GLN A 193
None
1.17A 6g1pB-2moqA:
undetectable
6g1pB-2moqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2moq IRON-REGULATED
SURFACE DETERMINANT
PROTEIN B


(Staphylococcus
aureus)
PF05031
(NEAT)
3 PHE A 242
ARG A 130
GLN A 193
None
0.99A 6g1pB-2moqA:
undetectable
6g1pB-2moqA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpr MALTOPORIN

(Salmonella
enterica)
PF02264
(LamB)
3 PHE A  23
ARG A 411
GLN A  21
None
0.91A 6g1pB-2mprA:
undetectable
6g1pB-2mprA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens)
PF00089
(Trypsin)
PF00092
(VWA)
3 PHE A 713
ARG A 714
GLN A 716
None
1.18A 6g1pB-2odpA:
undetectable
6g1pB-2odpA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbp ENOYL-COA HYDRATASE
SUBUNIT I


(Geobacillus
kaustophilus)
PF00378
(ECH_1)
3 PHE A 255
ARG A  51
GLN A 200
None
1.06A 6g1pB-2pbpA:
undetectable
6g1pB-2pbpA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q0f RNA URIDYLYL
TRANSFERASE


(Trypanosoma
brucei)
PF03828
(PAP_assoc)
3 PHE A 247
ARG A 202
GLN A 201
None
1.09A 6g1pB-2q0fA:
undetectable
6g1pB-2q0fA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1


(Alphapapillomavirus
9)
PF00500
(Late_protein_L1)
3 PHE A 305
ARG A 336
GLN A 155
None
1.18A 6g1pB-2r5jA:
undetectable
6g1pB-2r5jA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5j MAJOR CAPSID PROTEIN
L1


(Alphapapillomavirus
9)
PF00500
(Late_protein_L1)
3 PHE A 462
ARG A 466
GLN A 461
None
1.04A 6g1pB-2r5jA:
undetectable
6g1pB-2r5jA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r5k MAJOR CAPSID PROTEIN
L1


(Alphapapillomavirus
10)
PF00500
(Late_protein_L1)
3 PHE A 458
ARG A 462
GLN A 457
None
1.06A 6g1pB-2r5kA:
undetectable
6g1pB-2r5kA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wss ATP SYNTHASE SUBUNIT
B, MITOCHONDRIAL


(Bos taurus)
PF05405
(Mt_ATP-synt_B)
3 PHE T 125
ARG T 129
GLN T 128
None
1.09A 6g1pB-2wssT:
undetectable
6g1pB-2wssT:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
3 PHE A 559
ARG A 124
GLN A 170
None
1.15A 6g1pB-2x40A:
undetectable
6g1pB-2x40A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum)
PF00199
(Catalase)
PF06628
(Catalase-rel)
3 PHE A 681
ARG A 684
GLN A 656
None
0.98A 6g1pB-2xf2A:
undetectable
6g1pB-2xf2A:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjc CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE


(Homo sapiens)
PF00233
(PDEase_I)
3 PHE A 736
ARG A 740
GLN A 827
None
1.14A 6g1pB-3bjcA:
undetectable
6g1pB-3bjcA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d5l REGULATORY PROTEIN
RECX


(Lactobacillus
reuteri)
PF02631
(RecX)
3 PHE A  36
ARG A  37
GLN A  35
None
1.12A 6g1pB-3d5lA:
undetectable
6g1pB-3d5lA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
3 PHE A 996
ARG A 997
GLN A1000
None
1.11A 6g1pB-3egwA:
undetectable
6g1pB-3egwA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h5t TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Corynebacterium
glutamicum)
PF00356
(LacI)
PF13377
(Peripla_BP_3)
3 PHE A 256
ARG A 252
GLN A 253
None
1.13A 6g1pB-3h5tA:
undetectable
6g1pB-3h5tA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq9 CYTOCHROME C551
PEROXIDASE


(Geobacter
sulfurreducens)
PF00034
(Cytochrom_C)
PF03150
(CCP_MauG)
3 PHE A 115
ARG A 268
GLN A 114
BU3  A 350 ( 4.2A)
HEM  A 400 (-4.3A)
BU3  A 350 (-4.1A)
1.00A 6g1pB-3hq9A:
undetectable
6g1pB-3hq9A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3inn PANTOTHENATE
SYNTHETASE


