SIMILAR PATTERNS OF AMINO ACIDS FOR 6FK2_A_SORA302_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ARG A 198
GLU A 675
GLU A 883
ARG A 881
 None
 1.02A 6fk2A-1c7tA:
undetectable		 6fk2A-1c7tA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF03173
(CHB_HEX)
PF03174
(CHB_HEX_C) 		4 ARG A 881
GLU A 883
GLU A 675
ARG A 198
 None
 1.00A 6fk2A-1c7tA:
undetectable		 6fk2A-1c7tA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT

(Methanosarcina
barkeri) 		PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		4 ARG B2272
GLU B2255
GLU B2275
ARG B2271
 None
 1.23A 6fk2A-1e6yB:
undetectable		 6fk2A-1e6yB:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fw3 OUTER MEMBRANE
PHOSPHOLIPASE A

(Escherichia
coli) 		PF02253
(PLA1) 		4 ARG A 110
GLU A  66
GLU A 247
ARG A 258
 None
 1.31A 6fk2A-1fw3A:
undetectable		 6fk2A-1fw3A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkw DIAMINOPIMELATE
DECARBOXYLASE

(Mycobacterium
tuberculosis) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ARG A  81
GLU A  85
GLU A  47
ARG A  51
 None
 1.20A 6fk2A-1hkwA:
undetectable		 6fk2A-1hkwA:
15.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hlc HUMAN LECTIN

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A  49
GLU A  52
GLU A  68
ARG A  70
 BGC  A 999 ( 2.7A)
None
BGC  A 999 ( 2.8A)
BGC  A 999 (-4.3A)
 0.59A 6fk2A-1hlcA:
19.8		 6fk2A-1hlcA:
30.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1hlc HUMAN LECTIN

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A  70
GLU A  68
GLU A  52
ARG A  49
 BGC  A 999 (-4.3A)
BGC  A 999 ( 2.8A)
None
BGC  A 999 ( 2.7A)
 1.10A 6fk2A-1hlcA:
19.8		 6fk2A-1hlcA:
30.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kq0 METHIONINE
AMINOPEPTIDASE 2

(Homo sapiens) 		PF00557
(Peptidase_M24) 		4 ARG A 465
GLU A 470
GLU A 163
ARG A 170
 None
 1.32A 6fk2A-1kq0A:
undetectable		 6fk2A-1kq0A:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qd6 PROTEIN (OUTER
MEMBRANE
PHOSPHOLIPASE
(OMPLA))

(Escherichia
coli) 		PF02253
(PLA1) 		4 ARG C 110
GLU C  66
GLU C 247
ARG C 258
 None
 1.20A 6fk2A-1qd6C:
undetectable		 6fk2A-1qd6C:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1svd RIBULOSE-1,5-BISPHOS
PHATE
CARBOXYLASE/OXYGENAS
E LARGE SUBUNIT

(Halothiobacillus
neapolitanus) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ARG A  79
GLU A  81
GLU A 349
ARG A 351
 None
 1.28A 6fk2A-1svdA:
undetectable		 6fk2A-1svdA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF09152
(DUF1937) 		4 ARG A 106
GLU A  78
GLU A 116
ARG A   2
 None
 1.14A 6fk2A-1t1jA:
undetectable		 6fk2A-1t1jA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ule GALECTIN-2

(Coprinopsis
cinerea) 		PF00337
(Gal-bind_lectin) 		4 ARG A  55
GLU A  58
GLU A  75
ARG A  77
 NAG  A 153 ( 2.8A)
None
NAG  A 153 ( 2.8A)
NAG  A 153 (-3.5A)
 0.59A 6fk2A-1uleA:
17.3		 6fk2A-1uleA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ule GALECTIN-2

