SIMILAR PATTERNS OF AMINO ACIDS FOR 6G1P_A_ACTA403

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1db3 GDP-MANNOSE
4,6-DEHYDRATASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		3 TYR A  16
ASP A  13
GLN A  12
 None
 0.94A 6g1pA-1db3A:
0.0		 6g1pA-1db3A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5w MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 201
ASP A 197
GLN A 196
 None
 0.80A 6g1pA-1e5wA:
0.0		 6g1pA-1e5wA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ef1 MOESIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 201
ASP A 197
GLN A 196
 None
 0.62A 6g1pA-1ef1A:
0.0		 6g1pA-1ef1A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1elp GAMMA-D CRYSTALLIN

(Bos taurus) 		PF00030
(Crystall) 		3 TYR A  62
ASP A  64
GLN A  67
 None
 0.95A 6g1pA-1elpA:
undetectable		 6g1pA-1elpA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fn9 OUTER-CAPSID PROTEIN
SIGMA 3

(Reovirus sp.) 		PF00979
(Reovirus_cap) 		3 TYR A 166
ASP A 164
GLN A 165
 None
 0.83A 6g1pA-1fn9A:
0.0		 6g1pA-1fn9A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gc7 RADIXIN

(Mus musculus) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 201
ASP A 197
GLN A 196
 TYR  A 201 ( 1.3A)
ASP  A 197 ( 0.6A)
GLN  A 196 ( 0.6A)
 0.61A 6g1pA-1gc7A:
0.0		 6g1pA-1gc7A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4r MERLIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 217
ASP A 213
GLN A 212
 None
 0.73A 6g1pA-1h4rA:
0.0		 6g1pA-1h4rA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9) 		3 TYR A 408
ASP A 402
GLN A 405
 None
 0.95A 6g1pA-1ia7A:
0.4		 6g1pA-1ia7A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jl0 S-ADENOSYLMETHIONINE
DECARBOXYLASE
PROENZYME

(Homo sapiens) 		PF01536
(SAM_decarbox) 		3 TYR A 264
ASP A 266
GLN A 261
 None
 0.96A 6g1pA-1jl0A:
0.0		 6g1pA-1jl0A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4z BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 TYR A 225
ASP A 224
GLN A 226
 None
 0.88A 6g1pA-1o4zA:
undetectable		 6g1pA-1o4zA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ojl TRANSCRIPTIONAL
REGULATORY PROTEIN
ZRAR

(Salmonella
enterica) 		PF00158
(Sigma54_activat)
PF02954
(HTH_8) 		3 TYR A 300
ASP A 297
GLN A 296
 None
 0.77A 6g1pA-1ojlA:
0.0		 6g1pA-1ojlA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT

(Bacillus
subtilis) 		PF11563
(Protoglobin) 		3 TYR A  49
ASP A  45
GLN A  21
 None
 0.95A 6g1pA-1or4A:
undetectable		 6g1pA-1or4A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		3 TYR A 107
ASP A 104
GLN A 103
 None
 0.96A 6g1pA-1poiA:
undetectable		 6g1pA-1poiA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvt TRANSACTIVATOR
PROTEIN

(Equine
infectious
anemia virus) 		PF00539
(Tat) 		3 TYR A  73
ASP A  48
GLN A  72
 None
 0.76A 6g1pA-1tvtA:
undetectable		 6g1pA-1tvtA:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tye INTEGRIN BETA-3

(Homo sapiens) 		PF00362
(Integrin_beta)
PF17205
(PSI_integrin) 		3 TYR B 190
ASP B 224
GLN B 228
 None
 0.96A 6g1pA-1tyeB:
undetectable		 6g1pA-1tyeB:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urx BETA-AGARASE A

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 TYR A 182
ASP A 181
GLN A 183
 None
GLA  A1292 ( 4.8A)
None
 0.89A 6g1pA-1urxA:
undetectable		 6g1pA-1urxA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		3 TYR A 403
ASP A 400
GLN A 399
 None
 0.90A 6g1pA-1venA:
undetectable		 6g1pA-1venA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w3f HEMOLYTIC LECTIN
FROM LAETIPORUS
SULPHUREUS

