SIMILAR PATTERNS OF AMINO ACIDS FOR 6FGD_A_ACTA826

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		3 HIS A 207
ARG A 361
ILE A 320
 None
 0.73A 6fgdA-1bs0A:
2.2		 6fgdA-1bs0A:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		3 HIS B 291
ARG B 149
ILE B 324
 TAR  B 900 (-4.7A)
TAR  B 900 (-3.8A)
None
 0.61A 6fgdA-1ccwB:
undetectable		 6fgdA-1ccwB:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fui L-FUCOSE ISOMERASE

(Escherichia
coli) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 HIS A 554
ARG A 563
ILE A 541
 None
 0.83A 6fgdA-1fuiA:
4.0		 6fgdA-1fuiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		3 HIS A  16
ARG A 157
ILE A  15
 None
 0.69A 6fgdA-1jx2A:
undetectable		 6fgdA-1jx2A:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		3 HIS A 234
ARG A  13
ILE A 220
 None
 0.80A 6fgdA-1konA:
undetectable		 6fgdA-1konA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nuq FKSG76

(Homo sapiens) 		PF01467
(CTP_transf_like) 		3 HIS A 100
ARG A  79
ILE A  45
 None
 0.68A 6fgdA-1nuqA:
3.2		 6fgdA-1nuqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o0w RIBONUCLEASE III

(Thermotoga
maritima) 		PF00035
(dsrm)
PF14622
(Ribonucleas_3_3) 		3 HIS A  32
ARG A 121
ILE A 124
 None
 0.86A 6fgdA-1o0wA:
undetectable		 6fgdA-1o0wA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1obg PHOSPHORIBOSYLAMIDOI
MIDAZOLE-
SUCCINOCARBOXAMIDE
SYNTHASE

(Saccharomyces
cerevisiae) 		PF01259
(SAICAR_synt) 		3 HIS A 112
ARG A  73
ILE A 230
 None
 0.53A 6fgdA-1obgA:
undetectable		 6fgdA-1obgA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p6p FATTY ACID-BINDING
PROTEIN, LIVER

(Rhinella
arenarum) 		PF14651
(Lipocalin_7) 		3 HIS A  98
ARG A 120
ILE A 111
 None
 0.75A 6fgdA-1p6pA:
undetectable		 6fgdA-1p6pA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		3 HIS A 378
ARG A 474
ILE A 452
 None
 0.69A 6fgdA-1pz3A:
undetectable		 6fgdA-1pz3A:
23.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlm METHENYLTETRAHYDROME
THANOPTERIN
CYCLOHYDROLASE

(Methanopyrus
kandleri) 		PF02289
(MCH) 		3 HIS A  70
ARG A 288
ILE A 305
 None
 0.74A 6fgdA-1qlmA:
undetectable		 6fgdA-1qlmA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s4e GALACTOKINASE

(Pyrococcus
furiosus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		3 HIS A 234
ARG A 205
ILE A 206
 None
 0.85A 6fgdA-1s4eA:
undetectable		 6fgdA-1s4eA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yy5 FMS1 PROTEIN

(Saccharomyces
cerevisiae) 		PF01593
(Amino_oxidase) 		3 HIS A 383
ARG A 393
ILE A 387
 None
 0.72A 6fgdA-1yy5A:
4.7		 6fgdA-1yy5A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zp2 RNA POLYMERASE II
HOLOENZYME
CYCLIN-LIKE SUBUNIT

(Schizosaccharomyces
pombe) 		PF00134
(Cyclin_N) 		3 HIS A  95
ARG A 115
ILE A  96
 None
 0.83A 6fgdA-1zp2A:
undetectable		 6fgdA-1zp2A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zr6 GLUCOOLIGOSACCHARIDE
OXIDASE