(Coprinopsis
cinerea) 		PF00337
(Gal-bind_lectin) 		4 ARG A  77
GLU A  75
GLU A  58
ARG A  55
 NAG  A 153 (-3.5A)
NAG  A 153 ( 2.8A)
None
NAG  A 153 ( 2.8A)
 0.96A 6fk2A-1uleA:
17.3		 6fk2A-1uleA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A 223
GLU A 196
GLU A  73
ARG A 271
 None
 1.24A 6fk2A-1v2dA:
undetectable		 6fk2A-1v2dA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2d GLUTAMINE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 ARG A 271
GLU A  73
GLU A 196
ARG A 223
 None
 1.07A 6fk2A-1v2dA:
undetectable		 6fk2A-1v2dA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcj PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ARG A 621
GLU A 617
GLU A 497
ARG A 611
 None
 1.14A 6fk2A-1zcjA:
undetectable		 6fk2A-1zcjA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5u COLICIN E3

(Escherichia
coli) 		PF03515
(Cloacin)
PF09000
(Cytotoxic)
PF11570
(E2R135) 		4 ARG A 306
GLU A 302
GLU A 309
ARG A 305
 None
 1.31A 6fk2A-2b5uA:
undetectable		 6fk2A-2b5uA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bjr MFP2B

(Ascaris suum) 		PF12150
(MFP2b) 		4 ARG A 243
GLU A 224
GLU A 261
ARG A 263
 None
 1.13A 6fk2A-2bjrA:
undetectable		 6fk2A-2bjrA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 ARG A 518
GLU A 478
GLU A 563
ARG A 521
 None
 1.13A 6fk2A-2d0oA:
undetectable		 6fk2A-2d0oA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
HYPOTHETICAL UPF0116
PROTEIN YHEM

(Escherichia
coli;
Escherichia
coli) 		PF02635
(DrsE)
PF02635
(DrsE) 		4 ARG A  41
GLU B  20
GLU A  42
ARG A  85
 None
 0.81A 6fk2A-2d1pA:
undetectable		 6fk2A-2d1pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1p HYPOTHETICAL UPF0163
PROTEIN YHEN
HYPOTHETICAL UPF0116
PROTEIN YHEM

(Escherichia
coli;
Escherichia
coli) 		PF02635
(DrsE)
PF02635
(DrsE) 		4 ARG A  85
GLU A  42
GLU B  20
ARG A  41
 None
 1.25A 6fk2A-2d1pA:
undetectable		 6fk2A-2d1pA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		4 ARG A 808
GLU A 810
GLU A 766
ARG A 672
 None
 0.95A 6fk2A-2q1fA:
5.2		 6fk2A-2q1fA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		4 ARG A  49
GLU A  53
GLU A  82
ARG A 196
 None
 1.32A 6fk2A-2qveA:
undetectable		 6fk2A-2qveA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0h CGL3 LECTIN

(Coprinopsis
cinerea) 		PF00337
(Gal-bind_lectin) 		4 ARG A  64
GLU A  67
GLU A  84
ARG A  86
 CTO  A 165 (-2.6A)
CTO  A 165 ( 4.7A)
CTO  A 165 (-2.7A)
CTO  A 165 ( 4.0A)
 0.51A 6fk2A-2r0hA:
16.1		 6fk2A-2r0hA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0h CGL3 LECTIN

(Coprinopsis
cinerea) 		PF00337
(Gal-bind_lectin) 		4 ARG A  86
GLU A  84
GLU A  67
ARG A  64
 CTO  A 165 ( 4.0A)
CTO  A 165 (-2.7A)
CTO  A 165 ( 4.7A)
CTO  A 165 (-2.6A)
 1.00A 6fk2A-2r0hA:
16.1		 6fk2A-2r0hA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		4 ARG A 495
GLU A 419
GLU A 605
ARG A 653
 None
 0.95A 6fk2A-2wyhA:
undetectable		 6fk2A-2wyhA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x58 PEROXISOMAL
BIFUNCTIONAL ENZYME

