SIMILAR PATTERNS OF AMINO ACIDS FOR 6FZB_B_SRYB301_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b12 SIGNAL PEPTIDASE I

(Escherichia
coli) 		PF00717
(Peptidase_S24)
PF10502
(Peptidase_S26) 		5 ASP A 245
LEU A 164
ASP A 273
ILE A 237
THR A 239
 None
 1.44A 6fzbB-1b12A:
0.0		 6fzbB-1b12A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ej6 LAMBDA1

(Reovirus sp.) 		no annotation 5 ASP B1152
ASP B1224
ASP B1187
HIS B1188
ILE B1220
 None
 1.32A 6fzbB-1ej6B:
0.0		 6fzbB-1ej6B:
5.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m2w MANNITOL
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 ASP A 190
ASP A  69
LEU A  76
HIS A  31
ILE A  60
 NAD  A5500 (-3.6A)
NAD  A5500 (-3.0A)
None
None
None
 1.32A 6fzbB-1m2wA:
0.0		 6fzbB-1m2wA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 177
GLU A 175
ASP A 293
LEU A 337
ILE A 268
 None
GOL  A 503 ( 4.7A)
None
None
None
 1.49A 6fzbB-1pz3A:
0.0		 6fzbB-1pz3A:
9.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1usy ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Thermotoga
maritima) 		PF13393
(tRNA-synt_His) 		5 LEU C 197
ASP C 196
ASP C 182
ILE C 179
THR C 226
 None
 1.38A 6fzbB-1usyC:
0.0		 6fzbB-1usyC:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xmb IAA-AMINO ACID
HYDROLASE HOMOLOG 2

(Arabidopsis
thaliana) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ASP A 114
GLU A 173
LEU A 383
HIS A 142
ILE A 196
 None
 1.46A 6fzbB-1xmbA:
0.4		 6fzbB-1xmbA:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xw8 UPF0271 PROTEIN YBGL

(Escherichia
coli) 		PF03746
(LamB_YcsF) 		5 GLU A 158
ASP A   8
LEU A  20
HIS A 102
ILE A  54
 None
 1.43A 6fzbB-1xw8A:
0.3		 6fzbB-1xw8A:
15.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5z HELICASE OF THE
SNF2/RAD54 FAMILY

(Sulfolobus
solfataricus) 		PF00271
(Helicase_C) 		5 GLU A 834
ASP A 866
LEU A 861
ASP A 884
ILE A 887
 None
 1.14A 6fzbB-1z5zA:
0.0		 6fzbB-1z5zA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfm THERMOSTABLE DNA
LIGASE

(Pyrococcus
furiosus) 		PF01068
(DNA_ligase_A_M)
PF04675
(DNA_ligase_A_N)
PF04679
(DNA_ligase_A_C) 		5 ASP A 429
GLU A 504
ASP A 251
LEU A 393
ILE A 421
 None
 1.28A 6fzbB-2cfmA:
undetectable		 6fzbB-2cfmA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr1 386AA LONG
HYPOTHETICAL SERINE
AMINOTRANSFERASE

(Pyrococcus
horikoshii) 		PF00266
(Aminotran_5) 		5 GLU A 287
LEU A 369
HIS A 356
ILE A 354
THR A 316
 None
 1.46A 6fzbB-2dr1A:
undetectable		 6fzbB-2dr1A:
11.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mbb IMMUNOGLOBULIN
G-BINDING PROTEIN
G/DNA POLYMERASE
IOTA FUSION PROTEIN
POLYUBIQUITIN-B

(Homo sapiens;
Streptococcus
sp. 'group G') 		PF00240
(ubiquitin)
no annotation 		5 GLU A  73
GLN A  72
ASP A  81
HIS B 268
ILE B 244
 None
 1.45A 6fzbB-2mbbA:
undetectable		 6fzbB-2mbbA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wda PUTATIVE SECRETED
LYASE

(Streptomyces
violaceoruber) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		5 ASP A 197
TRP A 140
ASP A  82
ILE A  87
THR A  88
 PEG  A1775 (-3.3A)
GOL  A1773 ( 4.2A)
None
None
None
 1.37A 6fzbB-2wdaA:
undetectable		 6fzbB-2wdaA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		5 ASP A 217
GLU A 215
ASP A 339
LEU A 395
ILE A 314
 None
 1.34A 6fzbB-2y2wA:
undetectable		 6fzbB-2y2wA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0k UPF0064 PROTEIN YCCW

(Escherichia
coli) 		PF10672
(Methyltrans_SAM) 		5 GLU A 134
ASP A 155
LEU A 124
ILE A 105
THR A 116
 None
 1.46A 6fzbB-3c0kA:
undetectable		 6fzbB-3c0kA:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijt PUTATIVE
UNCHARACTERIZED
PROTEIN