(Sarocladium
strictum) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 HIS A  15
ARG A  90
ILE A  42
 None
 0.69A 6fgdA-1zr6A:
undetectable		 6fgdA-1zr6A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2akj FERREDOXIN--NITRITE
REDUCTASE,
CHLOROPLAST

(Spinacia
oleracea) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		3 HIS A 238
ARG A 350
ILE A 520
 None
 0.76A 6fgdA-2akjA:
2.1		 6fgdA-2akjA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Synechococcus
elongatus) 		PF00202
(Aminotran_3) 		3 HIS A  54
ARG A 303
ILE A 300
 None
 0.74A 6fgdA-2cfbA:
undetectable		 6fgdA-2cfbA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		3 HIS A 194
ARG A 114
ILE A 244
 None
 0.86A 6fgdA-2cuyA:
2.3		 6fgdA-2cuyA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cwo RNA SILENCING
SUPPRESSOR

(Beet yellows
virus) 		PF11479
(Suppressor_P21) 		3 HIS A 139
ARG A 115
ILE A 116
 None
 0.63A 6fgdA-2cwoA:
undetectable		 6fgdA-2cwoA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i5h HYPOTHETICAL PROTEIN
AF1531

(Archaeoglobus
fulgidus) 		PF04919
(DUF655) 		3 HIS A 130
ARG A 150
ILE A 147
 None
 0.87A 6fgdA-2i5hA:
undetectable		 6fgdA-2i5hA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2of5 LEUCINE-RICH REPEAT
AND DEATH
DOMAIN-CONTAINING
PROTEIN

(Homo sapiens) 		PF00531
(Death) 		3 HIS H 834
ARG H 819
ILE H 820
 None
 0.85A 6fgdA-2of5H:
undetectable		 6fgdA-2of5H:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q37 OHCU DECARBOXYLASE

(Arabidopsis
thaliana) 		PF09349
(OHCU_decarbox) 		3 HIS A  58
ARG A 153
ILE A 149
 3AL  A 200 (-3.9A)
3AL  A 200 ( 4.5A)
3AL  A 200 (-4.3A)
 0.80A 6fgdA-2q37A:
undetectable		 6fgdA-2q37A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz8 PROBABLE
TRANSCRIPTIONAL
REGULATORY PROTEIN

(Mycobacterium
tuberculosis) 		PF01037
(AsnC_trans_reg)
PF13412
(HTH_24) 		3 HIS A  90
ARG A 124
ILE A  91
 None
 0.83A 6fgdA-2qz8A:
undetectable		 6fgdA-2qz8A:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rcd UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF11533
(DUF3225) 		3 HIS A  40
ARG A  60
ILE A  56
 None
 0.81A 6fgdA-2rcdA:
undetectable		 6fgdA-2rcdA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v3c SIGNAL RECOGNITION
54 KDA PROTEIN

(Methanocaldococcus
jannaschii) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 HIS C  73
ARG C  58
ILE C  77
 None
 0.81A 6fgdA-2v3cC:
2.6		 6fgdA-2v3cC:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		3 HIS A 725
ARG A 685
ILE A 715
 None
 0.67A 6fgdA-2vwkA:
undetectable		 6fgdA-2vwkA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w7y PROBABLE SUGAR ABC
TRANSPORTER,
SUGAR-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF13416
(SBP_bac_8) 		3 HIS A 395
ARG A 207
ILE A 206
 None
A2G  A1428 (-3.3A)
None
 0.78A 6fgdA-2w7yA:
undetectable		 6fgdA-2w7yA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wal GROWTH ARREST AND
DNA-DAMAGE-INDUCIBLE
PROTEIN GADD45 GAMMA

(Homo sapiens) 		PF01248
(Ribosomal_L7Ae) 		3 HIS A  27
ARG A 100
ILE A 104
 None
 0.85A 6fgdA-2walA:
undetectable		 6fgdA-2walA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wdw PUTATIVE HEXOSE
OXIDASE