(Rattus
norvegicus) 		PF00378
(ECH_1)
PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ARG A 621
GLU A 617
GLU A 497
ARG A 611
 None
 1.11A 6fk2A-2x58A:
undetectable		 6fk2A-2x58A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ARG A  63
GLU A  66
GLU A  83
ARG A  85
 None
 0.70A 6fk2A-2zgkA:
16.1		 6fk2A-2zgkA:
26.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zgk ANTI-TUMOR LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ARG A  85
GLU A  83
GLU A  66
ARG A  63
 None
 1.00A 6fk2A-2zgkA:
16.1		 6fk2A-2zgkA:
26.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ayd GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 162
GLU A 165
GLU A 184
ARG A 186
 A2G  A 252 ( 3.1A)
None
A2G  A 252 (-3.0A)
GAL  A 256 ( 3.8A)
 0.31A 6fk2A-3aydA:
27.4		 6fk2A-3aydA:
97.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ayd GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 186
GLU A 184
GLU A 165
ARG A 162
 GAL  A 256 ( 3.8A)
A2G  A 252 (-3.0A)
None
A2G  A 252 ( 3.1A)
 0.96A 6fk2A-3aydA:
27.4		 6fk2A-3aydA:
97.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 ARG B 135
GLU B 132
GLU B 170
ARG B 168
 None
 1.14A 6fk2A-3bn3B:
undetectable		 6fk2A-3bn3B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn3 INTERCELLULAR
ADHESION MOLECULE 5

(Homo sapiens) 		PF03921
(ICAM_N) 		4 ARG B 168
GLU B 170
GLU B 132
ARG B 135
 None
 1.01A 6fk2A-3bn3B:
undetectable		 6fk2A-3bn3B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqh L-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE ULAE

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 ARG A  24
GLU A  12
GLU A  19
ARG A  49
 None
 0.94A 6fk2A-3cqhA:
undetectable		 6fk2A-3cqhA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fhh OUTER MEMBRANE HEME
RECEPTOR SHUA

(Shigella
dysenteriae) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 ARG A  69
GLU A 421
GLU A 448
ARG A 415
 None
 1.24A 6fk2A-3fhhA:
undetectable		 6fk2A-3fhhA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwq D-SERINE DEAMINASE

(Paraburkholderia
xenovorans) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		4 ARG A 115
GLU A 141
GLU A 271
ARG A 241
 None
 1.32A 6fk2A-3gwqA:
undetectable		 6fk2A-3gwqA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyr PHENOXAZINONE
SYNTHASE

(Streptomyces
antibioticus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ARG A 305
GLU A 238
GLU A 227
ARG A 223
 None
 1.31A 6fk2A-3gyrA:
undetectable		 6fk2A-3gyrA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jap EIF3A

(Saccharomyces
cerevisiae) 		PF00411
(Ribosomal_S11) 		4 ARG o 431
GLU o 392
GLU o 339
ARG o 363
 None
 1.05A 6fk2A-3japo:
undetectable		 6fk2A-3japo:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kdj PROTEIN PHOSPHATASE
2C 56

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		4 ARG B 227
GLU B 231
GLU B 198
ARG B 191
 None
 1.16A 6fk2A-3kdjB:
undetectable		 6fk2A-3kdjB:
19.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 239
GLU A 242
GLU A 258
ARG A 260
 NAG  A 502 ( 2.7A)
None
NAG  A 502 ( 2.7A)
NAG  A 502 (-4.0A)
 0.54A 6fk2A-3nv3A:
24.7		 6fk2A-3nv3A:
40.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nv3 GALECTIN 9 SHORT
ISOFORM VARIANT

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 260
GLU A 258
GLU A 242
ARG A 239
 NAG  A 502 (-4.0A)
NAG  A 502 ( 2.7A)
None
NAG  A 502 ( 2.7A)
 1.03A 6fk2A-3nv3A:
24.7		 6fk2A-3nv3A:
40.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojy COMPLEMENT COMPONENT
C8 BETA CHAIN

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00090
(TSP_1)
PF01823
(MACPF) 		4 ARG B 242
GLU B 301
GLU B 211
ARG B 374
 None
 1.22A 6fk2A-3ojyB:
undetectable		 6fk2A-3ojyB:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pig BETA-FRUCTOFURANOSID
ASE

