SIMILAR PATTERNS OF AMINO ACIDS FOR 6FOS_B_PQNB2002_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1biy LACTOFERRIN

(Bubalus bubalis) 		PF00405
(Transferrin) 		4 MET A 129
ARG A 121
TRP A 125
ALA A 123
 None
CO3  A 692 (-4.2A)
None
CO3  A 692 (-3.2A)
 1.19A 6fosB-1biyA:
undetectable		 6fosB-1biyA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvl HULYS11

(Homo sapiens;
Mus musculus) 		PF07686
(V-set) 		4 MET A  50
TRP A  47
LEU A 103
ALA A  96
 None
 1.15A 6fosB-1bvlA:
undetectable		 6fosB-1bvlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg7 FORMYLTETRAHYDROFOLA
TE SYNTHETASE

(Moorella
thermoacetica) 		PF01268
(FTHFS) 		4 MET A1146
ALA A1248
LEU A1250
ALA A1139
 None
 1.23A 6fosB-1eg7A:
undetectable		 6fosB-1eg7A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2c MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		4 ARG A 137
ALA A 118
LEU A 117
ALA A 113
 None
 1.23A 6fosB-1h2cA:
undetectable		 6fosB-1h2cA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2d MATRIX PROTEIN VP40

(Ebola virus sp.) 		PF07447
(VP40) 		4 ARG A 137
ALA A 118
LEU A 117
ALA A 113
 None
 1.22A 6fosB-1h2dA:
undetectable		 6fosB-1h2dA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h76 SEROTRANSFERRIN

(Sus scrofa) 		PF00405
(Transferrin) 		4 MET A 131
ARG A 123
TRP A 127
ALA A 125
 None
CO3  A 700 (-3.6A)
None
CO3  A 700 (-3.3A)
 1.11A 6fosB-1h76A:
undetectable		 6fosB-1h76A:
7.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io0 TROPOMODULIN

(Gallus gallus) 		no annotation 4 ARG A 327
ALA A 303
LEU A 306
ALA A 331
 None
 1.07A 6fosB-1io0A:
undetectable		 6fosB-1io0A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq7 OVOTRANSFERRIN

(Gallus gallus) 		PF00405
(Transferrin) 		4 MET A 468
ARG A 460
TRP A 464
ALA A 457
 None
 1.18A 6fosB-1iq7A:
undetectable		 6fosB-1iq7A:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kip MONOCLONAL ANTIBODY
D1.3

(Mus musculus) 		PF07686
(V-set) 		4 MET B  50
TRP B  47
LEU B 103
ALA B  96
 None
 1.17A 6fosB-1kipB:
undetectable		 6fosB-1kipB:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1los OROTIDINE
MONOPHOSPHATE
DECARBOXYLASE

(Methanothermobacter
thermautotrophicus) 		PF00215
(OMPdecase) 		4 MET A  19
ALA A 208
LEU A 207
ALA A 203
 None
None
None
UP6  A5001 (-3.3A)
 1.10A 6fosB-1losA:
undetectable		 6fosB-1losA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o3x ADP-RIBOSYLATION
FACTOR BINDING
PROTEIN GGA1

(Homo sapiens) 		PF03127
(GAT) 		4 ARG A 214
ALA A 276
LEU A 277
ALA A 267
 None
 1.12A 6fosB-1o3xA:
2.6		 6fosB-1o3xA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rbl RIBULOSE 1,5
BISPHOSPHATE
CARBOXYLASE/OXYGENAS
E (LARGE CHAIN)

(Synechococcus
elongatus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 TRP A 385
ALA A 458
LEU A 455
ALA A 423
 None
 1.23A 6fosB-1rblA:
undetectable		 6fosB-1rblA:
8.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tkc TRANSKETOLASE

(Saccharomyces
cerevisiae) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 MET A 613
ALA A 572
LEU A 576
ALA A 583
 None
 0.99A 6fosB-1tkcA:
undetectable		 6fosB-1tkcA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukw ACYL-COA
DEHYDROGENASE

