SIMILAR PATTERNS OF AMINO ACIDS FOR 6FTP_B_DM2B501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b97 RESTRICTION
ENDONUCLEASE ECORV

(Escherichia
coli) 		PF09233
(Endonuc-EcoRV) 		5 LEU A  40
SER A  41
PHE A  44
VAL A 166
ASN A  15
 None
 1.32A 6ftpA-1b97A:
0.0
6ftpB-1b97A:
undetectable		 6ftpA-1b97A:
14.48
6ftpB-1b97A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jae ALPHA-AMYLASE

(Tenebrio
molitor) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C) 		5 LEU A 195
SER A 196
PHE A 199
LEU A 202
VAL A 184
 None
 1.25A 6ftpA-1jaeA:
0.0
6ftpB-1jaeA:
undetectable		 6ftpA-1jaeA:
9.59
6ftpB-1jaeA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr7 HYPOTHETICAL 37.4
KDA PROTEIN IN
ILEY-GABD INTERGENIC
REGION

(Escherichia
coli) 		PF08943
(CsiD) 		5 LEU A 262
SER A 263
GLU A 267
LEU A 191
ASN A 161
 None
 1.09A 6ftpA-1jr7A:
0.0
6ftpB-1jr7A:
undetectable		 6ftpA-1jr7A:
12.86
6ftpB-1jr7A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lb4 TNF
RECEPTOR-ASSOCIATED
FACTOR 6

(Homo sapiens) 		no annotation 5 GLN A 367
LEU A 393
SER A 408
LEU A 479
VAL A 373
 None
 1.48A 6ftpA-1lb4A:
0.0
6ftpB-1lb4A:
undetectable		 6ftpA-1lb4A:
16.55
6ftpB-1lb4A:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pto PERTUSSIS TOXIN
(SUBUNIT S5)

(Bordetella
pertussis) 		PF09276
(Pertus-S5-tox) 		5 LEU F  42
SER F  43
PHE F  26
GLU F  25
LEU F  17
 None
 1.48A 6ftpA-1ptoF:
0.0
6ftpB-1ptoF:
undetectable		 6ftpA-1ptoF:
20.62
6ftpB-1ptoF:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		5 LEU A 394
SER A 395
PHE A 368
LEU A 371
VAL A 339
 None
 1.14A 6ftpA-1ru4A:
0.0
6ftpB-1ru4A:
undetectable		 6ftpA-1ru4A:
10.78
6ftpB-1ru4A:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w36 EXODEOXYRIBONUCLEASE
V GAMMA CHAIN

(Escherichia
coli) 		PF04257
(Exonuc_V_gamma) 		5 GLN C 165
LEU C  95
PHE C 135
LEU C 134
TRP C 169
 None
 1.28A 6ftpA-1w36C:
0.0
6ftpB-1w36C:
undetectable		 6ftpA-1w36C:
4.99
6ftpB-1w36C:
3.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg6 DNA-3-METHYLADENINE
GLYCOSIDASE

(Staphylococcus
aureus) 		PF03352
(Adenine_glyco) 		5 LEU A 166
SER A 164
PHE A 165
GLU A  38
LEU A 157
 None
 1.49A 6ftpA-2jg6A:
0.0
6ftpB-2jg6A:
undetectable		 6ftpA-2jg6A:
17.74
6ftpB-2jg6A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwh SUCROSE ISOMERASE

([Pseudomonas]
mesoacidophila) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 LEU A 518
SER A 543
PHE A 516
LEU A 546
ASN A 488
 None
 1.38A 6ftpA-2pwhA:
0.0
6ftpB-2pwhA:
undetectable		 6ftpA-2pwhA:
10.33
6ftpB-2pwhA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uur COLLAGEN ALPHA-1(IX)
CHAIN

(Homo sapiens) 		no annotation 5 LEU A 152
SER A 150
PHE A 153
LEU A 101
ASN A 104
 None
 1.49A 6ftpA-2uurA:
undetectable
6ftpB-2uurA:
undetectable		 6ftpA-2uurA:
17.24
6ftpB-2uurA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xry DEOXYRIBODIPYRIMIDIN
E PHOTOLYASE

(Methanosarcina
mazei) 		PF00875
(DNA_photolyase) 		5 GLN A  29
LEU A  83
SER A  82
GLU A  78
LEU A  76
 None
 1.31A 6ftpA-2xryA:
undetectable
6ftpB-2xryA:
undetectable		 6ftpA-2xryA:
13.97
6ftpB-2xryA:
6.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cia COLD-ACTIVE
AMINOPEPTIDASE