(Laetiporus
sulphureus) 		PF03318
(ETX_MTX2) 		3 TYR A  47
ASP A  45
GLN A  46
 GOL  A1319 ( 4.3A)
GOL  A1315 (-3.9A)
GOL  A1315 (-3.7A)
 0.89A 6g1pA-1w3fA:
undetectable		 6g1pA-1w3fA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydx TYPE I RESTRICTION
ENZYME SPECIFICITY
PROTEIN MG438

(Mycoplasma
genitalium) 		PF01420
(Methylase_S) 		3 TYR A 351
ASP A 349
GLN A 350
 None
 0.96A 6g1pA-1ydxA:
undetectable		 6g1pA-1ydxA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvl SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind)
PF02865
(STAT_int) 		3 TYR A 170
ASP A 168
GLN A 167
 None
 0.81A 6g1pA-1yvlA:
undetectable		 6g1pA-1yvlA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2acm MUCIN-1

(Homo sapiens) 		PF01390
(SEA) 		3 TYR A1066
ASP A1064
GLN A1067
 None
 0.92A 6g1pA-2acmA:
undetectable		 6g1pA-2acmA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cqm RIBOSOMAL PROTEIN
L17 ISOLOG

(Homo sapiens) 		PF01196
(Ribosomal_L17) 		3 TYR A  97
ASP A  99
GLN A 100
 None
 0.94A 6g1pA-2cqmA:
undetectable		 6g1pA-2cqmA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dlq GLI-KRUPPEL FAMILY
MEMBER HKR3

(Mus musculus) 		PF00096
(zf-C2H2)
PF13894
(zf-C2H2_4) 		3 TYR A  95
ASP A 109
GLN A 106
 None
 0.84A 6g1pA-2dlqA:
undetectable		 6g1pA-2dlqA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dv6 NITRITE REDUCTASE

(Hyphomicrobium
denitrificans) 		PF07732
(Cu-oxidase_3) 		3 TYR A  84
ASP A  82
GLN A  83
 None
 0.95A 6g1pA-2dv6A:
undetectable		 6g1pA-2dv6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhi IMMUNOGENIC PROTEIN
MPT64

(Mycobacterium
tuberculosis) 		PF11738
(DUF3298) 		3 TYR A   6
ASP A  40
GLN A  41
 None
 0.90A 6g1pA-2hhiA:
undetectable		 6g1pA-2hhiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2huj LIN2004 PROTEIN

(Listeria
innocua) 		PF08807
(DUF1798) 		3 TYR A 100
ASP A  98
GLN A 101
 None
 0.91A 6g1pA-2hujA:
undetectable		 6g1pA-2hujA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 201
ASP A 197
GLN A 196
 None
 0.71A 6g1pA-2i1jA:
undetectable		 6g1pA-2i1jA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2juj E3 UBIQUITIN-PROTEIN
LIGASE CBL

(Homo sapiens) 		PF00627
(UBA) 		3 TYR A  21
ASP A  23
GLN A  22
 None
 0.83A 6g1pA-2jujA:
undetectable		 6g1pA-2jujA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3m COPPER-ION-BINDING
PROTEIN

(Bacillus
anthracis) 		PF00403
(HMA) 		3 TYR A  68
ASP A  65
GLN A  66
 None
 0.77A 6g1pA-2l3mA:
undetectable		 6g1pA-2l3mA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nbr GAMMA-CRYSTALLIN C

(Homo sapiens) 		PF00030
(Crystall) 		3 TYR A  62
ASP A  64
GLN A  67
 None
 0.85A 6g1pA-2nbrA:
undetectable		 6g1pA-2nbrA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o04 PECTATE LYASE

(Bacillus
subtilis) 		PF00544
(Pec_lyase_C) 		3 TYR A 183
ASP A 223
GLN A 182
 None
CA  A 404 (-2.2A)
None
 0.84A 6g1pA-2o04A:
undetectable		 6g1pA-2o04A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q09 IMIDAZOLONEPROPIONAS
E

(unidentified) 		PF01979
(Amidohydro_1) 		3 TYR A 235
ASP A 233
GLN A 234
 None
 0.73A 6g1pA-2q09A:
undetectable		 6g1pA-2q09A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v2u GAMMA CRYSTALLIN C

(Mus musculus) 		PF00030
(Crystall) 		3 TYR A  62
ASP A  64
GLN A  67
 None
 0.89A 6g1pA-2v2uA:
undetectable		 6g1pA-2v2uA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8j PECTATE LYASE