(Thermus
thermophilus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 TRP A 195
ALA A 193
LEU A 150
ALA A 149
 None
 1.17A 6fosB-1ukwA:
2.9		 6fosB-1ukwA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 MET A 376
ALA A 382
LEU A 381
ALA A 419
 C2E  A 503 ( 4.8A)
None
None
None
 1.06A 6fosB-1w25A:
undetectable		 6fosB-1w25A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ARG A 129
ALA A 122
LEU A 127
ALA A 100
 None
 0.88A 6fosB-1wdtA:
undetectable		 6fosB-1wdtA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdw TRYPTOPHAN SYNTHASE
ALPHA CHAIN
TRYPTOPHAN SYNTHASE
BETA CHAIN 1

(Pyrococcus
furiosus) 		PF00290
(Trp_syntA)
PF00291
(PALP) 		4 ARG B 170
ALA A  46
LEU B 169
ALA B 168
 None
 1.16A 6fosB-1wdwB:
undetectable		 6fosB-1wdwB:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wxd SHIKIMATE
5-DEHYDROGENASE

(Thermus
thermophilus) 		PF01488
(Shikimate_DH)
PF08501
(Shikimate_dh_N) 		4 ARG A 151
ALA A 124
LEU A 155
ALA A 154
 SO4  A1403 (-3.8A)
None
None
None
 1.23A 6fosB-1wxdA:
undetectable		 6fosB-1wxdA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6o FERRITIN HEAVY CHAIN

(Trichoplusia ni) 		PF00210
(Ferritin) 		4 MET M 171
ALA M 108
LEU M 109
ALA M 164
 None
 1.19A 6fosB-1z6oM:
3.2		 6fosB-1z6oM:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb1 O-ACETYL HOMOSERINE
SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		4 ARG A  64
ALA A   7
LEU A   6
ALA A  67
 None
 1.12A 6fosB-2cb1A:
undetectable		 6fosB-2cb1A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfz SDS HYDROLASE SDSA1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B)
PF14863
(Alkyl_sulf_dimr)
PF14864
(Alkyl_sulf_C) 		4 ARG A 517
ALA A 490
LEU A 493
ALA A 512
 None
 1.22A 6fosB-2cfzA:
undetectable		 6fosB-2cfzA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2chc PROTEIN RV3472

(Mycobacterium
tuberculosis) 		PF13577
(SnoaL_4) 		4 ARG A  57
ALA A  34
LEU A  56
ALA A  55
 None
 1.17A 6fosB-2chcA:
undetectable		 6fosB-2chcA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpn GLYCEROL KINASE

(Thermus
thermophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ARG A  89
ALA A 159
LEU A 211
ALA A 210
 None
 1.08A 6fosB-2dpnA:
undetectable		 6fosB-2dpnA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dwc 433AA LONG
HYPOTHETICAL
PHOSPHORIBOSYLGLYCIN
AMIDE FORMYL
TRANSFERASE

(Pyrococcus
horikoshii) 		PF02222
(ATP-grasp) 		4 MET A 119
ALA A  97
LEU A  98
ALA A 112
 None
 1.20A 6fosB-2dwcA:
undetectable		 6fosB-2dwcA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fu2 HYPOTHETICAL PROTEIN
SPY2152

(Streptococcus
pyogenes) 		PF08951
(EntA_Immun) 		4 MET A  42
ALA A  10
LEU A  11
ALA A  34
 None
 1.17A 6fosB-2fu2A:
undetectable		 6fosB-2fu2A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g38 PE FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00934
(PE) 		4 ARG A  19
ALA A  77
LEU A  80
ALA A  14
 None
 1.15A 6fosB-2g38A:
4.6		 6fosB-2g38A:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iip NICOTINAMIDE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF01234
(NNMT_PNMT_TEMT) 		4 ARG A 181
ALA A 228
LEU A 180
ALA A 179
 None
 1.21A 6fosB-2iipA:
undetectable		 6fosB-2iipA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyf OLEANDOMYCIN
GLYCOSYLTRANSFERASE