(Colwellia
psychrerythraea) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 LEU A 304
SER A 305
PHE A 306
LEU A 290
ASN A 169
 None
 1.44A 6ftpA-3ciaA:
undetectable
6ftpB-3ciaA:
undetectable		 6ftpA-3ciaA:
8.35
6ftpB-3ciaA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6w METHYL-ACCEPTING/DNA
RESPONSE REGULATOR

(Bacillus cereus) 		PF04397
(LytTR) 		5 LEU A 157
PHE A 154
GLU A 153
LEU A 151
VAL A 110
 None
 1.25A 6ftpA-3d6wA:
undetectable
6ftpB-3d6wA:
undetectable		 6ftpA-3d6wA:
19.64
6ftpB-3d6wA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcy REGULATOR PROTEIN

(Homo sapiens) 		PF00300
(His_Phos_1) 		5 LEU A 205
SER A 204
PHE A 206
LEU A 226
VAL A   8
 None
 1.08A 6ftpA-3dcyA:
undetectable
6ftpB-3dcyA:
undetectable		 6ftpA-3dcyA:
15.13
6ftpB-3dcyA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gxo MMCR

(Streptomyces
lavendulae) 		PF00891
(Methyltransf_2) 		5 LEU A 289
SER A 315
PHE A 319
GLU A 318
VAL A 285
 None
 1.49A 6ftpA-3gxoA:
undetectable
6ftpB-3gxoA:
undetectable		 6ftpA-3gxoA:
13.57
6ftpB-3gxoA:
7.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld2 PUTATIVE
ACETYLTRANSFERASE

(Streptococcus
mutans) 		PF00583
(Acetyltransf_1) 		5 LEU A 101
PHE A 100
GLU A 103
LEU A  62
VAL A 111
 None
 1.19A 6ftpA-3ld2A:
undetectable
6ftpB-3ld2A:
undetectable		 6ftpA-3ld2A:
24.14
6ftpB-3ld2A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob8 BETA-GALACTOSIDASE

(Kluyveromyces
lactis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N) 		5 LEU A 547
SER A 520
PHE A 521
GLU A 508
LEU A 511
 None
 1.17A 6ftpA-3ob8A:
undetectable
6ftpB-3ob8A:
undetectable		 6ftpA-3ob8A:
6.66
6ftpB-3ob8A:
5.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pu9 PROTEIN
SERINE/THREONINE
PHOSPHATASE

(Sphaerobacter
thermophilus) 		PF07228
(SpoIIE) 		5 GLN A 127
LEU A 197
PHE A 176
LEU A 177
VAL A 159
 None
 1.46A 6ftpA-3pu9A:
undetectable
6ftpB-3pu9A:
undetectable		 6ftpA-3pu9A:
14.89
6ftpB-3pu9A:
9.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		5 LEU A 202
SER A 201
GLU A 204
LEU A 195
VAL A 218
 None
 1.17A 6ftpA-3q1yA:
undetectable
6ftpB-3q1yA:
undetectable		 6ftpA-3q1yA:
13.94
6ftpB-3q1yA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfk UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 GLN A 247
LEU A 198
PHE A 194
GLU A 195
VAL A 245
 None
 1.16A 6ftpA-3qfkA:
undetectable
6ftpB-3qfkA:
undetectable		 6ftpA-3qfkA:
9.92
6ftpB-3qfkA:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rio PTSGHI OPERON
ANTITERMINATOR

(Bacillus
subtilis) 		PF00874
(PRD)
PF03123
(CAT_RBD) 		5 LEU A  66
PHE A  63
LEU A  54
VAL A  75
ASN A  79
 None
 1.44A 6ftpA-3rioA:
undetectable
6ftpB-3rioA:
undetectable		 6ftpA-3rioA:
15.93
6ftpB-3rioA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uhj PROBABLE GLYCEROL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00465
(Fe-ADH) 		5 GLN A 231
LEU A 307
PHE A 199
GLU A 200
LEU A 195
 None
 1.45A 6ftpA-3uhjA:
undetectable
6ftpB-3uhjA:
undetectable		 6ftpA-3uhjA:
11.66
6ftpB-3uhjA:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3un9 NLR FAMILY MEMBER X1

(Homo sapiens) 		PF13516
(LRR_6) 		5 GLN A 969
LEU A 914
SER A 915
LEU A 921
ASN A 702
 None
 1.50A 6ftpA-3un9A:
undetectable
6ftpB-3un9A:
undetectable		 6ftpA-3un9A:
11.56
6ftpB-3un9A:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 LEU A1859
PHE A1875
GLU A1876
LEU A1867
VAL A1807
 None
 1.15A 6ftpA-3vkgA:
undetectable
6ftpB-3vkgA:
undetectable		 6ftpA-3vkgA:
2.29
6ftpB-3vkgA:
1.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfc UVRABC SYSTEM
PROTEIN A