(Yersinia
enterocolitica) 		PF06917
(Pectate_lyase_2) 		3 TYR A 235
ASP A 233
GLN A 234
 None
 0.92A 6g1pA-2v8jA:
undetectable		 6g1pA-2v8jA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vm6 BCL-2-RELATED
PROTEIN A1

(Homo sapiens) 		PF00452
(Bcl-2) 		3 TYR A  16
ASP A  15
GLN A  38
 None
 0.94A 6g1pA-2vm6A:
undetectable		 6g1pA-2vm6A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vsa MOSQUITOCIDAL TOXIN

(Lysinibacillus
sphaericus) 		PF05588
(Botulinum_HA-17)
PF14200
(RicinB_lectin_2) 		3 TYR A 669
ASP A 667
GLN A 668
 None
 0.95A 6g1pA-2vsaA:
undetectable		 6g1pA-2vsaA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxx STARVATION INDUCED
DNA BINDING PROTEIN

(Synechococcus
elongatus) 		PF00210
(Ferritin) 		3 TYR A  70
ASP A  68
GLN A  67
 None
None
ZN  A 201 ( 4.8A)
 0.81A 6g1pA-2vxxA:
undetectable		 6g1pA-2vxxA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsc PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF03244
(PSI_PsaH) 		3 TYR H  24
ASP H  22
GLN H  20
 None
 0.86A 6g1pA-2wscH:
undetectable		 6g1pA-2wscH:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy3 SPBC2
PROPHAGE-DERIVED
DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE
YOSS

(Bacillus
subtilis) 		PF00692
(dUTPase) 		3 TYR A   7
ASP A   9
GLN A  12
 None
 0.86A 6g1pA-2xy3A:
undetectable		 6g1pA-2xy3A:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9f HEMOLYTIC LECTIN
LSLA

(Laetiporus
sulphureus) 		no annotation 3 TYR A  47
ASP A  45
GLN A  46
 None
 0.96A 6g1pA-2y9fA:
undetectable		 6g1pA-2y9fA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9f HEMOLYTIC LECTIN
LSLA

(Laetiporus
sulphureus) 		no annotation 3 TYR A 143
ASP A 141
GLN A 142
 None
 0.94A 6g1pA-2y9fA:
undetectable		 6g1pA-2y9fA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		3 TYR A 246
ASP A 247
GLN A 250
 None
 0.95A 6g1pA-3anvA:
undetectable		 6g1pA-3anvA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f4l PUTATIVE
OXIDOREDUCTASE YHHX

(Escherichia
coli) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 TYR A 173
ASP A 169
GLN A 168
 None
 0.89A 6g1pA-3f4lA:
undetectable		 6g1pA-3f4lA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3grh ACYL-COA THIOESTER
HYDROLASE YBGC

(Escherichia
coli) 		PF01095
(Pectinesterase) 		3 TYR A 154
ASP A 155
GLN A 158
 None
 0.93A 6g1pA-3grhA:
undetectable		 6g1pA-3grhA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpc SNX5 PROTEIN

(Rattus
norvegicus) 		PF00787
(PX) 		3 TYR X 168
ASP X 169
GLN X 170
 None
 0.80A 6g1pA-3hpcX:
undetectable		 6g1pA-3hpcX:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hum PENICILLIN-BINDING
PROTEIN 4

(Staphylococcus
aureus) 		PF00768
(Peptidase_S11)
PF09211
(DUF1958) 		3 TYR A 315
ASP A 313
GLN A 314
 None
 0.82A 6g1pA-3humA:
undetectable		 6g1pA-3humA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3li9 HYPOTHETICAL SENSORY
TRANSDUCTION
HISTIDINE KINASE

(Methanosarcina
mazei) 		PF02743
(dCache_1) 		3 TYR A 182
ASP A 166
GLN A  66
 None
 0.82A 6g1pA-3li9A:
undetectable		 6g1pA-3li9A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzg PUTATIVE RACEMASE

(Pseudovibrio
sp. JE062) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 TYR A  91
ASP A  92
GLN A  95
 None
 0.91A 6g1pA-3nzgA:
undetectable		 6g1pA-3nzgA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ofl L1