(Streptococcus
mutans) 		no annotation 5 ASP A  73
TRP A  26
LEU A 135
ASP A  15
ILE A  88
 None
 1.34A 6fzbB-3ijtA:
undetectable		 6fzbB-3ijtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis) 		PF01804
(Penicil_amidase) 		5 ASP B 534
ASP B  43
LEU A  25
HIS A  16
ILE B  35
 None
 1.42A 6fzbB-3ml0B:
undetectable		 6fzbB-3ml0B:
9.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		5 ASP A  47
GLU A  87
GLN A 108
TRP A 112
THR A 189
 None
 1.03A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 ASP A 130
TRP A 173
ASP A 178
ASP A 182
ILE A 186
THR A 189
 None
 0.96A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		5 GLN A 108
LEU A 172
ASP A 182
ILE A 186
THR A 189
 None
 1.22A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
TRP A 112
ASP A 130
ASP A 182
ILE A 186
THR A 189
 None
 1.27A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 GLN A 108
TRP A 112
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 1.47A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 LEU A 172
TRP A 173
ASP A 178
ASP A 182
ILE A 186
THR A 189
 None
 0.91A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE

(Salmonella
enterica) 		PF01909
(NTP_transf_2)
PF13427
(DUF4111) 		6 TRP A 173
ASP A 178
ASP A 182
HIS A 185
ILE A 186
THR A 189
 None
 0.76A 6fzbB-4cs6A:
37.6		 6fzbB-4cs6A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX

(Bacillus cereus) 		PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF) 		5 ASP A 245
GLN A 127
TRP A 248
ASP A 401
ASP A 393
 None
 1.47A 6fzbB-4fxqA:
0.9		 6fzbB-4fxqA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jqt PUTATIVE GLYCOSYL
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF06439
(DUF1080) 		5 GLN A 185
LEU A 130
ASP A 174
ILE A 160
THR A 162
 NA  A 501 (-3.2A)
None
None
None
None
 1.06A 6fzbB-4jqtA:
undetectable		 6fzbB-4jqtA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lbw ELONGATION FACTOR
TU-A

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 ASP A 227
GLU A 226
GLN A  98
ILE A  50
THR A  62
 None
None
None
None
MG  A 502 (-2.9A)
 1.49A 6fzbB-4lbwA:
undetectable		 6fzbB-4lbwA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lq1 1,4-ALPHA-GLUCAN
BRANCHING ENZYME
GLGB

(Escherichia
coli) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 ASP A 345
ASP A 295
ASP A 335
ILE A 289
THR A 309
 None
 1.44A 6fzbB-4lq1A:
undetectable		 6fzbB-4lq1A:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ASP A 247
GLU A 248
GLN A 204
LEU A 311
ILE A 323
 None
 1.46A 6fzbB-4xg1A:
undetectable		 6fzbB-4xg1A:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xhl CASEIN KINASE I
HOMOLOG HRR25

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 GLN A 190
ASP A 195
ASP A 132
ASP A 149
ILE A 148
 None
None
None
None
CKI  A 401 ( 3.7A)
 1.39A 6fzbB-4xhlA:
0.8		 6fzbB-4xhlA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfl AMIDOHYDROLASE EGTC

(Mycolicibacterium
smegmatis) 		PF13522
(GATase_6) 		5 ASP A 201
GLN A  28
ASP A 211
ASP A 208
ILE A 209
 None
 1.07A 6fzbB-4zflA:
undetectable		 6fzbB-4zflA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cz2 POL POLYPROTEIN

(Mouse mammary
tumor virus) 		PF00665
(rve) 		5 ASP A 122
LEU A 188
HIS A 161
ILE A 164
THR A 160
 MG  A 301 (-2.6A)
None
None
None
None
 1.42A 6fzbB-5cz2A:
undetectable		 6fzbB-5cz2A:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqd CASEIN KINASE I
ISOFORM ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLN C 198
ASP C 203
ASP C 140
ASP C 157
ILE C 156
 None
 1.37A 6fzbB-5fqdC:
undetectable		 6fzbB-5fqdC:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hh7 ORIGIN OF
REPLICATION COMPLEX
SUBUNIT 1B

(Arabidopsis
thaliana) 		PF00628
(PHD)
PF01426
(BAH) 		5 ASP A 261
GLU A 258
ASP A 298
ASP A 146
ILE A 304
 None
 1.35A 6fzbB-5hh7A:
undetectable		 6fzbB-5hh7A:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imw INTERMEDILYSIN

(Streptococcus
intermedius) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ASP A 237
ASP A 407
HIS A 242
ILE A 409
THR A 411
 None
 1.39A 6fzbB-5imwA:
undetectable		 6fzbB-5imwA:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imy VAGINOLYSIN

(Gardnerella
vaginalis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 ASP A 224
ASP A 394
HIS A 229
ILE A 396
THR A 398
 None
 1.46A 6fzbB-5imyA:
undetectable		 6fzbB-5imyA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okt CASEIN KINASE I
ISOFORM DELTA

(Homo sapiens) 		no annotation 5 GLN C 190
ASP C 195
ASP C 132
ASP C 149
ILE C 148
 GOL  C 309 (-2.9A)
GOL  C 309 (-3.6A)
None
None
9XK  C 301 ( 3.6A)
 1.43A 6fzbB-5oktC:
0.7		 6fzbB-5oktC:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yu1 LYSINE
CYCLODEAMINASE

(Streptomyces
pristinaespiralis) 		no annotation 5 ASP A 236
GLN A 268
ASP A 300
ASP A 221
THR A 207
 NAD  A 402 (-3.9A)
None
NA  A 401 (-3.6A)
None
None
 1.39A 6fzbB-5yu1A:
undetectable		 6fzbB-5yu1A:
25.00