(Bifidobacterium
longum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ARG A 461
GLU A 392
GLU A 360
ARG A 363
 None
 1.06A 6fk2A-3pigA:
9.9		 6fk2A-3pigA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtf UDP-GLUCOSE
6-DEHYDROGENASE

(Pyrobaculum
islandicum) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ARG A 137
GLU A 141
GLU A 101
ARG A 105
 None
 1.18A 6fk2A-3vtfA:
undetectable		 6fk2A-3vtfA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		4 ARG A  64
GLU A  67
GLU A  83
ARG A  85
 FUC  A 202 (-2.7A)
FUC  A 202 (-2.9A)
FUC  A 202 (-2.7A)
FUC  A 202 ( 4.1A)
 0.55A 6fk2A-3vv1A:
21.7		 6fk2A-3vv1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vv1 PROTEIN LEC-6

(Caenorhabditis
elegans) 		PF00337
(Gal-bind_lectin) 		4 ARG A  85
GLU A  83
GLU A  67
ARG A  64
 FUC  A 202 ( 4.1A)
FUC  A 202 (-2.7A)
FUC  A 202 (-2.9A)
FUC  A 202 (-2.7A)
 1.00A 6fk2A-3vv1A:
21.7		 6fk2A-3vv1A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg1 GALACTOSIDE-BINDING
LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ARG A  66
GLU A  69
GLU A  86
ARG A  88
 LAT  A 201 (-3.0A)
None
LAT  A 201 (-2.8A)
LAT  A 201 (-4.4A)
 0.85A 6fk2A-3wg1A:
15.8		 6fk2A-3wg1A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wg1 GALACTOSIDE-BINDING
LECTIN

(Agrocybe
aegerita) 		PF00337
(Gal-bind_lectin) 		4 ARG A  88
GLU A  86
GLU A  69
ARG A  66
 LAT  A 201 (-4.4A)
LAT  A 201 (-2.8A)
None
LAT  A 201 (-3.0A)
 0.97A 6fk2A-3wg1A:
15.8		 6fk2A-3wg1A:
24.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 239
GLU A 242
GLU A 258
ARG A 260
 GLC  A 405 (-2.7A)
GLC  A 405 ( 4.8A)
GLC  A 405 ( 2.8A)
GLC  A 405 (-4.3A)
 0.63A 6fk2A-3wv6A:
23.9		 6fk2A-3wv6A:
30.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3wv6 GALECTIN-9

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 260
GLU A 258
GLU A 242
ARG A 239
 GLC  A 405 (-4.3A)
GLC  A 405 ( 2.8A)
GLC  A 405 ( 4.8A)
GLC  A 405 (-2.7A)
 1.05A 6fk2A-3wv6A:
23.9		 6fk2A-3wv6A:
30.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 ARG A  56
GLU A 264
GLU A 105
ARG A 108
 None
 1.24A 6fk2A-3zdnA:
undetectable		 6fk2A-3zdnA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zdn MONOAMINE OXIDASE N

(Aspergillus
niger) 		PF01593
(Amino_oxidase) 		4 ARG A 108
GLU A 105
GLU A 264
ARG A  56
 None
 1.24A 6fk2A-3zdnA:
undetectable		 6fk2A-3zdnA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agv GALECTIN

(Cinachyrella) 		PF00337
(Gal-bind_lectin) 		4 ARG A  47
GLU A  53
GLU A  71
ARG A  73
 None
 0.32A 6fk2A-4agvA:
17.9		 6fk2A-4agvA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agv GALECTIN

