SIMILAR PATTERNS OF AMINO ACIDS FOR 6FU4_C_HSMC401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator)
PF01036
(Bac_rhodopsin)
5 TYR A 191
GLU A 210
GLU A 200
TYR A  89
ASP A 218
RET  A 255 (-3.7A)
None
None
None
RET  A 255 (-4.4A)
1.38A 6fu4C-1uazA:
0.0
6fu4C-1uazA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lic SENSOR PROTEIN

(Shewanella
oneidensis)
PF02743
(dCache_1)
5 TYR A 127
TRP A 154
TYR A 170
ASP A 172
ASP A 200
EDO  A   1 (-4.1A)
EDO  A   1 (-3.4A)
None
EDO  A   1 (-2.9A)
EDO  A   1 (-2.7A)
0.78A 6fu4C-3licA:
20.7
6fu4C-3licA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fbz DELTARHODOPSIN

(Haloterrigena
thermotolerans)
PF01036
(Bac_rhodopsin)
5 TYR A 184
GLU A 204
GLU A 193
TYR A  82
ASP A 212
RET  A 301 (-3.5A)
None
None
None
RET  A 301 (-4.5A)
1.42A 6fu4C-4fbzA:
0.0
6fu4C-4fbzA:
15.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6f9g METHYL-ACCEPTING
CHEMOTAXIS PROTEIN
MCPU


(Pseudomonas
putida)
no annotation 7 TYR A 120
TYR A 152
GLU A 164
TRP A 186
TYR A 202
ASP A 204
ASP A 233
PUT  A 401 (-4.2A)
PUT  A 401 ( 3.5A)
None
PUT  A 401 (-3.5A)
None
PUT  A 401 (-2.7A)
PUT  A 401 (-2.9A)
0.55A 6fu4C-6f9gA:
37.1
6fu4C-6f9gA:
68.75