(Nonomuraea
gerenzanensis) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 HIS A 206
ARG A 194
ILE A 196
 None
 0.44A 6fgdA-2wdwA:
undetectable		 6fgdA-2wdwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wk8 CAI-1 AUTOINDUCER
SYNTHASE

(Vibrio cholerae) 		PF00155
(Aminotran_1_2) 		3 HIS A 205
ARG A 358
ILE A 317
 PLP  A 600 (-3.9A)
None
None
 0.88A 6fgdA-2wk8A:
undetectable		 6fgdA-2wk8A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5f ASPARTATE_TYROSINE_P
HENYLALANINE
PYRIDOXAL-5'
PHOSPHATE-DEPENDENT
AMINOTRANSFERASE

(Staphylococcus
aureus) 		PF00155
(Aminotran_1_2) 		3 HIS A 357
ARG A 428
ILE A 424
 None
 0.86A 6fgdA-2x5fA:
undetectable		 6fgdA-2x5fA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2b SERINE
PALMITOYLTRANSFERASE

(Sphingobacterium
multivorum) 		PF00155
(Aminotran_1_2) 		3 HIS A 213
ARG A 367
ILE A 326
 PLP  A 400 (-4.1A)
None
None
 0.81A 6fgdA-3a2bA:
2.4		 6fgdA-3a2bA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 HIS A 558
ARG A 567
ILE A 545
 None
 0.52A 6fgdA-3a9sA:
6.3		 6fgdA-3a9sA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ajb PEROXISOMAL
BIOGENESIS FACTOR 3

(Homo sapiens) 		PF04882
(Peroxin-3) 		3 HIS A 334
ARG A 114
ILE A 333
 None
 0.84A 6fgdA-3ajbA:
undetectable		 6fgdA-3ajbA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqi FERROCHELATASE

(Homo sapiens) 		PF00762
(Ferrochelatase) 		3 HIS A 388
ARG A 184
ILE A 186
 None
 0.86A 6fgdA-3aqiA:
6.4		 6fgdA-3aqiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3av6 DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC)
PF12047
(DNMT1-RFD) 		3 HIS A1415
ARG A1548
ILE A1380
 None
 0.70A 6fgdA-3av6A:
2.4		 6fgdA-3av6A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddn D-3-PHOSPHOGLYCERATE
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00389
(2-Hacid_dh)
PF01842
(ACT)
PF02826
(2-Hacid_dh_C) 		3 HIS A 101
ARG A 152
ILE A 100
 None
 0.80A 6fgdA-3ddnA:
3.6		 6fgdA-3ddnA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm5 SIGNAL RECOGNITION
54 KDA PROTEIN

(Pyrococcus
furiosus) 		PF00448
(SRP54)
PF02881
(SRP54_N)
PF02978
(SRP_SPB) 		3 HIS A  74
ARG A  59
ILE A  78
 None
 0.80A 6fgdA-3dm5A:
4.5		 6fgdA-3dm5A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 HIS A 155
ARG A 127
ILE A 236
 EPE  A 401 (-4.4A)
None
None
 0.86A 6fgdA-3ec7A:
3.5		 6fgdA-3ec7A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en8 UNCHARACTERIZED
NTF-2 LIKE PROTEIN

(Paraburkholderia
xenovorans) 		PF12680
(SnoaL_2) 		3 HIS A 104
ARG A  43
ILE A  34
 ACT  A 129 ( 4.5A)
None
ACT  A 129 (-4.3A)
 0.64A 6fgdA-3en8A:
undetectable		 6fgdA-3en8A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g64 PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
coelicolor) 		PF00378
(ECH_1) 		3 HIS A 172
ARG A 190
ILE A 191
 None
 0.86A 6fgdA-3g64A:
undetectable		 6fgdA-3g64A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		3 HIS A 480
ARG A 453
ILE A 464
 None
 0.74A 6fgdA-3higA:
undetectable		 6fgdA-3higA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 HIS B 639
ARG B 545
ILE B 581
 None
 0.43A 6fgdA-3hkzB:
undetectable		 6fgdA-3hkzB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i45 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL
PROTEIN