(Streptomyces
antibioticus) 		PF00201
(UDPGT) 		4 ARG A 374
ALA A 370
LEU A 373
ALA A 318
 None
 1.20A 6fosB-2iyfA:
undetectable		 6fosB-2iyfA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 ARG A 221
ALA A 245
LEU A 244
ALA A 225
 None
 1.13A 6fosB-2nlzA:
undetectable		 6fosB-2nlzA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 ARG A 293
ALA A 381
LEU A 292
ALA A 291
 ARG  A 293 (-0.6A)
ALA  A 381 ( 0.0A)
LEU  A 292 ( 0.6A)
ALA  A 291 ( 0.0A)
 1.19A 6fosB-2ogsA:
undetectable		 6fosB-2ogsA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjo TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Paraburkholderia
phytofirmans) 		PF13407
(Peripla_BP_4) 		4 ARG A 252
ALA A 257
LEU A 251
ALA A 250
 None
 1.11A 6fosB-2rjoA:
undetectable		 6fosB-2rjoA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium) 		PF16990
(CBM_35) 		4 ARG A  67
ALA A 119
LEU A 118
ALA A 112
 CA  A1138 ( 4.5A)
None
None
None
 1.05A 6fosB-2w3jA:
undetectable		 6fosB-2w3jA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wgb TETR FAMILY
TRANSCRIPTIONAL
REPRESSOR LFRR

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N) 		4 MET A 155
ARG A 148
TRP A 152
LEU A 132
 None
 1.16A 6fosB-2wgbA:
undetectable		 6fosB-2wgbA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 MET A 173
ALA A 185
LEU A 188
ALA A 189
 None
 0.86A 6fosB-2xdrA:
undetectable		 6fosB-2xdrA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn GLYCOSYLTRANSFERASE

(Saccharopolyspora
erythraea) 		PF06722
(DUF1205) 		4 MET A 127
ALA A  58
LEU A  59
ALA A  55
 None
 1.17A 6fosB-2yjnA:
undetectable		 6fosB-2yjnA:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 ARG A 211
ALA A  70
LEU A  69
ALA A  93
 None
 1.17A 6fosB-2yrrA:
undetectable		 6fosB-2yrrA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8t FUMARATE LYASE

(Chelativorans
sp. BNC1) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 MET A 355
ALA A 177
LEU A 147
ALA A 146
 None
 1.05A 6fosB-3c8tA:
2.0		 6fosB-3c8tA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cnh HYDROLASE FAMILY
PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		4 MET A  80
TRP A  19
ALA A  46
LEU A  49
 None
 1.15A 6fosB-3cnhA:
undetectable		 6fosB-3cnhA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6c THERMONUCLEASE

(Staphylococcus
aureus) 		PF00565
(SNase) 		4 MET A  65
ALA A 109
LEU A 108
ALA A  58
 None
 1.12A 6fosB-3d6cA:
undetectable		 6fosB-3d6cA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbk ELASTASE

(Pseudomonas
aeruginosa) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 MET A 169
ALA A 289
LEU A 236
ALA A 237
 None
 1.10A 6fosB-3dbkA:
undetectable		 6fosB-3dbkA:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoq PUTATIVE ZINC
PROTEASE

(Thermus
thermophilus) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 MET A 350
ALA A  95
LEU A  26
ALA A 187
 None
 1.14A 6fosB-3eoqA:
undetectable		 6fosB-3eoqA:
10.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3io1 AMINOBENZOYL-GLUTAMA
TE UTILIZATION
PROTEIN

(Klebsiella
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 MET A  63
ALA A 338
LEU A 379
ALA A 189
 None
 1.17A 6fosB-3io1A:
undetectable		 6fosB-3io1A:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix7 UNCHARACTERIZED
PROTEIN TTHA0540