(Escherichia
coli) 		no annotation 5 LEU B 150
SER B 220
PHE B 221
LEU B 225
VAL B 139
 None
 1.39A 6ftpA-4dfcB:
undetectable
6ftpB-4dfcB:
undetectable		 6ftpA-4dfcB:
20.47
6ftpB-4dfcB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 5 GLN B2197
LEU B2212
SER B2210
LEU B2199
VAL B2193
 None
 1.30A 6ftpA-4f6lB:
undetectable
6ftpB-4f6lB:
undetectable		 6ftpA-4f6lB:
11.02
6ftpB-4f6lB:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6l AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		no annotation 5 GLN B2197
LEU B2212
SER B2210
PHE B2208
LEU B2199
 None
 1.36A 6ftpA-4f6lB:
undetectable
6ftpB-4f6lB:
undetectable		 6ftpA-4f6lB:
11.02
6ftpB-4f6lB:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4faj PRGZ

(Enterococcus
faecalis) 		PF00496
(SBP_bac_5) 		5 LEU A 441
SER A 412
LEU A 407
VAL A 338
ASN A 335
 None
 1.28A 6ftpA-4fajA:
undetectable
6ftpB-4fajA:
undetectable		 6ftpA-4fajA:
9.72
6ftpB-4fajA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6j F-BOX/LRR-REPEAT
PROTEIN 3

(Homo sapiens) 		PF12937
(F-box-like) 		5 LEU B 397
SER B 372
PHE B 376
LEU B 351
VAL B 412
 None
 1.29A 6ftpA-4i6jB:
undetectable
6ftpB-4i6jB:
undetectable		 6ftpA-4i6jB:
10.70
6ftpB-4i6jB:
7.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jb9 ANTIBODY VRC06 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set) 		5 LEU H  82
SER H  17
PHE H  82
GLU H  81
LEU H  80
 None
 1.50A 6ftpA-4jb9H:
undetectable
6ftpB-4jb9H:
undetectable		 6ftpA-4jb9H:
18.45
6ftpB-4jb9H:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrf PUTATIVE CELL
ADHESION PROTEIN

(Bacteroides
ovatus) 		PF15495
(Fimbrillin_C) 		5 SER A 298
PHE A 297
LEU A 293
VAL A 325
ASN A 242
 None
 1.34A 6ftpA-4jrfA:
undetectable
6ftpB-4jrfA:
undetectable		 6ftpA-4jrfA:
11.24
6ftpB-4jrfA:
5.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k2p T-LYMPHOMA INVASION
AND
METASTASIS-INDUCING
PROTEIN 1

(Homo sapiens) 		PF00169
(PH) 		5 LEU A 563
PHE A 621
LEU A 570
VAL A 550
ASN A 499
 None
 1.26A 6ftpA-4k2pA:
undetectable
6ftpB-4k2pA:
undetectable		 6ftpA-4k2pA:
14.86
6ftpB-4k2pA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lub PUTATIVE PREPHENATE
DEHYDRATASE

(Streptococcus
mutans) 		PF00800
(PDT) 		5 LEU A 199
SER A 198
PHE A 246
LEU A 225
VAL A 254
 None
 1.12A 6ftpA-4lubA:
undetectable
6ftpB-4lubA:
undetectable		 6ftpA-4lubA:
16.67
6ftpB-4lubA:
10.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		5 LEU A 244
SER A 245
PHE A 246
LEU A 225
VAL A 181
 None
 1.29A 6ftpA-4mq0A:
undetectable
6ftpB-4mq0A:
undetectable		 6ftpA-4mq0A:
10.91
6ftpB-4mq0A:
6.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mx8 PERIPLASMIC BINDING
PROTEIN

(Xylanimonas
cellulosilytica) 		PF01497
(Peripla_BP_2) 		5 LEU A 191
SER A 233
PHE A 234
GLU A 235
VAL A 265
 None
 1.30A 6ftpA-4mx8A:
undetectable
6ftpB-4mx8A:
undetectable		 6ftpA-4mx8A:
12.17
6ftpB-4mx8A:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pyz UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF12436
(USP7_ICP0_bdg) 		5 LEU A 609
SER A 608
PHE A 605
LEU A 602
VAL A 567
 None
 1.41A 6ftpA-4pyzA:
undetectable
6ftpB-4pyzA:
undetectable		 6ftpA-4pyzA:
18.32
6ftpB-4pyzA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q7e RESPONSE REGULATOR
OF A TWO COMPONENT
REGULATORY SYSTEM