(Rhodospirillum
rubrum) 		PF13458
(Peripla_BP_6) 		3 HIS A  75
ARG A  45
ILE A   6
 None
 0.76A 6fgdA-3i45A:
3.6		 6fgdA-3i45A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3imh GALACTOSE-1-EPIMERAS
E

(Lactobacillus
acidophilus) 		PF01263
(Aldose_epim) 		3 HIS A 100
ARG A  75
ILE A  99
 GOL  A 340 (-4.2A)
GOL  A 341 ( 3.2A)
None
 0.87A 6fgdA-3imhA:
undetectable		 6fgdA-3imhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jyo QUINATE/SHIKIMATE
DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF08501
(Shikimate_dh_N) 		3 HIS A 257
ARG A 277
ILE A 256
 None
 0.59A 6fgdA-3jyoA:
3.8		 6fgdA-3jyoA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l76 ASPARTOKINASE

(Synechocystis
sp. PCC 6803) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		3 HIS A 307
ARG A 450
ILE A 306
 None
 0.74A 6fgdA-3l76A:
undetectable		 6fgdA-3l76A:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lk6 LIPOPROTEIN YBBD

(Bacillus
subtilis) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		3 HIS A 222
ARG A 191
ILE A 188
 PEG  A 645 (-3.3A)
PEG  A 645 ( 3.5A)
PEG  A 645 ( 4.8A)
 0.81A 6fgdA-3lk6A:
5.2		 6fgdA-3lk6A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfw FLAVIN
REDUCTASE-LIKE,
FMN-BINDING PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF01613
(Flavin_Reduct) 		3 HIS A 116
ARG A 101
ILE A 109
 None
 0.55A 6fgdA-3nfwA:
undetectable		 6fgdA-3nfwA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o7j OHCU DECARBOXYLASE

(Klebsiella
pneumoniae) 		PF09349
(OHCU_decarbox) 		3 HIS A  67
ARG A 159
ILE A 155
 None
None
2AL  A 451 (-4.1A)
 0.87A 6fgdA-3o7jA:
undetectable		 6fgdA-3o7jA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os7 GALACTOSE
MUTAROTASE-LIKE
PROTEIN

(Clostridium
acetobutylicum) 		PF01263
(Aldose_epim) 		3 HIS A 108
ARG A  81
ILE A 107
 TLA  A 401 (-3.9A)
TLA  A 401 ( 4.1A)
None
 0.88A 6fgdA-3os7A:
undetectable		 6fgdA-3os7A:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ou6 SAM-DEPENDENT
METHYLTRANSFERASE

(Streptomyces
luridus) 		PF13649
(Methyltransf_25) 		3 HIS A 119
ARG A 168
ILE A 178
 SO4  A 301 (-4.0A)
SO4  A 301 (-2.8A)
None
 0.77A 6fgdA-3ou6A:
undetectable		 6fgdA-3ou6A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		3 HIS A  54
ARG A 180
ILE A 136
 None
 0.82A 6fgdA-3q9cA:
3.0		 6fgdA-3q9cA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s5k FALCILYSIN

(Plasmodium
falciparum) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C)
PF08367
(M16C_assoc) 		3 HIS A 133
ARG A1043
ILE A 239
 ZN  A1194 (-4.0A)
None
None
 0.73A 6fgdA-3s5kA:
undetectable		 6fgdA-3s5kA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		3 HIS A 155
ARG A 212
ILE A 181
 None
 0.51A 6fgdA-3swdA:
undetectable		 6fgdA-3swdA:
24.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7s PUTATIVE
METHYLTRANSFERASE

