SIMILAR PATTERNS OF AMINO ACIDS FOR 6FU4_D_HSMD401_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)

Filter list by:

	Hit	Macromolecule/ Organism	Pfam	Res.	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1uaz	ARCHAERHODOPSIN-1 (Halorubrum chaoviator)	PF01036 (Bac_rhodopsin)	5	TYR A 191 GLU A 210 GLU A 200 TYR A 89 ASP A 218	RET A 255 (-3.7A) None None None RET A 255 (-4.4A)	1.40A	6fu4D-1uazA: 0.0	6fu4D-1uazA: 16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3li9	HYPOTHETICAL SENSORY TRANSDUCTION HISTIDINE KINASE (Methanosarcina mazei)	PF02743 (dCache_1)	5	TYR A 105 TYR A 135 GLU A 146 TYR A 172 ASP A 199	BTB A 1 (-3.6A) BTB A 1 (-4.1A) None BTB A 1 (-4.6A) BTB A 1 (-2.9A)	1.14A	6fu4D-3li9A: 26.9	6fu4D-3li9A: 12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3lic	SENSOR PROTEIN (Shewanella oneidensis)	PF02743 (dCache_1)	5	TYR A 127 TRP A 154 TYR A 170 ASP A 172 ASP A 200	EDO A 1 (-4.1A) EDO A 1 (-3.4A) None EDO A 1 (-2.9A) EDO A 1 (-2.7A)	0.77A	6fu4D-3licA: 20.3	6fu4D-3licA: 13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4fbz	DELTARHODOPSIN (Haloterrigena thermotolerans)	PF01036 (Bac_rhodopsin)	5	TYR A 184 GLU A 204 GLU A 193 TYR A 82 ASP A 212	RET A 301 (-3.5A) None None None RET A 301 (-4.5A)	1.44A	6fu4D-4fbzA: 0.0	6fu4D-4fbzA: 15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	6f9g	METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU (Pseudomonas putida)	no annotation	7	TYR A 120 TYR A 152 GLU A 164 TRP A 186 TYR A 202 ASP A 204 ASP A 233	PUT A 401 (-4.2A) PUT A 401 ( 3.5A) None PUT A 401 (-3.5A) None PUT A 401 (-2.7A) PUT A 401 (-2.9A)	0.49A	6fu4D-6f9gA: 36.8	6fu4D-6f9gA: 68.75

[["6FU4_D_HSMD401_1","1uaz","Halorubrum chaoviator","ARCHAERHODOPSIN-1","PF01036(Bac_rhodopsin)",5,"TYR A 191;GLU A 210;GLU A 200;TYR A  89;ASP A 218","RET A 255 (-3.7A);None;None;None;RET A 255 (-4.4A)","1.40A","6fu4D-1uazA:0.0","6fu4D-1uazA:16.38"],["6FU4_D_HSMD401_1","3li9","Methanosarcina mazei","HYPOTHETICAL SENSORY TRANSDUCTION HISTIDINE KINASE","PF02743(dCache_1)",5,"TYR A 105;TYR A 135;GLU A 146;TYR A 172;ASP A 199","BTB A   1 (-3.6A);BTB A   1 (-4.1A);None;BTB A   1 (-4.6A);BTB A   1 (-2.9A)","1.14A","6fu4D-3li9A:26.9","6fu4D-3li9A:12.98"],["6FU4_D_HSMD401_1","3lic","Shewanella oneidensis","SENSOR PROTEIN","PF02743(dCache_1)",5,"TYR A 127;TRP A 154;TYR A 170;ASP A 172;ASP A 200","EDO A   1 (-4.1A);EDO A   1 (-3.4A);None;EDO A   1 (-2.9A);EDO A   1 (-2.7A)","0.77A","6fu4D-3licA:20.3","6fu4D-3licA:13.87"],["6FU4_D_HSMD401_1","4fbz","Haloterrigena thermotolerans","DELTARHODOPSIN","PF01036(Bac_rhodopsin)",5,"TYR A 184;GLU A 204;GLU A 193;TYR A  82;ASP A 212","RET A 301 (-3.5A);None;None;None;RET A 301 (-4.5A)","1.44A","6fu4D-4fbzA:0.0","6fu4D-4fbzA:15.06"],["6FU4_D_HSMD401_1","6f9g","Pseudomonas putida","METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPU","no annotation",7,"TYR A 120;TYR A 152;GLU A 164;TRP A 186;TYR A 202;ASP A 204;ASP A 233","PUT A 401 (-4.2A);PUT A 401 ( 3.5A);None;PUT A 401 (-3.5A);None;PUT A 401 (-2.7A);PUT A 401 (-2.9A)","0.49A","6fu4D-6f9gA:36.8","6fu4D-6f9gA:68.75"]]