(Cinachyrella) 		PF00337
(Gal-bind_lectin) 		4 ARG A  73
GLU A  71
GLU A  53
ARG A  47
 None
 1.07A 6fk2A-4agvA:
17.9		 6fk2A-4agvA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 ARG A 131
GLU A 128
GLU A 149
ARG A 156
 None
 1.19A 6fk2A-4dmgA:
undetectable		 6fk2A-4dmgA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		4 ARG A 548
GLU A 546
GLU A  44
ARG A 613
 None
 1.26A 6fk2A-4el8A:
undetectable		 6fk2A-4el8A:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 ARG D 331
GLU D 400
GLU D 495
ARG D 491
 None
 1.08A 6fk2A-4em6D:
undetectable		 6fk2A-4em6D:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 4 ARG D 491
GLU D 495
GLU D 400
ARG D 331
 None
 1.07A 6fk2A-4em6D:
undetectable		 6fk2A-4em6D:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00248
(Aldo_ket_red) 		4 ARG A  86
GLU A  87
GLU A 130
ARG A 128
 None
 1.32A 6fk2A-4exbA:
undetectable		 6fk2A-4exbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exb PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF00248
(Aldo_ket_red) 		4 ARG A 128
GLU A 130
GLU A  87
ARG A  86
 None
 1.01A 6fk2A-4exbA:
undetectable		 6fk2A-4exbA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fus RTX TOXINS AND
RELATED CA2+-BINDING
PROTEIN

(Hahella
chejuensis) 		PF02011
(Glyco_hydro_48) 		4 ARG A 584
GLU A 582
GLU A  72
ARG A 648
 GOL  A 804 ( 4.8A)
None
CBI  A 802 ( 3.3A)
CBI  A 802 (-3.7A)
 1.15A 6fk2A-4fusA:
undetectable		 6fk2A-4fusA:
11.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hst GLUTARYL-7-AMINOCEPH
ALOSPORANIC ACID
ACYLASE ALPHA CHAIN

(Pseudomonas) 		PF01804
(Penicil_amidase) 		4 ARG A  78
GLU A  81
GLU A 147
ARG A  73
 None
 1.17A 6fk2A-4hstA:
undetectable		 6fk2A-4hstA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		4 ARG A 199
GLU A 196
GLU A 499
ARG A 475
 None
 1.21A 6fk2A-4ia5A:
undetectable		 6fk2A-4ia5A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7m PROTEIN DOM3Z

(Mus musculus) 		PF08652
(RAI1) 		4 ARG A 171
GLU A 166
GLU A  98
ARG A 174
 None
 1.11A 6fk2A-4j7mA:
undetectable		 6fk2A-4j7mA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jre NITRITE EXTRUSION
PROTEIN 1

(Escherichia
coli) 		PF07690
(MFS_1) 		4 ARG A 394
GLU A 398
GLU A 388
ARG A 384
 None
 1.16A 6fk2A-4jreA:
undetectable		 6fk2A-4jreA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7a UNCHARACTERIZED
PROTEIN

(Bacteroides
caccae) 		PF15890
(Peptidase_Mx1) 		4 ARG A 284
GLU A 105
GLU A 287
ARG A 283
 None
 1.02A 6fk2A-4l7aA:
undetectable		 6fk2A-4l7aA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nez ENGINEERED PROTEIN
OR276

(synthetic
construct) 		no annotation 4 ARG A  46
GLU A  35
GLU A  86
ARG A 129
 None
4NE  A 202 ( 4.6A)
None
4NE  A 202 ( 4.1A)
 0.96A 6fk2A-4nezA:
undetectable		 6fk2A-4nezA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nez ENGINEERED PROTEIN
OR276

(synthetic
construct) 		no annotation 4 ARG A 129
GLU A  86
GLU A  35
ARG A  46
 4NE  A 202 ( 4.1A)
None
4NE  A 202 ( 4.6A)
None
 1.02A 6fk2A-4nezA:
undetectable		 6fk2A-4nezA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 ARG A 392
GLU A 387
GLU A 452
ARG A 456
 None
 1.01A 6fk2A-4nz0A:
undetectable		 6fk2A-4nz0A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nz0 GENOME POLYPROTEIN

(Cardiovirus A) 		PF00680
(RdRP_1) 		4 ARG A 456
GLU A 452
GLU A 387
ARG A 392
 None
 0.89A 6fk2A-4nz0A:
undetectable		 6fk2A-4nz0A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ARG A 467
GLU A 464
GLU A 177
ARG A 165
 None
 1.17A 6fk2A-4p72A:
undetectable		 6fk2A-4p72A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		4 ARG A 243
GLU A 269
GLU A 280
ARG A 272
 None
 1.12A 6fk2A-4p7hA:
undetectable		 6fk2A-4p7hA:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4plb CHIMERA PROTEIN OF
DNA GYRASE SUBUNITS
B AND A