(Bacteroides
vulgatus) 		PF13649
(Methyltransf_25) 		3 HIS A 234
ARG A 217
ILE A 230
 None
 0.87A 6fgdA-3t7sA:
undetectable		 6fgdA-3t7sA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqo CYSTEINYL-TRNA
SYNTHETASE

(Coxiella
burnetii) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		3 HIS A  98
ARG A 114
ILE A  94
 None
 0.85A 6fgdA-3tqoA:
2.8		 6fgdA-3tqoA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsm OCCLUSION-DERIVED
VIRUS ENVELOPE
PROTEIN E66

(Autographa
californica
multiple
nucleopolyhedrovirus) 		PF04850
(Baculo_E66) 		3 HIS A 205
ARG A 159
ILE A 155
 None
 0.77A 6fgdA-3vsmA:
undetectable		 6fgdA-3vsmA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wr7 SPERMIDINE
N1-ACETYLTRANSFERASE

(Escherichia
coli) 		PF13302
(Acetyltransf_3) 		3 HIS A  77
ARG A  56
ILE A  75
 None
 0.84A 6fgdA-3wr7A:
2.1		 6fgdA-3wr7A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4auk RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M

(Escherichia
coli) 		PF01728
(FtsJ) 		3 HIS A 351
ARG A 208
ILE A 200
 None
 0.74A 6fgdA-4aukA:
undetectable		 6fgdA-4aukA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2g GH3-1 AUXIN
CONJUGATING ENZYME

(Vitis vinifera) 		PF03321
(GH3) 		3 HIS A 372
ARG A 434
ILE A 417
 None
 0.67A 6fgdA-4b2gA:
undetectable		 6fgdA-4b2gA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c22 L-FUCOSE ISOMERASE

(Streptococcus
pneumoniae) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		3 HIS A 551
ARG A 560
ILE A 538
 None
 0.65A 6fgdA-4c22A:
7.2		 6fgdA-4c22A:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cxh ELONGATION FACTOR 1A

(Oryctolagus
cuniculus) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		3 HIS A  94
ARG A  68
ILE A  70
 A  c4567 ( 4.3A)
A  c4567 ( 4.5A)
None
 0.60A 6fgdA-4cxhA:
2.6		 6fgdA-4cxhA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d90 EGF-LIKE REPEAT AND
DISCOIDIN I-LIKE
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00008
(EGF) 		3 HIS A 115
ARG A  96
ILE A 114
 None
 0.56A 6fgdA-4d90A:
undetectable		 6fgdA-4d90A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i0p HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DO ALPHA
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		3 HIS C  69
ARG C  76
ILE C  72
 None
 0.76A 6fgdA-4i0pC:
undetectable		 6fgdA-4i0pC:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iw7 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Francisella
tularensis) 		PF00155
(Aminotran_1_2) 		3 HIS A 188
ARG A 344
ILE A 303
 None
 0.71A 6fgdA-4iw7A:
undetectable		 6fgdA-4iw7A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 HIS A 155
ARG A 127
ILE A 237
 None
 0.74A 6fgdA-4l9rA:
3.2		 6fgdA-4l9rA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lct COP9 SIGNALOSOME
COMPLEX SUBUNIT 1

(Arabidopsis
thaliana) 		PF01399
(PCI)
PF10602
(RPN7) 		3 HIS A 326
ARG A  51
ILE A 325
 None
 0.76A 6fgdA-4lctA:
undetectable		 6fgdA-4lctA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 HIS A 648
ARG A 600
ILE A 651
 None
 0.76A 6fgdA-4oliA:
undetectable		 6fgdA-4oliA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tm5 D-AMINO ACID
AMINOTRANSFERASE

(Burkholderia
thailandensis) 		PF01063
(Aminotran_4) 		3 HIS A  62
ARG A 225
ILE A 224
 LLP  A 165 ( 4.8A)
LLP  A 165 ( 4.0A)
LLP  A 165 ( 3.7A)
 0.79A 6fgdA-4tm5A:
undetectable		 6fgdA-4tm5A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4u90 GEPHYRIN