(Thermus
thermophilus) 		no annotation 4 MET A 246
ALA A 229
LEU A 236
ALA A 254
 None
 1.16A 6fosB-3ix7A:
undetectable		 6fosB-3ix7A:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kty PROBABLE
METHYLTRANSFERASE

(Bordetella
pertussis) 		PF00588
(SpoU_methylase) 		4 MET A  46
ALA A  25
LEU A  36
ALA A  66
 None
 1.02A 6fosB-3ktyA:
undetectable		 6fosB-3ktyA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6d PUTATIVE
OXIDOREDUCTASE

(Pseudomonas
putida) 		PF03446
(NAD_binding_2) 		4 MET A  85
ALA A  62
LEU A  63
ALA A  91
 None
 1.02A 6fosB-3l6dA:
undetectable		 6fosB-3l6dA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lou FORMYLTETRAHYDROFOLA
TE DEFORMYLASE

(Burkholderia
mallei) 		PF00551
(Formyl_trans_N) 		4 MET A 100
ALA A 187
LEU A 191
ALA A 195
 None
 0.88A 6fosB-3louA:
undetectable		 6fosB-3louA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		4 MET A 154
ALA A  94
LEU A  95
ALA A  96
 None
 1.16A 6fosB-3njpA:
undetectable		 6fosB-3njpA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njr PRECORRIN-6Y
METHYLASE

(Rhodobacter
capsulatus) 		no annotation 4 ARG A 128
ALA A 104
LEU A  30
ALA A  29
 None
 1.17A 6fosB-3njrA:
undetectable		 6fosB-3njrA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nqx SECRETED
METALLOPROTEASE
MCP02

(Pseudoalteromonas
sp. SM9913) 		PF01447
(Peptidase_M4)
PF02868
(Peptidase_M4_C) 		4 MET A 374
ALA A 494
LEU A 441
ALA A 442
 None
 1.10A 6fosB-3nqxA:
undetectable		 6fosB-3nqxA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ntx CYTOPLASMIC
L-ASPARAGINASE I

(Yersinia pestis) 		PF00710
(Asparaginase) 		4 MET A  63
ALA A  72
LEU A 101
ALA A 100
 None
 1.06A 6fosB-3ntxA:
undetectable		 6fosB-3ntxA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ARG A 271
ALA A 238
LEU A 241
ALA A 275
 None
 1.23A 6fosB-3nyqA:
undetectable		 6fosB-3nyqA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 4 MET B   1
ALA B 130
LEU B 129
ALA B 125
 None
HEM  B 404 (-4.4A)
HEM  B 404 ( 4.3A)
DGG  B 406 ( 3.8A)
 1.18A 6fosB-3ozvB:
undetectable		 6fosB-3ozvB:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qhb SYMERYTHRIN

(Cyanophora
paradoxa) 		PF02915
(Rubrerythrin) 		4 MET A  63
ALA A 120
LEU A 117
ALA A  52
 None
 1.05A 6fosB-3qhbA:
undetectable		 6fosB-3qhbA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qvf FOMA PROTEIN

(Streptomyces
wedmorensis) 		PF00696
(AA_kinase) 		4 TRP A 145
ALA A  69
LEU A  72
ALA A 136
 None
 1.01A 6fosB-3qvfA:
undetectable		 6fosB-3qvfA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqb UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF13622
(4HBT_3) 		4 MET A 169
ARG A 175
ALA A 181
LEU A 177
 None
 0.94A 6fosB-3rqbA:
undetectable		 6fosB-3rqbA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcq MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		4 ARG A 137
ALA A 118
LEU A 117
ALA A 113
 None
 1.19A 6fosB-3tcqA:
undetectable		 6fosB-3tcqA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uoe DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF02615
(Ldh_2) 		4 MET A 137
ALA A 239
LEU A 240
ALA A 110
 None
 1.17A 6fosB-3uoeA:
undetectable		 6fosB-3uoeA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5r PROTEIN GAL3