(Alphapapillomavirus
7) 		PF00500
(Late_protein_L1) 		3 TYR A 463
ASP A 461
GLN A 462
 None
 0.73A 6g1pA-3oflA:
undetectable		 6g1pA-3oflA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		3 TYR A  79
ASP A  81
GLN A  80
 None
 0.94A 6g1pA-3opbA:
undetectable		 6g1pA-3opbA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 TYR A 180
ASP A 388
GLN A 390
 None
CA  A   1 (-2.8A)
None
 0.95A 6g1pA-3q5iA:
undetectable		 6g1pA-3q5iA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 TYR A 146
ASP A 147
GLN A 177
 None
 0.94A 6g1pA-3ttfA:
undetectable		 6g1pA-3ttfA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uul UTROPHIN

(Rattus
norvegicus) 		PF00435
(Spectrin) 		3 TYR A 314
ASP A 312
GLN A 315
 None
 0.95A 6g1pA-3uulA:
undetectable		 6g1pA-3uulA:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wz1 AGARASE

(Microbulbifer
thermotolerans) 		PF00722
(Glyco_hydro_16) 		3 TYR A 183
ASP A 182
GLN A 184
 None
None
GOL  A 404 (-2.6A)
 0.94A 6g1pA-3wz1A:
undetectable		 6g1pA-3wz1A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5v MICRONEMAL PROTEIN 4

(Toxoplasma
gondii) 		PF00024
(PAN_1) 		3 TYR A 124
ASP A 108
GLN A 105
 None
 0.88A 6g1pA-4a5vA:
undetectable		 6g1pA-4a5vA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asm BETA-AGARASE D

(Zobellia
galactanivorans) 		no annotation 3 TYR B 194
ASP B 193
GLN B 195
 None
None
PEG  B1361 (-3.0A)
 0.89A 6g1pA-4asmB:
undetectable		 6g1pA-4asmB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4atf BETA-AGARASE B

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 TYR A 225
ASP A 224
GLN A 226
 None
None
AAL  A1358 (-3.4A)
 0.94A 6g1pA-4atfA:
undetectable		 6g1pA-4atfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azw WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		3 TYR A 255
ASP A 257
GLN A 302
 None
 0.87A 6g1pA-4azwA:
undetectable		 6g1pA-4azwA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cak INTEGRIN ALPHA-IIB
INTEGRIN BETA-3

(Homo sapiens;
Homo sapiens) 		PF01839
(FG-GAP)
PF08441
(Integrin_alpha2)
PF00362
(Integrin_beta)
PF07965
(Integrin_B_tail)
PF07974
(EGF_2)
PF17205
(PSI_integrin) 		3 TYR A 380
ASP B 270
GLN B 267
 None
 0.84A 6g1pA-4cakA:
undetectable		 6g1pA-4cakA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cso ORFY PROTEIN,
TRANSCRIPTION FACTOR

(Thermoproteus
tenax) 		no annotation 3 TYR A 197
ASP A 199
GLN A 202
 None
 0.66A 6g1pA-4csoA:
undetectable		 6g1pA-4csoA:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4do7 AMIDOHYDROLASE 2

(Burkholderia
multivorans) 		PF04909
(Amidohydro_2) 		3 TYR A 254
ASP A 255
GLN A  46
 None
 0.85A 6g1pA-4do7A:
undetectable		 6g1pA-4do7A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		3 TYR A  55
ASP A  53
GLN A  56
 None
 0.82A 6g1pA-4e0tA:
undetectable		 6g1pA-4e0tA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbq DNA REPAIR AND
TELOMERE MAINTENANCE
PROTEIN NBS1,DNA
REPAIR PROTEIN RAD32
CHIMERIC PROTEIN

(Schizosaccharomyces
pombe) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		3 TYR A1243
ASP A1241
GLN A1240
 None
 0.77A 6g1pA-4fbqA:
undetectable		 6g1pA-4fbqA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fcx DNA REPAIR PROTEIN
RAD32

(Schizosaccharomyces
pombe) 		no annotation 3 TYR B 243
ASP B 241
GLN B 240
 None
 0.88A 6g1pA-4fcxB:
undetectable		 6g1pA-4fcxB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9q 4-CARBOXYMUCONOLACTO
NE DECARBOXYLASE

(Sinorhizobium
meliloti) 		PF02627
(CMD) 		3 TYR A  74
ASP A  76
GLN A  77
 None
 0.80A 6g1pA-4g9qA:
undetectable		 6g1pA-4g9qA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gcr GAMMA-B CRYSTALLIN

(Bos taurus) 		PF00030
(Crystall) 		3 TYR A  62
ASP A  64
GLN A  67
 None
 0.94A 6g1pA-4gcrA:
undetectable		 6g1pA-4gcrA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6m ACTIN-LIKE PROTEIN
ARP9

