SIMILAR PATTERNS OF AMINO ACIDS FOR 6FNM_A_1N1A1001_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 428
LYS A 430
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
SER A 538
 None
 0.76A 6fnmA-1k2pA:
26.0		 6fnmA-1k2pA:
36.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
MET A 269
 None
 0.88A 6fnmA-1k9aA:
32.4		 6fnmA-1k9aA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
MET A 269
 None
 0.97A 6fnmA-1k9aA:
32.4		 6fnmA-1k9aA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
MET A 269
GLY A 272
 None
 0.79A 6fnmA-1k9aA:
32.4		 6fnmA-1k9aA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
MET A 240
THR A 266
MET A 269
GLY A 272
 None
 1.07A 6fnmA-1k9aA:
32.4		 6fnmA-1k9aA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
SER A 331
 None
 0.74A 6fnmA-1k9aA:
32.4		 6fnmA-1k9aA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
LYS A 222
MET A 240
THR A 266
MET A 269
GLY A 272
LEU A 321
SER A 331
 None
 1.01A 6fnmA-1k9aA:
32.4		 6fnmA-1k9aA:
27.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 275
ALA A 288
ILE A 332
THR A 334
MET A 337
GLY A 340
LEU A 389
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.72A 6fnmA-1opkA:
32.3		 6fnmA-1opkA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 275
ALA A 288
LYS A 290
GLU A 305
ILE A 332
THR A 334
MET A 337
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
None
 0.81A 6fnmA-1opkA:
32.3		 6fnmA-1opkA:
27.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  86
ALA A  99
LYS A 101
ILE A 145
MET A 150
GLY A 153
LEU A 201
 ATP  A 535 (-4.1A)
ATP  A 535 (-3.6A)
ATP  A 535 ( 2.5A)
5EA  A1001 ( 3.7A)
None
ATP  A 535 ( 4.7A)
ATP  A 535 (-4.8A)
 0.66A 6fnmA-1s9iA:
22.3		 6fnmA-1s9iA:
27.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 369
VAL A 377
ALA A 389
LYS A 391
MET A 438
GLY A 441
LEU A 489
SER A 499
 None
 0.89A 6fnmA-1snxA:
24.9		 6fnmA-1snxA:
38.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
ILE X  80
THR X  82
MET X  85
LEU X 137
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
None
STU  X 902 (-4.4A)
 1.00A 6fnmA-2dq7X:
33.3		 6fnmA-2dq7X:
40.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL X  25
ALA X  37
MET X  58
ILE X  80
THR X  82
MET X  85
GLY X  88
LEU X 137
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.1A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.94A 6fnmA-2dq7X:
33.3		 6fnmA-2dq7X:
40.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		7 VAL A  27
ALA A  40
LYS A  42
GLU A  59
ILE A  91
MET A  96
LEU A 144
 ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
None
ADP  A 500 (-4.3A)
 0.81A 6fnmA-2f9gA:
16.7		 6fnmA-2f9gA:
27.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.50A 6fnmA-2h8hA:
30.8		 6fnmA-2h8hA:
26.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
ILE A 336
THR A 338
MET A 341
GLY A 344
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
QUE  A   1 (-3.3A)
None
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.51A 6fnmA-2hckA:
30.4		 6fnmA-2hckA:
29.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
GLY A 344
LEU A 393
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-3.0A)
QUE  A   1 (-4.4A)
 0.76A 6fnmA-2hckA:
30.4		 6fnmA-2hckA:
29.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		11 ILE A 635
VAL A 643
ALA A 659
LYS A 661
GLU A 678
MET A 682
ILE A 705
THR A 707
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.59A 6fnmA-2henA:
39.9		 6fnmA-2henA:
79.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 ILE A 635
VAL A 643
ALA A 659
LYS A 661
GLU A 678
THR A 707
MET A 710
GLY A 713
LEU A 761
SER A 771
 ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 ( 4.9A)
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.58A 6fnmA-2henA:
39.9		 6fnmA-2henA:
79.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
LYS A 273
GLU A 288
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.58A 6fnmA-2hk5A:
27.2		 6fnmA-2hk5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
LYS A 273
MET A 292
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.77A 6fnmA-2hk5A:
27.2		 6fnmA-2hk5A:
40.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 256
ALA A 269
LYS A 271
ILE A 313
THR A 315
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
 0.72A 6fnmA-2hz0A:
31.6		 6fnmA-2hz0A:
40.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 ILE A 428
VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
 4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
None
 0.74A 6fnmA-2j0jA:
34.5		 6fnmA-2j0jA:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2jkm FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		9 ILE A 428
VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
ILE A 497
GLY A 505
LEU A 553
 BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
None
None
None
BII  A1687 (-3.6A)
BII  A1687 (-4.2A)
 1.07A 6fnmA-2jkmA:
34.9		 6fnmA-2jkmA:
41.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
LYS A 273
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.73A 6fnmA-2og8A:
32.1		 6fnmA-2og8A:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 271
MET A 292
ILE A 314
THR A 316
MET A 319
GLY A 322
LEU A 371
 1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.89A 6fnmA-2og8A:
32.1		 6fnmA-2og8A:
41.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 259
ALA A 271
LYS A 273
ILE A 314
THR A 316
MET A 319
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 4.3A)
 0.73A 6fnmA-2og8A:
32.1		 6fnmA-2og8A:
41.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium) 		PF07714
(Pkinase_Tyr) 		8 ILE B  47
VAL B  55
ALA B  67
LYS B  69
GLU B  85
MET B 117
GLY B 120
LEU B 171
 None
 0.65A 6fnmA-2qkwB:
24.7		 6fnmA-2qkwB:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 204
ALA A 215
LYS A 217
GLU A 230
THR A 265
GLY A 271
LEU A 328
 ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
None
ADE  A 488 (-4.3A)
ADE  A 488 ( 4.1A)
ADE  A 488 (-4.4A)
 0.83A 6fnmA-2qluA:
26.0		 6fnmA-2qluA:
26.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 674
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.60A 6fnmA-2qobA:
30.9		 6fnmA-2qobA:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 635
ALA A 651
LYS A 653
GLU A 670
MET A 702
GLY A 705
LEU A 753
SER A 763
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
None
 0.77A 6fnmA-2qobA:
30.9		 6fnmA-2qobA:
69.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 ILE A 681
VAL A 689
ALA A 705
GLU A 724
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
SER A 817
 None
 0.56A 6fnmA-2r2pA:
38.3		 6fnmA-2r2pA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 ILE A 681
VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
MET A 756
GLY A 759
LEU A 807
 None
 0.54A 6fnmA-2r2pA:
38.3		 6fnmA-2r2pA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 ILE A 681
VAL A 689
ALA A 705
LYS A 707
GLU A 724
ILE A 751
MET A 756
GLY A 759
LEU A 807
SER A 817
 None
 0.70A 6fnmA-2r2pA:
38.3		 6fnmA-2r2pA:
73.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 732
ALA A 749
LYS A 751
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.75A 6fnmA-2r4bA:
28.3		 6fnmA-2r4bA:
39.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 ILE A 627
VAL A 635
ALA A 651
ILE A 697
THR A 699
MET A 702
GLY A 705
LEU A 753
SER A 763
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.59A 6fnmA-2xyuA:
34.3		 6fnmA-2xyuA:
77.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 ILE A 627
VAL A 635
ALA A 651
LYS A 653
ILE A 697
THR A 699
SER A 763
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-3.2A)
 0.81A 6fnmA-2xyuA:
34.3		 6fnmA-2xyuA:
77.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 ILE A 627
VAL A 635
ALA A 651
MET A 674
THR A 699
GLY A 705
LEU A 753
SER A 763
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-3.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