(Brucella
melitensis)
PF02569
(Pantoate_ligase)
3 PHE A  62
ARG A 121
GLN A  61
UNX  A 303 ( 4.0A)
UNX  A 303 ( 3.3A)
ATP  A 300 (-3.1A)
1.17A 6g1pB-3innA:
undetectable
6g1pB-3innA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j2v PREC/CORE PROTEIN

(Hepatitis B
virus)
no annotation 3 PHE C  24
ARG C  98
GLN C  99
None
1.03A 6g1pB-3j2vC:
undetectable
6g1pB-3j2vC:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kew DHHA1 DOMAIN PROTEIN

(Clostridium
perfringens)
PF01411
(tRNA-synt_2c)
PF07973
(tRNA_SAD)
3 PHE A  38
ARG A  89
GLN A  44
None
0.83A 6g1pB-3kewA:
undetectable
6g1pB-3kewA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krm INSULIN-LIKE GROWTH
FACTOR 2
MRNA-BINDING PROTEIN
1


(Homo sapiens)
PF00013
(KH_1)
3 PHE A 464
ARG A 551
GLN A 547
None
1.17A 6g1pB-3krmA:
undetectable
6g1pB-3krmA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l7g XAA-PRO DIPEPTIDASE

(Alteromonas sp.)
PF00557
(Peptidase_M24)
3 PHE A 230
ARG A 232
GLN A 197
None
0.93A 6g1pB-3l7gA:
undetectable
6g1pB-3l7gA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lmm UNCHARACTERIZED
PROTEIN


(Corynebacterium
diphtheriae)
PF04326
(AlbA_2)
PF13749
(HATPase_c_4)
3 PHE A 110
ARG A 106
GLN A 107
None
1.12A 6g1pB-3lmmA:
undetectable
6g1pB-3lmmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN


(Schizosaccharomyces
pombe)
PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
3 PHE A 505
ARG A 546
GLN A 503
None
0.87A 6g1pB-3mcaA:
undetectable
6g1pB-3mcaA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ovk AMINOPEPTIDASE P,
XAA-PRO DIPEPTIDASE


(Streptococcus
pyogenes)
PF01321
(Creatinase_N)
3 PHE A   4
ARG A   8
GLN A   7
None
1.00A 6g1pB-3ovkA:
undetectable
6g1pB-3ovkA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p30 1281 FAB HEAVY CHAIN

(Homo sapiens)
PF07654
(C1-set)
PF07686
(V-set)
3 PHE H  63
ARG H  66
GLN H  62
None
1.11A 6g1pB-3p30H:
undetectable
6g1pB-3p30H:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shq UBLCP1

(Drosophila
melanogaster)
PF00240
(ubiquitin)
PF03031
(NIF)
3 PHE A  35
ARG A  36
GLN A  39
None
1.16A 6g1pB-3shqA:
undetectable
6g1pB-3shqA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swx PROBABLE ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacteroides
abscessus)
PF00378
(ECH_1)
3 PHE A 258
ARG A  51
GLN A 203
None
0.85A 6g1pB-3swxA:
undetectable
6g1pB-3swxA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE


(Burkholderia
thailandensis)
PF02569
(Pantoate_ligase)
3 PHE A  58
ARG A 118
GLN A  57
None
MLT  A 284 (-3.3A)
EDO  A 285 ( 3.0A)
1.17A 6g1pB-3uk2A:
undetectable
6g1pB-3uk2A:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uy4 PANTOTHENATE
SYNTHETASE


(Campylobacter
jejuni)
PF02569
(Pantoate_ligase)
3 PHE A  61
ARG A 120
GLN A  60
None
PAU  A 302 (-3.1A)
PAU  A 302 (-2.9A)
1.18A 6g1pB-3uy4A:
undetectable
6g1pB-3uy4A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9i MULTIDRUG RESISTANCE
PROTEIN MEXB


(Pseudomonas
aeruginosa)
PF00873
(ACR_tran)
3 PHE A 666
ARG A 716
GLN A 575
None
1.05A 6g1pB-3w9iA:
undetectable
6g1pB-3w9iA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgb PHOSPHOENOLPYRUVATE
CARBOXYLASE