(Saccharomyces
cerevisiae) 		PF00022
(Actin) 		3 TYR B 177
ASP B 176
GLN B 157
 None
 0.95A 6g1pA-4i6mB:
undetectable		 6g1pA-4i6mB:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je5 AROMATIC/AMINOADIPAT
E AMINOTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		3 TYR A 416
ASP A 419
GLN A 422
 None
 0.80A 6g1pA-4je5A:
undetectable		 6g1pA-4je5A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox2 PHOSPHOENOLPYRUVATE
CARBOXYKINASE,
CYTOSOLIC [GTP]

(Rattus
norvegicus) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		3 TYR A 595
ASP A 598
GLN A 599
 None
 0.87A 6g1pA-4ox2A:
undetectable		 6g1pA-4ox2A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q88 UNCHARACTERIZED
PROTEIN

(Bacteroides
vulgatus) 		PF07470
(Glyco_hydro_88) 		3 TYR A  84
ASP A  80
GLN A  48
 None
 0.96A 6g1pA-4q88A:
undetectable		 6g1pA-4q88A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnl TAIL FIBER PROTEIN

(Escherichia
virus G7C) 		no annotation 3 TYR A 391
ASP A 393
GLN A 394
 None
 0.83A 6g1pA-4qnlA:
undetectable		 6g1pA-4qnlA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rap GLYCOSYLTRANSFERASE
TIBC

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		3 TYR A  26
ASP A  27
GLN A  18
 None
 0.94A 6g1pA-4rapA:
undetectable		 6g1pA-4rapA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4re2 BETA-MANNOSIDASE/BET
A-GLUCOSIDASE

(Oryza sativa) 		PF00232
(Glyco_hydro_1) 		3 TYR A 336
ASP A 338
GLN A 337
 None
 0.94A 6g1pA-4re2A:
undetectable		 6g1pA-4re2A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 201
ASP A 197
GLN A 196
 None
 0.64A 6g1pA-4rm9A:
undetectable		 6g1pA-4rm9A:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 TYR A 201
ASP A 197
GLN A 196
 None
 0.77A 6g1pA-4rmaA:
undetectable		 6g1pA-4rmaA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxe FARNESYL
PYROPHOSPHATE
SYNTHASE

(Trypanosoma
brucei) 		PF00348
(polyprenyl_synt) 		3 TYR A  99
ASP A 103
GLN A 172
 None
MG  A3004 (-2.5A)
MG  A3004 ( 3.8A)
 0.93A 6g1pA-4rxeA:
undetectable		 6g1pA-4rxeA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		3 TYR P 418
ASP P 371
GLN P 370
 None
 0.94A 6g1pA-4s2tP:
undetectable		 6g1pA-4s2tP:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tmc OLD YELLOW ENZYME

(Kluyveromyces
marxianus) 		PF00724
(Oxidored_FMN) 		3 TYR A 326
ASP A 329
GLN A 332
 None
 0.85A 6g1pA-4tmcA:
undetectable		 6g1pA-4tmcA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ug4 CHOLINE SULFATASE

(Sinorhizobium
meliloti) 		PF00884
(Sulfatase)
PF12411
(Choline_sulf_C) 		3 TYR A 245
ASP A 244
GLN A 246
 None
 0.96A 6g1pA-4ug4A:
undetectable		 6g1pA-4ug4A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqe THIOSULFATE
DEHYDROGENASE

(Allochromatium
vinosum) 		PF13442
(Cytochrome_CBB3) 		3 TYR A  31
ASP A  34
GLN A  38
 None
 0.83A 6g1pA-4wqeA:
undetectable		 6g1pA-4wqeA:
25.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 TYR A 141
ASP A 349
GLN A 351
 None
CA  A 501 (-2.7A)
None
 0.97A 6g1pA-4ysjA:
undetectable		 6g1pA-4ysjA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		3 TYR A 135
ASP A 165
GLN A 136
 None
 0.84A 6g1pA-5ahkA:
undetectable		 6g1pA-5ahkA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		3 TYR A1447
ASP A1449
GLN A1448
 None
 0.96A 6g1pA-5amqA:
undetectable		 6g1pA-5amqA:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fei DISTAL TUBE PROTEIN