Q9G  A1898 (-3.2A)
 0.95A 6fnmA-2xyuA:
34.3		 6fnmA-2xyuA:
77.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 VAL A 261
ALA A 273
LYS A 275
GLU A 290
MET A 294
ILE A 317
THR A 319
MET A 322
GLY A 325
LEU A 374
 None
 0.53A 6fnmA-2zv7A:
33.8		 6fnmA-2zv7A:
39.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
GLU A 236
ILE A 264
THR A 266
MET A 269
 None
 0.89A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
MET A 269
 None
 0.98A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
MET A 269
GLY A 272
 None
 0.79A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 201
VAL A 209
ALA A 220
LYS A 222
MET A 240
THR A 266
MET A 269
GLY A 272
 None
 1.07A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
LYS A 222
ILE A 264
THR A 266
MET A 269
GLY A 272
LEU A 321
SER A 331
 None
 0.74A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
LYS A 222
MET A 240
THR A 266
MET A 269
GLY A 272
LEU A 321
SER A 331
 None
 1.01A 6fnmA-3d7uA:
28.1		 6fnmA-3d7uA:
38.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 639
VAL A 647
ALA A 663
GLU A 682
MET A 686
ILE A 709
MET A 714
GLY A 717
LEU A 765
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
 0.78A 6fnmA-3dkoA:
37.0		 6fnmA-3dkoA:
70.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 ILE A 639
VAL A 647
ALA A 663
LYS A 665
GLU A 682
MET A 686
ILE A 709
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.8A)
IHZ  A1001 (-3.5A)
None
 0.77A 6fnmA-3dkoA:
37.0		 6fnmA-3dkoA:
70.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 ILE A 639
VAL A 647
ALA A 663
MET A 686
ILE A 709
GLY A 717
LEU A 765
SER A 775
 IHZ  A1001 ( 4.8A)
IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 ( 3.9A)
IHZ  A1001 (-4.6A)
IHZ  A1001 (-3.7A)
 0.94A 6fnmA-3dkoA:
37.0		 6fnmA-3dkoA:
70.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 209
VAL A 217
ALA A 228
LYS A 230
GLU A 243
GLY A 285
LEU A 340
 ADP  A 900 (-4.6A)
ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
 0.75A 6fnmA-3g2fA:
21.0		 6fnmA-3g2fA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 217
ALA A 228
LYS A 230
GLU A 243
GLY A 285
LEU A 340
SER A 350
 ADP  A 900 (-4.3A)
ADP  A 900 (-3.4A)
ADP  A 900 (-2.8A)
ADP  A 900 ( 4.7A)
ADP  A 900 ( 4.2A)
ADP  A 900 (-4.6A)
None
 0.67A 6fnmA-3g2fA:
21.0		 6fnmA-3g2fA:
30.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
ILE A 711
THR A 713
MET A 716
GLY A 719
LEU A 767
SER A 777
 None
None
None
None
None
GOL  A 403 (-3.4A)
None
None
 0.63A 6fnmA-3kulA:
36.0		 6fnmA-3kulA:
64.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
LYS A 667
ILE A 711
THR A 713
MET A 716
LEU A 767
SER A 777
 None
 0.75A 6fnmA-3kulA:
36.0		 6fnmA-3kulA:
64.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.80A 6fnmA-3my0A:
25.7		 6fnmA-3my0A:
30.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		7 ILE A  36
VAL A  44
ALA A  57
LYS A  59
GLU A  77
ILE A 109
LEU A 163
 ANP  A 430 (-4.4A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
ANP  A 430 ( 4.4A)
None
ANP  A 430 (-4.4A)
 0.82A 6fnmA-3nieA:
21.7		 6fnmA-3nieA:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 VAL A 200
ALA A 213
GLU A 234
MET A 266
GLY A 269
LEU A 318
SER A 328
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
None
None
None
AMP  A 577 (-4.8A)
None
 0.79A 6fnmA-3nyoA:
22.8		 6fnmA-3nyoA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 VAL A 200
ALA A 213
LYS A 215
GLU A 234
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.79A 6fnmA-3nyoA:
22.8		 6fnmA-3nyoA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q4t ACTIVIN RECEPTOR
TYPE-2A

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 206
ALA A 217
LYS A 219
GLU A 232
THR A 267
GLY A 273
LEU A 329
 TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-3.6A)
TAK  A   2 (-4.6A)
 0.76A 6fnmA-3q4tA:
25.5		 6fnmA-3q4tA:
25.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 431