(Staphylococcus
aureus) 		PF00521
(DNA_topoisoIV)
PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 ARG B1137
GLU B1134
GLU B1475
ARG B1479
 None
 1.32A 6fk2A-4plbB:
undetectable		 6fk2A-4plbB:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ro1 DIS3-LIKE
EXONUCLEASE 2

(Schizosaccharomyces
pombe) 		no annotation 4 ARG B 659
GLU B 663
GLU B 546
ARG B 550
 None
 0.83A 6fk2A-4ro1B:
undetectable		 6fk2A-4ro1B:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		4 ARG A 592
GLU A 590
GLU A  38
ARG A 682
 CBI  A 804 ( 4.5A)
None
CBI  A 804 (-3.5A)
CBI  A 804 (-3.5A)
 1.09A 6fk2A-5bv9A:
undetectable		 6fk2A-5bv9A:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5com PUTATIVE CONJUGATIVE
TRANSPOSON PROTEIN
TN1549-LIKE,
CTN5-ORF2

(Clostridioides
difficile) 		PF08020
(DUF1706) 		4 ARG A  77
GLU A  73
GLU A 135
ARG A 142
 None
 1.22A 6fk2A-5comA:
undetectable		 6fk2A-5comA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 ARG A1304
GLU A1301
GLU A1424
ARG A1441
 None
 1.15A 6fk2A-5cs4A:
undetectable		 6fk2A-5cs4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cs4 ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF08326
(ACC_central) 		4 ARG A1441
GLU A1424
GLU A1301
ARG A1304
 None
 1.09A 6fk2A-5cs4A:
undetectable		 6fk2A-5cs4A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 ARG A1304
GLU A1301
GLU A1424
ARG A1441
 None
 1.24A 6fk2A-5csaA:
undetectable		 6fk2A-5csaA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		4 ARG A1441
GLU A1424
GLU A1301
ARG A1304
 None
 1.31A 6fk2A-5csaA:
undetectable		 6fk2A-5csaA:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 ARG A1304
GLU A1301
GLU A1424
ARG A1441
 None
 1.25A 6fk2A-5cslA:
undetectable		 6fk2A-5cslA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		4 ARG A1441
GLU A1424
GLU A1301
ARG A1304
 None
 1.29A 6fk2A-5cslA:
undetectable		 6fk2A-5cslA:
4.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyg CYTOCHROME P450

(Marinobacter
hydrocarbonoclasticus) 		PF00067
(p450) 		4 ARG A 433
GLU A 437
GLU A 176
ARG A 180
 None
 1.30A 6fk2A-5fygA:
undetectable		 6fk2A-5fygA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5j FERREDOXIN--NADP
REDUCTASE

(Zea mays) 		PF00175
(NAD_binding_1) 		4 ARG A 100
GLU A  19
GLU A 162
ARG A 187
 None
 1.31A 6fk2A-5h5jA:
undetectable		 6fk2A-5h5jA:
17.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9p GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 162
GLU A 165
GLU A 184
ARG A 186
 TD2  A 301 (-2.8A)
TD2  A 301 ( 4.9A)
TD2  A 301 (-2.9A)
TD2  A 301 (-3.9A)
 0.12A 6fk2A-5h9pA:
29.8		 6fk2A-5h9pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5h9p GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 186
GLU A 184
GLU A 165
ARG A 162
 TD2  A 301 (-3.9A)
TD2  A 301 (-2.9A)
TD2  A 301 ( 4.9A)
TD2  A 301 (-2.8A)
 1.07A 6fk2A-5h9pA:
29.8		 6fk2A-5h9pA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jp5 GALECTIN-5