(Flaveria
pringlei)
PF00311
(PEPcase)
3 PHE A 682
ARG A 683
GLN A 686
None
1.15A 6g1pB-3zgbA:
undetectable
6g1pB-3zgbA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zq3 OBP3 PROTEIN

(Rattus
norvegicus)
PF00061
(Lipocalin)
3 PHE A  39
ARG A 175
GLN A  62
None
1.16A 6g1pB-3zq3A:
undetectable
6g1pB-3zq3A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2q ATP SYNTHASE SUBUNIT
B, MITOCHONDRIAL


(Bos taurus)
PF05405
(Mt_ATP-synt_B)
3 PHE T 125
ARG T 129
GLN T 128
None
0.73A 6g1pB-4b2qT:
undetectable
6g1pB-4b2qT:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpl IMPORTIN SUBUNIT
ALPHA-1A


(Oryza sativa)
PF00514
(Arm)
PF16186
(Arm_3)
3 PHE A 123
ARG A 126
GLN A 122
None
1.07A 6g1pB-4bplA:
undetectable
6g1pB-4bplA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE


(Aspergillus
fumigatus)
PF11991
(Trp_DMAT)
3 PHE A 146
ARG A 148
GLN A 204
None
1.16A 6g1pB-4e0tA:
undetectable
6g1pB-4e0tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0l AMIDOHYDROLASE

(Brucella
abortus)
PF01979
(Amidohydro_1)
3 PHE A  83
ARG A  87
GLN A 241
None
1.00A 6g1pB-4f0lA:
undetectable
6g1pB-4f0lA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmk POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 2


(Mus musculus)
PF07686
(V-set)
PF08205
(C2-set_2)
3 PHE A  93
ARG A  97
GLN A  92
None
1.14A 6g1pB-4fmkA:
undetectable
6g1pB-4fmkA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fzw 1,2-EPOXYPHENYLACETY
L-COA ISOMERASE


(Escherichia
coli)
PF00378
(ECH_1)
3 PHE C 259
ARG C  49
GLN C 204
None
1.18A 6g1pB-4fzwC:
undetectable
6g1pB-4fzwC:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g0r CAPSID PROTEIN VP1

(Rodent
protoparvovirus
1)
PF00740
(Parvo_coat)
3 PHE A 344
ARG A 413
GLN A 346
None
0.93A 6g1pB-4g0rA:
undetectable
6g1pB-4g0rA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g59 M152 PROTEIN

(Murid
betaherpesvirus
1)
PF11624
(M157)
3 PHE C  78
ARG C  77
GLN C  75
None
0.92A 6g1pB-4g59C:
undetectable
6g1pB-4g59C:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7e UREASE

(Cajanus cajan)
PF00449
(Urease_alpha)
PF00547
(Urease_gamma)
PF00699
(Urease_beta)
PF01979
(Amidohydro_1)
3 PHE B 124
ARG B  68
GLN B  69
None
1.17A 6g1pB-4g7eB:
undetectable
6g1pB-4g7eB:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvb KP6 KILLER TOXIN
SUBUNIT BETA


(Ustilago maydis
virus P6)
no annotation 3 PHE B  45
ARG B  47
GLN B  75
None
0.84A 6g1pB-4gvbB:
undetectable
6g1pB-4gvbB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hf7 PUTATIVE
ACYLHYDROLASE


(Bacteroides
thetaiotaomicron)
PF13472
(Lipase_GDSL_2)
3 PHE A  93
ARG A  96
GLN A  92
None
1.17A 6g1pB-4hf7A:
undetectable
6g1pB-4hf7A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN
GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE BETA CHAIN


(Pseudomonas;
Pseudomonas)
PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase)
3 PHE A 170
ARG A 174
GLN B 373
None
1.05A 6g1pB-4hstA:
undetectable
6g1pB-4hstA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivn TRANSCRIPTIONAL
REGULATOR


(Vibrio
vulnificus)
PF01380
(SIS)
PF01418
(HTH_6)
3 PHE A  38
ARG A  71
GLN A  37
None
1.02A 6g1pB-4ivnA:
undetectable
6g1pB-4ivnA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcd MAJOR CAPSID PROTEIN
VP1