(Leptospira
biflexa) 		PF00072
(Response_reg) 		5 LEU A 114
PHE A 110
GLU A 109
LEU A 107
VAL A  51
 None
None
None
SO4  A 203 ( 4.5A)
None
 0.96A 6ftpA-4q7eA:
undetectable
6ftpB-4q7eA:
undetectable		 6ftpA-4q7eA:
20.29
6ftpB-4q7eA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		5 LEU A 212
SER A 210
PHE A 208
GLU A 207
ASN A 190
 None
 1.44A 6ftpA-4r1zA:
undetectable
6ftpB-4r1zA:
undetectable		 6ftpA-4r1zA:
11.31
6ftpB-4r1zA:
7.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpz RNA POLYMERASE II
SUBUNIT A C-TERMINAL
DOMAIN PHOSPHATASE

(Schizosaccharomyces
pombe) 		PF03031
(NIF)
PF12738
(PTCB-BRCT) 		5 GLN A 339
SER A 326
PHE A 328
LEU A 277
ASN A 340
 None
 1.50A 6ftpA-4xpzA:
undetectable
6ftpB-4xpzA:
undetectable		 6ftpA-4xpzA:
10.70
6ftpB-4xpzA:
10.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7t UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 7

(Homo sapiens) 		PF00443
(UCH)
PF12436
(USP7_ICP0_bdg) 		5 LEU A 609
SER A 608
PHE A 605
LEU A 602
VAL A 567
 None
 1.18A 6ftpA-5j7tA:
undetectable
6ftpB-5j7tA:
undetectable		 6ftpA-5j7tA:
9.67
6ftpB-5j7tA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l44 K-26 DIPEPTIDYL
CARBOXYPEPTIDASE

(Astrosporangium
hypotensionis) 		PF01432
(Peptidase_M3) 		5 LEU A 639
SER A 640
PHE A 473
GLU A 475
LEU A 401
 None
 1.25A 6ftpA-5l44A:
undetectable
6ftpB-5l44A:
undetectable		 6ftpA-5l44A:
8.84
6ftpB-5l44A:
5.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lew DNA POLYMERASE III
SUBUNIT ALPHA

(Mycobacterium
tuberculosis) 		no annotation 5 SER A  60
PHE A  57
GLU A  56
VAL A  43
ASN A  15
 None
 1.25A 6ftpA-5lewA:
undetectable
6ftpB-5lewA:
undetectable		 6ftpA-5lewA:
6.39
6ftpB-5lewA:
3.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n8o DNA HELICASE I

(Escherichia
coli) 		PF07057
(TraI)
PF08751
(TrwC)
PF13604
(AAA_30) 		5 LEU A 175
SER A 176
PHE A 185
LEU A 120
VAL A 162
 None
 1.50A 6ftpA-5n8oA:
undetectable
6ftpB-5n8oA:
undetectable		 6ftpA-5n8oA:
4.26
6ftpB-5n8oA:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN
RIBULOSE
BISPHOSPHATE
CARBOXYLASE SMALL
CHAIN 1

(Rhodobacter
sphaeroides) 		PF00016
(RuBisCO_large)
PF00101
(RuBisCO_small)
PF02788
(RuBisCO_large_N) 		5 GLN I  22
SER I   9
PHE I   8
LEU I  14
VAL A 429
 None
 1.43A 6ftpA-5nv3I:
undetectable
6ftpB-5nv3I:
undetectable		 6ftpA-5nv3I:
19.49
6ftpB-5nv3I:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 LEU 2 985
PHE 2 986
GLU 2 983
LEU 21020
VAL 2 462
 None
 1.24A 6ftpA-5zvs2:
undetectable
6ftpB-5zvs2:
undetectable		 6ftpA-5zvs2:
23.46
6ftpB-5zvs2:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ans UNCHARACTERIZED
PROTEIN

(Burkholderia
cenocepacia) 		PF06742
(DUF1214) 		5 LEU A 113
SER A 114
PHE A 115
LEU A 170
VAL A 147
 None
 1.24A 6ftpA-6ansA:
undetectable
6ftpB-6ansA:
undetectable		 6ftpA-6ansA:
13.06
6ftpB-6ansA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 FACTOR VIII INTRON
22 PROTEIN

(Homo sapiens) 		no annotation 5 GLN B 323
LEU B 314
PHE B 319
GLU B 316
LEU B 320
 None
 1.41A 6ftpA-6ez8B:
undetectable
6ftpB-6ez8B:
undetectable		 6ftpA-6ez8B:
19.05
6ftpB-6ez8B:
18.18