SIMILAR PATTERNS OF AMINO ACIDS FOR 6FN9_B_BEZB302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hra RETINOIC ACID
RECEPTOR

(Homo sapiens) 		PF00105
(zf-C4) 		4 ILE A  36
MET A  40
GLN A  61
ARG A  34
 None
 1.27A 6fn9B-1hraA:
undetectable		 6fn9B-1hraA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yb4 AMIDOHYDROLASE

(Chromobacterium
violaceum) 		PF02811
(PHP) 		4 ILE A 132
MET A 106
GLN A 105
ARG A 104
 None
 1.31A 6fn9B-2yb4A:
0.0		 6fn9B-2yb4A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u7i SPARTIN

(Homo sapiens) 		PF04212
(MIT) 		4 ILE A  13
MET A  77
GLN A  76
ARG A  75
 None
 1.17A 6fn9B-4u7iA:
7.4		 6fn9B-4u7iA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csu 4-ALPHA-GLUCANOTRANS
FERASE DPE1,
CHLOROPLASTIC/AMYLOP
LASTIC

(Arabidopsis
thaliana) 		PF02446
(Glyco_hydro_77) 		4 ILE A 418
MET A 441
GLN A 465
ARG A 433
 None
 1.47A 6fn9B-5csuA:
0.0		 6fn9B-5csuA:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exr DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT
DNA POLYMERASE ALPHA
SUBUNIT B

(Homo sapiens;
Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1)
PF08996
(zf-DNA_Pol)
PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 ILE D 520
MET D 518
GLN D 515
ARG C1358
 None
 1.32A 6fn9B-5exrD:
0.0		 6fn9B-5exrD:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gs0 TOLL-LIKE RECEPTOR 3

(Homo sapiens) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		4 ILE A 668
MET A 642
GLN A 618
ARG A 643
 None
 1.47A 6fn9B-5gs0A:
0.0		 6fn9B-5gs0A:
16.72