(Human
polyomavirus 2)
PF00718
(Polyoma_coat)
3 PHE A  67
ARG A 161
GLN A 179
None
0.77A 6g1pB-4jcdA:
undetectable
6g1pB-4jcdA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6r SOLUBLE CYTOCHROME
B562 AND GLUCAGON
RECEPTOR CHIMERA


(Escherichia
coli;
Homo sapiens)
PF00002
(7tm_2)
PF07361
(Cytochrom_B562)
3 PHE A 303
ARG A 308
GLN A 232
None
0.98A 6g1pB-4l6rA:
undetectable
6g1pB-4l6rA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc3 PUTATIVE
UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE


(Burkholderia
cenocepacia)
PF01041
(DegT_DnrJ_EryC1)
3 PHE A 253
ARG A 257
GLN A 256
None
1.18A 6g1pB-4lc3A:
undetectable
6g1pB-4lc3A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mj0 VP1 CAPSID PROTEIN

(Human
polyomavirus 1)
PF00718
(Polyoma_coat)
3 PHE A  75
ARG A 169
GLN A 187
None
0.76A 6g1pB-4mj0A:
undetectable
6g1pB-4mj0A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nme PROLINE
DEHYDROGENASE AND
DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE


(Geobacter
sulfurreducens)
PF00171
(Aldedh)
PF01619
(Pro_dh)
3 PHE A 486
ARG A 249
GLN A 214
None
1.01A 6g1pB-4nmeA:
undetectable
6g1pB-4nmeA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe5 DELTA-1-PYRROLINE-5-
CARBOXYLATE
DEHYDROGENASE,
MITOCHONDRIAL


(Homo sapiens)
PF00171
(Aldedh)
3 PHE A 449
ARG A 399
GLN A 346
None
1.10A 6g1pB-4oe5A:
undetectable
6g1pB-4oe5A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT N


(Thermococcus
kodakarensis;
Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF01194
(RNA_pol_N)
3 PHE B 724
ARG N  47
GLN B 722
None
0.95A 6g1pB-4qiwB:
undetectable
6g1pB-4qiwB:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rbo PUTATIVE HOMEOBOX
PROTEIN NANOGP8


(Homo sapiens)
PF00046
(Homeobox)
3 PHE A 143
ARG A 147
GLN A 117
None
1.16A 6g1pB-4rboA:
undetectable
6g1pB-4rboA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u6u COG5

(Kluyveromyces
lactis)
PF10392
(COG5)
3 PHE B 244
ARG B 312
GLN B 311
None
1.16A 6g1pB-4u6uB:
undetectable
6g1pB-4u6uB:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwo ORGANOPHOSPHATE
ANHYDROLASE/PROLIDAS
E


(Alteromonas sp.)
PF00557
(Peptidase_M24)
3 PHE A 230
ARG A 232
GLN A 197
None
0.99A 6g1pB-4zwoA:
undetectable
6g1pB-4zwoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3y THERMOLYSIN

(Bacillus
thermoproteolyticus)
PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C)
3 PHE A  63
ARG A  11
GLN A  17
None
1.02A 6g1pB-5a3yA:
undetectable
6g1pB-5a3yA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II)
3 PHE K1065
ARG K1088
GLN K 978
None
0.86A 6g1pB-5anbK:
undetectable
6g1pB-5anbK:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263


(Nanoarchaeum
equitans;
Nanoarchaeum
equitans)
PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab)
3 PHE A 225
ARG B 326
GLN B 302
None
ANP  A 601 (-3.0A)
None
0.95A 6g1pB-5bn4A:
undetectable
6g1pB-5bn4A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c91 E3 UBIQUITIN-PROTEIN
LIGASE NEDD4


(Homo sapiens)
PF00632
(HECT)
3 PHE A 868
ARG A 870
GLN A 848
None
1.13A 6g1pB-5c91A:
undetectable
6g1pB-5c91A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfc VP1

(Cardiovirus B)
no annotation 3 PHE A  35
ARG A  32
GLN A  30
None
1.16A 6g1pB-5cfcA:
undetectable
6g1pB-5cfcA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cq9 SECRETED EFFECTOR
PROTEIN SOPD2


(Salmonella
enterica)
PF11047
(SopD)
3 PHE A 223
ARG A 216
GLN A 228
None
1.13A 6g1pB-5cq9A:
undetectable
6g1pB-5cq9A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f70 HEPATITIS A VIRUS
CELLULAR RECEPTOR 1