(Saccharomyces
cerevisiae) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 MET A 208
ALA A 221
LEU A  65
ALA A  66
 None
 1.19A 6fosB-3v5rA:
2.1		 6fosB-3v5rA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhd SERINE
HYDROXYMETHYLTRANSFE
RASE

(Methanocaldococcus
jannaschii) 		PF00464
(SHMT) 		4 MET A 374
ALA A 383
LEU A 291
ALA A 290
 None
 1.17A 6fosB-4bhdA:
undetectable		 6fosB-4bhdA:
10.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bk1 PROBABLE SALICYLATE
MONOOXYGENASE

(Rhodococcus
jostii) 		PF01494
(FAD_binding_3) 		4 TRP A  61
ALA A 318
LEU A  25
ALA A  26
 None
 1.24A 6fosB-4bk1A:
undetectable		 6fosB-4bk1A:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bko PUTATIVE REDUCTASE
BURPS305_1051

(Burkholderia
pseudomallei) 		PF07055
(Eno-Rase_FAD_bd)
PF12241
(Enoyl_reductase)
PF12242
(Eno-Rase_NADH_b) 		4 ARG A 255
ALA A 265
LEU A 254
ALA A 253
 GOL  A1398 (-3.8A)
None
None
None
 1.23A 6fosB-4bkoA:
undetectable		 6fosB-4bkoA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		4 MET A 539
ALA A 342
LEU A 318
ALA A 317
 None
 1.12A 6fosB-4byfA:
undetectable		 6fosB-4byfA:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d47 LEVANSUCRASE

(Erwinia
amylovora) 		PF02435
(Glyco_hydro_68) 		4 MET A 237
ALA A 310
LEU A 313
ALA A  16
 None
 1.15A 6fosB-4d47A:
undetectable		 6fosB-4d47A:
10.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4elx 1,4-DIHYDROXY-2-NAPH
THOYL-COA SYNTHASE

(Escherichia
coli) 		PF00378
(ECH_1) 		4 MET A 227
ALA A 250
LEU A 249
ALA A 234
 None
 1.23A 6fosB-4elxA:
undetectable		 6fosB-4elxA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eqf PEX5-RELATED PROTEIN

(Mus musculus) 		PF13181
(TPR_8)
PF13432
(TPR_16) 		4 MET A 294
ARG A 288
ALA A 303
LEU A 287
 None
 1.15A 6fosB-4eqfA:
undetectable		 6fosB-4eqfA:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 MET A 297
TRP A  36
LEU A  14
ALA A 152
 None
 1.08A 6fosB-4fnqA:
undetectable		 6fosB-4fnqA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw9 GLUTATHIONE
TRANSFERASE

(Mannheimia
haemolytica) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 MET A 168
ALA A  99
LEU A  98
ALA A 161
 None
 1.19A 6fosB-4iw9A:
undetectable		 6fosB-4iw9A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j72 PHOSPHO-N-ACETYLMURA
MOYL-PENTAPEPTIDE-TR
ANSFERASE

(Aquifex
aeolicus) 		PF00953
(Glycos_transf_4)
PF10555
(MraY_sig1) 		4 MET A 355
ALA A 292
LEU A 348
ALA A 349
 None
 1.15A 6fosB-4j72A:
undetectable		 6fosB-4j72A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ld8 MATRIX PROTEIN VP40

(Sudan
ebolavirus) 		PF07447
(VP40) 		4 ARG A 137
ALA A 118
LEU A 117
ALA A 113
 None
 1.21A 6fosB-4ld8A:
undetectable		 6fosB-4ld8A:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldm MATRIX PROTEIN VP40