(Rattus
norvegicus) 		PF00994
(MoCF_biosynth)
PF03453
(MoeA_N)
PF03454
(MoeA_C) 		3 HIS A 476
ARG A 644
ILE A 649
 None
 0.09A 6fgdA-4u90A:
50.7		 6fgdA-4u90A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		3 HIS A  36
ARG A 250
ILE A 252
 None
 0.78A 6fgdA-4zasA:
undetectable		 6fgdA-4zasA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zm6 N-ACETYL-BETA-D
GLUCOSAMINIDASE

(Rhizomucor
miehei) 		PF00583
(Acetyltransf_1)
PF00933
(Glyco_hydro_3) 		3 HIS A 180
ARG A 149
ILE A 146
 None
 0.87A 6fgdA-4zm6A:
5.2		 6fgdA-4zm6A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwe DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		3 HIS A 123
ARG A 318
ILE A 122
 None
 0.87A 6fgdA-4zweA:
undetectable		 6fgdA-4zweA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ao0 DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1

(Homo sapiens) 		PF01966
(HD) 		3 HIS A 123
ARG A 318
ILE A 122
 None
 0.65A 6fgdA-5ao0A:
undetectable		 6fgdA-5ao0A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0y EXOSOME COMPLEX
EXONUCLEASE RRP6

(Saccharomyces
cerevisiae) 		PF00570
(HRDC)
PF01612
(DNA_pol_A_exo1) 		3 HIS A 493
ARG A 455
ILE A 452
 None
 0.66A 6fgdA-5c0yA:
undetectable		 6fgdA-5c0yA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxf ENVELOPE
GLYCOPROTEIN B

(Human
betaherpesvirus
5) 		PF00606
(Glycoprotein_B)
PF17416
(Glycoprot_B_PH1)
PF17417
(Glycoprot_B_PH2) 		3 HIS A 319
ARG A 141
ILE A 305
 None
 0.79A 6fgdA-5cxfA:
undetectable		 6fgdA-5cxfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fnu KELCH-LIKE
ECH-ASSOCIATED
PROTEIN 1

(Mus musculus) 		PF01344
(Kelch_1) 		3 HIS A 436
ARG A 415
ILE A 461
 None
L6I  A1615 (-4.0A)
None
 0.76A 6fgdA-5fnuA:
undetectable		 6fgdA-5fnuA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gut DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Mus musculus) 		PF00145
(DNA_methylase)
PF01426
(BAH) 		3 HIS A1415
ARG A1548
ILE A1380
 None
 0.77A 6fgdA-5gutA:
3.0		 6fgdA-5gutA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i0p BETA-LACTAMASE
DOMAIN PROTEIN

(Burkholderia
ambifaria) 		PF00753
(Lactamase_B) 		3 HIS A 152
ARG A 345
ILE A 353
 None
 0.80A 6fgdA-5i0pA:
undetectable		 6fgdA-5i0pA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Saccharomyces
cerevisiae) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 HIS B 740
ARG B 605
ILE B 639
 None
 0.70A 6fgdA-5ip9B:
undetectable		 6fgdA-5ip9B:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k3j ACYL-COENZYME A
OXIDASE

(Caenorhabditis
elegans) 		PF01756
(ACOX)
PF02770
(Acyl-CoA_dh_M)
PF14749
(Acyl-CoA_ox_N) 		3 HIS A 109
ARG A 141
ILE A  77
 None
 0.81A 6fgdA-5k3jA:
undetectable		 6fgdA-5k3jA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k8d COAGULATION FACTOR
VIII,IG GAMMA-1
CHAIN C REGION

(Homo sapiens) 		PF00754
(F5_F8_type_C)
PF07731
(Cu-oxidase_2) 		3 HIS B2005
ARG B1917
ILE B1882
 CU  B2610 (-3.6A)
None
None
 0.80A 6fgdA-5k8dB:
undetectable		 6fgdA-5k8dB:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B