(Homo sapiens)
PF07686
(V-set)
3 PHE A  36
ARG A  87
GLN A  39
None
0.78A 6g1pB-5f70A:
undetectable
6g1pB-5f70A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1


(Caenorhabditis
elegans;
Homo sapiens)
PF00090
(TSP_1)
PF10250
(O-FucT)
3 PHE A 386
ARG A 387
GLN A 389
None
0.94A 6g1pB-5foeA:
1.6
6g1pB-5foeA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta)
PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8)
3 PHE A 420
ARG A 422
GLN A 419
None
SO4  A 917 (-3.9A)
None
1.13A 6g1pB-5gmhA:
undetectable
6g1pB-5gmhA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpk E3 UBIQUITIN-PROTEIN
LIGASE NEDD4-LIKE


(Homo sapiens)
PF00632
(HECT)
3 PHE A 923
ARG A 925
GLN A 903
None
0.98A 6g1pB-5hpkA:
undetectable
6g1pB-5hpkA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibx TRIOSEPHOSPHATE
ISOMERASE


(Streptococcus
pneumoniae)
PF00121
(TIM)
3 PHE A   6
ARG A 208
GLN A 210
None
1.01A 6g1pB-5ibxA:
undetectable
6g1pB-5ibxA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE


(Flavobacterium
psychrophilum)
PF10459
(Peptidase_S46)
3 PHE A 560
ARG A 558
GLN A  18
None
1.09A 6g1pB-5jxfA:
undetectable
6g1pB-5jxfA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku5 SENSOR KINASE CUSS

(Escherichia
coli)
no annotation 3 PHE A  43
ARG A 149
GLN A  46
AG  A 202 (-3.2A)
None
None
1.17A 6g1pB-5ku5A:
undetectable
6g1pB-5ku5A:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m3x ANGIOTENSINOGEN

(Homo sapiens)
no annotation 3 PHE A  79
ARG A  83
GLN A 330
None
0.90A 6g1pB-5m3xA:
undetectable
6g1pB-5m3xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN


(Thermus
thermophilus)
PF00005
(ABC_tran)
PF00664
(ABC_membrane)
3 PHE A 597
ARG A 594
GLN A 598
None
1.17A 6g1pB-5mkkA:
undetectable
6g1pB-5mkkA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt 40S RIBOSOMAL
PROTEIN SA


(Trypanosoma
cruzi)
no annotation 3 PHE f  91
ARG f  88
GLN f  95
None
1.13A 6g1pB-5optf:
undetectable
6g1pB-5optf:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opt RIBOSOMAL PROTEIN
S19, PUTATIVE


(Trypanosoma
cruzi)
no annotation 3 PHE o  39
ARG o  62
GLN o  41
None
None
A  E2031 ( 3.7A)
1.10A 6g1pB-5opto:
undetectable
6g1pB-5opto:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj7 NEDD4-LIKE E3
UBIQUITIN-PROTEIN
LIGASE WWP2


(Homo sapiens)
PF00397
(WW)
PF00632
(HECT)
3 PHE A 839
ARG A 841
GLN A 819
None
1.10A 6g1pB-5tj7A:
undetectable
6g1pB-5tj7A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw7 GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Neisseria
gonorrhoeae)
PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase)
3 PHE A 444
ARG A 256
GLN A 442
None
1.14A 6g1pB-5tw7A:
undetectable
6g1pB-5tw7A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnl CYTOCHROME B559
SUBUNIT ALPHA


(Pisum sativum)
PF00283
(Cytochrom_B559)
PF00284
(Cytochrom_B559a)
3 PHE E  56
ARG E  60
GLN E  61
None
1.13A 6g1pB-5xnlE:
undetectable
6g1pB-5xnlE:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1


(Mus musculus)
no annotation 3 PHE A2272
ARG A2377
GLN A2275
None
1.09A 6g1pB-6b3rA:
undetectable
6g1pB-6b3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eid ARCHAEAL-TYPE OPSIN
2


(Chlamydomonas
reinhardtii)
no annotation 3 PHE A 102
ARG A 115
GLN A 117
None
1.18A 6g1pB-6eidA:
undetectable
6g1pB-6eidA:
23.02