ALA A 443
LYS A 445
MET A 464
ILE A 487
THR A 489
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.92A 6fnmA-3sxsA:
32.6		 6fnmA-3sxsA:
36.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 431
ALA A 443
LYS A 445
MET A 464
THR A 489
GLY A 495
LEU A 543
SER A 553
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
PP2  A   1 (-3.5A)
 1.08A 6fnmA-3sxsA:
32.6		 6fnmA-3sxsA:
36.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wig DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  83
ALA A  96
LYS A  98
ILE A 142
MET A 147
GLY A 150
LEU A 198
 ANP  A 401 ( 4.3A)
ANP  A 401 (-3.2A)
ANP  A 401 (-2.7A)
CHU  A 403 (-3.8A)
None
ANP  A 401 ( 4.3A)
ANP  A 401 (-4.8A)
 0.43A 6fnmA-3wigA:
23.4		 6fnmA-3wigA:
26.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zbf PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ROS

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A1959
ALA A1978
LYS A1980
MET A2001
ILE A2024
MET A2029
GLY A2032
LEU A2086
 None
VGH  A3000 (-3.4A)
VGH  A3000 ( 4.7A)
None
None
None
VGH  A3000 (-3.5A)
VGH  A3000 (-4.3A)
 0.90A 6fnmA-3zbfA:
28.3		 6fnmA-3zbfA:
35.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ILE A 625
VAL A 633
ALA A 649
GLU A 668
MET A 700
GLY A 703
LEU A 751
SER A 761
 None
 0.65A 6fnmA-3zfxA:
39.1		 6fnmA-3zfxA:
85.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		11 ILE A 625
VAL A 633
ALA A 649
LYS A 651
GLU A 668
MET A 672
ILE A 695
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.58A 6fnmA-3zfxA:
39.1		 6fnmA-3zfxA:
85.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		12 ILE A  97
VAL A 105
ALA A 121
LYS A 123
GLU A 140
MET A 144
ILE A 167
THR A 169
MET A 172
GLY A 175
LEU A 223
SER A 233
 30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
30K  A1365 ( 3.7A)
 0.48A 6fnmA-4aw5A:
40.9		 6fnmA-4aw5A:
97.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 222
ALA A 233
LYS A 235
GLU A 248
THR A 283
GLY A 289
LEU A 343
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
None
TAK  A1507 (-3.6A)
TAK  A1507 (-3.5A)
TAK  A1507 (-4.7A)
 0.80A 6fnmA-4c02A:
25.6		 6fnmA-4c02A:
29.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2)
PF07714
(Pkinase_Tyr) 		9 ILE A 567
VAL A 575
ALA A 588
LYS A 590
GLU A 607
ILE A 634
GLY A 642
LEU A 690
SER A 700
 GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
GUI  A 901 (-3.5A)
GUI  A 901 (-4.3A)
GUI  A 901 (-3.1A)
 0.76A 6fnmA-4e93A:
35.7		 6fnmA-4e93A:
32.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 385
ALA A 400
LYS A 402
GLU A 420
MET A 424
GLY A 454
LEU A 501
SER A 511
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
0SB  A 701 (-3.5A)
0SB  A 701 (-4.4A)
0SB  A 701 (-3.2A)
 0.88A 6fnmA-4f4pA:
32.6		 6fnmA-4f4pA:
36.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fie SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00786
(PBD) 		7 ILE A 327
VAL A 335
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
 None
ANP  A1001 (-4.7A)
ANP  A1001 (-3.6A)
ANP  A1001 (-3.0A)
None
None
ANP  A1001 (-4.7A)
 0.87A 6fnmA-4fieA:
23.2		 6fnmA-4fieA:
23.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fod ALK TYROSINE KINASE
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A1130
ALA A1148
LYS A1150
ILE A1194
MET A1199
GLY A1202
LEU A1256
 0UV  A1501 (-4.5A)
0UV  A1501 (-3.4A)
0UV  A1501 (-3.7A)
None
None
0UV  A1501 (-3.6A)
0UV  A1501 (-4.6A)
 0.67A 6fnmA-4fodA:
26.3		 6fnmA-4fodA:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
ILE A 336
MET A 341
GLY A 344
LEU A 393
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
None
0J9  A 601 ( 4.1A)
0J9  A 601 (-4.5A)
 0.59A 6fnmA-4k11A:
30.6		 6fnmA-4k11A:
29.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ks8 SERINE/THREONINE-PRO
TEIN KINASE PAK 6

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A 413
VAL A 421
ALA A 434
LYS A 436
MET A 456
GLY A 487
LEU A 533