(Zaire
ebolavirus) 		PF07447
(VP40) 		4 ARG A 137
ALA A 118
LEU A 117
ALA A 113
 None
 1.23A 6fosB-4ldmA:
undetectable		 6fosB-4ldmA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjz OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Toxoplasma
gondii) 		PF00215
(OMPdecase) 		4 ARG A 115
ALA A 113
LEU A 111
ALA A 129
 None
 1.23A 6fosB-4mjzA:
undetectable		 6fosB-4mjzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		4 MET A 109
ARG A 351
ALA A 347
ALA A 103
 None
 1.01A 6fosB-4mm0A:
undetectable		 6fosB-4mm0A:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq3 CYANURIC ACID
AMIDOHYDROLASE

(Azorhizobium
caulinodans) 		PF09663
(Amido_AtzD_TrzD) 		4 MET A 125
ALA A 196
LEU A 197
ALA A 132
 None
 1.17A 6fosB-4nq3A:
undetectable		 6fosB-4nq3A:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf8 TRAP-T FAMILY
TRANSPORTER, DCTP
(PERIPLASMIC
BINDING) SUBUNIT

(Sulfitobacter
sp. NAS-14.1) 		PF03480
(DctP) 		4 MET A 119
ALA A 130
LEU A 131
ALA A 138
 None
 1.09A 6fosB-4pf8A:
undetectable		 6fosB-4pf8A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r72 ABC-TYPE FE3+
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Actinobacillus
pleuropneumoniae) 		PF13343
(SBP_bac_6) 		4 TRP A 262
ALA A 282
LEU A 268
ALA A 267
 None
 1.00A 6fosB-4r72A:
undetectable		 6fosB-4r72A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 MET A 691
ARG A 697
TRP A 700
ALA A 724
LEU A 725
 CLA  A9013 ( 3.6A)
None
PQN  A5001 ( 3.4A)
PQN  A5001 (-3.4A)
PQN  A5001 ( 3.7A)
 0.79A 6fosB-4rkuA:
28.2		 6fosB-4rkuA:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 MET B 662
ARG B 668
TRP B 671
ALA B 699
LEU B 700
 CLA  B9023 ( 3.3A)
None
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
 0.73A 6fosB-4rkuB:
32.8		 6fosB-4rkuB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rku PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Pisum sativum) 		PF00223
(PsaA_PsaB) 		5 MET B 662
TRP B 671
ALA B 699
LEU B 700
ALA B 705
 CLA  B9023 ( 3.3A)
PQN  B5002 ( 3.3A)
PQN  B5002 (-3.2A)
PQN  B5002 (-3.7A)
PQN  B5002 (-3.4A)
 0.55A 6fosB-4rkuB:
32.8		 6fosB-4rkuB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4k PE FAMILY PROTEIN
PE25

(Mycobacterium
tuberculosis) 		PF00934
(PE) 		4 ARG A  19
ALA A  77
LEU A  80
ALA A  14
 None
 1.14A 6fosB-4w4kA:
5.2		 6fosB-4w4kA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y4r BIFUNCTIONAL
LYSINE-SPECIFIC
DEMETHYLASE AND
HISTIDYL-HYDROXYLASE
NO66

(Homo sapiens) 		PF08007
(Cupin_4) 		4 MET A 538
ALA A 582
LEU A 610
ALA A 611
 None
 1.12A 6fosB-4y4rA:
undetectable		 6fosB-4y4rA:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		4 ARG A 192
ALA A 199
LEU A 191
ALA A 190
 None
 1.21A 6fosB-4y90A:
undetectable		 6fosB-4y90A:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypj BETA GALACTOSIDASE

(Bacillus
circulans) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 MET A 344
ALA A 390
LEU A 395
ALA A 374
 None
 1.11A 6fosB-4ypjA:
undetectable		 6fosB-4ypjA:
6.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		4 MET A  99
ALA A  79
LEU A  78
ALA A 312
 None
 0.89A 6fosB-5ci5A:
undetectable		 6fosB-5ci5A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cu1 DMSP LYASE