(Rattus
norvegicus) 		PF00337
(Gal-bind_lectin) 		4 ARG A  61
GLU A  64
GLU A  80
ARG A  82
 PEG  A 201 (-3.0A)
None
PEG  A 201 (-3.3A)
None
 0.50A 6fk2A-5jp5A:
24.6		 6fk2A-5jp5A:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5jp5 GALECTIN-5

(Rattus
norvegicus) 		PF00337
(Gal-bind_lectin) 		4 ARG A  82
GLU A  80
GLU A  64
ARG A  61
 None
PEG  A 201 (-3.3A)
None
PEG  A 201 (-3.0A)
 1.04A 6fk2A-5jp5A:
24.6		 6fk2A-5jp5A:
41.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nfb GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 162
GLU A 165
GLU A 184
ARG A 186
 8VT  A 301 (-2.7A)
8VT  A 301 (-3.5A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.4A)
 0.07A 6fk2A-5nfbA:
29.8		 6fk2A-5nfbA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5nfb GALECTIN-3

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		4 ARG A 186
GLU A 184
GLU A 165
ARG A 162
 8VT  A 301 (-3.4A)
8VT  A 301 (-2.7A)
8VT  A 301 (-3.5A)
8VT  A 301 (-2.7A)
 1.06A 6fk2A-5nfbA:
29.8		 6fk2A-5nfbA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 4 ARG A 171
GLU A 174
GLU A 217
ARG A 215
 None
 1.32A 6fk2A-5o0jA:
undetectable		 6fk2A-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ARG A  81
GLU A  30
GLU A 275
ARG A 523
 None
 1.29A 6fk2A-5u3cA:
undetectable		 6fk2A-5u3cA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3c CTP SYNTHASE

(Escherichia
coli) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		4 ARG A 523
GLU A 275
GLU A  30
ARG A  81
 None
 1.31A 6fk2A-5u3cA:
undetectable		 6fk2A-5u3cA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn6 OS07G0580900 PROTEIN

(Oryza sativa) 		PF00348
(polyprenyl_synt) 		4 ARG A 154
GLU A 151
GLU A 196
ARG A 217
 None
 1.28A 6fk2A-5xn6A:
undetectable		 6fk2A-5xn6A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yj6 DOCKERIN TYPE I
REPEAT-CONTAINING
PROTEIN

(Ruminiclostridium
thermocellum) 		no annotation 4 ARG A 578
GLU A 576
GLU A  76
ARG A 643
 None
None
33O  A 801 (-3.7A)
33O  A 801 ( 4.6A)
 1.29A 6fk2A-5yj6A:
undetectable		 6fk2A-5yj6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9b PLP-DEPENDENT
L-ARGININE
HYDROXYLASE MPPP

(Streptomyces
wadayamensis) 		no annotation 4 ARG A  55
GLU A  51
GLU A  63
ARG A 263
 None
 1.27A 6fk2A-6c9bA:
undetectable		 6fk2A-6c9bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 4 ARG A 351
GLU A 132
GLU A 357
ARG A 364
 None
 1.25A 6fk2A-6ci7A:
undetectable		 6fk2A-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ci7 YCAO

(Methanopyrus
kandleri) 		no annotation 4 ARG A 364
GLU A 357
GLU A 132
ARG A 351
 None
 1.14A 6fk2A-6ci7A:
undetectable		 6fk2A-6ci7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dzs HOMOSERINE
DEHYDROGENASE

(Mycolicibacterium
hassiacum) 		no annotation 4 ARG A 155
GLU A 255
GLU A 436
ARG A 269
 None
 1.22A 6fk2A-6dzsA:
undetectable		 6fk2A-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fof GALECTIN-3,GALECTIN-
3

(Homo sapiens) 		no annotation 4 ARG C 162
GLU C 165
GLU C 184
ARG C 186
 LAT  C 301 (-2.7A)
LAT  C 301 ( 4.7A)
LAT  C 301 ( 2.8A)
LAT  C 301 (-4.0A)
 0.22A 6fk2A-6fofC:
27.9		 6fk2A-6fofC:
undetectable