 B49  A 701 (-4.2A)
None
B49  A 701 (-3.2A)
None
None
B49  A 701 ( 3.7A)
B49  A 701 (-4.5A)
 0.78A 6fnmA-4ks8A:
24.4		 6fnmA-4ks8A:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  41
ALA A  54
LYS A  56
GLU A  70
MET A  74
ILE A  97
GLY A 105
LEU A 153
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
None
GOL  A 404 (-3.6A)
GOL  A 403 ( 4.4A)
 0.98A 6fnmA-4lg4A:
21.5		 6fnmA-4lg4A:
27.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
GLU A 310
ILE A 336
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.46A 6fnmA-4lggA:
31.5		 6fnmA-4lggA:
42.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
MET A 314
ILE A 336
MET A 341
GLY A 344
LEU A 393
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
None
VGG  A 601 ( 3.2A)
VGG  A 601 (-4.5A)
 0.65A 6fnmA-4lggA:
31.5		 6fnmA-4lggA:
42.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3

(Mus musculus) 		PF00069
(Pkinase) 		7 VAL A  36
ALA A  49
LYS A  51
THR A  95
MET A  98
GLY A 101
LEU A 150
 ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
ANP  A 401 (-3.8A)
None
None
ANP  A 401 (-4.8A)
 0.77A 6fnmA-4m69A:
23.7		 6fnmA-4m69A:
27.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 ILE A 619
VAL A 627
ALA A 644
GLU A 663
MET A 667
ILE A 690
THR A 692
MET A 695
GLY A 698
LEU A 746
 None
 0.78A 6fnmA-4p2kA:
37.5		 6fnmA-4p2kA:
65.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		9 ILE A 619
VAL A 627
ALA A 644
GLU A 663
THR A 692
MET A 695
GLY A 698
LEU A 746
SER A 756
 None
 0.88A 6fnmA-4p2kA:
37.5		 6fnmA-4p2kA:
65.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 ILE A  27
VAL A  35
ALA A  49
LYS A  51
ILE A 102
MET A 107
LEU A 156
 ANP  A 402 (-4.6A)
ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
None
None
ANP  A 402 (-4.6A)
 0.73A 6fnmA-4qnyA:
23.0		 6fnmA-4qnyA:
28.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtb MITOGEN-ACTIVATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  48
VAL A  56
ALA A  69
GLU A  88
ILE A 120
MET A 125
LEU A 173
 38Z  A 418 ( 4.4A)
None
38Z  A 418 (-3.4A)
38Z  A 418 (-3.4A)
None
None
38Z  A 418 (-4.4A)
 0.88A 6fnmA-4qtbA:
17.3		 6fnmA-4qtbA:
26.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		10 VAL A  22
ALA A  35
LYS A  37
GLU A  52
MET A  56
ILE A  79
THR A  81
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
None
None
ACP  A1264 (-4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.65A 6fnmA-4ueuA:
34.0		 6fnmA-4ueuA:
41.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbo RHODOPSIN KINASE

(Bos taurus) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 VAL A 201
ALA A 214
LYS A 216
MET A 267
GLY A 270
LEU A 321
SER A 331
 None
ANW  A 601 (-3.4A)
None
None
ANW  A 601 ( 4.5A)
ANW  A 601 (-4.9A)
ANW  A 601 ( 4.0A)
 0.80A 6fnmA-4wboA:
23.6		 6fnmA-4wboA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbr PROTEIN
FAM212A,SERINE/THREO
NINE-PROTEIN KINASE
PAK 4

(Homo sapiens) 		PF00069
(Pkinase)
PF15342
(FAM212) 		7 ILE A 327
VAL A 335
ALA A 348
LYS A 350
MET A 370
GLY A 401
LEU A 447
 None
ATP  A 601 (-4.4A)
ATP  A 601 ( 3.7A)
ATP  A 601 (-2.8A)
None
None
None
 0.89A 6fnmA-4xbrA:
19.2		 6fnmA-4xbrA:
26.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 8 VAL B 275
ALA B 288
LYS B 290
ILE B 332
THR B 334
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.43A 6fnmA-4xeyB:
27.1		 6fnmA-4xeyB:
32.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
SER A 538
 None
 0.67A 6fnmA-4xi2A:
30.7		 6fnmA-4xi2A:
26.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrl MITOGEN-ACTIVATED
PROTEIN KINASE 1

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 ILE A  29
VAL A  37
ALA A  50
LYS A  52
GLU A  69
ILE A 101
MET A 106
LEU A 154
 42A  A 402 ( 4.7A)
None
42A  A 402 (-3.2A)
42A  A 402 (-4.1A)
None
None
None
42A  A 402 ( 4.9A)
 0.76A 6fnmA-4xrlA:
23.5		 6fnmA-4xrlA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
LYS A 430
ILE A 472