(Ruegeria
pomeroyi) 		PF16867
(DMSP_lyase) 		4 MET A  51
ALA A 180
LEU A 139
ALA A 140
 None
 1.20A 6fosB-5cu1A:
undetectable		 6fosB-5cu1A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoc FAB FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 MET H  50
TRP H  47
LEU H 106
ALA H  97
 None
 1.20A 6fosB-5eocH:
undetectable		 6fosB-5eocH:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 4 MET A 170
ALA A  86
LEU A  89
ALA A  95
 None
 0.84A 6fosB-5h4vA:
undetectable		 6fosB-5h4vA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5p TRAP TRANSPORTER
SOLUTE BINDING
PROTEIN

(uncultured
marine
bacterium) 		PF03480
(DctP) 		4 MET A 178
ALA A 160
LEU A 163
ALA A 184
 None
 1.05A 6fosB-5i5pA:
1.5		 6fosB-5i5pA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko5 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Schistosoma
mansoni) 		PF01048
(PNP_UDP_1) 		4 ARG A 103
ALA A  99
LEU A 100
ALA A  12
 None
 1.22A 6fosB-5ko5A:
undetectable		 6fosB-5ko5A:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o27 NEUROGLOBIN

(Mus musculus) 		no annotation 4 MET A 144
TRP A 140
ALA A  75
LEU A  85
 None
XE  A 205 (-4.4A)
XE  A 205 ( 4.5A)
None
 1.15A 6fosB-5o27A:
undetectable		 6fosB-5o27A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 4 TRP A 235
ALA A 238
LEU A 241
ALA A  63
 None
 1.09A 6fosB-5o6vA:
undetectable		 6fosB-5o6vA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opg ENVELOPE
GLYCOPROTEIN GN

(Hantaan
orthohantavirus) 		PF01567
(Hanta_G1) 		4 MET A  25
ARG A 165
ALA A 160
LEU A 161
 None
 1.09A 6fosB-5opgA:
undetectable		 6fosB-5opgA:
13.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Synechocystis
sp. PCC 6803) 		no annotation 5 MET 1 684
ARG 1 690
TRP 1 693
ALA 1 717
LEU 1 718
 CLA  1 802 ( 3.2A)
None
PQN  1 842 ( 3.3A)
PQN  1 842 (-3.2A)
PQN  1 842 ( 3.6A)
 0.76A 6fosB-5oy01:
27.7		 6fosB-5oy01:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2

(Synechocystis
sp. PCC 6803) 		no annotation 6 MET b 659
ARG b 665
TRP b 668
ALA b 696
LEU b 697
ALA b 702
 CLA  b1807 ( 3.2A)
None
PQN  b1844 ( 3.4A)
PQN  b1844 (-3.2A)
PQN  b1844 ( 3.8A)
PQN  b1844 (-3.1A)
 0.60A 6fosB-5oy0b:
32.7		 6fosB-5oy0b:
85.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t13 CYANURIC ACID
AMIDOHYDROLASE

(Enterobacter
cloacae) 		PF09663
(Amido_AtzD_TrzD) 		4 MET A 132
ALA A 203
LEU A 204
ALA A 139
 None
 1.20A 6fosB-5t13A:
undetectable		 6fosB-5t13A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uoh CARBOXYLESTERASE A

(Mycobacterium
tuberculosis) 		PF00561
(Abhydrolase_1) 		4 MET A 248
ALA A 253
LEU A 474
ALA A 475
 None
 1.21A 6fosB-5uohA:
undetectable		 6fosB-5uohA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3r PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		no annotation 4 ARG A2295
TRP A2294
LEU A2293
ALA A2292
 None
 0.99A 6fosB-6b3rA:
undetectable		 6fosB-6b3rA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fah CAFFEYL-COA
REDUCTASE-ETF
COMPLEX SUBUNIT CARC

(Acetobacterium
woodii) 		no annotation 4 MET C   1
ALA C 318
LEU C 297
ALA C 294
 None
 1.20A 6fosB-6fahC:
3.4		 6fosB-6fahC:
23.17