(Bacillus virus
phi29) 		PF16838
(Caud_tail_N) 		3 TYR A  91
ASP A 112
GLN A 115
 None
 0.94A 6g1pA-5feiA:
undetectable		 6g1pA-5feiA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffj ENDONUCLEASE AND
METHYLASE LLAGI

(Lactococcus
lactis) 		PF00271
(Helicase_C)
PF02384
(N6_Mtase)
PF04851
(ResIII) 		3 TYR A1518
ASP A1516
GLN A1517
 None
 0.89A 6g1pA-5ffjA:
undetectable		 6g1pA-5ffjA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifg ANTITOXIN HIGA

(Escherichia
coli) 		PF01381
(HTH_3) 		3 TYR B  91
ASP B  89
GLN B  90
 None
 0.78A 6g1pA-5ifgB:
undetectable		 6g1pA-5ifgB:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 TYR A 254
ASP A 288
GLN A 320
 None
 0.94A 6g1pA-5im3A:
undetectable		 6g1pA-5im3A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		3 TYR A 102
ASP A 100
GLN A  99
 None
6G2  A 901 (-4.7A)
None
 0.74A 6g1pA-5j5tA:
undetectable		 6g1pA-5j5tA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqn ALIPHATIC AMIDASE

(Nesterenkonia
sp. AN1) 		PF00795
(CN_hydrolase) 		3 TYR A 146
ASP A 147
GLN A 113
 None
 0.78A 6g1pA-5jqnA:
undetectable		 6g1pA-5jqnA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbe MOPR

(Acinetobacter
calcoaceticus) 		PF02830
(V4R)
PF06505
(XylR_N) 		3 TYR A  59
ASP A  57
GLN A  60
 None
 0.86A 6g1pA-5kbeA:
undetectable		 6g1pA-5kbeA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE ALPHA
SUBUNIT

(Aromatoleum
aromaticum) 		PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N) 		3 TYR b 166
ASP b 164
GLN b 165
 None
None
EPE  B 802 (-4.0A)
 0.78A 6g1pA-5l9wb:
undetectable		 6g1pA-5l9wb:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lki TCDA1

(Photorhabdus
luminescens) 		PF03538
(VRP1) 		3 TYR A 968
ASP A 966
GLN A 969
 None
 0.83A 6g1pA-5lkiA:
undetectable		 6g1pA-5lkiA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mgv PHENYLALANINE--TRNA
LIGASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03147
(FDX-ACB) 		3 TYR A 346
ASP A 145
GLN A 146
 None
 0.92A 6g1pA-5mgvA:
undetectable		 6g1pA-5mgvA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t9x GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 3 TYR A 229
ASP A 228
GLN A 230
 None
 0.88A 6g1pA-5t9xA:
undetectable		 6g1pA-5t9xA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tte E3 UBIQUITIN-PROTEIN
LIGASE ARIH1

(Homo sapiens) 		PF01485
(IBR) 		3 TYR B 529
ASP B 527
GLN B 526
 None
 0.75A 6g1pA-5tteB:
undetectable		 6g1pA-5tteB:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8q INSULIN-LIKE GROWTH
FACTOR 1 RECEPTOR

(Homo sapiens) 		no annotation 3 TYR A 839
ASP A 845
GLN A 846
 None
 0.73A 6g1pA-5u8qA:
undetectable		 6g1pA-5u8qA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v5f AT3G11770

(Arabidopsis
thaliana) 		PF01612
(DNA_pol_A_exo1) 		3 TYR A 195
ASP A 196
GLN A 199
 None
 0.70A 6g1pA-5v5fA:
undetectable		 6g1pA-5v5fA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5y RNA POLYMERASE
I-SPECIFIC
TRANSCRIPTION
INITIATION FACTOR
RRN6

(Saccharomyces
cerevisiae) 		PF10214
(Rrn6) 		3 TYR O 686
ASP O 688
GLN O 689
 None
 0.86A 6g1pA-5w5yO:
undetectable		 6g1pA-5w5yO:
16.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 3 TYR B 119
ASP B 116
GLN B 117
 None
 0.88A 6g1pA-6et0B:
undetectable		 6g1pA-6et0B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fik POLYKETIDE SYNTHASE

(Cercospora
nicotianae) 		no annotation 3 TYR A 249
ASP A  14
GLN A  15
 None
 0.87A 6g1pA-6fikA:
undetectable		 6g1pA-6fikA:
undetectable