THR A 474
MET A 477
GLY A 480
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.62A 6fnmA-4y93A:
31.9		 6fnmA-4y93A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 VAL A 416
ALA A 428
LYS A 430
MET A 477
GLY A 480
LEU A 528
SER A 538
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
746  A 702 ( 3.8A)
 0.78A 6fnmA-4y93A:
31.9		 6fnmA-4y93A:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci6 MITOGEN-ACTIVATED
PROTEIN KINASE 6

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		8 ILE A  69
VAL A  77
ALA A  90
LYS A  92
GLU A 110
ILE A 142
MET A 147
LEU A 196
 None
 0.63A 6fnmA-5ci6A:
22.2		 6fnmA-5ci6A:
26.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.56A 6fnmA-5j9zA:
33.2		 6fnmA-5j9zA:
34.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ILE A 639
VAL A 647
ALA A 663
ILE A 709
THR A 711
MET A 714
LEU A 765
 6P6  A1001 (-4.0A)
None
6P6  A1001 (-3.3A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
None
6P6  A1001 (-4.5A)
 0.53A 6fnmA-5l6oA:
37.5		 6fnmA-5l6oA:
86.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
VAL A 897
ALA A 909
LYS A 911
GLU A 927
MET A 959
LEU A1016
 None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
None
ATP  A1200 (-4.6A)
 0.66A 6fnmA-5lpyA:
24.0		 6fnmA-5lpyA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpy PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		7 ILE A 889
VAL A 897
ALA A 909
LYS A 911
MET A 959
GLY A 962
LEU A1016
 None
ATP  A1200 ( 4.5A)
ATP  A1200 (-3.5A)
ATP  A1200 (-3.8A)
None
ATP  A1200 ( 4.0A)
ATP  A1200 (-4.6A)
 0.61A 6fnmA-5lpyA:
24.0		 6fnmA-5lpyA:
28.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		9 ILE A 889
VAL A 897
ALA A 909
LYS A 911
GLU A 927
MET A 959
GLY A 962
LEU A1016
SER A1026
 ADP  A1200 (-4.7A)
ADP  A1200 (-4.4A)
ADP  A1200 (-3.5A)
ADP  A1200 ( 4.3A)
None
None
ADP  A1200 ( 4.0A)
ADP  A1200 (-4.7A)
ADP  A1200 ( 4.6A)
 0.78A 6fnmA-5lpzA:
23.9		 6fnmA-5lpzA:
26.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 ILE A  98
VAL A 106
ALA A 119
LYS A 121
GLU A 140
MET A 172
LEU A 221
 None
 0.74A 6fnmA-5u7qA:
20.2		 6fnmA-5u7qA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 8 VAL A  32
ALA A  45
LYS A  47
ILE A  93
THR A  95
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.62A 6fnmA-5w5jA:
19.5		 6fnmA-5w5jA:
25.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 7 VAL A  36
ALA A  49
MET A  73
MET A  99
GLY A 102
LEU A 150
SER A 160
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
None
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
VX6  A 402 (-3.3A)
 0.81A 6fnmA-5wnmA:
28.3		 6fnmA-5wnmA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1

(Homo sapiens) 		no annotation 7 ILE A 218
VAL A 226
ALA A 237
LYS A 239
GLU A 259
GLY A 294
LEU A 347
 DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
DL1  A 601 (-3.5A)
DL1  A 601 (-3.9A)
 0.82A 6fnmA-6bfnA:
24.4		 6fnmA-6bfnA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bql CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 7 ILE A 171
VAL A 179
ALA A 192
LYS A 194
GLU A 236
GLY A 273
LEU A 319
 BI9  A 501 (-4.0A)
BI9  A 501 ( 4.8A)
BI9  A 501 (-3.3A)
NH4  A 506 ( 4.4A)
NH4  A 506 (-3.0A)
BI9  A 501 (-3.3A)
BI9  A 501 (-4.7A)
 0.66A 6fnmA-6bqlA:
23.9		 6fnmA-6bqlA:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cz4 PROTEIN-TYROSINE
KINASE 6

(Homo sapiens) 		no annotation 7 VAL A 205
ALA A 217
ILE A 262
THR A 264
MET A 267
GLY A 270
LEU A 319
 FKY  A9001 ( 4.6A)
FKY  A9001 (-3.3A)
None
FKY  A9001 (-3.0A)
None
FKY  A9001 (-3.3A)
FKY  A9001 ( 4.9A)
 0.64A 6fnmA-6cz4A:
24.4		 6fnmA-6cz4A:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 VAL A 200
ALA A 211
GLU A 233
MET A 265
GLY A 268
LEU A 318
SER A 328
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.9A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
CJT  A 502 ( 4.3A)
 0.84A 6fnmA-6f3dA:
25.0		 6fnmA-6f3dA:
13.24