(Mus musculus) 		PF00149
(Metallophos) 		3 HIS A 387
ARG A 381
ILE A 388
 None
 0.58A 6fgdA-5karA:
undetectable		 6fgdA-5karA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ku5 SENSOR KINASE CUSS

(Escherichia
coli) 		no annotation 3 HIS A 176
ARG A 149
ILE A 173
 AG  A 202 (-3.4A)
None
None
 0.88A 6fgdA-5ku5A:
undetectable		 6fgdA-5ku5A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		3 HIS B1025
ARG B 822
ILE B1028
 None
 0.75A 6fgdA-5kyuB:
3.0		 6fgdA-5kyuB:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n94 CG9323, ISOFORM A

(Drosophila
melanogaster) 		no annotation 3 HIS A 698
ARG A 705
ILE A 701
 None
 0.88A 6fgdA-5n94A:
3.0		 6fgdA-5n94A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN

(Chaetomium
thermophilum) 		PF12569
(NARP1)
PF13432
(TPR_16) 		3 HIS A 527
ARG A 125
ILE A 122
 None
 0.70A 6fgdA-5nnpA:
undetectable		 6fgdA-5nnpA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odo ISOMERASE

(Rhodococcus
erythropolis) 		no annotation 3 HIS A 471
ARG A 418
ILE A 429
 None
 0.47A 6fgdA-5odoA:
3.3		 6fgdA-5odoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 HIS T 353
ARG T 311
ILE T 310
 None
 0.79A 6fgdA-5ojsT:
undetectable		 6fgdA-5ojsT:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opj RHAMNOGALACTURONAN
LYASE

(Bacteroides
thetaiotaomicron) 		no annotation 3 HIS A 508
ARG A 524
ILE A 503
 None
 0.72A 6fgdA-5opjA:
undetectable		 6fgdA-5opjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uct ENDORIBONUCLEASE
MAZF3

(Mycobacterium
tuberculosis) 		PF02452
(PemK_toxin) 		3 HIS A   5
ARG A  24
ILE A  17
 None
 0.84A 6fgdA-5uctA:
undetectable		 6fgdA-5uctA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v07 EXONUCLEASE 1

(Homo sapiens) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		3 HIS Z 131
ARG Z 138
ILE Z 134
 None
 0.84A 6fgdA-5v07Z:
2.2		 6fgdA-5v07Z:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 3 HIS C 405
ARG C 398
ILE C 402
 None
 0.85A 6fgdA-5v8fC:
undetectable		 6fgdA-5v8fC:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vxc CITRATE LYASE
SUBUNIT BETA-LIKE
PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		no annotation 3 HIS A  40
ARG A  45
ILE A  43
 None
 0.87A 6fgdA-5vxcA:
undetectable		 6fgdA-5vxcA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 HIS B 740
ARG B 598
ILE B 632
 None
 0.66A 6fgdA-5xogB:
undetectable		 6fgdA-5xogB:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y51 -

(-) 		no annotation 3 HIS A  34
ARG A  67
ILE A  64
 None
 0.71A 6fgdA-5y51A:
2.7		 6fgdA-5y51A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yt4 GALECTIN-10

(Homo sapiens) 		no annotation 3 HIS A  41
ARG A  67
ILE A  50
 None
 0.88A 6fgdA-5yt4A:
undetectable		 6fgdA-5yt4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6exv DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB2

(Sus scrofa) 		no annotation 3 HIS B 695
ARG B 592
ILE B 627
 None
 0.80A 6fgdA-6exvB:
undetectable		 6fgdA-6exvB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2

(Saccharomyces
cerevisiae) 		no annotation 3 HIS B 672
ARG B 580
ILE B 614
 None
 0.67A 6fgdA-6f42B:
undetectable		 6fgdA-6f42B:
undetectable